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Gene Review

Thpo  -  thrombopoietin

Rattus norvegicus

Synonyms: Thrombopoietin
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Disease relevance of Thpo


High impact information on Thpo


Chemical compound and disease context of Thpo


Biological context of Thpo


Anatomical context of Thpo


Associations of Thpo with chemical compounds

  • LPS-treated rats showed a significant increase in hepatic TPO mRNA concentration [1].
  • We subsequently measured the level of thrombopoietin in the circulation over the entire time course after the administration of busulfan [2].
  • Oval cells expressed c-Mpl, a receptor for TPO as well as immature hematopoietic and hepatocytic surface markers such as CD34 and AFP [9].
  • Four cysteine residues and two of four N-glycosylation sites that are conserved among species were also found at the corresponding positions in feline TPO [13].
  • Thrombopoietin protects against in vitro and in vivo cardiotoxicity induced by doxorubicin [14].

Regulatory relationships of Thpo


Other interactions of Thpo


Analytical, diagnostic and therapeutic context of Thpo


  1. Hepatic thrombopoietin mRNA is increased in acute inflammation. Wolber, E.M., Fandrey, J., Frackowski, U., Jelkmann, W. Thromb. Haemost. (2001) [Pubmed]
  2. The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Kuter, D.J., Rosenberg, R.D. Blood (1995) [Pubmed]
  3. Signal transduction by the receptors for thrombopoietin (c-mpL) and interleukin-3 in hematopoietic and nonhematopoietic cells. Morella, K.K., Bruno, E., Kumaki, S., Lai, C.F., Fu, J., Wang, H.M., Murray, L., Hoffman, R., Timour, M., Bénit, L. Blood (1995) [Pubmed]
  4. Exogenous control of cardiac gene therapy: evidence of regulated myocardial transgene expression after adenovirus and adeno-associated virus transfer of expression cassettes containing corticosteroid response element promoters. Lee, L.Y., Zhou, X., Polce, D.R., El-Sawy, T., Patel, S.R., Thakker, G.D., Narumi, K., Crystal, R.G., Rosengart, T.K. J. Thorac. Cardiovasc. Surg. (1999) [Pubmed]
  5. Expression of hepatic thrombopoietin mRNA in primary cultured hepatocytes and in rats with acute liver injury or bone marrow suppression with or without cirrhosis. Ishikawa, T., Ichida, T., Matsuda, Y., Sugitani, S., Sugiyama, M., Kato, T., Miyazaki, H., Asakura, H. J. Gastroenterol. Hepatol. (2000) [Pubmed]
  6. Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets. Miyakawa, Y., Oda, A., Druker, B.J., Ozaki, K., Handa, M., Ohashi, H., Ikeda, Y. Blood (1997) [Pubmed]
  7. Reduced expression of thrombopoietin is involved in thrombocytopenia in human and rat liver cirrhosis. Ishikawa, T., Ichida, T., Matsuda, Y., Sugitani, S., Sugiyama, M., Kato, T., Miyazaki, H., Asakura, H. J. Gastroenterol. Hepatol. (1998) [Pubmed]
  8. The sequence of a rat cDNA encoding thrombopoietin. Ogami, K., Shimada, Y., Sohma, Y., Akahori, H., Kato, T., Kawamura, K., Miyazaki, H. Gene (1995) [Pubmed]
  9. Dual effects of adenovirus-mediated thrombopoietin gene transfer on hepatic oval cell proliferation and platelet counts. Ichiba, M., Shimomura, T., Murai, R., Hashiguchi, K., Saeki, T., Yoshida, Y., Kanbe, T., Tanabe, N., Tsuchiya, H., Miura, N., Tajima, F., Kurimasa, A., Hamada, H., Shiota, G. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  10. Production of thrombopoietin (TPO) by rat hepatocytes and hepatoma cell lines. Shimada, Y., Kato, T., Ogami, K., Horie, K., Kokubo, A., Kudo, Y., Maeda, E., Sohma, Y., Akahori, H., Kawamura, K. Exp. Hematol. (1995) [Pubmed]
  11. GpIIb/IIIa+ subpopulation of rat megakaryocyte progenitor cells exhibits high responsiveness to human thrombopoietin. Kato, T., Horie, K., Hagiwara, T., Maeda, E., Tsumura, H., Ohashi, H., Miyazaki, H. Exp. Hematol. (1996) [Pubmed]
  12. Thrombopoietin expression in normal and hypobaric hypoxia-induced thrombocytopenic rats. Nakanishi, K., Tajima, F., Osada, H., Kato, T., Miyazaki, H., Kawai, T., Torikata, C., Suga, T., Takishima, K., Aurues, T., Ikeda, T. Lab. Invest. (1999) [Pubmed]
  13. Molecular cloning and functional expression of feline thrombopoietin. Matsushiro, H., Kato, H., Tahara, T., Kato, T., Iwata, A., Watari, T., Tsujimoto, H., Hasegawa, A. Vet. Immunol. Immunopathol. (1998) [Pubmed]
  14. Thrombopoietin protects against in vitro and in vivo cardiotoxicity induced by doxorubicin. Li, K., Sung, R.Y., Huang, W.Z., Yang, M., Pong, N.H., Lee, S.M., Chan, W.Y., Zhao, H., To, M.Y., Fok, T.F., Li, C.K., Wong, Y.O., Ng, P.C. Circulation (2006) [Pubmed]
  15. Hepatocyte growth factor/scatter factor enhances the thrombopoietin mRNA expression in rat hepatocytes and cirrhotic rat livers. Yamashita, K., Matsuoka, H., Ochiai, T., Matsushita, R., Kubuki, Y., Suzuki, M., Tsubouchi, H. J. Gastroenterol. Hepatol. (2000) [Pubmed]
  16. Cloning of thrombopoietin and its therapeutic potential. Miyazaki, H. Cancer Chemother. Pharmacol. (1996) [Pubmed]
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