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Gene Review

RNF130  -  ring finger protein 130

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase RNF130, G1RZFP, GOLIATH, GP, Goliath homolog, ...
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Disease relevance of RNF130


High impact information on RNF130


Biological context of RNF130

  • Polyclonal antibodies to these peptides blocked fibrinogen binding to purified GP IIb-IIIa as well as platelet aggregation [8].
  • Three regions of the amplified GP IIIa cDNA derived from the Gro(a+) donor showed a different SSCP pattern when compared to that of the Gro(a-) donor [9].
  • Genetic polymorphism in human platelet glycoprotein GP Ib/IX/V complex is enriched in GP V (CD42d) [10].
  • Our results indicate that genetic variation in the GP Ib/IX/V complex is mostly tolerated in the GP V protein--whose function in the complex is not clear whereas the other components have only very limited genetic polymorphism [10].
  • Somatostatin analogues inhibit peptide release and cell growth through multiple postreceptor signal transduction mechanisms (PRSTM), including G proteins (GP), cyclic adenosine monophosphate (cAMP), calcium, protein kinase C (PKC), and tyrosine phosphatase (TP) [4].

Anatomical context of RNF130

  • In the interstitium, Goliath was exclusively present in Leydig cells [11].
  • This report is the first description of a differential regulation of the Goliath protein between germ cells and Leydig cells [11].
  • In tubules, Goliath was expressed mainly in postmeiotic germ cells and to a much lesser extent in Sertoli cells [11].
  • Using a series of immunolabeling, cellular fractionation, and electron microscopy experiments, we established that Goliath is present in mitochondria of the R2C Leydig cell line [11].
  • The rat Goliath mRNA (1.85 kb) was translated as a major ubiquitous protein species of 28-kDa and three larger isoforms (50, 46, and 36 kDa) expressed mainly in liver, lung, stomach, heart, and thymus and barely detectable in other tissues (kidney, skeletal muscle, brain, testis, intestine, and spleen) [11].

Associations of RNF130 with chemical compounds


Other interactions of RNF130


Analytical, diagnostic and therapeutic context of RNF130


  1. Sulfasalazine vs. steroids in Crohn's disease: David vs. Goliath? Hanauer, S.B. Gastroenterology (1991) [Pubmed]
  2. A new family linked to the RP13 locus for autosomal dominant retinitis pigmentosa on distal 17p. Tarttelin, E.E., Plant, C., Weissenbach, J., Bird, A.C., Bhattacharya, S.S., Inglehearn, C.F. J. Med. Genet. (1996) [Pubmed]
  3. Role of the 807 C/T polymorphism of the alpha2 gene in platelet GP Ia collagen receptor expression and function--effect in thromboembolic diseases. Corral, J., González-Conejero, R., Rivera, J., Ortuño, F., Aparicio, P., Vicente, V. Thromb. Haemost. (1999) [Pubmed]
  4. Postreceptor signal transduction mechanisms involved in octreotide-induced inhibition of angiogenesis. Patel, P.C., Barrie, R., Hill, N., Landeck, S., Kurozawa, D., Woltering, E.A. Surgery (1994) [Pubmed]
  5. Ultrastructural analysis of the distribution of the vitronectin receptor (alpha v beta 3) in human platelets and megakaryocytes reveals an intracellular pool and labelling of the alpha-granule membrane. Poujol, C., Nurden, A.T., Nurden, P. Br. J. Haematol. (1997) [Pubmed]
  6. The coupling of 5-oxo-eicosanoid receptors to heterotrimeric G proteins. O'Flaherty, J.T., Taylor, J.S., Kuroki, M. J. Immunol. (2000) [Pubmed]
  7. Nuclear pores: David and Goliath in nuclear transport. Moore, M.S. Curr. Biol. (1995) [Pubmed]
  8. Inhibition of fibrinogen binding to GP IIb-IIIa by a GP IIIa peptide. Charo, I.F., Nannizzi, L., Phillips, D.R., Hsu, M.A., Scarborough, R.M. J. Biol. Chem. (1991) [Pubmed]
  9. The Arg633His substitution responsible for the private platelet antigen Gro(a) unravelled by SSCP analysis and direct sequencing. Simsek, S., Folman, C., van der Schoot, C.E., von dem Borne, A.E. Br. J. Haematol. (1997) [Pubmed]
  10. Genetic polymorphism in human platelet glycoprotein GP Ib/IX/V complex is enriched in GP V (CD42d). Koskela, S., Kekomäki, R., Partanen, J. Tissue Antigens (1998) [Pubmed]
  11. Goliath, a ring-H2 mitochondrial protein, regulated by luteinizing hormone/human chorionic gonadotropin in rat leydig cells. Guais, A., Solhonne, B., Melaine, N., Guellaen, G., Bulle, F. Biol. Reprod. (2004) [Pubmed]
  12. Picotamide versus aspirin in diabetic patients with peripheral arterial disease: has David defeated Goliath? Gresele, P., Migliacci, R. Eur. Heart J. (2004) [Pubmed]
  13. Matrix-assisted laser desorption/ionization high-energy collision-induced dissociation of steroids: analysis of oxysterols in rat brain. Wang, Y., Hornshaw, M., Alvelius, G., Bodin, K., Liu, S., Sjövall, J., Griffiths, W.J. Anal. Chem. (2006) [Pubmed]
  14. Analysis of derivatised steroids by matrix-assisted laser desorption/ionisation and post-source decay mass spectrometry. Khan, M.A., Wang, Y., Heidelberger, S., Alvelius, G., Liu, S., Sjövall, J., Griffiths, W.J. Steroids (2006) [Pubmed]
  15. Targeting of transcriptional cofactors by the HPV E6 protein: another tale of David and Goliath. O'Connor, M.J. Trends Microbiol. (2000) [Pubmed]
  16. David and Goliath. New firm buys five hospitals from HCA. Galloro, V. Modern healthcare. (2005) [Pubmed]
  17. Evaluation of 99Tcm-labelled alpha-D-glucose 1-phosphate aerosols for SPECT ventilation lung imaging. Ercan, M.T., Ulutunçel, N., Naldöken, S. Nuclear medicine communications. (1993) [Pubmed]
  18. Presence of the entire coding region of GP IV mRNA in Nak(a)-negative platelets. Kashiwagi, H., Honda, S., Take, H., Mizutani, H., Imai, Y., Furubayashi, T., Tomiyama, Y., Kurata, Y., Yonezawa, T. Int. J. Hematol. (1993) [Pubmed]
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