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Gene Review

PEE1  -  preeclampsia/eclampsia 1

Homo sapiens

Synonyms: PEE, PIH, PREG1
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Disease relevance of PEE1


High impact information on PEE1


Chemical compound and disease context of PEE1


Biological context of PEE1


Anatomical context of PEE1


Associations of PEE1 with chemical compounds

  • The DHEA and PREG fractions were determined by gas chromatography-mass spectrometry, and the concentrations were converted into those of DHEA-S and PREG-S [20].
  • Progesterone selectively inhibited alpha(2) GlyRs, while PREG and its acetic ester potentiated alpha(1) GlyRs [21].
  • In response to ACTH, OO women had smaller responses to Adione (p less than 0.05), DHEA (p less than 0.005), DHEA-S (p less than 0.01), 17-OH progesterone (17 Prog) (p less than 0.01), and 17-OH pregnenolone (17 Preg) (p less than 0.1) [22].
  • Inhibition of the aggressive behavior of castrated male mice toward lactating female intruders by dehydroepiandrosterone (DHEA) is correlated with a decrease of pregnenolone sulfate (PREG S) concentrations in brain [23].
  • CONCLUSION: The study delineates an impaired catabolism of placental serotonin in preeclampsia-eclampsia [15].

Regulatory relationships of PEE1


Other interactions of PEE1


Analytical, diagnostic and therapeutic context of PEE1


  1. Haplotypic association of DDAH1 with susceptibility to pre-eclampsia. Akbar, F., Heinonen, S., Pirskanen, M., Uimari, P., Tuomainen, T.P., Salonen, J.T. Mol. Hum. Reprod. (2005) [Pubmed]
  2. Catastrophic antiphospholipid syndrome: response to repeated plasmapheresis over three years. Neuwelt, C.M., Daikh, D.I., Linfoot, J.A., Pfister, D.A., Young, R.G., Webb, R.L., London, S.S., Asherson, R.A. Arthritis Rheum. (1997) [Pubmed]
  3. Preeclampsia-eclampsia: clinical and neuroradiographic correlates and insights into the pathogenesis of hypertensive encephalopathy. Schwartz, R.B., Feske, S.K., Polak, J.F., DeGirolami, U., Iaia, A., Beckner, K.M., Bravo, S.M., Klufas, R.A., Chai, R.Y., Repke, J.T. Radiology. (2000) [Pubmed]
  4. Evidence for reduced thermic effect of insulin and glucose infusions in Pima Indians. Bogardus, C., Lillioja, S., Mott, D., Zawadzki, J., Young, A., Abbott, W. J. Clin. Invest. (1985) [Pubmed]
  5. Hypertension in pregnancy. Lindheimer, M.D. Hypertension (1993) [Pubmed]
  6. Action of magnesium sulfate in the treatment of preeclampsia-eclampsia. Sadeh, M. Stroke (1989) [Pubmed]
  7. Evidence for reduced 3 beta-ol-hydroxysteroid dehydrogenase activity in some hirsute women thought to have polycystic ovary syndrome. Lobo, R.A., Goebelsmann, U. J. Clin. Endocrinol. Metab. (1981) [Pubmed]
  8. Serum vitamin A, vitamin E, and beta-carotene levels in preeclamptic women in northern nigeria. Ziari, S.A., Mireles, V.L., Cantu, C.G., Cervantes, M., Idrisa, A., Bobsom, D., Tsin, A.T., Glew, R.H. American journal of perinatology. (1996) [Pubmed]
  9. Relation between birth weight and thyroid function in preeclampsia-eclampsia. Kaya, E., Sahin, Y., Ozkeçeci, Z., Paşaoğlu, H. Gynecol. Obstet. Invest. (1994) [Pubmed]
  10. Fine mapping and SNP analysis of positional candidates at the preeclampsia susceptibility locus (PREG1) on chromosome 2. Fitzpatrick, E., Göring, H.H., Liu, H., Borg, A., Forrest, S., Cooper, D.W., Brennecke, S.P., Moses, E.K. Hum. Biol. (2004) [Pubmed]
  11. Postpartum plasma exchange for atypical preeclampsia-eclampsia as HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome. Martin, J.N., Files, J.C., Blake, P.G., Perry, K.G., Morrison, J.C., Norman, P.H. Am. J. Obstet. Gynecol. (1995) [Pubmed]
  12. HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) presenting as generalized malaise. Tomsen, T.R. Am. J. Obstet. Gynecol. (1995) [Pubmed]
  13. Progesterone supplementation increases luteal phase endometrial thickness and oestradiol levels in in-vitro fertilization. Segal, S., Casper, R.F. Hum. Reprod. (1992) [Pubmed]
  14. Blood pressure in the midtrimester and future eclampsia. Chesley, L.C., Sibai, B.M. Am. J. Obstet. Gynecol. (1987) [Pubmed]
  15. Novel appearance of placental nuclear monoamine oxidase: biochemical and histochemical evidence for hyperserotonomic state in preeclampsia-eclampsia. Gujrati, V.R., Shanker, K., Vrat, S., Chandravati, n.u.l.l., Parmar, S.S. Am. J. Obstet. Gynecol. (1996) [Pubmed]
  16. Correlation between maternal thyroid function tests and endothelin in preeclampsia-eclampsia. Başbuğ, M., Aygen, E., Tayyar, M., Tutuş, A., Kaya, E., Oktem, O. Obstetrics and gynecology. (1999) [Pubmed]
  17. Strategies to prevent and treat preeclampsia: evidence from randomized controlled trials. Villar, J., Abalos, E., Nardin, J.M., Merialdi, M., Carroli, G. Semin. Nephrol. (2004) [Pubmed]
  18. Plasma exchange for preeclampsia. I. Postpartum use for persistently severe preeclampsia-eclampsia with HELLP syndrome. Martin, J.N., Files, J.C., Blake, P.G., Norman, P.H., Martin, R.W., Hess, L.W., Morrison, J.C., Wiser, W.L. Am. J. Obstet. Gynecol. (1990) [Pubmed]
  19. Observation of an organism found in patients with gestational trophoblastic disease and in patients with toxemia of pregnancy. Lueck, J., Brewer, J.I., Aladjem, S., Novotny, M. Am. J. Obstet. Gynecol. (1983) [Pubmed]
  20. Serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and pregnenolone sulfate concentrations in patients with hyperthyroidism and hypothyroidism. Tagawa, N., Tamanaka, J., Fujinami, A., Kobayashi, Y., Takano, T., Fukata, S., Kuma, K., Tada, H., Amino, N. Clin. Chem. (2000) [Pubmed]
  21. Subunit-specific modulation of glycine receptors by neurosteroids. Maksay, G., Laube, B., Betz, H. Neuropharmacology (2001) [Pubmed]
  22. The effects of estrogen on adrenal androgens in oophorectomized women. Lobo, R.A., Goebelsmann, U., Brenner, P.F., Mishell, D.R. Am. J. Obstet. Gynecol. (1982) [Pubmed]
  23. Neurosteroids in the mouse brain: behavioral and pharmacological effects of a 3 beta-hydroxysteroid dehydrogenase inhibitor. Young, J., Corpéchot, C., Perché, F., Eychenne, B., Haug, M., Baulieu, E.E., Robel, P. Steroids (1996) [Pubmed]
  24. Correlated plasma elastase and sera cytotoxicity in eclampsia. A possible role of endothelin-1 induced neutrophil activation in preeclampsia-eclampsia. Halim, A., Kanayama, N., El Maradny, E., Maehara, K., Bhuiyan, A.B., Terao, T. Am. J. Hypertens. (1996) [Pubmed]
  25. Increased plasma levels of Urotensin-II in preeclampsia-eclampsia: a new mediator in pathogenesis? Balat, O., Aksoy, F., Kutlar, I., Ugur, M.G., Iyikosker, H., Balat, A., Anarat, R. Eur. J. Obstet. Gynecol. Reprod. Biol. (2005) [Pubmed]
  26. Maternal mortality in Utah. Jacob, S., Bloebaum, L., Shah, G., Varner, M.W. Obstetrics and gynecology. (1998) [Pubmed]
  27. Stroke in women of reproductive age: comparison between stroke related and unrelated to pregnancy. Jeng, J.S., Tang, S.C., Yip, P.K. J. Neurol. Sci. (2004) [Pubmed]
  28. Preeclampsia. Part 2: experimental and genetic considerations. Pridjian, G., Puschett, J.B. Obstetrical & gynecological survey. (2002) [Pubmed]
  29. Oxidative-antioxidative system in peripartum acute renal failure and preeclampsia-eclampsia. Balal, M., Canacankatan, N., Paydas, S., Seyrek, N., Karayaylali, I., Kayrin, L. Renal failure. (2004) [Pubmed]
  30. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Uzunova, V., Sheline, Y., Davis, J.M., Rasmusson, A., Uzunov, D.P., Costa, E., Guidotti, A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  31. Severe preeclampsia-eclampsia in young primigravid women: subsequent pregnancy outcome and remote prognosis. Sibai, B.M., el-Nazer, A., Gonzalez-Ruiz, A. Am. J. Obstet. Gynecol. (1986) [Pubmed]
  32. Do gravid women with preeclampsia-eclampsia ever require plasmapheresis? Schwartz, M. Am. J. Obstet. Gynecol. (1997) [Pubmed]
  33. Management of hypertensive crises: the scientific basis for treatment decisions. Blumenfeld, J.D., Laragh, J.H. Am. J. Hypertens. (2001) [Pubmed]
  34. Impact of pregnancy-induced hypertension on fetal growth. Xiong, X., Mayes, D., Demianczuk, N., Olson, D.M., Davidge, S.T., Newburn-Cook, C., Saunders, L.D. Am. J. Obstet. Gynecol. (1999) [Pubmed]
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