The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

YARS  -  tyrosyl-tRNA synthetase

Homo sapiens

Synonyms: CMTDIC, TYRRS, TyrRS, Tyrosine--tRNA ligase, cytoplasmic, Tyrosyl-tRNA synthetase, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of YARS


High impact information on YARS


Chemical compound and disease context of YARS


Biological context of YARS


Anatomical context of YARS

  • Human tyrosyl-tRNA synthetase from mitochondria (mt-TyrRS) presents dual sequence features characteristic of eubacterial and archaeal TyrRSs, especially in the region containing amino acids recognizing the N1-N72 tyrosine identity pair [14].
  • In vivo ablation of CD8+ T cells with mAb YTS 169.4 converted cyst resistant B10.BAR12 mice to cyst susceptible [15].
  • Here we use mass spectrometry-based proteomic strategy to characterize protein expression in membrane-enriched fractions derived from human NK lymphoma cell line YTS [16].
  • This study shows that a short course of treatment with the non-depleting anti-CD4 monoclonal antibody, YTS 177, completely prevents salivary infiltration and reverses ongoing pathology in the salivary gland [17].
  • We highlight the expression of CD86 on YTS and its ability to co-stimulate TCR responses of human CD4+ T-cells, providing an unexpected link between innate and adaptive immune systems [16].

Associations of YARS with chemical compounds


Other interactions of YARS

  • In particular, adaptations to the anticodon recognition domain of TyrRS cause distinct appended domains in TyrRS and TrpRS to occupy the same 3D space and thus to mask a common surface on each synthetase [19].
  • The angiogenic activity of mini TyrRS can be opposed by anti-angiogenic chemokines like IP-10 [13].
  • One of the TyrRS fragments (mini TyrRS) contains features identical to those in CXC chemokines (like interleukin-8) that also act as angiogenic factors [13].
  • Eukaryote proteins other than human TyrRS that have EMAP II-like domains have variants of the heptapeptide motif [20].
  • Conformational Flexibility of Cytokine-Like C-Module of Tyrosyl-tRNA Synthetase Monitored by Trp144 Intrinsic Fluorescence [21].

Analytical, diagnostic and therapeutic context of YARS

  • Fersht and co-workers have applied a linear free energy relation (Brønsted equation) to analyze site-directed mutagenesis experiments involving the enzyme tyrosyl-tRNA synthetase and have suggested that the Brønsted exponent is linearly correlated with the value of the reaction coordinate at the transition state [22].
  • Data from 27 boys and 27 girls from YRS I and 48 boys and 22 girls from the YRS II were included, and a total of 139 and 108 measurements of body size and peak VO2 in boys and girls, respectively, were available [23].
  • CC chemokine expression by YTS and primary NK cells treated with or without alcohol was analyzed with the real-time RT-PCR and ELISA [24].
  • The present manuscript describes a method for cytoskeleton isolation based on capture with magnetic microbeads and its application to the analysis of the NK like cell line, YTS [25].
  • Immunofluorescence analysis of YTS cells indicated that a minor component of IQGAP1 was localized at the cell membrane with the remainder diffusely distributed through out the cytoplasm [26].


  1. Human tyrosyl-tRNA synthetase shares amino acid sequence homology with a putative cytokine. Kleeman, T.A., Wei, D., Simpson, K.L., First, E.A. J. Biol. Chem. (1997) [Pubmed]
  2. tRNA-like structures of plant viral RNAs: conformational requirements for adenylation and aminoacylation. Joshi, R.L., Joshi, S., Chapeville, F., Haenni, A.L. EMBO J. (1983) [Pubmed]
  3. High-efficient lentiviral vector-mediated gene transfer into primary human NK cells. Micucci, F., Zingoni, A., Piccoli, M., Frati, L., Santoni, A., Galandrini, R. Exp. Hematol. (2006) [Pubmed]
  4. Laparoscopic resection of gastric leiomyosarcoma. Dempsey, D.T., Kelberman, I.A., Dabezies, M.A. Journal of laparoendoscopic & advanced surgical techniques. Part A. (1997) [Pubmed]
  5. Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy. Jordanova, A., Irobi, J., Thomas, F.P., Van Dijck, P., Meerschaert, K., Dewil, M., Dierick, I., Jacobs, A., De Vriendt, E., Guergueltcheva, V., Rao, C.V., Tournev, I., Gondim, F.A., D'Hooghe, M., Van Gerwen, V., Callaerts, P., Van Den Bosch, L., Timmermans, J.P., Robberecht, W., Gettemans, J., Thevelein, J.M., De Jonghe, P., Kremensky, I., Timmerman, V. Nat. Genet. (2006) [Pubmed]
  6. Inhibition of tumor angiogenesis by a natural fragment of a tRNA synthetase. Tzima, E., Schimmel, P. Trends Biochem. Sci. (2006) [Pubmed]
  7. Formation of a WIP-, WASp-, actin-, and myosin IIA-containing multiprotein complex in activated NK cells and its alteration by KIR inhibitory signaling. Krzewski, K., Chen, X., Orange, J.S., Strominger, J.L. J. Cell Biol. (2006) [Pubmed]
  8. Crystal structure of a human aminoacyl-tRNA synthetase cytokine. Yang, X.L., Skene, R.J., McRee, D.E., Schimmel, P. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  9. Similarity in the hydropathy profile of tyrosyl-t RNA synthetase and the estrogen receptor. Tritsch, G.L. FASEB J. (1989) [Pubmed]
  10. Comparison of the catalytic roles played by the KMSKS motif in the human and Bacillus stearothermophilus trosyl-tRNA synthetases. Austin, J., First, E.A. J. Biol. Chem. (2002) [Pubmed]
  11. Potassium functionally replaces the second lysine of the KMSKS signature sequence in human tyrosyl-tRNA synthetase. Austin, J., First, E.A. J. Biol. Chem. (2002) [Pubmed]
  12. Catalysis of tyrosyl-adenylate formation by the human tyrosyl-tRNA synthetase. Austin, J., First, E.A. J. Biol. Chem. (2002) [Pubmed]
  13. Induction of angiogenesis by a fragment of human tyrosyl-tRNA synthetase. Wakasugi, K., Slike, B.M., Hood, J., Ewalt, K.L., Cheresh, D.A., Schimmel, P. J. Biol. Chem. (2002) [Pubmed]
  14. Human mitochondrial TyrRS disobeys the tyrosine identity rules. Bonnefond, L., Frugier, M., Giegé, R., Rudinger-Thirion, J. RNA (2005) [Pubmed]
  15. Class I MHC genes and CD8+ T cells determine cyst number in Toxoplasma gondii infection. Brown, C.R., McLeod, R. J. Immunol. (1990) [Pubmed]
  16. Proteomic analysis of human natural killer cells: insights on new potential NK immune functions. Hanna, J., Fitchett, J., Rowe, T., Daniels, M., Heller, M., Gonen-Gross, T., Manaster, E., Cho, S.Y., LaBarre, M.J., Mandelboim, O. Mol. Immunol. (2005) [Pubmed]
  17. Non-depleting anti-CD4 antibody not only prevents onset but resolves sialadenitis in NOD mice. Thompson, C., Jacobsen, H., Pomeranz Krummel, D., Nagai, K., Cooke, A. Autoimmunity (2004) [Pubmed]
  18. Expression, purification, and characterization of human tyrosyl-tRNA synthetase. Jia, J., Li, B., Jin, Y., Wang, D. Protein Expr. Purif. (2003) [Pubmed]
  19. Relationship of two human tRNA synthetases used in cell signaling. Yang, X.L., Schimmel, P., Ewalt, K.L. Trends Biochem. Sci. (2004) [Pubmed]
  20. Highly differentiated motifs responsible for two cytokine activities of a split human tRNA synthetase. Wakasugi, K., Schimmel, P. J. Biol. Chem. (1999) [Pubmed]
  21. Conformational Flexibility of Cytokine-Like C-Module of Tyrosyl-tRNA Synthetase Monitored by Trp144 Intrinsic Fluorescence. Kordysh, M., Kornelyuk, A. Journal of fluorescence. (2006) [Pubmed]
  22. The interpretation of site-directed mutagenesis experiments by linear free energy relations. Straub, J.E., Karplus, M. Protein Eng. (1990) [Pubmed]
  23. Scaling peak VO2 to body mass in young male and female distance runners. Eisenmann, J.C., Pivarnik, J.M., Malina, R.M. J. Appl. Physiol. (2001) [Pubmed]
  24. Alcohol suppresses IL-2-induced CC chemokine production by natural killer cells. Zhang, T., Guo, C.J., Douglas, S.D., Metzger, D.S., O'Brien, C.P., Li, Y., Wang, Y.J., Wang, X., Ho, W.Z. Alcohol. Clin. Exp. Res. (2005) [Pubmed]
  25. Compositional characterization of the cytoskeleton of NK-like cells. Meng, X., Wilkins, J.A. J. Proteome Res. (2005) [Pubmed]
  26. Characterization of IQGAP1-Containing Complexes in NK-Like Cells: Evidence for Rac 2 and RACK1 Association during Homotypic Adhesion. Meng, X., Krokhin, O., Cheng, K., Ens, W., Wilkins, J.A. J. Proteome Res. (2007) [Pubmed]
WikiGenes - Universities