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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Thrombasthenia


High impact information on Thrombasthenia


Chemical compound and disease context of Thrombasthenia


Biological context of Thrombasthenia


Anatomical context of Thrombasthenia


Gene context of Thrombasthenia

  • Coprecipitation of CD36, CD9, and alpha6beta1 was also observed on platelets from a patient with Glanzmann thrombasthenia, indicating that alphaII(b)beta3 is not required for the other proteins to associate [25].
  • Knowledge of the sequence and organization of the GPIIb and GPIIIa genes will help in understanding evolutionary relationships and functional homologies of this family of adhesion protein receptors and will facilitate analysis of molecular defects responsible for thrombasthenia [26].
  • Platelets from the patients with Glanzmann's thrombasthenia could also attach to the subendothelium, whereas those from a patient whose platelets lacked GPIa failed to attach to the extracellular matrix (ECM) [27].
  • Platelets from most patients with the autosomal recessive bleeding disorder, Glanzmann's thrombasthenia, are deficient in GPIIb and GPIIIa [28].
  • SFLLRN induced solubilization of CD40L also from the platelets of a Glanzmann's thrombasthenia patient lacking GPIIb-IIIa, albeit at a lower rate than from normal platelets, and fibrinogen enhanced the solubilization from washed normal platelets [29].

Analytical, diagnostic and therapeutic context of Thrombasthenia


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  3. Human IgG monoclonal anti-alpha(IIb)beta(3)-binding fragments derived from immunized donors using phage display. Jacobin, M.J., Laroche-Traineau, J., Little, M., Keller, A., Peter, K., Welschof, M., Nurden, A., Clofent-Sanchez, G. J. Immunol. (2002) [Pubmed]
  4. A quick method for screening platelet dysfunctions using the whole blood lumi-aggregometer. Ingerman-Wojenski, C.M., Silver, M.J. Thromb. Haemost. (1984) [Pubmed]
  5. Protein kinase mediators of integrin signal transduction. Hannigan, G.E., Dedhar, S. J. Mol. Med. (1997) [Pubmed]
  6. Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia. Nieuwenhuis, H.K., Akkerman, J.W., Houdijk, W.P., Sixma, J.J. Nature (1985) [Pubmed]
  7. Further characterization of the thrombasthenia-related idiotype OG. Antiidiotype defines a novel epitope(s) shared by fibrinogen B beta chain, vitronectin, and von Willebrand factor and required for binding to beta 3. Gruel, Y., Brojer, E., Nugent, D.J., Kunicki, T.J. J. Exp. Med. (1994) [Pubmed]
  8. A novel form of integrin dysfunction involving beta1, beta2, and beta3 integrins. McDowall, A., Inwald, D., Leitinger, B., Jones, A., Liesner, R., Klein, N., Hogg, N. J. Clin. Invest. (2003) [Pubmed]
  9. A two-amino acid insertion in the Cys146- Cys167 loop of the alphaIIb subunit is associated with a variant of Glanzmann thrombasthenia. Critical role of Asp163 in ligand binding. Honda, S., Tomiyama, Y., Shiraga, M., Tadokoro, S., Takamatsu, J., Saito, H., Kurata, Y., Matsuzawa, Y. J. Clin. Invest. (1998) [Pubmed]
  10. An inherited bleeding disorder linked to a defective interaction between ADP and its receptor on platelets. Its influence on glycoprotein IIb-IIIa complex function. Nurden, P., Savi, P., Heilmann, E., Bihour, C., Herbert, J.M., Maffrand, J.P., Nurden, A. J. Clin. Invest. (1995) [Pubmed]
  11. Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets. Ferrell, J.E., Martin, G.S. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  12. C-terminal peptide of thrombospondin-1 induces platelet aggregation through the Fc receptor gamma-chain-associated signaling pathway and by agglutination. Tulasne, D., Judd, B.A., Johansen, M., Asazuma, N., Best, D., Brown, E.J., Kahn, M., Koretzky, G.A., Watson, S.P. Blood (2001) [Pubmed]
  13. A Leu117-->Trp mutation within the RGD-peptide cross-linking region of beta3 results in Glanzmann thrombasthenia by preventing alphaIIb beta3 export to the platelet surface. Basani, R.B., Brown, D.L., Vilaire, G., Bennett, J.S., Poncz, M. Blood (1997) [Pubmed]
  14. Activation of the fibrinogen binding site on platelets isolated from a patient with the Strasbourg I variant of Glanzmann's thrombasthenia. Kouns, W.C., Steiner, B., Kunicki, T.J., Moog, S., Jutzi, J., Jennings, L.K., Cazenave, J.P., Lanza, F. Blood (1994) [Pubmed]
  15. Therapeutic expression of the platelet-specific integrin, alphaIIbbeta3, in a murine model for Glanzmann thrombasthenia. Fang, J., Hodivala-Dilke, K., Johnson, B.D., Du, L.M., Hynes, R.O., White, G.C., Wilcox, D.A. Blood (2005) [Pubmed]
  16. Molecular basis for Glanzmann's thrombasthenia (GT) in a compound heterozygote with glycoprotein IIb gene: a proposal for the classification of GT based on the biosynthetic pathway of glycoprotein IIb-IIIa complex. Kato, A., Yamamoto, K., Miyazaki, S., Jung, S.M., Moroi, M., Aoki, N. Blood (1992) [Pubmed]
  17. An exon 28 mutation resulting in alternative splicing of the glycoprotein IIb transcript and Glanzmann's thrombasthenia. Iwamoto, S., Nishiumi, E., Kajii, E., Ikemoto, S. Blood (1994) [Pubmed]
  18. Heterogeneity of membrane surface proteins in Glanzmann's thrombasthenia. Holahan, J.R., White, G.C. Blood (1981) [Pubmed]
  19. The human integrin beta3 gene is 63 kb and contains a 5'-UTR sequence regulating expression. Wilhide, C.C., Jin, Y., Guo, Q., Li, L., Li, S.X., Rubin, E., Bray, P.F. Blood (1997) [Pubmed]
  20. Identification of a novel integrin beta subunit expressed on cultured monocytes (macrophages). Evidence that one alpha subunit can associate with multiple beta subunits. Krissansen, G.W., Elliott, M.J., Lucas, C.M., Stomski, F.C., Berndt, M.C., Cheresh, D.A., Lopez, A.F., Burns, G.F. J. Biol. Chem. (1990) [Pubmed]
  21. Detection of carriers in Glanzmann's thrombasthenia. Zonneveld, G.T., van Leeuwen, E.F., Sturk, A., ten Cate, J.W. Thromb. Haemost. (1983) [Pubmed]
  22. Megakaryocytes from the marrow of a patient with Glanzmann's thrombasthenia lacked GP IIb-IIIa complexes. Hourdillé, P., Fialon, P., Belloc, F., Namur, M., Boisseau, M.R., Nurden, A.T. Thromb. Haemost. (1986) [Pubmed]
  23. Mutations in the alphaIIb and beta3 genes that cause Glanzmann thrombasthenia can be distinguished by a simple procedure using transformed B-lymphocytes. Rosenberg, N., Dardik, R., Rosenthal, E., Zivelin, A., Seligsohn, U. Thromb. Haemost. (1998) [Pubmed]
  24. Illegitimate transcription: its use for studying genetic abnormalities in lymphoblastoid cells from patients with Glanzmann thrombasthenia. Negrier, C., Vinciguerra, C., Attali, O., Grenier, C., Larcher, M.E., Dechavanne, M. Br. J. Haematol. (1998) [Pubmed]
  25. CD36 associates with CD9 and integrins on human blood platelets. Miao, W.M., Vasile, E., Lane, W.S., Lawler, J. Blood (2001) [Pubmed]
  26. Organization of the gene for platelet glycoprotein IIb. Heidenreich, R., Eisman, R., Surrey, S., Delgrosso, K., Bennett, J.S., Schwartz, E., Poncz, M. Biochemistry (1990) [Pubmed]
  27. Role of membrane glycoproteins in the interaction of blood platelets with the vessel wall--the study on platelet adhesion to in vitro cultured subendothelial matrix. Kawai, Y., Handa, M., Nagai, H., Kamata, T., Anbo, H., Kawano, K., Araki, Y., Yamamoto, M., Ikeda, Y., Watanabe, K. Nippon Ketsueki Gakkai Zasshi (1989) [Pubmed]
  28. Identification of an abnormal gene for the GPIIIa subunit of the platelet fibrinogen receptor resulting in Glanzmann's thrombasthenia. Bray, P.F., Shuman, M.A. Blood (1990) [Pubmed]
  29. Release of soluble CD40 ligand after platelet activation: studies on the solubilization phase. Otterdal, K., Pedersen, T.M., Solum, N.O. Thromb. Res. (2004) [Pubmed]
  30. Application of GPIIIa gene Taq I polymorphism to determination of carrier status in Glanzmann's thrombasthenia families of Chinese origin. Ruan, C., Gu, J., Wang, X., Chu, X., Pan, J. Thromb. Haemost. (1993) [Pubmed]
  31. Ultrastructural analysis of the distribution of the vitronectin receptor (alpha v beta 3) in human platelets and megakaryocytes reveals an intracellular pool and labelling of the alpha-granule membrane. Poujol, C., Nurden, A.T., Nurden, P. Br. J. Haematol. (1997) [Pubmed]
  32. Monoclonal antibodies against human platelet glycoprotein IIIa. Tetteroo, P.A., Lansdorp, P.M., Leeksma, O.C., von dem Borne, A.E. Br. J. Haematol. (1983) [Pubmed]
  33. Detection of an epitope specific for the dissociated form of glycoprotein IIIa of platelet membrane glycoprotein IIb-IIIa complex and its expression on the surface of adherent platelets. Khaspekova, S.G., Vlasik, T.N., Byzova, T.V., Vinogradov, D.V., Berndt, M.C., Mazurov, A.V. Br. J. Haematol. (1993) [Pubmed]
  34. Mechanism of platelet aggregation induced by a monoclonal antibody requiring Fc portion. Yu, A.X., Wu, X.W., Li, J.Z., Lian, E.C. Thromb. Res. (1993) [Pubmed]
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