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Gene Review

CCL26  -  chemokine (C-C motif) ligand 26

Homo sapiens

Synonyms: C-C motif chemokine 26, CC chemokine IMAC, Eotaxin-3, IMAC, MIP-4-alpha, ...
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Disease relevance of CCL26


High impact information on CCL26


Chemical compound and disease context of CCL26


Biological context of CCL26


Anatomical context of CCL26


Associations of CCL26 with chemical compounds

  • CCL24 challenge significantly accelerated epithelial wound closure, with similar effects exerted by CCL11 and CCL26 [13].
  • Cycloheximide and actinomycin D abrogated IL-4- and IL-13-dependent CCL26 but not CCL24 secretion [8].
  • Dexamethasone pre-treatment diminished induction of Eotaxin-3 mRNA expression [2].
  • In contrast, eotaxin-3/CCL26 production was inhibited similarly by PD98059 as well as U0126 and SB203580 [14].
  • Eotaxin-3 is monomeric under the conditions in this study and consists of an unstructured N-terminus before the first two conserved cysteine residues, an irregularly structured N-loop following the second conserved cysteine, a single turn of 3(10)-helix, a three-stranded antiparallel beta-sheet, an alpha-helix, and an unstructured C-terminal tail [15].

Physical interactions of CCL26


Regulatory relationships of CCL26


Other interactions of CCL26


Analytical, diagnostic and therapeutic context of CCL26


  1. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. Kitaura, M., Suzuki, N., Imai, T., Takagi, S., Suzuki, R., Nakajima, T., Hirai, K., Nomiyama, H., Yoshie, O. J. Biol. Chem. (1999) [Pubmed]
  2. Regulation of human eotaxin-3/CCL26 expression: modulation by cytokines and glucocorticoids. Banwell, M.E., Tolley, N.S., Williams, T.J., Mitchell, T.J. Cytokine (2002) [Pubmed]
  3. Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. Blanchard, C., Wang, N., Stringer, K.F., Mishra, A., Fulkerson, P.C., Abonia, J.P., Jameson, S.C., Kirby, C., Konikoff, M.R., Collins, M.H., Cohen, M.B., Akers, R., Hogan, S.P., Assa'ad, A.H., Putnam, P.E., Aronow, B.J., Rothenberg, M.E. J. Clin. Invest. (2006) [Pubmed]
  4. TGF-beta differentially regulates TH2 cytokine-induced eotaxin and eotaxin-3 release by human airway smooth muscle cells. Zuyderduyn, S., Hiemstra, P.S., Rabe, K.F. J. Allergy Clin. Immunol. (2004) [Pubmed]
  5. Shear-dependent eosinophil transmigration on interleukin 4-stimulated endothelial cells: a role for endothelium-associated eotaxin-3. Cuvelier, S.L., Patel, K.D. J. Exp. Med. (2001) [Pubmed]
  6. Eotaxin-3 is a natural antagonist for CCR2 and exerts a repulsive effect on human monocytes. Ogilvie, P., Paoletti, S., Clark-Lewis, I., Uguccioni, M. Blood (2003) [Pubmed]
  7. Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge. Ravensberg, A.J., Ricciardolo, F.L., van Schadewijk, A., Rabe, K.F., Sterk, P.J., Hiemstra, P.S., Mauad, T. J. Allergy Clin. Immunol. (2005) [Pubmed]
  8. Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation. Abonyo, B.O., Alexander, M.S., Heiman, A.S. Am. J. Physiol. Lung Cell Mol. Physiol. (2005) [Pubmed]
  9. Eotaxin-3 but not eotaxin gene expression is upregulated in asthmatics 24 hours after allergen challenge. Berkman, N., Ohnona, S., Chung, F.K., Breuer, R. Am. J. Respir. Cell Mol. Biol. (2001) [Pubmed]
  10. Activation of eotaxin-3/CCLl26 gene expression in human dermal fibroblasts is mediated by STAT6. Hoeck, J., Woisetschläger, M. J. Immunol. (2001) [Pubmed]
  11. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. Shinkai, A., Yoshisue, H., Koike, M., Shoji, E., Nakagawa, S., Saito, A., Takeda, T., Imabeppu, S., Kato, Y., Hanai, N., Anazawa, H., Kuga, T., Nishi, T. J. Immunol. (1999) [Pubmed]
  12. Interleukin-4 and interleukin-13 enhance CCL26 production in a human keratinocyte cell line, HaCaT cells. Kagami, S., Saeki, H., Komine, M., Kakinuma, T., Tsunemi, Y., Nakamura, K., Sasaki, K., Asahina, A., Tamaki, K. Clin. Exp. Immunol. (2005) [Pubmed]
  13. Functional analysis of the chemokine receptor CCR3 on airway epithelial cells. Beck, L.A., Tancowny, B., Brummet, M.E., Asaki, S.Y., Curry, S.L., Penno, M.B., Foster, M., Bahl, A., Stellato, C. J. Immunol. (2006) [Pubmed]
  14. Differential Regulation of Eotaxin-1/CCL11 and Eotaxin-3/CCL26 Production by the TNF-alpha and IL-4 Stimulated Human Lung Fibroblast. Rokudai, A., Terui, Y., Kuniyoshi, R., Mishima, Y., Mishima, Y., Aizu-Yokota, E., Sonoda, Y., Kasahara, T., Hatake, K. Biol. Pharm. Bull. (2006) [Pubmed]
  15. NMR solution structure and backbone dynamics of the CC chemokine eotaxin-3. Ye, J., Mayer, K.L., Mayer, M.R., Stone, M.J. Biochemistry (2001) [Pubmed]
  16. Eotaxin-3/CCL26 is a natural antagonist for CC chemokine receptors 1 and 5. A human chemokine with a regulatory role. Petkovic, V., Moghini, C., Paoletti, S., Uguccioni, M., Gerber, B. J. Biol. Chem. (2004) [Pubmed]
  17. Upregulation of interleukin-4 receptor by interferon-gamma: enhanced interleukin-4-induced eotaxin-3 production in airway epithelium. Yamamoto, S., Kobayashi, I., Tsuji, K., Nishi, N., Muro, E., Miyazaki, M., Zaitsu, M., Inada, S., Ichimaru, T., Hamasaki, Y. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  18. Regulation of eotaxin gene expression by TNF-alpha and IL-4 through mRNA stabilization: involvement of the RNA-binding protein HuR. Atasoy, U., Curry, S.L., López de Silanes, I., Shyu, A.B., Casolaro, V., Gorospe, M., Stellato, C. J. Immunol. (2003) [Pubmed]
  19. Significant elevation of serum levels of eotaxin-3/CCL26, but not of eotaxin-2/CCL24, in patients with atopic dermatitis: serum eotaxin-3/CCL26 levels reflect the disease activity of atopic dermatitis. Kagami, S., Kakinuma, T., Saeki, H., Tsunemi, Y., Fujita, H., Nakamura, K., Takekoshi, T., Kishimoto, M., Mitsui, H., Torii, H., Komine, M., Asahina, A., Tamaki, K. Clin. Exp. Immunol. (2003) [Pubmed]
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