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Gene Review

Adora2a  -  adenosine A2a receptor

Rattus norvegicus

Synonyms: A2ar, ADENO, Adenosine receptor A2a, Adora2l1
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Disease relevance of Adora2a


Psychiatry related information on Adora2a


High impact information on Adora2a

  • Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain [3].
  • Stable restoration of the sarcoglycan complex in dystrophic muscle perfused with histamine and a recombinant adeno-associated viral vector [10].
  • Efficient gene transduction with rescue of the sarcoglycan complex in muscle fibers of the distal hindlimb was also obtained after infusion of recombinant adeno-associated virus into the femoral artery in conjunction with histamine-induced endothelial permeabilization [10].
  • Peroral gene therapy of lactose intolerance using an adeno-associated virus vector [11].
  • Here we show that an orally administered adeno-associated viral vector leads to persistent expression of a beta-galactosidase transgene in both gut epithelial and lamina propria cells, and that this approach results in long-term phenotypic recovery in an animal model of lactose intolerance [11].

Chemical compound and disease context of Adora2a

  • Northern blot analysis revealed that the A2AR mRNA level was substantially increased after a 3-h exposure to hypoxia (5% O2), which reached a peak at 12 h [12].
  • MATERIALS AND METHODS: Recombinant adeno-associated virus encoding rat leptin cDNA (rAAV-leptin) or control vector were administered by intracerebroventricular injection to lean F344 x BN rats for up to 150 days, and food consumption, body weight, serum leptin and glucose tolerance were measured [13].
  • We have previously demonstrated that intratracheal instillation of perfluorochemical (PFC) liquids along with instillation of recombinant adenovirus and adeno-associated virus vectors, or with cationic liposome vectors, increased total lung gene expression and enhanced distribution of gene expression throughout the lung [14].
  • To test this approach, we cloned a 729-bp NMDA receptor (NMDAR1) cDNA fragment in the antisense orientation into adeno-associated virus (AAV) vectors, where expression was driven by either a tetracycline-off regulatable promoter (AAV-tTAK-NR1A) or a cytomegalovirus (CMV) promoter (AAV-CMV-NR1A) [15].
  • Genes could be transferred to DRG using polyethylenimine (PEI)/DNA complexes, Lipofectamine 2000/DNA complexes, adeno-associated virus vectors, or baculovirus vectors [16].

Biological context of Adora2a


Anatomical context of Adora2a


Associations of Adora2a with chemical compounds


Regulatory relationships of Adora2a


Other interactions of Adora2a


Analytical, diagnostic and therapeutic context of Adora2a

  • Colocalization, co-immunoprecipitation, and pull-down experiments showed a close and specific interaction between A2AR and alpha-actinin in transfected HEK-293 cells and also in rat striatal tissue [40].
  • On the other hand, perfusion with 20 microM 2-[4-(2-carboxyethyl)phenethylamino]-5'-N-ethyl-carboxamide-adenos ine (CGS21680), a selective adenosine A2A receptor agonist, enhanced taurine release, while perfusion with 1 mM 3,7-dimethyl-propagylxanthine (DMPX), an adenosine A2 receptor antagonist, did not affect taurine release [41].
  • Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors [42].
  • We previously found that gene transduction by adeno-associated virus (AAV) vectors in cell culture can be stimulated over 100-fold by treatment of the target cells with agents that affect DNA metabolism, such as irradiation or topoisomerase inhibitors [42].
  • Gel retardation assays with nuclear rat liver proteins reveal two DNA-protein complexes: Complex 1 can be competed by the USF/MLTF binding site of the adeno major late promoter whereas complex 2 is a distinct protein we refer to as BAP (B-activator protein) [43].


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  5. Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Mandel, R.J., Spratt, S.K., Snyder, R.O., Leff, S.E. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  6. Adeno-associated viral glutamate decarboxylase expression in the lateral nucleus of the rat hypothalamus reduces feeding behavior. Noordmans, A.J., Song, D.K., Noordmans, C.J., Garrity-Moses, M., During, M.J., Fitzsimons, H.L., Imperiale, M.J., Boulis, N.M. Gene Ther. (2004) [Pubmed]
  7. The effect of vascular endothelial growth factor and adeno-associated virus mediated brain derived neurotrophic factor on neurogenic and vasculogenic erectile dysfunction induced by hyperlipidemia. Gholami, S.S., Rogers, R., Chang, J., Ho, H.C., Grazziottin, T., Lin, C.S., Lue, T.F. J. Urol. (2003) [Pubmed]
  8. Strong rebound of wakefulness follows prostaglandin D2- or adenosine A2a receptor agonist-induced sleep. Gerashchenko, D., Okano, Y., Urade, Y., Inoué, S., Hayaishi, O. Journal of sleep research. (2000) [Pubmed]
  9. Expression pattern of FOS in orexin neurons during sleep induced by an adenosine A2A receptor agonist. Satoh, S., Matsumura, H., Kanbayashi, T., Yoshida, Y., Urakami, T., Nakajima, T., Kimura, N., Nishino, S., Yoneda, H. Behav. Brain Res. (2006) [Pubmed]
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  11. Peroral gene therapy of lactose intolerance using an adeno-associated virus vector. During, M.J., Xu, R., Young, D., Kaplitt, M.G., Sherwin, R.S., Leone, P. Nat. Med. (1998) [Pubmed]
  12. Stimulation of expression for the adenosine A2A receptor gene by hypoxia in PC12 cells. A potential role in cell protection. Kobayashi, S., Millhorn, D.E. J. Biol. Chem. (1999) [Pubmed]
  13. Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats. Scarpace, P.J., Matheny, M., Tümer, N., Cheng, K.Y., Zhang, Y. Diabetologia (2005) [Pubmed]
  14. Use of perfluorochemical liquid allows earlier detection of gene expression and use of less vector in normal lung and enhances gene expression in acutely injured lung. Weiss, D.J., Bonneau, L., Liggitt, D. Mol. Ther. (2001) [Pubmed]
  15. Therapeutic liabilities of in vivo viral vector tropism: adeno-associated virus vectors, NMDAR1 antisense, and focal seizure sensitivity. Haberman, R., Criswell, H., Snowdy, S., Ming, Z., Breese, G., Samulski, R., McCown, T. Mol. Ther. (2002) [Pubmed]
  16. Gene transfer to dorsal root ganglia by intrathecal injection: effects on regeneration of peripheral nerves. Wang, X., Wang, C., Zeng, J., Xu, X., Hwang, P.Y., Yee, W.C., Ng, Y.K., Wang, S. Mol. Ther. (2005) [Pubmed]
  17. Enhanced adenosine A2A receptor facilitation of synaptic transmission in the hippocampus of aged rats. Rebola, N., Sebastião, A.M., de Mendonca, A., Oliveira, C.R., Ribeiro, J.A., Cunha, R.A. J. Neurophysiol. (2003) [Pubmed]
  18. Purinergic P2 receptors trigger adenosine release leading to adenosine A2A receptor activation and facilitation of long-term potentiation in rat hippocampal slices. Almeida, T., Rodrigues, R.J., de Mendonça, A., Ribeiro, J.A., Cunha, R.A. Neuroscience (2003) [Pubmed]
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  20. Cyclooxygenase-2 expression in rat microglia is induced by adenosine A2a-receptors. Fiebich, B.L., Biber, K., Lieb, K., van Calker, D., Berger, M., Bauer, J., Gebicke-Haerter, P.J. Glia (1996) [Pubmed]
  21. Effect of adenosine receptor blockade on pial arteriolar dilation during sciatic nerve stimulation. Meno, J.R., Crum, A.V., Winn, H.R. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  22. Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at rat motor nerve endings. Magalhães-Cardoso, M.T., Pereira, M.F., Oliveira, L., Ribeiro, J.A., Cunha, R.A., Correia-de-Sá, P. J. Physiol. (Lond.) (2003) [Pubmed]
  23. Adenosine A2A receptor-mediated facilitation of noradrenaline release involves protein kinase C activation and attenuation of presynaptic inhibitory receptor-mediated effects in the rat vas deferens. Queiroz, G., Talaia, C., Gonçalves, J. J. Neurochem. (2003) [Pubmed]
  24. Effects of an adenosine A2A receptor blockade in the nucleus accumbens on locomotion, feeding, and prepulse inhibition in rats. Nagel, J., Schladebach, H., Koch, M., Schwienbacher, I., Müller, C.E., Hauber, W. Synapse (2003) [Pubmed]
  25. Adenosine A2a-receptor activation enhances cardiomyocyte shortening via Ca2+-independent and -dependent mechanisms. Woodiwiss, A.J., Honeyman, T.W., Fenton, R.A., Dobson, J.G. Am. J. Physiol. (1999) [Pubmed]
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  28. Brief, repeated, oxygen-glucose deprivation episodes protect neurotransmission from a longer ischemic episode in the in vitro hippocampus: role of adenosine receptors. Pugliese, A.M., Latini, S., Corradetti, R., Pedata, F. Br. J. Pharmacol. (2003) [Pubmed]
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  30. Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state. Fischer, D., He, Z., Benowitz, L.I. J. Neurosci. (2004) [Pubmed]
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  32. Gene therapy for detached retina by adeno-associated virus vector expressing glial cell line-derived neurotrophic factor. Wu, W.C., Lai, C.C., Chen, S.L., Xiao, X., Chen, T.L., Tsai, R.J., Kuo, S.W., Tsao, Y.P. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  33. Regulation of K+ channel mRNA expression by stimulation of adenosine A2a-receptors in cultured rat microglia. Küst, B.M., Biber, K., van Calker, D., Gebicke-Haerter, P.J. Glia (1999) [Pubmed]
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  37. Valerian extract Ze 911 inhibits postsynaptic potentials by activation of adenosine A1 receptors in rat cortical neurons. Vissiennon, Z., Sichardt, K., Koetter, U., Brattström, A., Nieber, K. Planta Med. (2006) [Pubmed]
  38. Species-dependent hemodynamic effects of adenosine A3-receptor agonists IB-MECA and Cl-IB-MECA. Lasley, R.D., Narayan, P., Jahania, M.S., Partin, E.L., Kraft, K.R., Mentzer, R.M. Am. J. Physiol. (1999) [Pubmed]
  39. Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats. Shklyaev, S., Aslanidi, G., Tennant, M., Prima, V., Kohlbrenner, E., Kroutov, V., Campbell-Thompson, M., Crawford, J., Shek, E.W., Scarpace, P.J., Zolotukhin, S. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  40. The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin. Burgueño, J., Blake, D.J., Benson, M.A., Tinsley, C.L., Esapa, C.T., Canela, E.I., Penela, P., Mallol, J., Mayor, F., Lluis, C., Franco, R., Ciruela, F. J. Biol. Chem. (2003) [Pubmed]
  41. Activation of adenosine A2 receptors enhances high K(+)-evoked taurine release from rat hippocampus: a microdialysis study. Hada, J., Kaku, T., Morimoto, K., Hayashi, Y., Nagai, K. Amino Acids (1998) [Pubmed]
  42. Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors. Koeberl, D.D., Alexander, I.E., Halbert, C.L., Russell, D.W., Miller, A.D. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  43. BAP, a rat liver protein that activates transcription through a promoter element with similarity to the USF/MLTF binding site. Kugler, W., Kaling, M., Ross, K., Wagner, U., Ryffel, G.U. Nucleic Acids Res. (1990) [Pubmed]
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