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Gene Review

OMG  -  oligodendrocyte myelin glycoprotein

Homo sapiens

Synonyms: OMGP, Oligodendrocyte-myelin glycoprotein
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Disease relevance of OMG


Psychiatry related information on OMG


High impact information on OMG


Biological context of OMG


Anatomical context of OMG


Associations of OMG with chemical compounds


Other interactions of OMG

  • Whether altered expression of OMGP might play a role in the clinical heterogeneity of NF1 is as yet unclear [1].
  • Prediction of mRNA and protein secondary structures revealed that two changes lead to putative structural alterations in the mutated c.2254C>G CDK5R1 3'UTR and in OMG T408A gene product [5].
  • The RTN4R gene is located in the 22q11 region and it encodes a subunit of the receptor complex (RTN4R-p75NTR) which results in neuronal growth inhibitory signals in response to Nogo-66, MAG or OMG signaling [16].
  • NgR binds to several myelin-associated ligands (Nogo-66, myelin associated glycoprotein, and oligodendrocyte-myelin glycoprotein), which, among other inhibitory proteins, impair axonal regeneration in the CNS of adult mammals [17].
  • In the absence of thymoma, thymectomy is usually not considered in OMG, although a few studies have described histological abnormalities in thymuses from patients with OMG [15].

Analytical, diagnostic and therapeutic context of OMG


  1. The gene encoding the oligodendrocyte-myelin glycoprotein is embedded within the neurofibromatosis type 1 gene. Viskochil, D., Cawthon, R., O'Connell, P., Xu, G.F., Stevens, J., Culver, M., Carey, J., White, R. Mol. Cell. Biol. (1991) [Pubmed]
  2. Oligodendrocyte myelin glycoprotein growth inhibition function requires its conserved leucine-rich repeat domain, not its glycosylphosphatidyl-inositol anchor. Vourc'h, P., Moreau, T., Arbion, F., Marouillat-Védrine, S., Müh, J.P., Andres, C. J. Neurochem. (2003) [Pubmed]
  3. Ocular myasthenia gravis: predictive value of single-fiber electromyography. Weinberg, D.H., Rizzo, J.F., Hayes, M.T., Kneeland, M.D., Kelly, J.J. Muscle Nerve (1999) [Pubmed]
  4. Influence of acute renal failure on FPIA rapid serum assay of midazolam and its main metabolite. Bouton, V., Bourget, P., Lesne-Hulin, A., Amstutz, P., Benayed, M., Benhamou, D., Dufieux, J.L., Goursot, G., Grobuis, S., Haberer, J.P., Jardin, F., Kirstetter, P., Marty, J., Mercatello, A., Page, B., Pourriat, J.L., Vassal, T. International journal of clinical pharmacology and therapeutics. (1997) [Pubmed]
  5. Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation. Venturin, M., Moncini, S., Villa, V., Russo, S., Bonati, M.T., Larizza, L., Riva, P. Neurogenetics (2006) [Pubmed]
  6. Molecular analysis of the oligodendrocyte myelin glycoprotein gene in autistic disorder. Vourc'h, P., Martin, I., Marouillat, S., Adrien, J.L., Barthélémy, C., Moraine, C., Müh, J.P., Andres, C. Neurosci. Lett. (2003) [Pubmed]
  7. The oligodendrocyte-myelin glycoprotein belongs to a distinct family of proteins and contains the HNK-1 carbohydrate. Mikol, D.D., Gulcher, J.R., Stefansson, K. J. Cell Biol. (1990) [Pubmed]
  8. Structure and chromosomal localization of the gene for the oligodendrocyte-myelin glycoprotein. Mikol, D.D., Alexakos, M.J., Bayley, C.A., Lemons, R.S., Le Beau, M.M., Stefansson, K. J. Cell Biol. (1990) [Pubmed]
  9. Oligodendrocyte myelin glycoprotein (OMgp): evolution, structure and function. Vourc'h, P., Andres, C. Brain Res. Brain Res. Rev. (2004) [Pubmed]
  10. From cell death to neuronal regeneration, effects of the p75 neurotrophin receptor depend on interactions with partner subunits. Bandtlow, C., Dechant, G. Sci. STKE (2004) [Pubmed]
  11. Repertoires of autoantibodies against homologous eye muscle in ocular and generalized myasthenia gravis differ. Zimmermann, C.W., Eblen, F. The Clinical investigator. (1993) [Pubmed]
  12. Nogo and the Nogo-66 receptor. Fournier, A.E., GrandPré, T., Gould, G., Wang, X., Strittmatter, S.M. Prog. Brain Res. (2002) [Pubmed]
  13. Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats. Carlezon, W.A., Mague, S.D., Parow, A.M., Stoll, A.L., Cohen, B.M., Renshaw, P.F. Biol. Psychiatry (2005) [Pubmed]
  14. A new melanoma diagnosis active support system. Fiorini, R., Dacquino, G., Laguteta, G. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference (2004) [Pubmed]
  15. Immunosuppressive treatment of ocular myasthenia gravis. Tackenberg, B., Hemmer, B., Oertel, W.H., Sommer, N. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. (2001) [Pubmed]
  16. No association between the genetic polymorphisms in the RTN4R gene and schizophrenia in the Chinese population. Meng, J., Shi, Y., Zhao, X., Guo, S., Wang, H., Zheng, Y., Tang, R., Feng, G., Gu, N., Liu, H., Zhu, S., He, L. Journal of neural transmission (Vienna, Austria : 1996) (2007) [Pubmed]
  17. Identification of Nogo-66 receptor (NgR) and homologous genes in fish. Klinger, M., Taylor, J.S., Oertle, T., Schwab, M.E., Stuermer, C.A., Diekmann, H. Mol. Biol. Evol. (2004) [Pubmed]
  18. Characterization of three human oligodendroglial cell lines as a model to study oligodendrocyte injury: morphology and oligodendrocyte-specific gene expression. Buntinx, M., Vanderlocht, J., Hellings, N., Vandenabeele, F., Lambrichts, I., Raus, J., Ameloot, M., Stinissen, P., Steels, P. J. Neurocytol. (2003) [Pubmed]
  19. Identification of Gal(beta 1-3)GalNAc bearing glycoproteins at the nodes of Ranvier in peripheral nerve. Apostolski, S., Sadiq, S.A., Hays, A., Corbo, M., Suturkova-Milosevic, L., Chaliff, P., Stefansson, K., LeBaron, R.G., Ruoslahti, E., Hays, A.P. J. Neurosci. Res. (1994) [Pubmed]
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