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MeSH Review

HELLP Syndrome

 
 
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Disease relevance of HELLP Syndrome

 

High impact information on HELLP Syndrome

  • CONCLUSIONS: Taken together, these data suggest that CD95L derived from the placenta acts systemically and is a primary cause of liver damage in HELLP syndrome [6].
  • Association of HELLP syndrome with autoimmune antibodies and glucose intolerance [7].
  • Association of a decrease in antithrombin III activity with a perinatal elevation in aspartate aminotransferase in women with twin pregnancies: relevance to the HELLP syndrome [8].
  • A remarkable association between LCHAD deficiency and the hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome, which is a severe complication of pregnancy, has been reported [9].
  • In the group of women with a history of HELLP syndrome, the prevalence of the common LCHAD mutation was also low (1:113) [9].
 

Chemical compound and disease context of HELLP Syndrome

 

Biological context of HELLP Syndrome

 

Anatomical context of HELLP Syndrome

 

Gene context of HELLP Syndrome

 

Analytical, diagnostic and therapeutic context of HELLP Syndrome

References

  1. A fetal fatty-acid oxidation disorder as a cause of liver disease in pregnant women. Ibdah, J.A., Bennett, M.J., Rinaldo, P., Zhao, Y., Gibson, B., Sims, H.F., Strauss, A.W. N. Engl. J. Med. (1999) [Pubmed]
  2. Glutathione S-transferase alpha as marker for hepatocellular damage in pre-eclampsia and HELLP syndrome. Steegers, E.A., Mulder, T.P., Bisseling, J.G., Delemarre, F.M., Peters, W.H. Lancet (1995) [Pubmed]
  3. HELLP syndrome associated with factor V R506Q mutation. Brenner, B., Lanir, N., Thaler, I. Br. J. Haematol. (1996) [Pubmed]
  4. Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Sibai, B.M. Obstetrics and gynecology. (2004) [Pubmed]
  5. Syndromes of disseminated intravascular coagulation in obstetrics, pregnancy, and gynecology. Objective criteria for diagnosis and management. Bick, R.L. Hematol. Oncol. Clin. North Am. (2000) [Pubmed]
  6. Placenta-derived CD95 ligand causes liver damage in hemolysis, elevated liver enzymes, and low platelet count syndrome. Strand, S., Strand, D., Seufert, R., Mann, A., Lotz, J., Blessing, M., Lahn, M., Wunsch, A., Broering, D.C., Hahn, U., Grischke, E.M., Rogiers, X., Otto, G., Gores, G.J., Galle, P.R. Gastroenterology (2004) [Pubmed]
  7. Association of HELLP syndrome with autoimmune antibodies and glucose intolerance. Weitgasser, R., Spitzer, D., Kartnig, I., Zajc, M., Staudach, A., Sandhofer, F. Diabetes Care (2000) [Pubmed]
  8. Association of a decrease in antithrombin III activity with a perinatal elevation in aspartate aminotransferase in women with twin pregnancies: relevance to the HELLP syndrome. Minakami, H., Watanabe, T., Izumi, A., Matsubara, S., Koike, T., Sayama, M., Moriyama, I., Sato, I. J. Hepatol. (1999) [Pubmed]
  9. Heterozygosity for the common LCHAD mutation (1528g>C) is not a major cause of HELLP syndrome and the prevalence of the mutation in the Dutch population is low. den Boer, M.E., Ijlst, L., Wijburg, F.A., Oostheim, W., van Werkhoven, M.A., van Pampus, M.G., Heymans, H.S., Wanders, R.J. Pediatr. Res. (2000) [Pubmed]
  10. Better maternal outcomes are achieved with dexamethasone therapy for postpartum HELLP (hemolysis, elevated liver enzymes, and thrombocytopenia) syndrome. Martin, J.N., Perry, K.G., Blake, P.G., May, W.A., Moore, A., Robinette, L. Am. J. Obstet. Gynecol. (1997) [Pubmed]
  11. Haptoglobin helps diagnose the HELLP syndrome. Poldre, P.A. Am. J. Obstet. Gynecol. (1987) [Pubmed]
  12. Obstetric implications of antepartum corticosteroid therapy for HELLP syndrome. Rose, C.H., Thigpen, B.D., Bofill, J.A., Cushman, J., May, W.L., Martin, J.N. Obstetrics and gynecology. (2004) [Pubmed]
  13. The spectrum of severe preeclampsia: comparative analysis by HELLP (hemolysis, elevated liver enzyme levels, and low platelet count) syndrome classification. Martin, J.N., Rinehart, B.K., May, W.L., Magann, E.F., Terrone, D.A., Blake, P.G. Am. J. Obstet. Gynecol. (1999) [Pubmed]
  14. The transplacental passage of prednisolone in pregnancies complicated by early-onset HELLP syndrome. van Runnard Heimel, P.J., Schobben, A.F., Huisjes, A.J., Franx, A., Bruinse, H.W. Placenta (2005) [Pubmed]
  15. Prospective screening for pediatric mitochondrial trifunctional protein defects in pregnancies complicated by liver disease. Yang, Z., Yamada, J., Zhao, Y., Strauss, A.W., Ibdah, J.A. JAMA (2002) [Pubmed]
  16. A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia. Zusterzeel, P.L., Peters, W.H., Visser, W., Hermsen, K.J., Roelofs, H.M., Steegers, E.A. J. Med. Genet. (2001) [Pubmed]
  17. Neonatal outcome in growth-restricted versus appropriately grown preterm infants. Simchen, M.J., Beiner, M.E., Strauss-Liviathan, N., Dulitzky, M., Kuint, J., Mashiach, S., Schiff, E. American journal of perinatology. (2000) [Pubmed]
  18. Hyperparathyroidism in pregnancy: diagnostic dilemma? Murray, J.A., Newman, W.A., Dacus, J.V. Obstetrical & gynecological survey. (1997) [Pubmed]
  19. Erythrocyte glutathione balance and membrane stability during preeclampsia. Spickett, C.M., Reglinski, J., Smith, W.E., Wilson, R., Walker, J.J., McKillop, J. Free Radic. Biol. Med. (1998) [Pubmed]
  20. Hemolysis in hypertensive disorders of pregnancy. Schröcksnadel, H., Sitte, B., Steckel-Berger, G., Dapunt, O. Gynecol. Obstet. Invest. (1992) [Pubmed]
  21. Placental expression of nitric oxide synthase during HELLP syndrome: the correlation with maternal-fetal Doppler velocimetry. Tranquilli, A.L., Giannubilo, S.R., Tedeschi, E., Bezzeccheri, V., Suzuki, H., Menegazzi, M. Acta obstetricia et gynecologica Scandinavica. (2005) [Pubmed]
  22. Plasma endothelin and big endothelin levels in women with severe preeclampsia or HELLP-syndrome. Bussen, S., Sütterlin, M., Steck, T. Arch. Gynecol. Obstet. (1999) [Pubmed]
  23. No association of polymorphisms in the glutathione S-transferase genes with pre-eclampsia, eclampsia and HELLP syndrome in a Turkish population. Cetin, M., Pinarbasi, E., Percin, F.E., Akgün, E., Percin, S., Pinarbasi, H., Gurlek, F., Cetin, A. J. Obstet. Gynaecol. Res. (2005) [Pubmed]
  24. Adrenomedullin, calcitonin gene-related peptide and their receptors: evidence for a decreased placental mRNA content in preeclampsia and HELLP syndrome. Knerr, I., Dachert, C., Beinder, E., Metzler, M., Dötsch, J., Repp, R., Rascher, W. Eur. J. Obstet. Gynecol. Reprod. Biol. (2002) [Pubmed]
  25. Low whole blood glutathione levels in pregnancies complicated by preeclampsia or the hemolysis, elevated liver enzymes, low platelets syndrome. Knapen, M.F., Mulder, T.P., Van Rooij, I.A., Peters, W.H., Steegers, E.A. Obstetrics and gynecology. (1998) [Pubmed]
  26. Postoperative incision complications after cesarean section in patients with antepartum syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP): does delayed primary closure make a difference? Briggs, R., Chari, R.S., Mercer, B., Sibai, B. Am. J. Obstet. Gynecol. (1996) [Pubmed]
  27. Plasma exchange for preeclampsia. I. Postpartum use for persistently severe preeclampsia-eclampsia with HELLP syndrome. Martin, J.N., Files, J.C., Blake, P.G., Norman, P.H., Martin, R.W., Hess, L.W., Morrison, J.C., Wiser, W.L. Am. J. Obstet. Gynecol. (1990) [Pubmed]
  28. Time course of recovery and complications of HELLP syndrome with two different treatments: heparin or dexamethasone. Mecacci, F., Carignani, L., Cioni, R., Parretti, E., Mignosa, M., Piccioli, A., Scarselli, G., Mello, G. Thromb. Res. (2001) [Pubmed]
  29. Postpartum heparin therapy for patients with the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP) is associated with significant hemorrhagic complications. Detti, L., Mecacci, F., Piccioli, A., Ferrarello, S., Carignani, L., Mello, G., Ferguson, J.E., Scarselli, G. Journal of perinatology : official journal of the California Perinatal Association. (2005) [Pubmed]
 
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