Disease relevance of OMD

• Musculoskeletal pain is one of its frequent symptoms but also occurs in other chronic noninflammatory muscle disorders (OMD) [1].
• We have investigated 36 DM1 patients belonging to 22 unrelated families, 10 patients with other myotonic disorders (OMD) and 22 age-matched healthy controls from the clinical, biochemical and molecular point of view [2].
• INTRODUCTION: Primary cervical and oromandibular dystonia (CD and OMD, respectively) are well-recognized movement disorders, often treated with botulinum toxin (BTx) [3].
• Two-color flow-cytometric analysis on peripheral blood lymphocytes of 46 untreated multiple sclerosis patients (MS), 36 other medical disease patients (OMD) and 19 healthy control subjects (HC) was performed to know the relationships between T and B cell subpopulations [4].
• The novel fusion partners appear well suited to drive USP6 transcription in the bone/mesenchymal context: osteomodulin is expressed strongly in osteoblastic lineages, and the COL1A1 promoter has an oncogenic role in the mesenchymal cancer dermatofibrosarcoma protuberans [5].

Psychiatry related information on OMD

• OBJECTIVE: To compare the cost and utilization of health care services for various comorbid conditions among employees with bipolar disorder (BPD) and two other population cohorts: employees without BPD and employees with other mental disorders (OMD) [6].
• Specific multiaxial psychopathological instruments and psychometric tests in multiple assessments used for gerontopsychiatry demonstrated strong improvements after AS administration in early-moderate stages of Alzheimer or vascular dementia, as well as in other OMD [7].
• We sought a better understanding of this comorbidity among psychiatric inpatients, in particular differentiating two groups of "dual diagnosis" patients, (1) those with independent mental disorders complicated by substance use disorders, and (2) those with psychoactive substance use disorder-induced organic mental disorders (PSUD-induced OMD) [8].

High impact information on OMD

• In 8 of the patients with DM2/PROMM and in 3 of the patients with OMD, musculoskeletal pain was the most disabling symptom [1].
• OBJECTIVES: To characterize the phenotype of DM2/PROMM-associated musculoskeletal pain and to test whether it shows features distinct from OMD [1].
• Orosomucoid (OMD) contains complex bi-, tri- and tetra-antennary glycan chains [9].
• The results indicate that the 'site-directed' model of processing offers the most consistent explanation for the structures seen at the individual glycosylation sites of OMD [9].
• Standard h.p.l.c. profiles have been developed to analyse the percentage and distribution of the glycoforms present at each glycosylation site in OMD and its molecular variants [9].

Biological context of OMD

• We investigated the promoter region of OSAD by in silico analysis and found that the proximal promoter region contains sites for Smad-3, Smad-4, and AP-1 [10].
• In explant cultures, semiquantitative reverse-transcription polymerase chain reaction (RT-PCR) analysis indicated that the growth factor stimulated OSAD gene expression in early secretory odontoblasts and in pulpal fibroblasts [11].
• Antibiotic resistance markedly reduced the cure rates and accounted for most of the poor results with the triple therapies: 89% versus 23%; 77% versus 26%; 100% versus 60%; and 67% versus 23% for OMC, OMA, OMT, and OMD, respectively [12].

Anatomical context of OMD

• Our results indicate that the mature human odontoblasts overexpress the OSAD gene as compared with cells present in the pulp core [13].
• Expression of the small leucine-rich proteoglycan osteoadherin/osteomodulin in human dental pulp and developing rat teeth [13].
• Here, we report the expression of OSAD messenger RNA (mRNA) in human dental tissues and during the development of rat molars, using in situ hybridization [13].
• For this purpose, we constructed a probe for OSAD mRNA transcripts from human odontoblast cells cultured in vitro [13].
• Recently, osteoadherin (OSAD) has been described as a new member of this family, that is expressed by mature bovine osteoblasts [13].

Associations of OMD with chemical compounds

• Dietary Mg concentration should be in the range 1.5-2.5 g/kg OMD [14].
• In vivo, about 5 g of P and 1.8 g of S/kg OMD should be available (a) in the rumen [14].
• The inherent problem of instability of DEPC-modified histidine residues was overcome by adjusting the time scale of the postreaction processing of modified OMD [15].
• The chemical modification reagent diethylpyrocarbonate (DEPC) was used to modify alpha 1-acid glycoprotein (orosomucoid, OMD) under various conditions [15].
• However, seasonal averages for N, Ca and P content and in vitro OM disappearance (OMD) were greater (P less than .05) and NDF was lower (P less than .05) in tall fescue from mefluidide-treated pastures than in untreated pastures [16].

Regulatory relationships of OMD

• Taken together, these results indicate that OSAD expression is stimulated by TGF beta 1 in pulpal fibroblasts and in early secretory and mature odontoblasts [11].

Other interactions of OMD

• TGF beta 1 signaling and stimulation of osteoadherin in human odontoblasts in vitro [11].
• High performance liquid chromatography-electrospray mass spectrometry (HPLC-ESI/MS) was used to identify which of the five N-linked glycosylation sites of human plasma alpha1-acid-glycoprotein (orosomucoid, OMD) contain the sialyl Lewis(x) antigen [17].
• Alpha v beta 3 integrin expression in human odontoblasts and co-localization with osteoadherin [18].
• Among them, two clones were of particular interest: reelin, which was first detected in the brain and osteoadherin, which was first located in bone [19].
• To characterize the way odontoblasts may interact with other cells and the extracellular matrix in human teeth, we studied expression of alpha v beta 3 integrin, a putative receptor for osteoadherin [18].

Analytical, diagnostic and therapeutic context of OMD

• The resulting modified OMD was analyzed using enzyme digestion, reverse-phase HPLC, electrospray ionization-mass spectrometry (ESI/MS), and matrix-assisted laser desorption ionization time-of-flight-mass spectrometry (MALDI-TOF/MS) [15].

References