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MeSH Review

Riboflavin Deficiency

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Disease relevance of Riboflavin Deficiency


High impact information on Riboflavin Deficiency

  • The effects of riboflavin deficiency on the metabolism of N-nitrosodimethylamine [(DMN) CAS: 62-75-9] and other nitrosamines were examined in rats [3].
  • For the first time, a significant riboflavin deficiency has been found to be related to CTS [4].
  • In certain cases, such as thiamin deficiency and mild riboflavin deficiency, however, enhanced rates of metabolism of xenobiotics were observed [5].
  • These results suggest that in some patients with multiple acyl-CoA dehydrogenase deficiency riboflavin supplementation may be effective in restoring the activity of SCAD, and possibly of other mitochondrial flavin-dependent enzymes [6].
  • The most prominent biochemical consequence of riboflavin deficiency in rats is a drastic decrease in various acyl-CoA dehydrogenase activities, especially that of short chain and isovaleryl-CoA dehydrogenase (IVD) [7].

Chemical compound and disease context of Riboflavin Deficiency


Biological context of Riboflavin Deficiency


Anatomical context of Riboflavin Deficiency


Gene context of Riboflavin Deficiency


Analytical, diagnostic and therapeutic context of Riboflavin Deficiency


  1. Alterations in dimethylnitrosamine-induced lethality and acute hepatotoxicity in rats during dietary thiamin, riboflavin and pyridoxine deficiencies. Ruchirawat, M., Navasumrit, P., Aramphongphan, A., Mahathanatrakul, W., Frank, N. J. Cancer Res. Clin. Oncol. (1990) [Pubmed]
  2. The influence of riboflavin deficiency on Plasmodium berghei infection in rats. Kaikai, P., Thurnham, D.I. Trans. R. Soc. Trop. Med. Hyg. (1983) [Pubmed]
  3. Effects of riboflavin deficiency on metabolism of nitrosamines by rat liver microsomes. Wang, T., Miller, K.W., Tu, Y.Y., Yang, C.S. J. Natl. Cancer Inst. (1985) [Pubmed]
  4. Enzymology of the response of the carpal tunnel syndrome to riboflavin and to combined riboflavin and pyridoxine. Folkers, K., Wolaniuk, A., Vadhanavikit, S. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  5. Dietary effects on cytochromes P450, xenobiotic metabolism, and toxicity. Yang, C.S., Brady, J.F., Hong, J.Y. FASEB J. (1992) [Pubmed]
  6. Normalization of short-chain acylcoenzyme A dehydrogenase after riboflavin treatment in a girl with multiple acylcoenzyme A dehydrogenase-deficient myopathy. DiDonato, S., Gellera, C., Peluchetti, D., Uziel, G., Antonelli, A., Lus, G., Rimoldi, M. Ann. Neurol. (1989) [Pubmed]
  7. FAD-dependent regulation of transcription, translation, post-translational processing, and post-processing stability of various mitochondrial acyl-CoA dehydrogenases and of electron transfer flavoprotein and the site of holoenzyme formation. Nagao, M., Tanaka, K. J. Biol. Chem. (1992) [Pubmed]
  8. Nutrition in cryptogenic cirrhosis and chronic aggressive hepatitis. Morgan, A.G., Kelleher, J., Walker, B.E., Losowsky, M.S. Gut (1976) [Pubmed]
  9. Dependence of pyridoxine metabolism on riboflavin status in sickle cell patients. Adelekan, D.A., Adekile, A.D., Thurnham, D.I. Am. J. Clin. Nutr. (1987) [Pubmed]
  10. Riboflavin (vitamin B-2) and health. Powers, H.J. Am. J. Clin. Nutr. (2003) [Pubmed]
  11. Effect of riboflavin status on the homocysteine-lowering effect of folate in relation to the MTHFR (C677T) genotype. Moat, S.J., Ashfield-Watt, P.A., Powers, H.J., Newcombe, R.G., McDowell, I.F. Clin. Chem. (2003) [Pubmed]
  12. Hepatic peroxisomal and mitochondrial fatty acid oxidation in the riboflavin-deficient rat. Brady, P.S., Hoppel, C.L. Biochem. J. (1985) [Pubmed]
  13. Lipid metabolism in riboflavin-deficient rats. 1. Effect of dietary lipids on riboflavin status and fatty acid profiles. Olpin, S.E., Bates, C.J. Br. J. Nutr. (1982) [Pubmed]
  14. Acute ethanol exposure alters hepatic glutathione metabolism in riboflavin deficiency. Dutta, P., Seirafi, J., Halpin, D., Pinto, J., Rivlin, R. Alcohol (1995) [Pubmed]
  15. Vitamin E deficiency in phrynoderma cases from Sri Lanka. Christiansen, E.N., Piyasena, C., Bjørneboe, G.E., Bibow, K., Nilsson, A., Wandel, M. Am. J. Clin. Nutr. (1988) [Pubmed]
  16. Effects of riboflavin deficiency and clofibrate treatment on the five acyl-CoA dehydrogenases in rat liver mitochondria. Veitch, K., Draye, J.P., Van Hoof, F., Sherratt, H.S. Biochem. J. (1988) [Pubmed]
  17. Hepatic mitochondrial and peroxisomal oxidative capacity in riboflavin deficiency: effect of age, dietary fat and starvation in rats. Brady, P.S., Knoeber, C.M., Brady, L.J. J. Nutr. (1986) [Pubmed]
  18. Investigation into the relative effects of riboflavin deprivation on iron economy in the weanling rat and the adult. Powers, H.J. Ann. Nutr. Metab. (1986) [Pubmed]
  19. Effects of riboflavin deficiency upon age-related changes in beta-adrenergic and adenosine receptor binding in rat adipocytes. Dutta, P., Pinto, J., Rivlin, R. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1987) [Pubmed]
  20. Age-related changes of glutathione content, glutathione reductase and glutathione peroxidase activity of human erythrocytes. Matsubara, L.S., Machado, P.E. Braz. J. Med. Biol. Res. (1991) [Pubmed]
  21. Glutathione reductase activity, riboflavin status, and disease activity in rheumatoid arthritis. Mulherin, D.M., Thurnham, D.I., Situnayake, R.D. Ann. Rheum. Dis. (1996) [Pubmed]
  22. The influence of G-6-PD activity on the response of erythrocyte glutathione reductase to riboflavin deficiency. Prentice, A.M., Bates, C.J., Prentice, A., Welch, S.G., Williams, K., McGregor, I.A. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1981) [Pubmed]
  23. Thiamine, riboflavin and pyridoxine deficiency in psychiatric in-patients. Carney, M.W., Ravindran, A., Rinsler, M.G., Williams, D.G. The British journal of psychiatry : the journal of mental science. (1982) [Pubmed]
  24. The effect of reduced dietary protein level on the activity of transketolase and glutathione reductase in pig erythrocytes. Młodkowski, M., Młodkowska, I. Acta physiologica Polonica. (1983) [Pubmed]
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