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Gene Review

Prdx6  -  peroxiredoxin 6

Rattus norvegicus

Synonyms: 1-Cys PRX, 1-Cys peroxiredoxin, Acidic calcium-independent phospholipase A2, Aipla2, Antioxidant protein 2, ...
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Psychiatry related information on Prdx6

  • Thyrocytes have several defense mechanisms against ROS, including TSA and SOD (superoxide anion dismutase) [1].

High impact information on Prdx6


Biological context of Prdx6


Anatomical context of Prdx6


Associations of Prdx6 with chemical compounds

  • The extent of adduction of each protein was calculated, and two proteins, peroxiredoxin 6 and biliverdin reductase, were adducted at high specific activities (0.36-0.70 and 1.0 nmol adduct/nmol protein) [10].
  • Peroxiredoxin-6, glucose-regulated protein 78, zinc-alpha2-glycoprotein, and phospholipase Calpha are also secreted [11].
  • Other growth factors (e.g., insulin, transferrin and hydrocortisone) did not alter TSA expression [1].

Other interactions of Prdx6


Analytical, diagnostic and therapeutic context of Prdx6


  1. Thyroid-stimulating hormone transcriptionally regulates the thiol-specific antioxidant gene. Kim, H., Park, S., Suh, J.M., Chung, H.K., Shong, M., Kwon, O.Y. Cell. Physiol. Biochem. (2001) [Pubmed]
  2. Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product. Hirotsu, S., Abe, Y., Okada, K., Nagahara, N., Hori, H., Nishino, T., Hakoshima, T. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. An antisense oligonucleotide to 1-cys peroxiredoxin causes lipid peroxidation and apoptosis in lung epithelial cells. Pak, J.H., Manevich, Y., Kim, H.S., Feinstein, S.I., Fisher, A.B. J. Biol. Chem. (2002) [Pubmed]
  4. A novel glutathione peroxidase in bovine eye. Sequence analysis, mRNA level, and translation. Singh, A.K., Shichi, H. J. Biol. Chem. (1998) [Pubmed]
  5. Identification of a 28 kDa secretory protein from rat olfactory epithelium as a thiol-specific antioxidant. Peshenko, I.V., Novoselov, V.I., Evdokimov, V.A., Nikolaev, Y.V., Kamzalov, S.S., Shuvaeva, T.M., Lipkin, V.M., Fesenko, E.E. Free Radic. Biol. Med. (1998) [Pubmed]
  6. Regulation of 1-cys peroxiredoxin expression in the process of stromal wound healing after photorefractive keratectomy. Tchah, H., Kim, M.J., Kim, T.I., Choi, H.J., Kim, J.Y., Kim, M.J., Pak, J.H. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  7. Novel 28-kDa secretory protein from rat olfactory epithelium. Peshenko, I.V., Novoselov, V.I., Evdokimov, V.A., Nikolaev YuV, n.u.l.l., Shuvaeva, T.M., Lipkin, V.M., Fesenko, E.E. FEBS Lett. (1996) [Pubmed]
  8. Rat pachytene spermatocytes down-regulate a polo-like kinase and up-regulate a thiol-specific antioxidant protein, whereas sertoli cells down-regulate a phosphodiesterase and up-regulate an oxidative stress protein after exposure to methoxyethanol and methoxyacetic acid. Syed, V., Hecht, N.B. Endocrinology (1998) [Pubmed]
  9. Role of phospholipase A2 enzymes in degradation of dipalmitoylphosphatidylcholine by granular pneumocytes. Fisher, A.B., Dodia, C. J. Lipid Res. (1996) [Pubmed]
  10. In vivo effects of ozone exposure on protein adduct formation by 1-nitronaphthalene in rat lung. Wheelock, A.M., Boland, B.C., Isbell, M., Morin, D., Wegesser, T.C., Plopper, C.G., Buckpitt, A.R. Am. J. Respir. Cell Mol. Biol. (2005) [Pubmed]
  11. Identification of prostatic-secreted proteins in mice by mass spectrometric analysis and evaluation of lobe-specific and androgen-dependent mRNA expression. Fujimoto, N., Akimoto, Y., Suzuki, T., Kitamura, S., Ohta, S. J. Endocrinol. (2006) [Pubmed]
  12. Transient elevation of glutathione peroxidase 1 around the time of eyelid opening in the neonatal rat. Fujii, T., Ikeda, Y., Yamashita, H., Fujii, J. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (2003) [Pubmed]
  13. Expression profiles of peroxiredoxin proteins of the rodent malaria parasite Plasmodium yoelii. Kawazu, S., Nozaki, T., Tsuboi, T., Nakano, Y., Komaki-Yasuda, K., Ikenoue, N., Torii, M., Kano, S. Int. J. Parasitol. (2003) [Pubmed]
  14. Characterization of acidic Ca(2+)-independent phospholipase A2 of bovine lung. Akiba, S., Dodia, C., Chen, X., Fisher, A.B. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (1998) [Pubmed]
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