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Gene Review

IFT122  -  intraflagellar transport 122

Homo sapiens

Synonyms: CED, CED1, Intraflagellar transport protein 122 homolog, SPG, WD repeat-containing protein 10, ...
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Disease relevance of IFT122

  • In particular, docosahexaenoyl, 22:6(n-3), groups were uniformly increased in Down's syndrome compared with controls by 54% and 33% in EPG and SPG, respectively, while arachidonoyl, 20:4(n-6), groups were decreased by 16% and 30%, respectively [1].
  • Allan-Herndon-Dudley syndrome: should the locus for this hereditary spastic paraplegia be designated SPG 22 [2]?
  • Adjuvant immunochemotherapy using the antitumour polysaccharide sizofiran (SPG), an extract from the culture broth of Schizophyllum commune Fries, was prescribed randomly for 386 Japanese patients with resectable gastric cancer [3].
  • The viability of the TWAR organism in chlamydia transport medium SPG was also studied [4].
  • Familial spastic paraparesis (SPG) is a clinically and genetically heterogeneous group of disorders [5].

Psychiatry related information on IFT122


High impact information on IFT122

  • Planulae processed with the SPG histofluorescence technique, specific only for catecholamines, exhibited blue-green fluorophores which were most prominent in the anterior ectoderm [7].
  • However, after several hours, radioactivity was transferred from the TG and CPG pools, some going to the serine and ethanolamine phosphoglyceride (SPG and EPG) pools [8].
  • In contrast, in adult human corneas the adrenergic nerves could be identified only with the SPG technique, whereas with FIF the identification of specific catecholamine fluoresence was not possible due to extensive collagen autofluorescence [9].
  • The techniques included both sodium-potassium-glyoxylic acid-induced fluorescence (SPG) and formaldehyde-induced fluorescence after freeze-drying (FIF) procedure [9].
  • In fetal corneas the presence of adrenergic nerve fibers could be demonstrated by both SPG and FIF techniques [9].

Chemical compound and disease context of IFT122

  • As this may relate to the composition of polyunsaturated acyl groups (PUFA) in phospholipids, we have examined the PUFA of ethanolamine and serine phosphoglycerides (EPG and SPG), which are particularly rich in PUFA, in the same series of cerebral cortex specimens of Down's syndrome and age-matched control fetuses [1].
  • Adjuvant immunochemotherapy using Schizophyllan (SPG), an extract from the culture broth of Schizophyllum commune Fries, was prescribed at random for 326 Japanese patients with resectable gastric cancer [10].
  • The antitumor effect of the combined administration with recombinant human interleukin-2 (rIL-2) and sizofiran (SPG), a single glucan of Shizophyllum commune Fries, was studied in vivo in C57BL/6 mice intraperitoneally inoculated with EL-4 lymphoma [11].

Biological context of IFT122

  • Clinical severity was found to be correlated with the nature of the mutation, suggesting a distinct strategy for detection of PLP point mutations between severe PMD, mild PMD and SPG [12].
  • However, no technique was available to transfect double-stranded DNAs (dsDNA) or plasmid DNA using SPG [13].
  • Two-point and multi-point linkage analyses in nine families provided supportive evidence that the most common form of SPG is linked to chromosome 2 (SPG4) [5].
  • When protein transduction peptides were attached to SPG and this modified SPG was complexed with ssODNs, the resultant complex could induce cellular transfection of the bound ODNs, without producing serious cytotoxicity [13].
  • By haplotype analysis, the disease in at least one family does not appear to be linked to any of the presently known SPG loci, suggesting that there is at least one additional SPG gene [5].

Anatomical context of IFT122

  • We report the cloning and initial characterization of a novel gene, WDR10, which encodes a 140-kD protein that is highly expressed in pituitary and testis [14].
  • Immunoregulatory effects of sizofiran (SPG) on lymphocytes and polymorphonuclear leukocytes [15].
  • The effect of SPG on leukocytes has been studied in 20 patients with oral carcinoma and the actions have been analysed in vitro [15].
  • From the above results, enhancement of PMNL O2-generation by SPG seems to be a direct action of SPG, but the mechanism of elevation of the non-specific killing activity of PMNL and NK cells is not known [15].
  • A comparison was made of stimulated (excess saliva) and resting parotid gland (SPG and RPG, respectively) [16].

Associations of IFT122 with chemical compounds

  • This protein, WDR10p, contains an AF-2 domain as well as seven N-terminal WD repeats and is highly conserved through evolution [14].
  • We here demonstrate the creation of novel poly(aniline) (PANI) nanofiber structures by a polymer wrapping method using schizophyllan (SPG) [17].
  • Mannose-modified SPG can also wrap PANIs to give nanofibers having a lectin affinity [17].
  • The antitumour activity of alkylating agents is not correlated with the levels of glutathione, glutathione transferase and O6-alkylguanine-DNA-alkyltransferase of human tumour xenografts. EORTC SPG and PAMM Groups [18].
  • A modification of the sucrose-potassium phosphate-glyoxylic acid (SPG) histofluorescence method has resulted in consistent standardization of the fluorescent intensity while also eliminating a cumbersome step in the procedure [19].

Analytical, diagnostic and therapeutic context of IFT122

  • Although the overall survival probability for 5 years did not differ between the SPG and control groups, in 264 patients with curatively resected cancer, the probability to 5 year survival and to recurrence in the sizofiran-administered patients was better than in the controls [3].
  • We investigated 52 PMD and 28 SPG families without large PLP duplications or deletions by genomic PCR amplification and sequencing of the PLP gene [12].
  • The outcomes of these studies can now be used to achieve miniaturized electrochemical immunoassays on LTCC materials where both plain and SPG surfaces are present [20].
  • The serum insulin level remained low during anesthesia and extracorporeal circulation in the SPG and LPGH but rose during the postoperative period; the maximal values were recorded on the first postoperative day [21].
  • Spleens from representatives of the three amphibian orders were examined using sucrose-potassium phosphate-glyoxylic acid (SPG) histofluorescence to detect catecholamines and immunocytochemistry to detect several neural antigens [22].


  1. Altered composition of polyunsaturated fatty acyl groups in phosphoglycerides of Down's syndrome fetal brain. Brooksbank, B.W., Martinez, M., Balazs, R. J. Neurochem. (1985) [Pubmed]
  2. Allan-Herndon-Dudley syndrome: should the locus for this hereditary spastic paraplegia be designated SPG 22? Bohan, T.P., Azizi, P. Arch. Neurol. (2004) [Pubmed]
  3. Clinical outcome of postoperative adjuvant immunochemotherapy with sizofiran for patients with resectable gastric cancer: a randomised controlled study. Fujimoto, S., Furue, H., Kimura, T., Kondo, T., Orita, K., Taguchi, T., Yoshida, K., Ogawa, N. Eur. J. Cancer (1991) [Pubmed]
  4. Factors affecting viability and growth in HeLa 229 cells of Chlamydia sp. strain TWAR. Kuo, C.C., Grayston, J.T. J. Clin. Microbiol. (1988) [Pubmed]
  5. Familial spastic paraparesis: evaluation of locus heterogeneity, anticipation, and haplotype mapping of the SPG4 locus on the short arm of chromosome 2. Raskind, W.H., Pericak-Vance, M.A., Lennon, F., Wolff, J., Lipe, H.P., Bird, T.D. Am. J. Med. Genet. (1997) [Pubmed]
  6. Improvement of long-term prognosis in patients with ovarian cancers by adjuvant sizofiran immunotherapy: a prospective randomized controlled study. Inoue, M., Tanaka, Y., Sugita, N., Yamasaki, M., Yamanaka, T., Minagawa, J., Nakamuro, K., Tani, T., Okudaira, Y., Karita, T. Biotherapy (Dordrecht, Netherlands) (1993) [Pubmed]
  7. Morphological, cytochemical and neuropharmacological evidence for the presence of catecholamines in hydrozoan planulae. Kolberg, K.J., Martin, V.J. Development (1988) [Pubmed]
  8. The metabolism of fatty acids in human Bietti crystalline dystrophy. Lee, J., Jiao, X., Hejtmancik, J.F., Kaiser-Kupfer, M., Gahl, W.A., Markello, T.C., Guo, J., Chader, G.J. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  9. Histochemical demonstration of adrenergic nerves in the stroma of human cornea. Toivanen, M., Tervo, T., Partanen, M., Vannas, A., Hervonen, A. Invest. Ophthalmol. Vis. Sci. (1987) [Pubmed]
  10. Clinical evaluation of schizophyllan adjuvant immunochemotherapy for patients with resectable gastric cancer--a randomized controlled trial. Fujimoto, S., Furue, H., Kimura, T., Kondo, T., Orita, K., Taguchi, T., Yoshida, K., Ogawa, N. The Japanese journal of surgery. (1984) [Pubmed]
  11. Augmentation of antitumor effect by combined administration with interleukin-2 and sizofiran, a single glucan, on murine EL-4 lymphoma. Kano, Y., Kakuta, H., Hashimoto, J. Biotherapy (Dordrecht, Netherlands) (1996) [Pubmed]
  12. Genotype-phenotype correlation in inherited brain myelination defects due to proteolipid protein gene mutations. Clinical European Network on Brain Dysmyelinating Disease. Cailloux, F., Gauthier-Barichard, F., Mimault, C., Isabelle, V., Courtois, V., Giraud, G., Dastugue, B., Boespflug-Tanguy, O. Eur. J. Hum. Genet. (2000) [Pubmed]
  13. Linear double-stranded DNA that mimics an infective tail of virus genome to enhance transfection. Anada, T., Karinaga, R., Koumoto, K., Mizu, M., Nagasaki, T., Kato, Y., Taira, K., Shinkai, S., Sakurai, K. Journal of controlled release : official journal of the Controlled Release Society. (2005) [Pubmed]
  14. Cloning and characterization of human WDR10, a novel gene located at 3q21 encoding a WD-repeat protein that is highly expressed in pituitary and testis. Gross, C., De Baere, E., Lo, A., Chang, W., Messiaen, L. DNA Cell Biol. (2001) [Pubmed]
  15. Immunoregulatory effects of sizofiran (SPG) on lymphocytes and polymorphonuclear leukocytes. Yoneda, K., Ueta, E., Yamamoto, T., Osaki, T. Clin. Exp. Immunol. (1991) [Pubmed]
  16. Functional analysis of human parotid gland in vivo using the (1)H MRS MT effect. Saito, M., Umeda, M., Fujiwara, K., Kakimoto, N., Tanaka, C., Murakami, S., Furukawa, S. NMR in biomedicine. (2002) [Pubmed]
  17. Beta-1,3-glucan (schizophyllan) can act as a one-dimensional host for creation of novel poly(aniline) nanofiber structures. Numata, M., Hasegawa, T., Fujisawa, T., Sakurai, K., Shinkai, S. Org. Lett. (2004) [Pubmed]
  18. The antitumour activity of alkylating agents is not correlated with the levels of glutathione, glutathione transferase and O6-alkylguanine-DNA-alkyltransferase of human tumour xenografts. EORTC SPG and PAMM Groups. D'Incalci, M., Bonfanti, M., Pifferi, A., Mascellani, E., Tagliabue, G., Berger, D., Fiebig, H.H. Eur. J. Cancer (1998) [Pubmed]
  19. Standardization of the sucrose-potassium phosphate-glyoxylic acid histofluorescence method for tissue monoamines. de la Torre, J.C. Neurosci. Lett. (1980) [Pubmed]
  20. Evaluation of screen-printed gold on low-temperature co-fired ceramic as a substrate for the immobilization of electrochemical immunoassays. Fakunle, E.S., Aguilar, Z.P., Shultz, J.L., Toland, A.D., Fritsch, I. Langmuir : the ACS journal of surfaces and colloids (2006) [Pubmed]
  21. Effects of open-heart surgery on carbohydrate and lipid metabolism. Nuutinen, L.S., Mononen, P., Kairaluoma, M., Tuononen, S. J. Thorac. Cardiovasc. Surg. (1977) [Pubmed]
  22. Noradrenergic and peptidergic innervation of the amphibian spleen: comparative studies. Kinney, K.S., Cohen, N., Felten, S.Y. Dev. Comp. Immunol. (1994) [Pubmed]
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