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Chemical Compound Review

ornithine     (2S)-2,5-diaminopentanoic acid

Synonyms: Ornitina, Ornithinum, polyornithine, L-ornithine, L( )-Ornithine, ...
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Disease relevance of ornithine


High impact information on ornithine

  • When various ECM constituents were adsorbed to polyornithine-conditioned glass, a favorable substrate for neural cells, the neurons avoided J1/tenascin-, but not laminin- or fibronectin-coated surfaces, while they grew on J1/tenascin-free, polyornithine-containing areas of the coverslip [6].
  • Zinc uptake in normal and leukemic lymphocytes: effect of poly-L-ornithine [1].
  • In contrast, suppression of GAP-43 expression prevented growth cone and neurite formation when DRG neurons were plated on poly-L-ornithine [7].
  • Motoneurons from E5 chicken spinal cord were incubated with pAntp, purified by panning on SC1 antibody and plated on polyornithine/laminin substrata without further addition of pAntp [8].
  • When postnatal granule cell neurons were cultured on tenascin adsorbed to polyornithine, both the percentage of neurite-bearing cells and the length of outgrowing neurites were increased when compared to neurons growing on polyornithine alone [9].

Chemical compound and disease context of ornithine


Biological context of ornithine


Anatomical context of ornithine


Associations of ornithine with other chemical compounds


Gene context of ornithine

  • Surprisingly, in view of a previous study carried out using polyornithine as a substrate for neuronal cell attachment, on laminin-coated dishes BDNF also sustained survival and neurite outgrowth from a high percentage (60-70%) of DRG neurons taken from E6 embryos [24].
  • Compared to growth on polyornithine alone, oligodendroblast differentiation in the added presence of MAG or N-CAM was qualitatively unchanged; > 90% of surviving cells developed into OCs that matured further by immunocytochemical and morphological criteria [25].
  • When the neural precursor cells were carried in the presence of poly-l-ornithine (PLO), there was a strong induction of the expression of iNOS proteins, indicating the possibility that this isoform is amenable to modulation by extracellular cues [26].
  • CNTF, but not NGF, slightly enhanced survival at 7 days on either PORN or LN [27].
  • Ciliary ganglion neurons extend neuritic processes when cultured for 24 h in medium containing ciliary neuronotrophic factor (CNTF) and on a polyornithine substratum precoated with either laminin or a Schwannoma-derived neurite promoting factor (PNPF) [28].

Analytical, diagnostic and therapeutic context of ornithine


  1. Zinc uptake in normal and leukemic lymphocytes: effect of poly-L-ornithine. Phillips, J.L., Tuley, J.A., Bowman, R.P. J. Natl. Cancer Inst. (1977) [Pubmed]
  2. Laminin promotes neuritic regeneration from cultured peripheral and central neurons. Manthorpe, M., Engvall, E., Ruoslahti, E., Longo, F.M., Davis, G.E., Varon, S. J. Cell Biol. (1983) [Pubmed]
  3. Conjugation of poly-L-lysine to albumin and horseradish peroxidase: a novel method of enhancing the cellular uptake of proteins. Shen, W.C., Ryser, H.J. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  4. Depolarization and laminin independently enable bFGF to promote neuronal survival through different second messenger pathways. Schmidt, M.F., Kater, S.B. Dev. Biol. (1995) [Pubmed]
  5. Epidermal growth factor labeled beta-amanitin-poly-L-ornithine: preparation and evidence for specific cytotoxicity. Bermbach, U., Faulstich, H. Biochemistry (1990) [Pubmed]
  6. J1/tenascin is a repulsive substrate for central nervous system neurons. Faissner, A., Kruse, J. Neuron (1990) [Pubmed]
  7. Depletion of 43-kD growth-associated protein in primary sensory neurons leads to diminished formation and spreading of growth cones. Aigner, L., Caroni, P. J. Cell Biol. (1993) [Pubmed]
  8. Antennapedia homeobox peptide enhances growth and branching of embryonic chicken motoneurons in vitro. Bloch-Gallego, E., Le Roux, I., Joliot, A.H., Volovitch, M., Henderson, C.E., Prochiantz, A. J. Cell Biol. (1993) [Pubmed]
  9. Tenascin promotes cerebellar granule cell migration and neurite outgrowth by different domains in the fibronectin type III repeats. Husmann, K., Faissner, A., Schachner, M. J. Cell Biol. (1992) [Pubmed]
  10. Comparison of DNA facilitators in the uptake and intracellular fate of infectious herpes simplex virus type 2 DNA. Farber, F.E. Biochim. Biophys. Acta (1976) [Pubmed]
  11. Cytoskeletal movements and substrate interactions during initiation of neurite outgrowth by sympathetic neurons in vitro. Smith, C.L. J. Neurosci. (1994) [Pubmed]
  12. Efficient DNA transfection of quiescent mammalian cells using poly-L-ornithine. Dong, Y., Skoultchi, A.I., Pollard, J.W. Nucleic Acids Res. (1993) [Pubmed]
  13. Laminin through its long arm E8 fragment promotes the proliferation and differentiation of murine neuroepithelial cells in vitro. Drago, J., Nurcombe, V., Bartlett, P.F. Exp. Cell Res. (1991) [Pubmed]
  14. Poly-L-ornithine-mediated transfection of human keratinocytes. Nead, M.A., McCance, D.J. J. Invest. Dermatol. (1995) [Pubmed]
  15. Astrocyte-regulated synaptogenesis: an in vitro ultrastructural study. Rouget, M., Araud, D., Seite, R., Prochiantz, A., Autillo-Touati, A. Neurosci. Lett. (1993) [Pubmed]
  16. J1/tenascin in substrate-bound and soluble form displays contrary effects on neurite outgrowth. Lochter, A., Vaughan, L., Kaplony, A., Prochiantz, A., Schachner, M., Faissner, A. J. Cell Biol. (1991) [Pubmed]
  17. The heparin-binding domain of laminin is responsible for its effects on neurite outgrowth and neuronal survival. Edgar, D., Timpl, R., Thoenen, H. EMBO J. (1984) [Pubmed]
  18. Early cytoplasmic specialization at the presumptive acetylcholine receptor cluster: a meshwork of thin filaments. Peng, H.B., Phelan, K.A. J. Cell Biol. (1984) [Pubmed]
  19. Poly-L-ornithine-mediated transformation of mammalian cells. Bond, V.C., Wold, B. Mol. Cell. Biol. (1987) [Pubmed]
  20. Stimulation of clonal growth of normal fibroblasts with substrata coated with basic polymers. McKeehan, W.L., Ham, R.G. J. Cell Biol. (1976) [Pubmed]
  21. Differential susceptibility to neurotoxicity mediated by neurotrophins and neuronal nitric oxide synthase. Samdani, A.F., Newcamp, C., Resink, A., Facchinetti, F., Hoffman, B.E., Dawson, V.L., Dawson, T.M. J. Neurosci. (1997) [Pubmed]
  22. Basic fibroblast growth factor promotes adhesive interactions of neuroepithelial cells from chick neural tube with extracellular matrix proteins in culture. Kinoshita, Y., Kinoshita, C., Heuer, J.G., Bothwell, M. Development (1993) [Pubmed]
  23. Muscle-derived factors that support survival and promote fiber outgrowth from embryonic chick spinal motor neurons in culture. Dohrmann, U., Edgar, D., Sendtner, M., Thoenen, H. Dev. Biol. (1986) [Pubmed]
  24. Placode and neural crest-derived sensory neurons are responsive at early developmental stages to brain-derived neurotrophic factor. Lindsay, R.M., Thoenen, H., Barde, Y.A. Dev. Biol. (1985) [Pubmed]
  25. In vitro oligodendrogliotrophic properties of cell adhesion molecules in the immunoglobulin superfamily: myelin-associated glycoprotein and N-CAM. Gard, A.L., Maughon, R.H., Schachner, M. J. Neurosci. Res. (1996) [Pubmed]
  26. Differential expression of nitric oxide synthases in EGF-responsive mouse neural precursor cells. Wang, T., FitzGerald, T.J., Haregewoin, A. Cell Tissue Res. (1999) [Pubmed]
  27. Neuron-enriched cultures of adult rat dorsal root ganglia: establishment, characterization, survival, and neuropeptide expression in response to trophic factors. Grothe, C., Unsicker, K. J. Neurosci. Res. (1987) [Pubmed]
  28. Parameters of neuritic growth from ciliary ganglion neurons in vitro: influence of laminin, schwannoma polyornithine-binding neurite promoting factor and ciliary neuronotrophic factor. Davis, G.E., Manthorpe, M., Varon, S. Brain Res. (1985) [Pubmed]
  29. Binding of isolated rheumatoid factors to histone proteins and basic polycations. Hobbs, R.N., Lea, D.J., Phua, K.K., Johnson, P.M. Ann. Rheum. Dis. (1983) [Pubmed]
  30. Accelerated functional maturation of isolated neonatal porcine cell clusters: in vitro and in vivo results in NOD mice. Luca, G., Nastruzzi, C., Calvitti, M., Becchetti, E., Baroni, T., Neri, L.M., Capitani, S., Basta, G., Brunetti, P., Calafiore, R. Cell transplantation. (2005) [Pubmed]
  31. Survival and neurite growth of chick embryo spinal cord cells in serum-free culture. Tanaka, H., Obata, K. Brain Res. (1982) [Pubmed]
  32. Preparation and in vitro and in vivo characterization of composite microcapsules for cell encapsulation. Blasi, P., Giovagnoli, S., Schoubben, A., Ricci, M., Rossi, C., Luca, G., Basta, G., Calafiore, R. International journal of pharmaceutics. (2006) [Pubmed]
  33. Atomic force microscopy study of DNA deposited on poly L-ornithine-coated mica. Podesta, A., Imperadori, L., Colnaghi, W., Finzi, L., Milani, P., Dunlap, D. Journal of microscopy. (2004) [Pubmed]
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