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Gene Review

Retn  -  resistin

Rattus norvegicus

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Disease relevance of Retn

  • Similarly, fasting and central administration of the adipocyte-derived factor, leptin, evoked a significant reduction in testicular resistin mRNA levels, whereas they remained unaltered in a model of diet-induced obesity [1].
  • Stimulated resistin expression in white adipose of rats with bile duct ligation-induced liver cirrhosis: relationship to cirrhotic hyperinsulinemia and increased tumor necrosis factor-alpha [2].
  • Further study is necessary to document the role of resistin in metabolic abnormalities of liver cirrhosis [2].
  • Lowest glucose tolerances were found in HsF and particularly in LC-HsF-HP-fed animals irrespective of line, but this paralleled reduced plasma adiponectin levels, elevated plasma resistin levels, higher retroperitoneal fat masses, and reduced insulin sensitivity (indexed by insulin-induced hypoglycemia) only in Wistar rats [3].
  • However, since resistin-induced satiety was modest and transient, as central administration for several days did not affect body weight, the physiological relevance and therapeutic potential of the observed principal phenomenon may be limited [4].

Psychiatry related information on Retn


High impact information on Retn

  • The adipose-derived hormone resistin is postulated to link obesity to insulin resistance and diabetes [6].
  • Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production [6].
  • In the presence of physiologic hyperinsulinemia, the infusion of purified recombinant resistin, increasing circulating resistin levels by approximately twofold to 15-fold, inhibited glucose metabolism such that lower rates of glucose infusion were required to maintain the plasma glucose concentration at basal levels [6].
  • Glucose uptake was associated with increased expression of FDPs, including resistin ( approximately 5-fold), adiponectin ( approximately 2-fold), leptin ( approximately 15-fold), plasminogen activating inhibitor-1 ( approximately 10-fold), and angiotensinogen ( approximately 4-fold) in visceral fat, but markedly less in subcutaneous fat [7].
  • However, the most dramatic increase was observed with FIZZ1 (found in inflammatory zone; also known as RELM-alpha or resistin-like molecule-alpha), which was induced 17-fold to approximately 25-fold at the peak of expression [8].

Chemical compound and disease context of Retn

  • To explore this possibility, we have investigated effects of acute euglycemic (5.2+/-0.1 mmol/L) hyperinsulinemia (96+/-8 microU/mL) with and without concurrent infusion of lipid plus heparin (to raise or lower plasma free fatty acid [FFA] levels) on glucose turnover and plasma resistin levels in alert rats [9].
  • Adiponectin and resistin in the neonatal rat: effects of dexamethasone and hypoxia [10].

Biological context of Retn


Anatomical context of Retn


Associations of Retn with chemical compounds


Regulatory relationships of Retn


Other interactions of Retn


Analytical, diagnostic and therapeutic context of Retn


  1. Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors. Nogueiras, R., Barreiro, M.L., Caminos, J.E., Gaytán, F., Suominen, J.S., Navarro, V.M., Casanueva, F.F., Aguilar, E., Toppari, J., Diéguez, C., Tena-Sempere, M. J. Cell. Sci. (2004) [Pubmed]
  2. Stimulated resistin expression in white adipose of rats with bile duct ligation-induced liver cirrhosis: relationship to cirrhotic hyperinsulinemia and increased tumor necrosis factor-alpha. Lin, S.Y., Sheu, W.H., Chen, W.Y., Lee, F.Y., Huang, C.J. Mol. Cell. Endocrinol. (2005) [Pubmed]
  3. Low-carbohydrate diets affect energy balance and fuel homeostasis differentially in lean and obese rats. Morens, C., Sirot, V., Scheurink, A.J., van Dijk, G. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2006) [Pubmed]
  4. Central administration of resistin promotes short-term satiety in rats. Tovar, S., Nogueiras, R., Tung, L.Y., Castañeda, T.R., Vázquez, M.J., Morris, A., Williams, L.M., Dickson, S.L., Diéguez, C. Eur. J. Endocrinol. (2005) [Pubmed]
  5. Resistin is expressed in different rat tissues and is regulated in a tissue- and gender-specific manner. Nogueiras, R., Gallego, R., Gualillo, O., Caminos, J.E., García-Caballero, T., Casanueva, F.F., Diéguez, C. FEBS Lett. (2003) [Pubmed]
  6. Adipose-derived resistin and gut-derived resistin-like molecule-beta selectively impair insulin action on glucose production. Rajala, M.W., Obici, S., Scherer, P.E., Rossetti, L. J. Clin. Invest. (2003) [Pubmed]
  7. Differential responses of visceral and subcutaneous fat depots to nutrients. Einstein, F.H., Atzmon, G., Yang, X.M., Ma, X.H., Rincon, M., Rudin, E., Muzumdar, R., Barzilai, N. Diabetes (2005) [Pubmed]
  8. FIZZ1 stimulation of myofibroblast differentiation. Liu, T., Dhanasekaran, S.M., Jin, H., Hu, B., Tomlins, S.A., Chinnaiyan, A.M., Phan, S.H. Am. J. Pathol. (2004) [Pubmed]
  9. Effects of free fatty acids on plasma resistin and insulin resistance in awake rats. Yang, G., Li, L., Fang, C., Zhang, L., Li, Q., Tang, Y., Boden, G. Metab. Clin. Exp. (2005) [Pubmed]
  10. Adiponectin and resistin in the neonatal rat: effects of dexamethasone and hypoxia. Raff, H., Bruder, E.D. Endocrine (2006) [Pubmed]
  11. Transgenic and recombinant resistin impair skeletal muscle glucose metabolism in the spontaneously hypertensive rat. Pravenec, M., Kazdová, L., Landa, V., Zidek, V., Mlejnek, P., Jansa, P., Wang, J., Qi, N., Kurtz, T.W. J. Biol. Chem. (2003) [Pubmed]
  12. Lipid metabolism and resistin gene expression in insulin-resistant Fischer 344 rats. Levy, J.R., Davenport, B., Clore, J.N., Stevens, W. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  13. Alternative splicing generates a novel non-secretable resistin isoform in Wistar rats. Del Arco, A., Peralta, S., Carrascosa, J.M., Ros, M., Andrés, A., Arribas, C. FEBS Lett. (2003) [Pubmed]
  14. CNS melanocortin and leptin effects on stearoyl-CoA desaturase-1 and resistin expression. Lin, J., Choi, Y.H., Hartzell, D.L., Li, C., Della-Fera, M.A., Baile, C.A. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  15. Programming of rat muscle and fat metabolism by in utero overexposure to glucocorticoids. Cleasby, M.E., Kelly, P.A., Walker, B.R., Seckl, J.R. Endocrinology (2003) [Pubmed]
  16. Glucose intolerance and resistin expression in rat offspring exposed to ethanol in utero: modulation by postnatal high-fat diet. Chen, L., Nyomba, B.L. Endocrinology (2003) [Pubmed]
  17. Resistin mRNA levels are downregulated by estrogen in vivo and in vitro. Huang, S.W., Seow, K.M., Ho, L.T., Chien, Y., Chung, D.Y., Chang, C.L., Lai, Y.H., Hwang, J.L., Juan, C.C. FEBS Lett. (2005) [Pubmed]
  18. Effect of acute cold exposure on the expression of the adiponectin, resistin and leptin genes in rat white and brown adipose tissues. Puerta, M., Abelenda, M., Rocha, M., Trayhurn, P. Horm. Metab. Res. (2002) [Pubmed]
  19. Increased resistin expression in the adipose tissue of male prolactin transgenic mice and in male mice with elevated androgen levels. Ling, C., Kindblom, J., Wennbo, H., Billig, H. FEBS Lett. (2001) [Pubmed]
  20. Contrasting effects of insulin and cellular differentiation on expression of the novel insulin receptor substrate APS in skeletal muscle. Rea, R., Gray, S., Donnelly, R. Biochem. Pharmacol. (2005) [Pubmed]
  21. Insulin sensitivity and resistin expression in nitric oxide-deficient rats. Juan, C.C., Chang, C.L., Chuang, T.Y., Huang, S.W., Kwok, C.F., Ho, L.T. Diabetologia (2006) [Pubmed]
  22. Regulation of resistin by gonadal, thyroid hormone, and nutritional status. Nogueiras, R., Gualillo, O., Caminos, J.E., Casanueva, F.F., Diéguez, C. Obes. Res. (2003) [Pubmed]
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