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Gene Review

MAP9  -  microtubule-associated protein 9

Homo sapiens

Synonyms: ASAP, Aster-associated protein, FLJ21159, Microtubule-associated protein 9
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Disease relevance of MAP9


Psychiatry related information on MAP9

  • Agency follow-up contacts were made for those individuals referred by ASAP to extended substance abuse treatment, with information limited to whether or not the client contacted the designated referral resource [6].
  • Source of referral to ASAP, interest in treatment, and prior sexual risk behavior change were significant predictors of intervention outcome [6].
  • The data were gathered within the context of the Assaulted Staff Action Program (ASAP), a crisis intervention service for staff victims [7].
  • In a single-case design, in which the facility served as its own control, an ASAP program was fielded in a community mental health center [8].
  • Characteristics of assaultive patients with schizophrenia versus personality disorder: six year analysis of the Assaulted Staff Action Program (ASAP) [9].

High impact information on MAP9


Chemical compound and disease context of MAP9


Biological context of MAP9

  • Allele-specific polymorphism (ASAP) analysis is a modification of single-strand conformation polymorphism (SSCP) mutation screening under optimized temperature conditions in a minigel format with ethidium bromide detection [15].
  • The automated sequence annotation pipeline (ASAP) is designed to ease routine investigation of new functional annotations on unknown sequences, such as expressed sequence tags (ESTs), through querying of web-accessible resources and maintenance of a local database [16].
  • Mini-hairpin primers with short arbitrary cores and primers complementary to simple sequence repeats present in microsatellites were also used to generate arbitrary signatures from amplification profiles (ASAP) [17].
  • This review focuses on the study of AMACR (P504S) expression in small focal prostate cancer and atypical small acinar proliferation (ASAP) on needle biopsies and emphasizes the utility of AMACR (P504S) in routine surgical pathology practice [18].
  • ASAP is a comprehensive web-based system for community genome annotation and analysis [19].

Anatomical context of MAP9

  • CONCLUSION ASAP identified in incidental prostates represented marginally sampled cancer in at least two of 10 foci assessed [2].
  • In the second study, we assessed the association between plasma concentration of lycopene and intima-media thickness of the common carotid artery wall (CCA-IMT) in a cross-sectional analysis of the Antioxidant Supplementation in the Atherosclerosis Prevention (ASAP) study data in 520 asymptomatic men and women [20].

Associations of MAP9 with chemical compounds

  • The suspicious morphology of ASAP on haematoxylin and eosin-stained slides was supported by the finding of elevated proliferative activity [21].
  • To further elucidate the underlying mechanisms that retarded the progression of atherosclerosis in the ASAP study, we investigated the effect of a combined intake of vitamin E and vitamin C on inflammatory markers in vivo [4].
  • The subjects were examined in 1994-95 at the baseline of the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study, a randomized double-blind placebo-controlled two by two factorial trial on the effect of vitamin E and C supplementation in the prevention of atherosclerotic progression [22].
  • Likewise, the number of biopsy cores and histologic findings including number of acini per focus of ASAP, number of foci of ASAP, degree of nuclear and nucleolar enlargement, and presence of luminal pink granular secretions, mucin, or crystalloids were not predictive of cancer [23].
  • Mini-hairpin primers and ASAP analysis significantly increased detection of polymorphic DNA, separating closely related bermudagrass (Cynodon) cultivars and detecting putatively linked markers in bulked segregant analysis of the soybean (Glycine max) supernodulation (nitrate-tolerant symbiosis) locus [17].

Other interactions of MAP9

  • Foci of ASAP found in the absence of cancer were assessed with additional sectioning, high-molecular weight keratin (CK903), and alpha-methylacyl coenzyme A racemase (AMACR) immunohistochemistry [2].
  • ASAP screening extends to unique ASAP-DNA fingerprinting as an identifying signature for each novel hTR-beta mutation detected thus far [15].
  • Of the 1,327 patients 71 (5.3%) had suspicious cytokeratin negative lesions diagnosed as ASAP, as confirmed by a review pathologist [5].
  • Independent of the status of the basal cell layer, the mean MIB-1 proliferation index of ASAP was significantly higher than that of clearly benign lesions and did not differ from that of low grade carcinoma [24].

Analytical, diagnostic and therapeutic context of MAP9

  • The term 'atypical small acinar proliferation' (ASAP) in the differential diagnosis of carcinoma has recently evoked considerable discussion [21].
  • We evaluated 33 cases of ASAP with at least one follow-up needle biopsy seen at Mayo Clinic from 1993 to 1996 [25].
  • We determined the incidence of ASAP at our institution and evaluated the role of immediate radical prostatectomy (RP) in these patients [5].
  • Of the 71 patients 25 underwent pelvic bilateral lymphadenectomy and RP with a nerve sparing procedure immediately after the diagnosis of ASAP [5].
  • Patient age, digital rectal examination status, prostate specific antigen, free prostate specific antigen, number of cores and biopsy interval were not independent predictors of cancer in men with ASAP [3].


  1. Prostate cancer detection in men with an initial diagnosis of atypical small acinar proliferation. Mancuso, P.A., Chabert, C., Chin, P., Kovac, P., Skyring, T., Watt, W.H., Napaki, S. BJU Int. (2007) [Pubmed]
  2. Atypical small acinar proliferation: biopsy artefact or distinct pathological entity? Flury, S.C., Galgano, M.T., Mills, S.E., Smolkin, M.E., Theodorescu, D. BJU Int. (2007) [Pubmed]
  3. Prognostic significance of high grade prostatic intraepithelial neoplasia and atypical small acinar proliferation in the contemporary era. Moore, C.K., Karikehalli, S., Nazeer, T., Fisher, H.A., Kaufman, R.P., Mian, B.M. J. Urol. (2005) [Pubmed]
  4. Long-term combined supplementations with alpha-tocopherol and vitamin C have no detectable anti-inflammatory effects in healthy men. Bruunsgaard, H., Poulsen, H.E., Pedersen, B.K., Nyyssönen, K., Kaikkonen, J., Salonen, J.T. J. Nutr. (2003) [Pubmed]
  5. Immediate radical prostatectomy in patients with atypical small acinar proliferation. Over treatment? Brausi, M., Castagnetti, G., Dotti, A., De Luca, G., Olmi, R., Cesinaro, A.M. J. Urol. (2004) [Pubmed]
  6. Evaluation of a hospital based substance abuse intervention and referral service for HIV affected patients. Guydish, J., Temoshok, L., Dilley, J., Rinaldi, J. General hospital psychiatry. (1990) [Pubmed]
  7. Characteristics of Assaultive Psychiatric Patients: Fifteen-Year Analysis of the Assaulted Staff Action Program (ASAP). Flannery, R.B., Juliano, J., Cronin, S., Walker, A.P. The Psychiatric quarterly. (2006) [Pubmed]
  8. The Assaulted Staff Action Program (ASAP) and declines in the prevalence of assaults: community-based replication. Flannery, R.B., Penk, W.E., Corrigan, M. International journal of emergency mental health. (1999) [Pubmed]
  9. Characteristics of assaultive patients with schizophrenia versus personality disorder: six year analysis of the Assaulted Staff Action Program (ASAP). Flannery, R.B., Rachlin, S., Walker, A.P. J. Forensic Sci. (2002) [Pubmed]
  10. ASAP, a human microtubule-associated protein required for bipolar spindle assembly and cytokinesis. Saffin, J.M., Venoux, M., Prigent, C., Espeut, J., Poulat, F., Giorgi, D., Abrieu, A., Rouquier, S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  11. Raised serum levels of soluble CD40 ligand in patients with familial hypercholesterolemia: downregulatory effect of statin therapy. Semb, A.G., van Wissen, S., Ueland, T., Smilde, T., Waehre, T., Tripp, M.D., Frøland, S.S., Kastelein, J.J., Gullestad, L., Pedersen, T.R., Aukrust, P., Stalenhoef, A.F. J. Am. Coll. Cardiol. (2003) [Pubmed]
  12. Changing perceptions of riskiness in drinking, drugs, and driving: an emergency department-based alcohol and substance abuse prevention program. Bernstein, E., Woodall, W.G. Annals of emergency medicine. (1987) [Pubmed]
  13. Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study. Salonen, R.M., Nyyssönen, K., Kaikkonen, J., Porkkala-Sarataho, E., Voutilainen, S., Rissanen, T.H., Tuomainen, T.P., Valkonen, V.P., Ristonmaa, U., Lakka, H.M., Vanharanta, M., Salonen, J.T., Poulsen, H.E. Circulation (2003) [Pubmed]
  14. How does cystitis affect a comparative risk profile of tiaprofenic acid with other non-steroidal antiinflammatory drugs? An international study based on spontaneous reports and drug usage data. ADR Signals Analysis Project (ASAP) Team. Lindquist, M., Pettersson, M., Edwards, I.R., Sanderson, J.H., Taylor, N.F., Fletcher, A.P., Schou, J.S., Savage, R. Pharmacol. Toxicol. (1997) [Pubmed]
  15. Allele-specific associated polymorphism analysis: novel modification of SSCP for mutation detection in heterozygous alleles using the paradigm of resistance to thyroid hormone. Grace, M.B., Buzard, G.S., Weintraub, B.D. Hum. Mutat. (1995) [Pubmed]
  16. ASAP: automated sequence annotation pipeline for web-based updating of sequence information with a local dynamic database. Kossenkov, A., Manion, F.J., Korotkov, E., Moloshok, T.D., Ochs, M.F. Bioinformatics (2003) [Pubmed]
  17. Generation of sequence signatures from DNA amplification fingerprints with mini-hairpin and microsatellite primers. Caetano-Anollés, G., Gresshoff, P.M. BioTechniques (1996) [Pubmed]
  18. Diagnostic utility of alpha-methylacyl CoA racemase (P504S) on prostate needle biopsy. Jiang, Z., Woda, B.A. Advances in anatomic pathology. (2004) [Pubmed]
  19. ASAP: a resource for annotating, curating, comparing, and disseminating genomic data. Glasner, J.D., Rusch, M., Liss, P., Plunkett, G., Cabot, E.L., Darling, A., Anderson, B.D., Infield-Harm, P., Gilson, M.C., Perna, N.T. Nucleic Acids Res. (2006) [Pubmed]
  20. Lycopene, atherosclerosis, and coronary heart disease. Rissanen, T., Voutilainen, S., Nyyssönen, K., Salonen, J.T. Exp. Biol. Med. (Maywood) (2002) [Pubmed]
  21. Limiting the diagnosis of atypical small glandular proliferations in needle biopsies of the prostate by the use of immunohistochemistry. Helpap, B., Köllermann, J., Oehler, U. J. Pathol. (2001) [Pubmed]
  22. Association between elevated plasma total homocysteine and increased common carotid artery wall thickness. Voutilainen, S., Alfthan, G., Nyyssönen, K., Salonen, R., Salonen, J.T. Ann. Med. (1998) [Pubmed]
  23. Diagnosis of "suspicious for malignancy" in prostate biopsies: predictive value for cancer. Iczkowski, K.A., Bassler, T.J., Schwob, V.S., Bassler, I.C., Kunnel, B.S., Orozco, R.E., Bostwick, D.G. Urology (1998) [Pubmed]
  24. Atypical acinar proliferations of the prostate. Helpap, B., Köllermann, J. Pathol. Res. Pract. (1999) [Pubmed]
  25. Atypical small acinar proliferation suspicious for malignancy in prostate needle biopsies: clinical significance in 33 cases. Iczkowski, K.A., MacLennan, G.T., Bostwick, D.G. Am. J. Surg. Pathol. (1997) [Pubmed]
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