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Gene Review

TDGF1P3  -  teratocarcinoma-derived growth factor 1...

Homo sapiens

Synonyms: CR-3, CRIPTO, CRIPTO-3, CRIPTO3, Cripto-3 growth factor, ...
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Disease relevance of TDGF3


High impact information on TDGF3

  • The interaction between CR3 and FHA involves recognition of the Arg-Gly-Asp (RGD) sequence at positions 1097-1099 in FHA [4].
  • We studied neutrophil activation in patients with burns by serial immunofluorescent measurement of neutrophil expression of the complement opsonin receptors CR1 and CR3 [5].
  • Although attachment and invasion of human macrophages by L. pneumophila is mediated in part by the complement receptors CR1 and CR3, the protozoan receptor involved in bacterial attachment and invasion has not been identified [6].
  • Recent studies (Cai, T.-Q., and S.D. Wright 1995. J. Biol. Chem. 270:14358) suggest that adhesion may be favored by stimulus-dependent changes in the kinetics of ligand binding by CR3 [7].
  • We show that an FHA Arg-Gly-Asp site induces enhanced B. pertussis binding to monocytes, and that this enhancement is blocked by antibodies directed against CR3 [8].

Chemical compound and disease context of TDGF3


Biological context of TDGF3


Anatomical context of TDGF3

  • Expression of teratocarcinoma-derived growth factor-1 (TDGF-1) in testis germ cell tumors and its effects on growth and differentiation of embryonal carcinoma cell line NTERA2/D1 [2].
  • We show that TDGF-1 expression is markedly elevated in a subset of human testicular germ cell tumors as compared to normal testes [2].
  • Granulocyte-macrophage colony-stimulating factor increases synthesis and expression of CR1 and CR3 by human peripheral blood neutrophils [16].
  • Sixteen hours after a short (1-h) pretreatment of human monocyte monolayers with zymosan opsonized with human AB serum (250 micrograms/ml), CR3 expression (as assessed by flow cytometric analysis with mAb Mo1) was significantly reduced by 59 +/- 3% (mean +/- SEM, n = 15, p less than 0.001) [17].
  • Monoclonal antibodies to human CR1 and CR3 (3D9, 1B4, C511, 2B6, anti-B2, Mo1, and anti-Mac-1), in general, did not block adherence of test erythrocytes [18].

Associations of TDGF3 with chemical compounds

  • The teratocarcinoma-derived growth factor-1 (TDGF-1) gene codes for a 188-aminoacid glycoprotein that shares structural homology with the epidermal growth factor (EGF) family of growth factors [2].
  • However, TDGF-1 protein treatment was unable to block differentiation induced by both RA and HMBA [2].
  • Antisense 20-mer phosphorothioate oligodeoxynucleotides (AS S-oligos) directed against CR, AR, and TGF-alpha mRNAs were equipotent in their ability to inhibit both the anchorage-dependent growth and the anchorage-independent growth (AIG) of GEO cells, with a 50% inhibitory concentration of about 5 micrometer in the AIG assay [19].
  • We have found that the EGF-CFC family member human Cripto-1 (CR) is modified with fucose and through a combination of peptide mapping, mass spectrometry, and sequence analysis localized the site of attachment to Thr-88 [20].
  • Macrophage C3 was deposited rapidly, within 10 min, on the zymosan particles and mediated binding, ingestion, and stimulation of superoxide release in BCG-activated and thioglycollate-elicited peritoneal M phi via CR3 [21].

Other interactions of TDGF3

  • The present study found that incubation for 40 h of human monocytes or monocyte-derived macrophages in the presence of IL-10 caused a significant enhancement of their capacity to ingest particles coated with immunoglobulin G (Fc gamma R-mediated ingestion) or with C3b/C3bi fragments of the complement system (CR1/CR3-mediated ingestion) [22].
  • Sixty-four patients underwent transplantation in first remission (CR1), 16 in CR2 or CR3, and 47 patients had relapsed ALL or primary induction failure (PIF) [23].
  • The actuarial probability of relapse is 20%, 26%, and 48% for those transplanted in CR1, CR2, and CR3, respectively [24].
  • Eighteen patients in first complete remission (CR1), 36 in CR2, 16 in CR3, and four in CR4 were transplanted [24].
  • Germ Cell Nuclear Factor Is a Repressor of CRIPTO-1 and CRIPTO-3 [25].

Analytical, diagnostic and therapeutic context of TDGF3

  • To assess the role of TDGF-1 in the onset and/or progression of human germ cell tumors, we analysed TDGF-1 expression by Northern blot and immunostaining in a panel of 59 human germ cell tumors of different histological origins [2].
  • The 5-year event-free survival (EFS) rates for patients transplanted in CR1, CR2, and CR3 are 42%, 43%, and 25%, respectively, at median follow-up times of 57, 54, and 72 months, respectively [24].
  • CR1, CR3 and class I proteins immunoprecipitated from lysates of 35S-methionine pulse-labeled PMN were resolved by SDS-PAGE, fluorographed and quantified by densitometry [16].
  • The expression of cripto, a member of the epidermal growth factor (EGF) family, was examined by immunohistochemistry in benign lesions and carcinomas of the gall bladder [26].
  • The AS S-oligos were also able to inhibit specifically the expression of either AR, CR, or TGF-alpha proteins in GEO cells, as assessed using immunocytochemistry or Western blot analysis [19].


  1. Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence. Dono, R., Montuori, N., Rocchi, M., De Ponti-Zilli, L., Ciccodicola, A., Persico, M.G. Am. J. Hum. Genet. (1991) [Pubmed]
  2. Expression of teratocarcinoma-derived growth factor-1 (TDGF-1) in testis germ cell tumors and its effects on growth and differentiation of embryonal carcinoma cell line NTERA2/D1. Baldassarre, G., Romano, A., Armenante, F., Rambaldi, M., Paoletti, I., Sandomenico, C., Pepe, S., Staibano, S., Salvatore, G., De Rosa, G., Persico, M.G., Viglietto, G. Oncogene (1997) [Pubmed]
  3. A truncated form of teratocarcinoma-derived growth factor-1 (cripto-1) mRNA expressed in human colon carcinoma cell lines and tumors. Baldassarre, G., Tucci, M., Lembo, G., Pacifico, F.M., Dono, R., Lago, C.T., Barra, A., Bianco, C., Viglietto, G., Salomon, D., Persico, M.G. Tumour Biol. (2001) [Pubmed]
  4. Recognition of a bacterial adhesion by an integrin: macrophage CR3 (alpha M beta 2, CD11b/CD18) binds filamentous hemagglutinin of Bordetella pertussis. Relman, D., Tuomanen, E., Falkow, S., Golenbock, D.T., Saukkonen, K., Wright, S.D. Cell (1990) [Pubmed]
  5. Neutrophil activation in thermal injury as assessed by increased expression of complement receptors. Moore, F.D., Davis, C., Rodrick, M., Mannick, J.A., Fearon, D.T. N. Engl. J. Med. (1986) [Pubmed]
  6. Identification of a Gal/GalNAc lectin in the protozoan Hartmannella vermiformis as a potential receptor for attachment and invasion by the Legionnaires' disease bacterium. Venkataraman, C., Haack, B.J., Bondada, S., Abu Kwaik, Y. J. Exp. Med. (1997) [Pubmed]
  7. Human leukocyte elastase is an endogenous ligand for the integrin CR3 (CD11b/CD18, Mac-1, alpha M beta 2) and modulates polymorphonuclear leukocyte adhesion. Cai, T.Q., Wright, S.D. J. Exp. Med. (1996) [Pubmed]
  8. Bordetella pertussis filamentous hemagglutinin interacts with a leukocyte signal transduction complex and stimulates bacterial adherence to monocyte CR3 (CD11b/CD18). Ishibashi, Y., Claus, S., Relman, D.A. J. Exp. Med. (1994) [Pubmed]
  9. Endogenously opsonized particles divert prostanoid action from lethal to protective in models of experimental endotoxemia. Eierman, D.F., Yagami, M., Erme, S.M., Minchey, S.R., Harmon, P.A., Pratt, K.J., Janoff, A.S. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  10. Functional differentiation of normal human neutrophils. Glasser, L., Fiederlein, R.L. Blood (1987) [Pubmed]
  11. Targeting of natural killer cells to mammary carcinoma via naturally occurring tumor cell-bound iC3b and beta-glucan-primed CR3 (CD11b/CD18). Vetvicka, V., Thornton, B.P., Wieman, T.J., Ross, G.D. J. Immunol. (1997) [Pubmed]
  12. Subversion of monocyte functions by coxiella burnetii: impairment of the cross-talk between alphavbeta3 integrin and CR3. Capo, C., Lindberg, F.P., Meconi, S., Zaffran, Y., Tardei, G., Brown, E.J., Raoult, D., Mege, J.L. J. Immunol. (1999) [Pubmed]
  13. Assignment of human teratocarcinoma derived growth factor (TDGF) sequences to chromosomes 2q37, 3q22, 6p25 and 19q13.1. Scognamiglio, B., Baldassarre, G., Cassano, C., Tucci, M., Montuori, N., Dono, R., Lembo, G., Barra, A., Lago, C.T., Viglietto, G., Rocchi, M., Persico, M.G. Cytogenet. Cell Genet. (1999) [Pubmed]
  14. Cripto: roles in mammary cell growth, survival, differentiation and transformation. Niemeyer, C.C., Persico, M.G., Adamson, E.D. Cell Death Differ. (1998) [Pubmed]
  15. Characterization of the mouse Tdgf1 gene and Tdgf pseudogenes. Liguori, G., Tucci, M., Montuori, N., Dono, R., Lago, C.T., Pacifico, F., Armenante, F., Persico, M.G. Mamm. Genome (1996) [Pubmed]
  16. Granulocyte-macrophage colony-stimulating factor increases synthesis and expression of CR1 and CR3 by human peripheral blood neutrophils. Neuman, E., Huleatt, J.W., Jack, R.M. J. Immunol. (1990) [Pubmed]
  17. Phagocytosis of serum-opsonized zymosan down-regulates the expression of CR3 and FcRI in the membrane of human monocytes. Wolf, H.M., Mannhalter, J.W., Salzmann, H.C., Göttlicher, J., Ahmad, R., Eibl, M.M. J. Immunol. (1988) [Pubmed]
  18. Expression of specific binding sites on Candida with functional and antigenic characteristics of human complement receptors. Edwards, J.E., Gaither, T.A., O'Shea, J.J., Rotrosen, D., Lawley, T.J., Wright, S.A., Frank, M.M., Green, I. J. Immunol. (1986) [Pubmed]
  19. Growth inhibition of human colon carcinoma cells by combinations of anti-epidermal growth factor-related growth factor antisense oligonucleotides. Normanno, N., Bianco, C., Damiano, V., de Angelis, E., Selvam, M.P., Grassi, M., Magliulo, G., Tortora, G., Bianco, A.R., Mendelsohn, J., Salomon, D.S., Ciardiello, F. Clin. Cancer Res. (1996) [Pubmed]
  20. Fucosylation of Cripto is required for its ability to facilitate nodal signaling. Schiffer, S.G., Foley, S., Kaffashan, A., Hronowski, X., Zichittella, A.E., Yeo, C.Y., Miatkowski, K., Adkins, H.B., Damon, B., Whitman, M., Salomon, D., Sanicola, M., Williams, K.P. J. Biol. Chem. (2001) [Pubmed]
  21. Local opsonization by secreted macrophage complement components. Role of receptors for complement in uptake of zymosan. Ezekowitz, R.A., Sim, R.B., Hill, M., Gordon, S. J. Exp. Med. (1984) [Pubmed]
  22. IL-10 up-regulates human monocyte phagocytosis in the presence of IL-4 and IFN-gamma. Capsoni, F., Minonzio, F., Ongari, A.M., Carbonelli, V., Galli, A., Zanussi, C. J. Leukoc. Biol. (1995) [Pubmed]
  23. Unrelated marrow transplantation for adult patients with poor-risk acute lymphoblastic leukemia: strong graft-versus-leukemia effect and risk factors determining outcome. Cornelissen, J.J., Carston, M., Kollman, C., King, R., Dekker, A.W., Löwenberg, B., Anasetti, C. Blood (2001) [Pubmed]
  24. Allogeneic bone marrow transplantation for patients with high-risk acute lymphoblastic leukemia. Wingard, J.R., Piantadosi, S., Santos, G.W., Saral, R., Vriesendorp, H.M., Yeager, A.M., Burns, W.H., Ambinder, R.F., Braine, H.G., Elfenbein, G. J. Clin. Oncol. (1990) [Pubmed]
  25. Germ Cell Nuclear Factor Is a Repressor of CRIPTO-1 and CRIPTO-3. Hentschke, M., Kurth, I., Borgmeyer, U., H??bner, C.A. J. Biol. Chem. (2006) [Pubmed]
  26. Expression of cripto in human gall bladder lesions. Fujii, K., Yasui, W., Kuniyasu, H., Itoh, M., Hanada, K., Kajiyama, G., Tahara, E. J. Pathol. (1996) [Pubmed]
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