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Gene Review

POTEKP  -  POTE ankyrin domain family, member K,...

Homo sapiens

Synonyms: ACT, ACTBL3, FKSG30, Kappa-actin, POTE ankyrin domain family member K, ...
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Disease relevance of FKSG30


High impact information on FKSG30

  • The distribution of the proteins in different species of bacteria, and the similarity of their sequence to eukaryotic actins, suggest that the MreB-like proteins have a cytoskeletal, actin-like role in bacterial cell morphogenesis [1].
  • On the one hand, the determination of the structure of a bacterial actin-like protein MreB reveals the prokaryotic origins of the actin cytoskeleton, whereas on the other, cryo-electron microscopy and crystallography have yielded reconstructions of many actin crosslinking, regulatory and binding proteins in complex with F-actin [6].
  • ParM, the actin-like ATPase of plasmid R1, forms dynamic filaments that segregate plasmids paired at mid-cell to daughter cells [7].
  • By using fluorescently labeled phalloidin we have examined, at the light microscope level, the three-dimensional distribution and reorganization of actin-like microfilaments (mfs) during plant cell cycle and differentiation [8].
  • The latter technique reveals that actin-like microfilaments are identifiable in spindles of glycerinated cells before and after addition of S-1 or HMM [9].

Chemical compound and disease context of FKSG30


Biological context of FKSG30

  • Biogenesis of actin-like bacterial cytoskeletal filaments destined for positioning prokaryotic magnetic organelles [11].
  • This revealed a structural flexibility that has previously been described as a "butterfly-like" cleft opening around the active site in other actin-like superfamily proteins [12].
  • The high-resolution crystal structure of the putative Aquifex aeolicus PPX/GPPA phosphatase from the actin-like ATPase domain superfamily has been determined, providing the first insights to features of the common catalytic core of the PPX/GPPA family [12].
  • It is concluded that microfilaments in theca fibroblasts are actin-like and may contract to provide the mechanism of expulsion for the oocyte during ovulation [13].
  • The presence of both actin-like and myosin-like proteins would be consistent with a role in gliding and other cell motility processes of this parasite [14].

Anatomical context of FKSG30

  • It is suggested that cytoplasmic and perinuclear NGF may be be in contact with a pool of tubulin or actin-like proteins in their soluble or organized form and play a key role in the process of arrest of division and neurite growth [15].
  • Treatment of the membranes of labeled cells in a low ionic strength alkaline medium did not alter radioactive peaks and demonstrated that Peak C differed from the actin-like membrane protein [16].
  • It has been suggested that angiogenin binds to an actin-like molecule present on the surface of endothelial cells [17].
  • It is suggested that actin-like filaments are localized in the region of the fibrous collar and in the epiplasm, and that these are involved in tentacle retraction; whilst the microtubules of the axoneme are concerned with feeding, and play only a cytoskeletal role in the contractile mechanism [18].
  • An actin-like protein was purified to apparent homogeneity from chick-embryo homogenates and chick-embryo fibroblasts by the use of poly-L-proline-agarose affinity chromatography; we therefore refer to this protein as PBP (poly-L-proline-binding protein) [19].

Associations of FKSG30 with chemical compounds


Physical interactions of FKSG30


Other interactions of FKSG30

  • Two genetically closely related sequences, FKSG30 and an actin-like sequence in the Cat Eye syndrome region, were found to cluster with the kappa-actins [24].
  • The actin-like protein, component 5, is identical with human uterine actin in its ability to form 50-70-A filaments to stimulate myosin ATPase activity, and to bind rabbit heavy meromyoson specit heavy meromyosin specifically [25].
  • We propose that this third actin-like protein is probably smooth muscle alpha-actin and that different expressions of this third actin may possibly serve as a sensitive biochemical marker for the diagnosis of human malignant melanoma [5].

Analytical, diagnostic and therapeutic context of FKSG30

  • Previous studies have identified an "actin-like" protein in human sperm by indirect immunofluorescence microscopy with various probes, but no real biochemical confirmation of actin was made [26].
  • Identification of actin-like proteins in alcoholic hyaline by immunofluorescence [27].
  • Further characterisation of this protein by two-dimensional gel electrophoresis suggested that it is an actin-like polypeptide [28].
  • Actin and/or actin-like protein have been localized in the cellular and acellular components of the glomerular walls of mouse kidney by means of immunoelectron microscopy, employing human antibodies to smooth muscle (SMA) [29].
  • When a planarian is induced to regenerate by head amputation, the immunostaining of the alpha-sm actin-like molecule becomes important in the area of growing blastema, reaching a maximum between 70-120 hours after injury [30].


  1. Control of cell shape in bacteria: helical, actin-like filaments in Bacillus subtilis. Jones, L.J., Carballido-López, R., Errington, J. Cell (2001) [Pubmed]
  2. Increased expression of actin-like protein in human and ethylnitrosourea-induced tumors of the nervous system. Toh, B.H., Qvist, R., Randell, V.B., Elrick, W.L. Cancer Res. (1977) [Pubmed]
  3. The structure of the cytoplasmic domain of EpsL, an inner membrane component of the type II secretion system of Vibrio cholerae: an unusual member of the actin-like ATPase superfamily. Abendroth, J., Bagdasarian, M., Sandkvist, M., Hol, W.G. J. Mol. Biol. (2004) [Pubmed]
  4. Ultrastructural comparison of the interface between epithelium and stroma in basal cell carcinoma and control human skin. McNutt, N.S. Lab. Invest. (1976) [Pubmed]
  5. Differential expression of smooth muscle alpha-like actin between benign and malignant human pigment tissues. Taniguchi, S., Inoue, M., Nakayama, J., Sadano, H., Hori, Y., Baba, T. Cancer Lett. (1989) [Pubmed]
  6. Structural insights into actin-binding, branching and bundling proteins. Winder, S.J. Curr. Opin. Cell Biol. (2003) [Pubmed]
  7. Plasmid segregation mechanisms. Ebersbach, G., Gerdes, K. Annu. Rev. Genet. (2005) [Pubmed]
  8. Microfilaments: dynamic arrays in higher plant cells. Seagull, R.W., Falconer, M.M., Weerdenburg, C.A. J. Cell Biol. (1987) [Pubmed]
  9. Myosin subfragment binding for the localization of actin-like microfilaments in cultured cells. A light and electron microscope study. Schloss, J.A., Milsted, A., Goldman, R.D. J. Cell Biol. (1977) [Pubmed]
  10. Actin-like contractile protein in carbon tetrachloride-induced cirrhosis in the rat. Toh, B.H., Cauchi, M.N., Muller, H.K. Pathology. (1977) [Pubmed]
  11. Biogenesis of actin-like bacterial cytoskeletal filaments destined for positioning prokaryotic magnetic organelles. Pradel, N., Santini, C.L., Bernadac, A., Fukumori, Y., Wu, L.F. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  12. Structural characterization of the stringent response related exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family. Kristensen, O., Laurberg, M., Liljas, A., Kastrup, J.S., Gajhede, M. Biochemistry (2004) [Pubmed]
  13. Microfilaments interacting with heavy meromyosin and deoxyribonuclease I in cells of the ovarian follicle of a lizard. Laughran, L.J., Larsen, J.H., Schroeder, P.C. Cell Tissue Res. (1981) [Pubmed]
  14. Myosin-like protein (M(r) 175,000) in Gregarina blaberae. Ghazali, M., Schrével, J. J. Eukaryot. Microbiol. (1993) [Pubmed]
  15. Intracellular distribution of nerve growth factor in rat pheochromocytoma PC12 cells: evidence for a perinuclear and intranuclear location. Marchisio, P.C., Naldini, L., Calissano, P. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  16. Topography of the external surface of the human red blood cell membrane studied with a nonpenetrating label, [125I]diazodiiodosulfanilic acid. Sears, D.A., Friedman, J.M., George, J.N. J. Biol. Chem. (1977) [Pubmed]
  17. Antiplasmin activity of a peptide that binds to the receptor-binding site of angiogenin. Gho, Y.S., Yoon, W.H., Chae, C.B. J. Biol. Chem. (2002) [Pubmed]
  18. Tentacle contraction in glycerinated Discophrya collini and the localization of HMM-binding filaments. Hackney, C.M., Butler, R.D. J. Cell. Sci. (1981) [Pubmed]
  19. A novel isoform of cytoplasmic actin that binds poly-L-proline. Kedersha, N.L., Broek, D., Berg, R.A. Biochem. J. (1986) [Pubmed]
  20. Protein transduction assisted by polyethylenimine-cationized carrier proteins. Kitazoe, M., Murata, H., Futami, J., Maeda, T., Sakaguchi, M., Miyazaki, M., Kosaka, M., Tada, H., Seno, M., Huh, N.H., Namba, M., Nishikawa, M., Maeda, Y., Yamada, H. J. Biochem. (2005) [Pubmed]
  21. Association of adenylate cyclase with an actin-like protein in the human myometrium. Bajo, A.M., Prieto, J.C., Valenzuela, P., Martínez, P., Menor, C., Marina, A., Vázquez, J., Guijarro, L.G. Gynecol. Endocrinol. (2004) [Pubmed]
  22. Dystrophin isoform Dp7l is present in lamellipodia and focal complexes in human astrocytoma cells U-373 MG. García-Tovar, C.G., Luna, J., Mena, R., Soto-Zárate, C.I., Cortés, R., Pérez, A., León-Avila, G., Mornet, D., Rendón, A., Hernández, J.M. Acta Histochem. (2002) [Pubmed]
  23. Coevolution of actin and associated proteins: an alpha-actinin-like protein in a cyanobacterium (Spirulina platensis). Usmanova, A., Astier, C., Méjean, C., Hubert, F., Feinberg, J., Benyamin, Y., Roustan, C. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1998) [Pubmed]
  24. Identification of a novel actin isoform in hepatocellular carcinoma. Chang, K.W., Yang, P.Y., Lai, H.Y., Yeh, T.S., Chen, T.C., Yeh, C.T. Hepatol. Res. (2006) [Pubmed]
  25. Relationships of the spectrin complex of human erythrocyte membranes to the actomyosins of muscle cells. Sheetz, M.P., Painter, R.G., Singer, S.J. Biochemistry (1976) [Pubmed]
  26. Actin in ejaculated human sperm cells. Ochs, D., Wolf, D.P. Biol. Reprod. (1985) [Pubmed]
  27. Identification of actin-like proteins in alcoholic hyaline by immunofluorescence. Nenci, I. Lab. Invest. (1975) [Pubmed]
  28. Chemical composition of cholinergic synaptic vesicles from Torpedo marmorata based on improved purification. Tashiro, T., Stadler, H. Eur. J. Biochem. (1978) [Pubmed]
  29. Immunoelectron microscopic evidence of contractile proteins in the cellular and acellular components of mouse kidney glomeruli. Accinni, L., Natali, P.G., Vassallo, L., Hsu, K.S., De Martino, C. Cell Tissue Res. (1975) [Pubmed]
  30. The mammalian anti-alpha-smooth muscle actin monoclonal antibody recognizes an alpha-actin-like protein in planaria (Dugesia lugubris s.l.). Pascolini, R., Di Rosa, I., Fagotti, A., Panara, F., Gabbiani, G. Differentiation (1992) [Pubmed]
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