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Gene Review

Cdca4  -  cell division cycle associated 4

Mus musculus

Synonyms: 2410018C03Rik, Cell division cycle-associated protein 4, HEPP, Hematopoietic progenitor protein, Hepp, ...
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Disease relevance of Cdca4


High impact information on Cdca4


Chemical compound and disease context of Cdca4


Biological context of Cdca4

  • We independently isolated the murine Cdca4 gene in a genomic expression-based screen for genes involved in mammalian craniofacial development, and show that Cdca4 is expressed in a spatio-temporally restricted pattern during mouse embryogenesis [16].
  • Through differential screening of mouse hematopoietic stem cell (HSC) and progenitor-subtracted cDNA libraries we have identified a progenitor cell-specific transcript that represents a novel gene, named Hepp (hematopoietic progenitor protein) [17].
  • Among MAPC-derived GFP(+)CD45.2(+) cells in the bone marrow of engrafted mice, HSCs were present that could radioprotect and reconstitute multilineage hematopoiesis in secondary and tertiary recipients, as well as myeloid and lymphoid hematopoietic progenitor subsets and functional GFP(+) MAPC-derived lymphocytes that were functional [18].
  • These results indicated that at least a set of T3+ LGL with rearranged TCR genes could be directly differentiated from isolated hematopoietic progenitor cells in vitro [19].
  • Adherent, CD11b(+)/F4/80(+) cells capable of phagocytosis were detected in PU.1(Spi-B/Spi-B) embryoid bodies, and myeloid colonies were present in hematopoietic progenitor assays [20].

Anatomical context of Cdca4


Associations of Cdca4 with chemical compounds


Regulatory relationships of Cdca4


Other interactions of Cdca4


Analytical, diagnostic and therapeutic context of Cdca4


  1. Allogeneic bone marrow cells that facilitate complete chimerism and eliminate tumor cells express both CD8 and T-cell antigen receptor-alphabeta. Lan, F., Zeng, D., Huie, P., Higgins, J.P., Strober, S. Blood (2001) [Pubmed]
  2. Human immunodeficiency virus-1 infection interrupts thymopoiesis and multilineage hematopoiesis in vivo. Jenkins, M., Hanley, M.B., Moreno, M.B., Wieder, E., McCune, J.M. Blood (1998) [Pubmed]
  3. Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9. So, C.W., Karsunky, H., Wong, P., Weissman, I.L., Cleary, M.L. Blood (2004) [Pubmed]
  4. CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Schmits, R., Filmus, J., Gerwin, N., Senaldi, G., Kiefer, F., Kundig, T., Wakeham, A., Shahinian, A., Catzavelos, C., Rak, J., Furlonger, C., Zakarian, A., Simard, J.J., Ohashi, P.S., Paige, C.J., Gutierrez-Ramos, J.C., Mak, T.W. Blood (1997) [Pubmed]
  5. Osteoclast-mediated bone resorption is stimulated during short-term administration of granulocyte colony-stimulating factor but is not responsible for hematopoietic progenitor cell mobilization. Takamatsu, Y., Simmons, P.J., Moore, R.J., Morris, H.A., To, L.B., Lévesque, J.P. Blood (1998) [Pubmed]
  6. Suppression of hematopoietic-progenitor-cell proliferation by ethanol and acetaldehyde. Meagher, R.C., Sieber, F., Spivak, J.L. N. Engl. J. Med. (1982) [Pubmed]
  7. Retroviral vector-mediated gene transfer into human hematopoietic progenitor cells. Gruber, H.E., Finley, K.D., Hershberg, R.M., Katzman, S.S., Laikind, P.K., Seegmiller, J.E., Friedmann, T., Yee, J.K., Jolly, D.J. Science (1985) [Pubmed]
  8. Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells. Sayegh, C., Jhunjhunwala, S., Riblet, R., Murre, C. Genes Dev. (2005) [Pubmed]
  9. A GATA-2/estrogen receptor chimera functions as a ligand-dependent negative regulator of self-renewal. Heyworth, C., Gale, K., Dexter, M., May, G., Enver, T. Genes Dev. (1999) [Pubmed]
  10. PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors. Scott, E.W., Fisher, R.C., Olson, M.C., Kehrli, E.W., Simon, M.C., Singh, H. Immunity (1997) [Pubmed]
  11. Matching of chemotherapy to mouse strain and lymphoid tumor type to prevent tumor-induced suppression of specific T- and B-cell functions. Faanes, R.B., Merluzzi, V.J., Williams, N., Tarnowski, G.S., Ralph, P. Cancer Res. (1979) [Pubmed]
  12. Manipulation of mouse hematopoietic progenitors by specific retroviral infection. Murphy, G.J., Göttgens, B., Vegiopoulos, A., Sanchez, M.J., Leavitt, A.D., Watson, S.P., Green, A.R., Frampton, J. J. Biol. Chem. (2003) [Pubmed]
  13. Comparative hematopoietic toxicity of doxorubicin and 4'-epirubicin. OKunewick, J.P., Kociban, D.L., Buffo, M.J. Proc. Soc. Exp. Biol. Med. (1990) [Pubmed]
  14. A mouse-based strategy for cyclophosphamide pharmacogenomic discovery. Watters, J.W., Kloss, E.F., Link, D.C., Graubert, T.A., McLeod, H.L. J. Appl. Physiol. (2003) [Pubmed]
  15. Evaluation of the toxic and teratogenic potential of the anticonvulsant drug 4-hydroxy, 4-ethyl, 4-phenylbutyramide in mice. Chamorro, G., Salazar, M., Salazar, S., Ulloa, V., Carvajal, G., Martínez, D. Arch. Med. Res. (1994) [Pubmed]
  16. Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP). Bennetts, J.S., Fowles, L.F., Berkman, J.L., van Bueren, K.L., Richman, J.M., Simpson, F., Wicking, C. Gene (2006) [Pubmed]
  17. Cloning and characterization of Hepp, a novel gene expressed preferentially in hematopoietic progenitors and mature blood cells. Abdullah, J.M., Jing, X., Spassov, D.S., Nachtman, R.G., Jurecic, R. Blood Cells Mol. Dis. (2001) [Pubmed]
  18. Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells. Serafini, M., Dylla, S.J., Oki, M., Heremans, Y., Tolar, J., Jiang, Y., Buckley, S.M., Pelacho, B., Burns, T.C., Frommer, S., Rossi, D.J., Bryder, D., Panoskaltsis-Mortari, A., O'shaughnessy, M.J., Nelson-Holte, M., Fine, G.C., Weissman, I.L., Blazar, B.R., Verfaillie, C.M. J. Exp. Med. (2007) [Pubmed]
  19. Differentiation in vitro of T3+ large granular lymphocytes with characteristic cytotoxic activity from an isolated hematopoietic progenitor colony. Minato, N., Hattori, M., Sudo, T., Kano, S., Miura, Y., Suda, J., Suda, T. J. Exp. Med. (1988) [Pubmed]
  20. Spi-B can functionally replace PU.1 in myeloid but not lymphoid development. Dahl, R., Ramirez-Bergeron, D.L., Rao, S., Simon, M.C. EMBO J. (2002) [Pubmed]
  21. Quantitative trait analysis reveals transforming growth factor-beta2 as a positive regulator of early hematopoietic progenitor and stem cell function. Langer, J.C., Henckaerts, E., Orenstein, J., Snoeck, H.W. J. Exp. Med. (2004) [Pubmed]
  22. A novel protein tyrosine phosphatase expressed in lin(lo)CD34(hi)Sca(hi) hematopoietic progenitor cells. Cheng, J., Daimaru, L., Fennie, C., Lasky, L.A. Blood (1996) [Pubmed]
  23. Suppression and potentiation of mouse hematopoietic progenitor cell proliferation by ouabain. Spivak, J.L., Misiti, J., Stuart, R., Sharkis, S.J., Sensenbrenner, L.L. Blood (1980) [Pubmed]
  24. Sulfated glycans induce rapid hematopoietic progenitor cell mobilization: evidence for selectin-dependent and independent mechanisms. Frenette, P.S., Weiss, L. Blood (2000) [Pubmed]
  25. Integrin alpha4beta7 and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into bone marrow following transplantation. Katayama, Y., Hidalgo, A., Peired, A., Frenette, P.S. Blood (2004) [Pubmed]
  26. Role of estrogen receptor alpha in hematopoietic stem cell development and B lymphocyte maturation in the male mouse. Thurmond, T.S., Murante, F.G., Staples, J.E., Silverstone, A.E., Korach, K.S., Gasiewicz, T.A. Endocrinology (2000) [Pubmed]
  27. Survivin regulates hematopoietic progenitor cell proliferation through p21WAF1/Cip1-dependent and -independent pathways. Fukuda, S., Mantel, C.R., Pelus, L.M. Blood (2004) [Pubmed]
  28. Vascular endothelial growth factor receptor-2 induces survival of hematopoietic progenitor cells. Larrivée, B., Lane, D.R., Pollet, I., Olive, P.L., Humphries, R.K., Karsan, A. J. Biol. Chem. (2003) [Pubmed]
  29. Transforming growth factor beta directly regulates primitive murine hematopoietic cell proliferation. Keller, J.R., Mcniece, I.K., Sill, K.T., Ellingsworth, L.R., Quesenberry, P.J., Sing, G.K., Ruscetti, F.W. Blood (1990) [Pubmed]
  30. Tumor necrosis factor alpha directly and indirectly regulates hematopoietic progenitor cell proliferation: role of colony-stimulating factor receptor modulation. Jacobsen, S.E., Ruscetti, F.W., Dubois, C.M., Keller, J.R. J. Exp. Med. (1992) [Pubmed]
  31. In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit. Corbin, A.S., Demehri, S., Griswold, I.J., Wang, Y., Metcalf, C.A., Sundaramoorthi, R., Shakespeare, W.C., Snodgrass, J., Wardwell, S., Dalgarno, D., Iuliucci, J., Sawyer, T.K., Heinrich, M.C., Druker, B.J., Deininger, M.W. Blood (2005) [Pubmed]
  32. Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. Mazo, I.B., Gutierrez-Ramos, J.C., Frenette, P.S., Hynes, R.O., Wagner, D.D., von Andrian, U.H. J. Exp. Med. (1998) [Pubmed]
  33. Induction of the granulocyte-macrophage colony-stimulating factor (CSF) receptor by granulocyte CSF increases the differentiative options of a murine hematopoietic progenitor cell. Kreider, B.L., Phillips, P.D., Prystowsky, M.B., Shirsat, N., Pierce, J.H., Tushinski, R., Rovera, G. Mol. Cell. Biol. (1990) [Pubmed]
  34. The Steel factor. Williams, D.E., de Vries, P., Namen, A.E., Widmer, M.B., Lyman, S.D. Dev. Biol. (1992) [Pubmed]
  35. Interleukin 4 alone or in combination with interleukin 1 stimulates 3T3 fibroblasts to produce colony-stimulating factors. Tushinski, R.J., Larsen, A., Park, L.S., Spoor, E., Williams, D.E., Mochizuki, D.Y. Exp. Hematol. (1991) [Pubmed]
  36. Thrombopoietin expands hematopoietic stem cells after transplantation. Fox, N., Priestley, G., Papayannopoulou, T., Kaushansky, K. J. Clin. Invest. (2002) [Pubmed]
  37. Hematopoietic growth-promoting effects of natural killer cells in mice in response to in vivo administration of human interleukin-2. Murphy, W.J., Longo, D.L. J. Natl. Cancer Inst. (1992) [Pubmed]
  38. Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase. Hadjur, S., Ung, K., Wadsworth, L., Dimmick, J., Rajcan-Separovic, E., Scott, R.W., Buchwald, M., Jirik, F.R. Blood (2001) [Pubmed]
  39. Development of a murine hematopoietic progenitor complementary DNA microarray using a subtracted complementary DNA library. Ma, X., Husain, T., Peng, H., Lin, S., Mironenko, O., Maun, N., Johnson, S., Tuck, D., Berliner, N., Krause, D.S., Perkins, A.S. Blood (2002) [Pubmed]
  40. Total body irradiation causes profound changes in endothelial traffic molecules for hematopoietic progenitor cell recruitment to bone marrow. Mazo, I.B., Quackenbush, E.J., Lowe, J.B., von Andrian, U.H. Blood (2002) [Pubmed]
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