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Gene Review

fn1  -  fibronectin 1

Xenopus (Silurana) tropicalis

Synonyms: FN, cig, fibronectin, finc, lets, ...
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High impact information on fn1


Biological context of fn1


Anatomical context of fn1

  • These data suggest that mesoderm induction activates the position-specific recognition of the synergy site of FN in vivo [1].
  • In premigratory stages of the crest, both in Xenopus (stage 22) and the axolotl (stage 25), FN was found subepidermally and in extracellular spaces around the neural tube, notochord and somites [6].
  • FN is present in the embryonic ECM before the onset of neural crest migration.(ABSTRACT TRUNCATED AT 400 WORDS)[6]
  • Normal gastrula cells lack integrin alpha4 and, correspondingly, are unable to adhere to the alpha4 ligand, the V-region of FN [7].
  • In media supplemented with LM, FN or CO, the SPPs showed little change but the neurite bundle patterns were qualitatively different [8].

Associations of fn1 with chemical compounds

  • It is shown that the adhesion of ectodermal cells is modified by their interaction with a heparin-binding domain of the FN molecule [9].
  • Triflavin, an Arg-Gly-Asp-dependent disintegrin, inhibited potentiating action of isoproterenol in neurons grown on FN substratum, suggesting that integrin is involved in the potentiation of the PKA pathway in the regulation of acetylcholine (ACh) release [4].
  • The substrates include plastic (UN), polylysine (PL), polyornithine (PO), laminin (LM), fibronectin (FN), and collagen type I (CO) [8].
  • The adhesive glycoprotein fibronectin (FN), which is a component of the network of extracellular matrix fibrils on the inner surface of the blastocoel roof (BCR), has been proposed to play a major role in directing mesodermal cell migration during amphibian gastrulation [3].
  • Serine and cysteinyl proteases play important roles in Fn disassembly caused by PKA activation, but not that caused by PKC inhibition [10].

Analytical, diagnostic and therapeutic context of fn1


  1. Xenopus embryonic cell adhesion to fibronectin: position-specific activation of RGD/synergy site-dependent migratory behavior at gastrulation. Ramos, J.W., DeSimone, D.W. J. Cell Biol. (1996) [Pubmed]
  2. The Wnt/Wg signal transducer beta-catenin controls fibronectin expression. Gradl, D., Kühl, M., Wedlich, D. Mol. Cell. Biol. (1999) [Pubmed]
  3. Mesodermal cell migration during Xenopus gastrulation. Winklbauer, R. Dev. Biol. (1990) [Pubmed]
  4. Modulation of protein kinase A activation by fibronectin matrix proteins at developing neuromuscular synapses in Xenopus laevis cell cultures. Liou, H.H., Lin, W., Liou, H.C., Huang, T.F., Fu, W.M. Mol. Pharmacol. (2001) [Pubmed]
  5. Identification and characterization of a second fibronectin gene in zebrafish. Sun, L., Zou, Z., Collodi, P., Xu, F., Xu, X., Zhao, Q. Matrix Biol. (2005) [Pubmed]
  6. The distribution of fibronectin and tenascin along migratory pathways of the neural crest in the trunk of amphibian embryos. Epperlein, H.H., Halfter, W., Tucker, R.P. Development (1988) [Pubmed]
  7. Differential regulation of cell adhesive functions by integrin alpha subunit cytoplasmic tails in vivo. Na, J., Marsden, M., DeSimone, D.W. J. Cell. Sci. (2003) [Pubmed]
  8. Embryonic and regenerating Xenopus retinal fibers are intrinsically different. Grant, P., Tseng, Y. Dev. Biol. (1986) [Pubmed]
  9. Differential interaction of Xenopus embryonic cells with fibronectin in vitro. Winklbauer, R. Dev. Biol. (1988) [Pubmed]
  10. Differential regulation of fibronectin fibrillogenesis by protein kinases A and C. Lin, W., Wang, S.M., Huang, T.F., Fu, W.M. Connect. Tissue Res. (2002) [Pubmed]
  11. Fibronectin visualized by scanning electron microscopy immunocytochemistry on the substratum for cell migration in Xenopus laevis gastrulae. Nakatsuji, N., Smolira, M.A., Wylie, C.C. Dev. Biol. (1985) [Pubmed]
  12. Assembly and remodeling of the fibrillar fibronectin extracellular matrix during gastrulation and neurulation in Xenopus laevis. Davidson, L.A., Keller, R., DeSimone, D.W. Dev. Dyn. (2004) [Pubmed]
  13. Fibronectin distribution during cell type conversion in newt lens regeneration. Elgert, K.L., Zalik, S.E. Anat. Embryol. (1989) [Pubmed]
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