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Chemical Compound Review

Dimension     [6-(difluoromethyl)-4-(2- methylpropyl)-5...

Synonyms: Dithiopyr, AC1L3MQS, MON 7200, LS-131153, MON 15100, ...
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Disease relevance of MON 7200

  • Falsely increased results consistent with myocardial infarction by the original Dimension cTnI assay and presumably attributable to HAs were identified in 0.17% of all patients with samples submitted for cTnI analysis [1].
  • Coronary stenosis increased subendocardial D slightly but consistently only in the DCLHb group (1.39 +/- 0.104; P < 0.05) [2].
  • Left anterior descending coronary artery stenosis changed neither D nor SC [3].
  • From this value, left ventricular pressure was estimated in 13 patients with aortic stenosis aged 4 to 17 years using the formula P = k-Ws/Ds [4].
  • The ABCD system of melanoma detection: a spectrophotometric analysis of the Asymmetry, Border, Color, and Dimension [5].

Psychiatry related information on MON 7200

  • After TSD we observed a worsening in psychotic as well as in depressive symptoms as rated on the Dimension of Delusional Experience Rating Scale and on Hamilton Rating Scale for Depression, respectively [6].
  • To assess nonlinear EEG activity in patients with Alzheimer's disease (AD) and vascular dementia (VaD), the authors estimated the correlation dimension (D2) and the first positive Lyapunov exponent (L1) of the EEGs in both patients and age-matched healthy control subjects [7].
  • Item scores are summarized into 6 Dimension scores (memory, instrumental activities of daily life, self-care, mood, social behavior, and disturbing behavior) which are clinically relevant in dementia, depression, and other psychiatric disorders of old age [8].
  • Significant differences were found between the PTSD and non-PTSD groups in the salience of Dimension 2 [9].
  • The Family Dimension Scale, the Child Behavior Checklist, the Teacher Report Form, the Self-Perceived Competence Scale, and the Body-Esteem Scale were filled out, as well as a specific weight-related questionnaire [10].

High impact information on MON 7200

  • The vascular networks of LCFS2 gene carriers showed higher complexity at the smaller scale (D (1-15): 1.59 (0.12) v 1.47 (0.07); p=0.034), and higher destructured randomness (L-Z: 0.85 (0.11) v 0.73 (0.05); p=0.013) than those of non-carriers [11].
  • Fractal dimension (D) at two scales (D (1-46), and D (1-15), tortuosity (minimum path dimension, Dmin), and relative Lempel-Ziev complexity (L-Z) of the vascular networks from the lower gingival and vestibular oral mucosa were measured [11].
  • RESULTS: The Dimension method was linear to 25.1 micromol/L (12.0 microg/mL) with a detection limit of 0.63 micromol/L (0.3 microg/mL) [12].
  • We describe an adaptation of a latex-enhanced competitive immunoassay for quantifying %HbA1c to the Dade International Dimension analyzer [13].
  • Upon removal of PDGF the cells reverted to their stellate shape (D = 1.26) [14].

Chemical compound and disease context of MON 7200

  • Critical coronary stenosis (critical CS) alone does not lead to an alteration of fractal dimension (D) under resting conditions in a pig model, indicating undisturbed local myocardial perfusion [15].
  • The PTSD patients were found to have lower D2 values than those of the healthy subjects in most channels (Fp1, F8, C4, P4, T3, T4, T5, T6, and O1), indicating that PTSD patients have globally reduced complexity in their EEG waveforms [16].
  • Self-Reported Discrimination and Mental Health Status Among African Descendants, Mexican Americans, and Other Latinos in the New Hampshire REACH 2010 Initiative: The Added Dimension of Immigration [17].

Biological context of MON 7200

  • DESIGN: The scoring algorithm provided an overall composite score and seven dimension scores: D1 (thoughts/desires), D2 (arousal), D3 (frequency of sexual activity), D4 (receptivity/initiation), D5 (pleasure/orgasm), D6 (relationship satisfaction), and D7 (problems affecting sexual function) [18].
  • In this regard, attention is given to the interaction of the Abusable Psychotropic Dimension, including the Abusable Psychotropic Variables (e.g., pharmacokinetics, abuse potential) and Pattern of Use Variables (e.g., social use, abuse, compulsive use), with the Young Person, Societal, and Time Dimensions [19].
  • Analysis of the changes in fractal dimension (D) with respect to time revealed specific rates of growth for each glial phenotype and a specific final D [20].
  • These three measures (RMS, PSD, and D) have been applied to the complex kinetics of tyrosine hydroxylase time courses (50-point curves) at various BH4 concentrations (near physiological, but far from equilibrium levels) [21].
  • GMFM Dimension 5 also improved, with no change in energy expenditure [22].

Anatomical context of MON 7200

  • Removal of both bFGF and PDGF resulted in oligodendrocyte differentiation after 3 days, with a fourfold increase in complexity of shape (D = 1.55 +/- 0.08), loss of Oct-6 transcripts, and gain of myelin transcripts [14].
  • In the present study the box-counting method was used to calculate the "D" values of rat cerebellar oligodendrocytes during their differentiation in primary culture [23].
  • Previous studies on glial cells have shown that as cells increase in morphological complexity, their "D" value increases, suggesting that "D" could be used to estimate their stage of differentiation [23].
  • The maximum D was greater for cells on poly(d-lysine) when compared with neurons on astrocytes [24].
  • At baseline, the fractcal dimension (D) of subendocardial myocardium was 1.31 +/- 0.083 (HSA) and 1.35 +/- 0.106 (DCLHb) (mean +/- SD) [2].

Associations of MON 7200 with other chemical compounds

  • The aca, Dimension, and CEDIA sequential immunoassays moderately overestimated the free digoxin concentration [25].
  • The results provided by the Dade Dimension immunoassay only presented a clinically significant difference with regard to the CBZ + CBZ-E value in the group of patients comedicated with valproic acid [26].
  • Serum iron, ferritin, transferrin, total iron binding capacity, hs-CRP, LDL cholesterol and magnesium in children; new reference intervals using the Dade Dimension Clinical Chemistry System [27].
  • The Dimension method correlated well with flame photometry for sodium and potassium; with the EPOS analyser for creatinine, calcium, uric acid, urea and inorganic phosphate; with atomic absorption spectroscopy for magnesium [28].
  • METHODS: The ACMI (Sur-Catch 3.0), Bard (Dimension 3.0), Boston Scientific (Zero-tip 2.4/3.0, Segura 2.4/3.0, Gemini 3.0, Parachute 3.1), Cook (N-Circle 2.2/3.0/3.2, N-Force 3.2, Flatwire 2.0), and Sacred Heart (Halo 1.9, Vantage 2.4, Summit 3.0, Hercules 3.0) were tested in triplicate [29].

Gene context of MON 7200

  • The evaluation of cardiac troponin I (cTnI) on the Dimension RxL-HM analyzer is presented [30].
  • MATERIALS AND METHODS: The Microvasive Zerotip (2.4Fr, 3.0Fr), Cook N-Circle (2.2Fr, 3.0Fr, 3.2Fr), Bard Dimension (3.0Fr, Sacred Heart Medical Halo (1.9Fr), Vantage (1.9Fr) and Circon-ACMI Sur-Catch-NT (3.0Fr) were tested by 3 novice and 3 experienced basket operators [31].
  • First, a baseline measurement was performed of the discriminative performance of the Spatial Gray-Level Dependence method, the Fourier Power Spectrum, the Fractal Dimension, and the Morphological Gradient Method on images, which were not affected by radiographic noise and blur [32].
  • Total Motor Score (TMS), MMS scores, and the duration of HD were significantly correlated with patients' scores on the SIP, and predicted a significant amount of variance of the Physical Dimension of the SIP, but not of the Psychosocial Dimension [33].
  • The 12MD walk correlated with the Sickness Impact Profile, Physical Dimension (r = -.45); forced expiratory volume in 1 second % predicted ( r = .40); maximal inspiratory pressure (PImax) (r = .52); and exercise-related breathlessness (r = -.49) [34].

Analytical, diagnostic and therapeutic context of MON 7200

  • NRSub is distributed as a flatfile in EMBL format (which is supported by most sequence analysis software packages) and as an ACNUC database, while SubtiList is distributed as a relational database under 4th Dimension [35].
  • Health indicator scores improved significantly: mean Physical Dimension (SIP) from 5.38 to 4.1 (P < 0.005); mean Psychosocial Dimension from 9.2 to 7 (P < 0.001); mean global SIP from 8.9 to 7.25 (P < 0.001); mean Karnofsky scale score from 75.6 to 78.4 (P < 0.01) [36].
  • We describe a fully automated, noncompetitive, homogeneous, light-scattering immunoassay that has been developed for this analyte on a Dimension (Dade) analyzer [37].
  • The perfusion heterogeneity in microvascular units was estimated using the measured heterogeneity (relative dispersion, RD = SD/mean) and D values [38].
  • In Line with the Ultrasound Beam, the Third Dimension to Ultrasound-guided Nerve Blocks [39].


  1. Performance of a revised cardiac troponin method that minimizes interferences from heterophilic antibodies. Kim, W.J., Laterza, O.F., Hock, K.G., Pierson-Perry, J.F., Kaminski, D.M., Mesguich, M., Braconnier, F., Zimmermann, R., Zaninotto, M., Plebani, M., Hanna, A., Cembrowski, G.S., Scott, M.G. Clin. Chem. (2002) [Pubmed]
  2. Effects of primary resuscitation from shock on distribution of myocardial blood flow. Kleen, M., Habler, O., Meisner, F., Kemming, G., Pape, A., Messmer, K. J. Appl. Physiol. (2000) [Pubmed]
  3. Myocardial blood flow heterogeneity in shock and small-volume resuscitation in pigs with coronary stenosis. Kleen, M., Welte, M., Lackermeier, P., Habler, O., Kemming, G., Messmer, K. J. Appl. Physiol. (1997) [Pubmed]
  4. Echocardiographic assessment of the severity of aortic stenosis in children and adolescents. Glanz, S., Hellenbrand, W.E., Berman, M.A., Talner, N.S. Am. J. Cardiol. (1976) [Pubmed]
  5. The ABCD system of melanoma detection: a spectrophotometric analysis of the Asymmetry, Border, Color, and Dimension. Bono, A., Tomatis, S., Bartoli, C., Tragni, G., Radaelli, G., Maurichi, A., Marchesini, R. Cancer (1999) [Pubmed]
  6. Worsening of delusional depression after sleep deprivation: case reports. Benedetti, F., Zanardi, R., Colombo, C., Smeraldi, E. Journal of psychiatric research. (1999) [Pubmed]
  7. Nonlinear dynamic analysis of the EEG in patients with Alzheimer's disease and vascular dementia. Jeong, J., Chae, J.H., Kim, S.Y., Han, S.H. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. (2001) [Pubmed]
  8. A new behavioral assessment scale for geriatric out- and in-patients: the NOSGER (Nurses' Observation Scale for Geriatric Patients). Spiegel, R., Brunner, C., Ermini-Fünfschilling, D., Monsch, A., Notter, M., Puxty, J., Tremmel, L. Journal of the American Geriatrics Society. (1991) [Pubmed]
  9. The dimensionality of trauma: a multidimensional scaling comparison of police officers with and without posttraumatic stress disorder. Carlier, I.V., Lamberts, R.D., Gersons, B.P. Psychiatry research. (2000) [Pubmed]
  10. Family functioning and psychosocial adjustment in overweight youngsters. Stradmeijer, M., Bosch, J., Koops, W., Seidell, J. The International journal of eating disorders. (2000) [Pubmed]
  11. Abnormal vascular network complexity: a new phenotypic marker in hereditary non-polyposis colorectal cancer syndrome. De Felice, C., Latini, G., Bianciardi, G., Parrini, S., Fadda, G.M., Marini, M., Laurini, R.N., Kopotic, R.J. Gut (2003) [Pubmed]
  12. Automated homogeneous immunoassay for gentamicin on the dimension clinical chemistry system. Wei, T.Q., Chu, V.P., Craig, A.R., Duffy, J.E., Obzansky, D.M., Kilgore, D., Masulli, I.S., Sanders, C.M., Thompson, J.C. Clin. Chem. (1999) [Pubmed]
  13. Adaptation of latex-enhanced assay for percent glycohemoglobin to a Dade Dimension analyzer. Holownia, P., Bishop, E., Newman, D.J., John, W.G., Price, C.P. Clin. Chem. (1997) [Pubmed]
  14. Distinct effects of bFGF and PDGF on oligodendrocyte progenitor cells. McKinnon, R.D., Smith, C., Behar, T., Smith, T., Dubois-Dalcq, M. Glia (1993) [Pubmed]
  15. A computer model of fractal myocardial perfusion heterogeneity to elucidate mechanisms of changes in critical coronary stenosis and hypotension. Meier, J., Kleen, M., Messmer, K. Bull. Math. Biol. (2004) [Pubmed]
  16. Dimensional complexity of the EEG in patients with posttraumatic stress disorder. Chae, J.H., Jeong, J., Peterson, B.S., Kim, D.J., Bahk, W.M., Jun, T.Y., Kim, S.Y., Kim, K.S. Psychiatry research. (2004) [Pubmed]
  17. Self-Reported Discrimination and Mental Health Status Among African Descendants, Mexican Americans, and Other Latinos in the New Hampshire REACH 2010 Initiative: The Added Dimension of Immigration. Gee, G.C., Ryan, A., Laflamme, D.J., Holt, J. American journal of public health. (2006) [Pubmed]
  18. The brief index of sexual functioning for women (BISF-W): a new scoring algorithm and comparison of normative and surgically menopausal populations. Mazer, N.A., Leiblum, S.R., Rosen, R.C. Menopause (New York, N.Y.) (2000) [Pubmed]
  19. The phenomenon of abusable psychotropic use among North American youth. Pagliaro, L.A., Pagliaro, A.M. Journal of clinical pharmacology. (1993) [Pubmed]
  20. Comparative fractal analysis of cultured glia derived from optic nerve and brain demonstrate different rates of morphological differentiation. Smith, T.G., Behar, T.N. Brain Res. (1994) [Pubmed]
  21. Metrics from nonlinear dynamics adapted for characterizing the behavior of nonequilibrium enzymatic rate functions. Russo, P.V., Mandell, A.J. Anal. Biochem. (1984) [Pubmed]
  22. Functional outcomes of strength training in spastic cerebral palsy. Damiano, D.L., Abel, M.F. Archives of physical medicine and rehabilitation. (1998) [Pubmed]
  23. Identification of living oligodendrocyte developmental stages by fractal analysis of cell morphology. Bernard, F., Bossu, J.L., Gaillard, S. J. Neurosci. Res. (2001) [Pubmed]
  24. The effect of type 1 astrocytes on neuronal complexity: a fractal analysis. Schaffner, A.E., Ghesquiere, A. Methods (2001) [Pubmed]
  25. Effects of digoxin immune Fab (ovine) on digoxin immunoassays. Rainey, P.M. Am. J. Clin. Pathol. (1989) [Pubmed]
  26. How suitable are currently used carbamazepine immunoassays for quantifying carbamazepine-10,11-epoxide in serum samples? Hermida, J., Tutor, J.C. Therapeutic drug monitoring. (2003) [Pubmed]
  27. Serum iron, ferritin, transferrin, total iron binding capacity, hs-CRP, LDL cholesterol and magnesium in children; new reference intervals using the Dade Dimension Clinical Chemistry System. Soldin, O.P., Bierbower, L.H., Choi, J.J., Choi, J.J., Thompson-Hoffman, S., Soldin, S.J. Clin. Chim. Acta (2004) [Pubmed]
  28. Quantitative urinalysis with a common predilution on a DuPont Dimension. Engel, H., Priem-Visser, D., Lindemans, J., Blijenberg, B.G. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. (1994) [Pubmed]
  29. Systematic evaluation of stone basket dimensions. Monga, M., Hendlin, K., Lee, C., Anderson, J.K. Urology (2004) [Pubmed]
  30. Analytical and clinical evaluation of troponin I determination on dimension RXL-HM. Hafner, G., Peetz, D., Dati, F., Post, F., Blankenberg, S., Peivandi, A.A., Sucké, B., Rupprecht, H.J., Dahm, M., von Kleist, R., Prellwitz, W. Clin. Chem. Lab. Med. (2000) [Pubmed]
  31. Comparison of nitinol tipless stone baskets in an in vitro caliceal model. Lukasewycz, S., Skenazy, J., Hoffman, N., Kuskowski, M., Hendlin, K., Monga, M. J. Urol. (2004) [Pubmed]
  32. Texture analysis in radiographs: the influence of modulation transfer function and noise on the discriminative ability of texture features. Veenland, J.F., Grashuis, J.L., Gelsema, E.S. Medical physics. (1998) [Pubmed]
  33. Impact of Huntington's disease on quality of life. Helder, D.I., Kaptein, A.A., van Kempen, G.M., van Houwelingen, J.C., Roos, R.A. Mov. Disord. (2001) [Pubmed]
  34. Reliability and validity of the 12-minute distance walk in patients with chronic obstructive pulmonary disease. Larson, J.L., Covey, M.K., Vitalo, C.A., Alex, C.G., Patel, M., Kim, M.J. Nursing research. (1996) [Pubmed]
  35. NRSub: a non-redundant database for Bacillus subtilis. Perrière, G., Moszer, I., Gojobori, T. Nucleic Acids Res. (1996) [Pubmed]
  36. Increasing the hematocrit has a beneficial effect on quality of life and is safe in selected hemodialysis patients. Spanish Cooperative Renal Patients Quality of Life Study Group of the Spanish Society of Nephrology. Moreno, F., Sanz-Guajardo, D., López-Gómez, J.M., Jofre, R., Valderrábano, F. J. Am. Soc. Nephrol. (2000) [Pubmed]
  37. Development and validation of an automated latex-enhanced immunoassay for prealbumin. Holownia, P., Newman, D.J., Thakkar, H., Bedzyk, W.D., Crane, H., Olabiran, Y., Davey, C.L., Price, C.P. Clin. Chem. (1998) [Pubmed]
  38. Perfusion heterogeneity in human skeletal muscle: fractal analysis of PET data. Kalliokoski, K.K., Kuusela, T.A., Nuutila, P., Tolvanen, T., Oikonen, V., Teräs, M., Takala, T.E., Knuuti, J. European journal of nuclear medicine. (2001) [Pubmed]
  39. In Line with the Ultrasound Beam, the Third Dimension to Ultrasound-guided Nerve Blocks. Gray, A.T. Anesthesiology (2006) [Pubmed]
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