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Gene Review

Si  -  sucrase-isomaltase (alpha-glucosidase)

Rattus norvegicus

Synonyms: Sucrase-isomaltase, intestinal
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Disease relevance of Si


Psychiatry related information on Si

  • Sucrase expression was further increased by prolonged food deprivation, whereas enzyme activity as well as the amount of SI mRNA dropped to reach the low level found in control sucklings when 48 h-starved pups were refed by returning them to their dams [5].

High impact information on Si


Biological context of Si


Anatomical context of Si


Associations of Si with chemical compounds

  • The apical sorting of the small intestinal membrane glycoprotein sucrase-isomaltase (SI) depends on the presence of O-linked glycans and the transmembrane domain [16].
  • The NH2-terminal sequence of purified pro-sucrase-isomaltase was identical with that of the isolated isomaltase subunit which possesses the membrane anchor for the mature enzyme complex but differed from the NH2-terminal sequence of the sucrase subunit [10].
  • We conclude that the O-glycans in the stalk region of SI act as an apical sorting signal within a sorting machinery that comprises at least a carbohydrate-binding protein and fulfills specific spatial requirements provided, for example by a polyglycine spacer in the context of rGH or the P-domain within the SI enzyme complex [16].
  • Recently, we cloned a cDNA (NaSi-1) localized to rat renal proximal tubules and encoding the brush-border membrane (BBM) Na gradient-dependent inorganic sulfate (Si) transport protein (Na-Si cotransporter) [17].
  • Lactase synthesis and processing was studied in 0- and 15-day-old rats after IP administration of [35S]methionine, and changes in precociously cortisone-induced sucrase-isomaltase were used as an internal control [9].

Physical interactions of Si


Regulatory relationships of Si

  • An increase in alkaline phosphatase and lactase activity was observed after 3-4 days in these colonies which could be enhanced to yield 90%-100% positive cells by the addition of dexamethasone to the medium while no sucrase-isomaltase activity was elicited [19].

Other interactions of Si


Analytical, diagnostic and therapeutic context of Si


  1. Protection of the Peyer's patch-associated crypt and villus epithelium against methotrexate-induced damage is based on its distinct regulation of proliferation. Renes, I.B., Verburg, M., Bulsing, N.P., Ferdinandusse, S., Büller, H.A., Dekker, J., Einerhand, A.W. J. Pathol. (2002) [Pubmed]
  2. Suppressive effect of insulin on the synthesis of sucrase-isomaltase complex in small intestinal epithelial cells, and abnormal increase in the complex under diabetic conditions. Takenoshita, M., Yamaji, R., Inui, H., Miyatake, K., Nakano, Y. Biochem. J. (1998) [Pubmed]
  3. Differentiation-dependent induction of CYP1A1 in cultured rat small intestinal epithelial cells, colonocytes, and human colon carcinoma cells: basement membrane-mediated apoptosis. Sterling, K.M., Cutroneo, K.R. J. Cell. Biochem. (2002) [Pubmed]
  4. Disordered expression of the sucrase-isomaltase complex in the small intestine in Otsuka Long-Evans tokushima fatty rats, a model of non-insulin-dependent diabetes mellitus with insulin resistance. Adachi, T., Takenoshita, M., Katsura, H., Yasuda, K., Tsuda, K., Seino, Y., Enomoto, T., Yamaji, R., Miyatake, K., Inui, H., Nakano, Y. Biochim. Biophys. Acta (1999) [Pubmed]
  5. Precocious and reversible expression of sucrase-isomaltase unrelated to intestinal cell turnover. Nsi-Emvo, E., Foltzer-Jourdainne, C., Raul, F., Gosse, F., Duluc, I., Koch, B., Freund, J.N. Am. J. Physiol. (1994) [Pubmed]
  6. The intestinal brush border membrane in diabetes. Studies of sucrase-isomaltase metabolism in rats with streptozotocin diabetes. Olsen, W.A., Korsmo, H. J. Clin. Invest. (1977) [Pubmed]
  7. Regulation of sucrase and lactase in developing rats: role of nuclear factors that bind to two gene regulatory elements. Hecht, A., Torbey, C.F., Korsmo, H.A., Olsen, W.A. Gastroenterology (1997) [Pubmed]
  8. Restriction of lactase gene expression along the proximal-to-distal axis of rat small intestine occurs during postnatal development. Rings, E.H., Krasinski, S.D., van Beers, E.H., Moorman, A.F., Dekker, J., Montgomery, R.K., Grand, R.J., Büller, H.A. Gastroenterology (1994) [Pubmed]
  9. Posttranslational cleavage of rat intestinal lactase occurs at the luminal side of the brush border membrane. Yeh, K.Y., Yeh, M., Pan, P.C., Holt, P.R. Gastroenterology (1991) [Pubmed]
  10. Biosynthesis of sucrase-isomaltase. Purification and NH2-terminal amino acid sequence of the rat sucrase-isomaltase precursor (pro-sucrase-isomaltase) from fetal intestinal transplants. Hauri, H.P., Wacker, H., Rickli, E.E., Bigler-Meier, B., Quaroni, A., Semenza, G. J. Biol. Chem. (1982) [Pubmed]
  11. Cloning and sequencing of a full-length rat sucrase-isomaltase-encoding cDNA. Chandrasena, G., Osterholm, D.E., Sunitha, I., Henning, S.J. Gene (1994) [Pubmed]
  12. Regulation of sucrase-isomaltase gene expression along the crypt-villus axis of rat small intestine. Traber, P.G. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  13. Biogenesis of intestinal plasma membrane: posttranslational route and cleavage of sucrase-isomaltase. Hauri, H.P., Quaroni, A., Isselbacher, K.J. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  14. Molecular cloning and characterization of a rat intestinal sucrase-isomaltase cDNA. Regulation of sucrase-isomaltase gene expression by sucrose feeding. Broyart, J.P., Hugot, J.P., Perret, C., Porteu, A. Biochim. Biophys. Acta (1990) [Pubmed]
  15. Synthesis and intracellular processing of sucrase-isomaltase in rat jejunum. Grand, R.J., Montgomery, R.K., Perez, A. Gastroenterology (1985) [Pubmed]
  16. Characteristics and structural requirements of apical sorting of the rat growth hormone through the O-glycosylated stalk region of intestinal sucrase-isomaltase. Spodsberg, N., Alfalah, M., Naim, H.Y. J. Biol. Chem. (2001) [Pubmed]
  17. Metabolic acidosis regulates rat renal Na-Si cotransport activity. Puttaparthi, K., Markovich, D., Halaihel, N., Wilson, P., Zajicek, H.K., Wang, H., Biber, J., Murer, H., Rogers, T., Levi, M. Am. J. Physiol. (1999) [Pubmed]
  18. Biochemistry and immunochemistry of membrane-bound enzymes. Kraml, J., Lojda, Z. Acta Universitatis Carolinae. Medica. Monographia. (1977) [Pubmed]
  19. Basement membrane components are potent promoters of rat intestinal epithelial cell differentiation in vitro. Hahn, U., Stallmach, A., Hahn, E.G., Riecken, E.O. Gastroenterology (1990) [Pubmed]
  20. Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: possible role in allergic reactions. Ware, J.A., Graf, M.L., Martin, B.M., Lustberg, L.R., Pohl, L.R. Chem. Res. Toxicol. (1998) [Pubmed]
  21. Glucagon-like peptide-2 increases sucrase-isomaltase but not caudal-related homeobox protein-2 gene expression. Kitchen, P.A., Fitzgerald, A.J., Goodlad, R.A., Barley, N.F., Ghatei, M.A., Legon, S., Bloom, S.R., Price, A., Walters, J.R., Forbes, A. Am. J. Physiol. Gastrointest. Liver Physiol. (2000) [Pubmed]
  22. Sucrase-isomaltase and hexose transporter gene expressions are coordinately enhanced by dietary fructose in rat jejunum. Kishi, K., Tanaka, T., Igawa, M., Takase, S., Goda, T. J. Nutr. (1999) [Pubmed]
  23. Tissue distribution and subcellular localization of the ClC-5 chloride channel in rat intestinal cells. Vandewalle, A., Cluzeaud, F., Peng, K.C., Bens, M., Lüchow, A., Günther, W., Jentsch, T.J. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
  24. Localization of sucrase-isomaltase in the rat enterocyte. Lorenzsonn, V., Korsmo, H., Olsen, W.A. Gastroenterology (1987) [Pubmed]
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