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Gene Review

SDPR  -  serum deprivation response

Homo sapiens

Synonyms: CAVIN2, Cavin-2, PS-p68, Phosphatidylserine-binding protein, SDR, ...
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Disease relevance of SDPR

  • Diabetic retinopathy was staged by ophthalmoscopic examination as non-diabetic (NDR), simple (SDR), preproliferative (PPDR), or proliferative (PDR) [1].
  • Relating total revascularization (R) to standardized death rate for ischaemic heart disease (SDR) and to gross domestic product (GDP), there was an increase from 1.0 to 1.8 R/SDR and 40 to 61 R/GDP in the central European group compared with an increase from 0.06 to 0.18 R/SDR and 43 to 85 R/GDP in the eastern group [2].
  • Under the long photoperiods, SDR/Y and SDNR/Y animals exhibited accelerated body weight gains and testicular growth from 18 to 69 days of age [3].
  • Those patients whose primary reason for attending the clinic was HIV antibody testing and used the same day result (SDR) service were significantly less likely to be screened for other infections than those using the normal waiting time (NWT) service, (P < 0.00001) [4].
  • The femurs of Wistar (WR) and Sprague Dawley (SDR) cadavers were prepared and analysed by x-rays in two standard planes [5].

Psychiatry related information on SDPR

  • Consistent with their ability to respond to short photoperiods, SDNR/Y young, in a second experiment, showed locomotor activity patterns similar to those of SDR/Ys in short days (9L:15D) [3].
  • The performance of two groups of patients with semantic dementia (SD), with predominant right (SDR) and left temporal lobe atrophy (SDL), was contrasted with that of cases with probable Alzheimer's disease (AD) on a range of standard episodic memory tasks [6].

High impact information on SDPR


Biological context of SDPR

  • The decrease in heart rate in response to increase in blood pressure by AII in nonpregnant animals was similar in SDR and SHR, but much greater in WKR [9].
  • As a member of the short-chain alcohol dehydrogenase/reductase (SDR) family, the overall protein fold and positioning of the catalytic triad in BphB are very similar to those observed in other SDR enzymes, although small differences occur in the cofactor binding site [10].
  • The LDF signal displayed a significant circadian rhythm, with the peak occurring at around midnight in SDR and TGR, despite inverse periodicity of ABP in TGR [11].
  • In conclusion, these data suggest the Tritrac ranks activity levels similarly to the PAL and SDR but it significantly underestimates free-living energy expenditure [12].
  • There was a general trend for a shortened LV diastole in LDR with a significantly shortened LV isovolumetric time in LDR (80+/-8 vs 107+/-8 ms for LDR and SDR, respectively; P < 0.05) [13].

Anatomical context of SDPR


Associations of SDPR with chemical compounds

  • In contrast with most known phospholipid-binding proteins, PS-p68 does not bind Ca2+ and does not require Ca2+ for its binding of phosphatidylserine [8].
  • This cDNA has an open reading frame of a 309-amino-acid protein, sharing significant homology to one of the short-chain alcohol dehydrogenase/reductase (SDR) families that can catalyze the first and rate-limiting step that generates retinaldehyde from retinol [15].
  • The results demonstrated that the SDR manifests (1) a blunted response to D-amphetamine (0.5-3.0 mg/kg; i.p.), and (2) lower levels of spontaneous locomotor and rearing activity in the latter part of the dark cycle, particularly at the transition of the cycle from dark to light [14].
  • The 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus is an NADP(H)-dependent member of the short-chain dehydrogenase/reductase superfamily (SDR) that belongs to the cP1 classical subfamily [16].
  • This study evaluated the predictive value of the QT interval, spatial, and transmural dispersions of repolarization (SDR and TDR) for further arrhythmic events after chronic amiodarone [17].

Analytical, diagnostic and therapeutic context of SDPR

  • However, the mean sensitivity in the central 30-degree area and that in the upper half of the central 20- to 30-degree concentric circular field were significantly decreased in B/Y perimetry in SDR patients (p < 0.05, p < 0.01, respectively) [18].
  • Composite fixation of segmental bone/joint defect replacement (SDR) prostheses. Clinical results and functional/device assessment [19].


  1. Abnormal light scattering detected by confocal biomicroscopy at the corneal epithelial basement membrane of subjects with type II diabetes. Morishige, N., Chikama, T.I., Sassa, Y., Nishida, T. Diabetologia (2001) [Pubmed]
  2. Evolution of percutaneous transluminal coronary angioplasty in Europe from 1992-1996. Maier, W., Windecker, S., Boersma, E., Meier, B. Eur. Heart J. (2001) [Pubmed]
  3. Testicular growth and locomotor activity of Siberian hamsters from short-day-responsive and short-day-nonresponsive lineages. Stanfield, K.M., Horton, T.H. Biol. Reprod. (1996) [Pubmed]
  4. Testing for HIV antibody: a comparison of two services offered in a genitourinary medicine clinic. Rowen, D., Carne, C.A., Sonnex, C., Jones, M., Maloney, M.E., Lefort, W., Wreghitt, T.G. International journal of STD & AIDS. (1995) [Pubmed]
  5. The critical size bony defect in a small animal for bone healing studies (I): Comparative anatomical study on rats' femur. Jäger, M., Sager, M., Lensing-Höhn, S., Krauspe, R. Biomedizinische Technik. Biomedical engineering. (2005) [Pubmed]
  6. Can episodic memory tasks differentiate semantic dementia from Alzheimer's disease? Scahill, V.L., Hodges, J.R., Graham, K.S. Neurocase : case studies in neuropsychology, neuropsychiatry, and behavioural neurology. (2005) [Pubmed]
  7. Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats. Delhanty, P.J., Mesotten, D., McDougall, F., Baxter, R.C. Endocrinology (2002) [Pubmed]
  8. Purification and characterization of a major phosphatidylserine-binding phosphoprotein from human platelets. Burgener, R., Wolf, M., Ganz, T., Baggiolini, M. Biochem. J. (1990) [Pubmed]
  9. Heart rate reflex responses during gestation in normotensive and spontaneously hypertensive rats following angiotensin II and vasopressin. Massicotte, G., St-Louis, J., Schiffrin, E.L. Proc. Soc. Exp. Biol. Med. (1987) [Pubmed]
  10. Crystal structure of cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase from a PCB degrader at 2.0 A resolution. Hülsmeyer, M., Hecht, H.J., Niefind, K., Hofer, B., Eltis, L.D., Timmis, K.N., Schomburg, D. Protein Sci. (1998) [Pubmed]
  11. Circadian periodicity of cerebral blood flow revealed by laser-Doppler flowmetry in awake rats: relation to blood pressure and activity. Wauschkuhn, C.A., Witte, K., Gorbey, S., Lemmer, B., Schilling, L. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  12. Field trial of a three-dimensional activity monitor: comparison with self report. Matthews, C.E., Freedson, P.S. Medicine and science in sports and exercise. (1995) [Pubmed]
  13. Systolic and diastolic cardiac function time intervals and exercise capacity in women. Libonati, J.R., Colby, A.M., Caldwell, T.M., Kasparian, R., Glassberg, H.L. Medicine and science in sports and exercise. (1999) [Pubmed]
  14. Behavioral and neurochemical profile of the spontaneously diabetic Wistar BB rat. Merali, Z., Ahmad, Q., Veitch, J. Behav. Brain Res. (1988) [Pubmed]
  15. Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion. Matsuzaka, Y., Okamoto, K., Tsuji, H., Mabuchi, T., Ozawa, A., Tamiya, G., Inoko, H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  16. Coenzyme specificity in fungal 17beta-hydroxysteroid dehydrogenase. Kristan, K., Stojan, J., Möller, G., Adamski, J., Rizner, T.L. Mol. Cell. Endocrinol. (2005) [Pubmed]
  17. Excessive increase in QT interval and dispersion of repolarization predict recurrent ventricular tachyarrhythmia after amiodarone. Aiba, T., Shimizu, W., Inagaki, M., Satomi, K., Taguchi, A., Kurita, T., Suyama, K., Aihara, N., Sunagawa, K., Kamakura, S. Pacing and clinical electrophysiology : PACE. (2004) [Pubmed]
  18. Blue-on-yellow perimetry to evaluate S cone sensitivity in diabetics. Nomura, R., Terasaki, H., Hirose, H., Miyake, Y. Ophthalmic Res. (2000) [Pubmed]
  19. Composite fixation of segmental bone/joint defect replacement (SDR) prostheses. Clinical results and functional/device assessment. Sim, F.H. La Chirurgia degli organi di movimento. (1990) [Pubmed]
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