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Gene Review

LCP1  -  lymphocyte cytosolic protein 1 (L-plastin)

Homo sapiens

Synonyms: CP64, HEL-S-37, L-PLASTIN, L-plastin, LC64P, ...
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Disease relevance of LCP1


Psychiatry related information on LCP1

  • METHOD: They measured the number of lymphocyte cytosolic glucocorticoid receptors and plasma cortisol concentrations in 15 consecutively admitted male combat Vietnam veterans with PTSD and in a normal comparison group of 11 subjects [5].

High impact information on LCP1


Chemical compound and disease context of LCP1


Biological context of LCP1


Anatomical context of LCP1


Associations of LCP1 with chemical compounds


Physical interactions of LCP1

  • Our recent finding that grancalcin interacts with L-plastin, a protein known to have actin bundling activity, suggests that grancalcin may play a role in regulation of adherence and migration of neutrophils [17].
  • ALP bound to the actin-bundling protein L-plastin and down-modulated filamentous actin assembly in response to stimulation with IgG-coated latex beads in granulocytes [18].
  • The biochemical characteristics (m.w. and isoelectric point) of p67 are identical with those of the actin binding protein L-plastin (Fimbrin), a cytoplasmic protein that contains two Ca2+ binding sites and a calmodulin binding domain [19].

Regulatory relationships of LCP1


Other interactions of LCP1

  • Low birthweight infants (< or =2500 g) received LCP1 formula (n = 16; 0.31% 18:3 omega6, 0.17% 20:5 omega3 and 0.20% 22:6 omega3) or LCP2 formula (n = 13; 0.32% 18:3 omega6, 0.34% 20:5 omega3 and 0.43% 22:6 omega3) [21].
  • This result indicates that the gene for LCP1 is closely linked to the ESD locus, which is assigned to the chromosomal region 13q14.11 [1].
  • This was substantiated by co-immunoprecipitation of grancalcin by anti-L-plastin antibodies and vice versa [22].
  • Depletion of intracellular calcium did not affect FcgammaRII-activated L-plastin phosphorylation, demonstrating that any potential regulation of plastin function by calcium did not affect its phosphorylation [12].
  • The leukocyte protein L-plastin induces proliferation, invasion and loss of E-cadherin expression in colon cancer cells [3].

Analytical, diagnostic and therapeutic context of LCP1


  1. Evidence for the close linkage between lymphocyte cytosol polypeptide with molecular weight of 64,000 (LCP1) and esterase D. Kondo, I., Hamaguchi, H. Am. J. Hum. Genet. (1985) [Pubmed]
  2. Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells. Lin, C.S., Park, T., Chen, Z.P., Leavitt, J. J. Biol. Chem. (1993) [Pubmed]
  3. The leukocyte protein L-plastin induces proliferation, invasion and loss of E-cadherin expression in colon cancer cells. Foran, E., McWilliam, P., Kelleher, D., Croke, D.T., Long, A. Int. J. Cancer (2006) [Pubmed]
  4. Discovery and characterization of two novel human cancer-related proteins using two-dimensional gel electrophoresis. Leavitt, J. Electrophoresis (1994) [Pubmed]
  5. Lymphocyte glucocorticoid receptor number in posttraumatic stress disorder. Yehuda, R., Lowy, M.T., Southwick, S.M., Shaffer, D., Giller, E.L. The American journal of psychiatry. (1991) [Pubmed]
  6. Functional differences between L- and T-plastin isoforms. Arpin, M., Friederich, E., Algrain, M., Vernel, F., Louvard, D. J. Cell Biol. (1994) [Pubmed]
  7. Fimbrin is a homologue of the cytoplasmic phosphoprotein plastin and has domains homologous with calmodulin and actin gelation proteins. de Arruda, M.V., Watson, S., Lin, C.S., Leavitt, J., Matsudaira, P. J. Cell Biol. (1990) [Pubmed]
  8. A role for the actin-bundling protein L-plastin in the regulation of leukocyte integrin function. Jones, S.L., Wang, J., Turck, C.W., Brown, E.J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  9. Upregulation of L-plastin gene by testosterone in breast and prostate cancer cells: identification of three cooperative androgen receptor-binding sequences. Lin, C.S., Lau, A., Yeh, C.C., Chang, C.H., Lue, T.F. DNA Cell Biol. (2000) [Pubmed]
  10. Steroid hormone induction and expression patterns of L-plastin in normal and carcinomatous prostate tissues. Zheng, J., Rudra-Ganguly, N., Miller, G.J., Moffatt, K.A., Cote, R.J., Roy-Burman, P. Am. J. Pathol. (1997) [Pubmed]
  11. A case report of a patient with retinoblastoma and chromosome 13q deletion: assignment of a new gene (gene for LCP1) on human chromosome 13. Kondo, I., Shin, K., Honmura, S., Nakajima, H., Yamamura, E., Satoh, H., Terauchi, M., Usuki, Y., Takita, H., Hamaguchi, H. Hum. Genet. (1985) [Pubmed]
  12. FcgammaRII-mediated adhesion and phagocytosis induce L-plastin phosphorylation in human neutrophils. Jones, S.L., Brown, E.J. J. Biol. Chem. (1996) [Pubmed]
  13. Identification of I-plastin, a human fimbrin isoform expressed in intestine and kidney. Lin, C.S., Shen, W., Chen, Z.P., Tu, Y.H., Matsudaira, P. Mol. Cell. Biol. (1994) [Pubmed]
  14. Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain. Lin, C.S., Aebersold, R.H., Leavitt, J. Mol. Cell. Biol. (1990) [Pubmed]
  15. Regulation of synthesis of the transformation-induced protein, leukocyte plastin, by ovarian steroid hormones. Leavitt, J., Chen, Z.P., Lockwood, C.J., Schatz, F. Cancer Res. (1994) [Pubmed]
  16. Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A. Wang, J., Brown, E.J. J. Biol. Chem. (1999) [Pubmed]
  17. Crystal structure of human grancalcin, a member of the penta-EF-hand protein family. Jia, J., Han, Q., Borregaard, N., Lollike, K., Cygler, M. J. Mol. Biol. (2000) [Pubmed]
  18. Antileukoproteinase: modulation of neutrophil function and therapeutic effects on anti-type II collagen antibody-induced arthritis. Sehnert, B., Cavcic, A., Böhm, B., Kalden, J.R., Nandakumar, K.S., Holmdahl, R., Burkhardt, H. Arthritis Rheum. (2004) [Pubmed]
  19. Serine phosphorylation of a 67-kDa protein in human T lymphocytes represents an accessory receptor-mediated signaling event. Henning, S.W., Meuer, S.C., Samstag, Y. J. Immunol. (1994) [Pubmed]
  20. N-Formyl peptide receptor subtypes in human neutrophils activate L-plastin phosphorylation through different signal transduction intermediates. Paclet, M.H., Davis, C., Kotsonis, P., Godovac-Zimmermann, J., Segal, A.W., Dekker, L.V. Biochem. J. (2004) [Pubmed]
  21. Does supplementation of formula with evening primrose and fish oils augment long chain polyunsaturated fatty acid status of low birthweight infants to that of breast-fed counterparts? Woltil, H.A., van Beusekom, C.M., Schaafsma, A., Okken, A., Muskiet, F.A. Prostaglandins Leukot. Essent. Fatty Acids (1999) [Pubmed]
  22. Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner. Lollike, K., Johnsen, A.H., Durussel, I., Borregaard, N., Cox, J.A. J. Biol. Chem. (2001) [Pubmed]
  23. Molecular cloning of three cDNAs that encode cysteine proteinases in the digestive gland of the American lobster (Homarus americanus). Laycock, M.V., MacKay, R.M., Di Fruscio, M., Gallant, J.W. FEBS Lett. (1991) [Pubmed]
  24. Sequence analysis and expression of a mRNA for a larval-specific cuticular protein, LCP1, from Helicoverpa armigera. Henry, S., Hobbs, A. Insect Mol. Biol. (1999) [Pubmed]
  25. Activation of the leukocyte plastin gene occurs in most human cancer cells. Park, T., Chen, Z.P., Leavitt, J. Cancer Res. (1994) [Pubmed]
  26. Trace determination of carbendazim, fuberidazole and thiabendazole in water by application of multivariate calibration to cross-sections of three-dimensional excitation-emission matrix fluorescence. Picón Zamora, D., Martínez Galera, M., Garrido Frenich, A., Martínez Vidal, J.L. The Analyst. (2000) [Pubmed]
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