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Gene Review

Igfbp2  -  insulin-like growth factor binding protein 2

Rattus norvegicus

Synonyms: BRL-BP, IBP-2, IGF-binding protein 2, IGFBP-2, ILGFBPA, ...
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Disease relevance of Igfbp2


Psychiatry related information on Igfbp2


High impact information on Igfbp2


Biological context of Igfbp2

  • Igfbp2 gene expression was transiently upregulated during the contractile phase of gestation (Days 21-23) solely in the gravid horn of unilaterally pregnant rats, but it was not affected in P4- or RU486-treated animals, supporting a role for mechanical stretch imposed by the growing fetuses [11].
  • We observed a dramatic up-regulation of insulin-like growth factor binding protein-2 (IGFBP-2) mRNA in cortical areas adjacent to the injury 24 h after impact, with a peak 10-fold increase engaging most of the ipsilateral cortex 2 and 3 days post-contusion [3].
  • Given the critical roles played by insulin-like growth factors in cellular mitogenesis, differentiation, and cell death, and that IGFBP-2 is the major brain resident IGFBP, we assessed IGFBP-2 expression in primary cortical neuroncultures subsequent to lithium treatment [12].
  • Indeed, we show that the addition of conditioned medium from growth-arrested cells on proliferative cells results in down-regulation of IGFBP-2 and increased expression of IGF-II and type 2 IGF receptor mRNA [13].
  • From the results presented in this study, it can be suggested that IGFBP-2, IGF-II, and type 2 IGF receptor play an important role in the transition of lung alveolar epithelial cells in and out of the cell cycle [13].

Anatomical context of Igfbp2


Associations of Igfbp2 with chemical compounds


Physical interactions of Igfbp2

  • We show in this study that insulin-like growth factor (IGF)-binding protein-2 (IGFBP-2) accumulates to high levels in culture medium of growth-arrested type 2 cells [13].
  • In the CSF, transported IGF-II is complexed to IGFBP-2 and essentially demonstrates an endocrine mode of action with a balance of locally produced IGFBPs modulating its bioactivity in the wound [21].
  • To test whether hormonal regulation of IGF-I receptor (IGF-IR) and IGF binding protein-2 (IGFBP-2) may be involved in the accumulation of IGF-I in tanycytes, we assessed the effect of ovarian hormones on the levels of these molecules in the mediobasal hypothalamus of adult female rats [22].
  • Insulin-like growth factor binding protein-2 binds to cell surface proteoglycans in the rat brain olfactory bulb [23].
  • IGFBP-2 also bound the proteoglycan aggrecan, an effect reduced by digestion of its glycosaminoglycans [23].

Regulatory relationships of Igfbp2


Other interactions of Igfbp2


Analytical, diagnostic and therapeutic context of Igfbp2


  1. Overexpression of insulin-like growth factor-binding protein-2 in C6 glioma cells results in conditional alteration of cellular growth. Bradshaw, S.L., D'Ercole, A.J., Han, V.K. Endocrinology (1999) [Pubmed]
  2. Decreased hepatic insulin-like growth factor (IGF)-I and increased IGF binding protein-1 and -2 gene expression in experimental uremia. Tönshoff, B., Powell, D.R., Zhao, D., Durham, S.K., Coleman, M.E., Domené, H.M., Blum, W.F., Baxter, R.C., Moore, L.C., Kaskel, F.J. Endocrinology (1997) [Pubmed]
  3. Increase of insulin-like growth factor (IGF)-1, IGF binding protein-2 and -4 mRNAs following cerebral contusion. Sandberg Nordqvist, A.C., von Holst, H., Holmin, S., Sara, V.R., Bellander, B.M., Schalling, M. Brain Res. Mol. Brain Res. (1996) [Pubmed]
  4. IGF-binding protein-2 is induced during development of urinary bladder hypertrophy in the diabetic rat. Chen, Y., Gustafsson, B., Arnqvist, H.J. Am. J. Physiol. (1997) [Pubmed]
  5. Astrocytes express insulin-like growth factor-I (IGF-I) and its binding protein, IGFBP-2, during demyelination induced by experimental autoimmune encephalomyelitis. Liu, X., Yao, D.L., Bondy, C.A., Brenner, M., Hudson, L.D., Zhou, J., Webster, H.D. Mol. Cell. Neurosci. (1994) [Pubmed]
  6. Insulin-like growth factor binding protein expression in the hypothyroid rat is age dependent. Näntö-Salonen, K., Rosenfeld, R.G. Endocrinology (1992) [Pubmed]
  7. Angiotensin II causes weight loss and decreases circulating insulin-like growth factor I in rats through a pressor-independent mechanism. Brink, M., Wellen, J., Delafontaine, P. J. Clin. Invest. (1996) [Pubmed]
  8. Expression and insulin-like growth factor-dependent proteolysis of insulin-like growth factor-binding protein-4 are regulated by cell confluence in vascular smooth muscle cells. Kamyar, A., Pirola, C.J., Wang, H.M., Sharifi, B., Mohan, S., Forrester, J.S., Fagin, J.A. Circ. Res. (1994) [Pubmed]
  9. Astrocytes upregulate glial fibrillary acidic protein (GFAP), but not insulin-like growth factor-I (IGF-I) during experimental autoimmune neuritis (EAN). Gehrmann, J., Yao, D.L., Bonetti, B., Brenner, M., Bondy, C., Wekerle, H., Kreutzberg, G.W., Webster, H.d.e. .F. Brain Pathol. (1995) [Pubmed]
  10. IGF binding protein-2 gene expression and the location of IGF-I and IGF-II in fetal rat lung. Klempt, M., Hutchins, A.M., Gluckman, P.D., Skinner, S.J. Development (1992) [Pubmed]
  11. Insulin-like Growth Factors and Their Binding Proteins Define Specific Phases of Myometrial Differentiation During Pregnancy in the Rat. Shynlova, O., Tsui, P., Dorogin, A., Langille, B.L., Lye, S.J. Biol. Reprod. (2007) [Pubmed]
  12. Insulin-like growth factor binding protein-2 expression is decreased by lithium. Bezchlibnyk, Y.B., Wang, J.F., Shao, L., Young, L.T. Neuroreport (2006) [Pubmed]
  13. Insulin-like growth factor-II (IGF-II), type 2 IGF receptor, and IGF-binding protein-2 gene expression in rat lung alveolar epithelial cells: relation to proliferation. Mouhieddine, O.B., Cazals, V., Maitre, B., Le Bouc, Y., Chadelat, K., Clement, A. Endocrinology (1994) [Pubmed]
  14. Insulin-like growth factor binding proteins show distinct patterns of expression in the rat uterus. Girvigian, M.R., Nakatani, A., Ling, N., Shimasaki, S., Erickson, G.F. Biol. Reprod. (1994) [Pubmed]
  15. The ontogeny of insulin-like growth factor (IGF) and IGF-binding protein gene expression in the rat pancreas. Hogg, J., Hill, D.J., Han, V.K. J. Mol. Endocrinol. (1994) [Pubmed]
  16. Tissue-specific expression of messenger ribonucleic acids for insulin-like growth factors and insulin-like growth factor-binding proteins during perinatal development of the rat uterus. Gu, Y., Branham, W.S., Sheehan, D.M., Webb, P.J., Moland, C.L., Streck, R.D. Biol. Reprod. (1999) [Pubmed]
  17. Depolarization induces insulin-like growth factor binding protein-2 expression in vivo via NMDA receptor stimulation. Holmin, S., Mathiesen, T., Langmoen, I.A., Sandberg Nordqvist, A.C. Growth Horm. IGF Res. (2001) [Pubmed]
  18. Mechanisms of thyroid hormone action on the insulin-like growth factor system: all thyroid hormone effects are not growth hormone mediated. Näntö-Salonen, K., Muller, H.L., Hoffman, A.R., Vu, T.H., Rosenfeld, R.G. Endocrinology (1993) [Pubmed]
  19. Expression, purification and characterization of the structure and disulfide linkages of insulin-like growth factor binding protein-4. Chelius, D., Baldwin, M.A., Lu, X., Spencer, E.M. J. Endocrinol. (2001) [Pubmed]
  20. Up-regulation of pituitary [125I]insulin-like growth factor-I (IGF-I) binding and IGF binding protein-2 and IGF-I gene expression by estrogen. Michels, K.M., Lee, W.H., Seltzer, A., Saavedra, J.M., Bondy, C.A. Endocrinology (1993) [Pubmed]
  21. Distinct sites of insulin-like growth factor (IGF)-II expression and localization in lesioned rat brain: possible roles of IGF binding proteins (IGFBPs) in the mediation of IGF-II activity. Walter, H.J., Berry, M., Hill, D.J., Cwyfan-Hughes, S., Holly, J.M., Logan, A. Endocrinology (1999) [Pubmed]
  22. Estradiol and progesterone regulate the expression of insulin-like growth factor-I receptor and insulin-like growth factor binding protein-2 in the hypothalamus of adult female rats. Cardona-G¿omez, G.P., Chowen, J.A., Garcia-Segura, L.M. J. Neurobiol. (2000) [Pubmed]
  23. Insulin-like growth factor binding protein-2 binds to cell surface proteoglycans in the rat brain olfactory bulb. Russo, V.C., Bach, L.A., Fosang, A.J., Baker, N.L., Werther, G.A. Endocrinology (1997) [Pubmed]
  24. Interaction of angiotensin II and the insulin-like growth factor system in vascular smooth muscle cells. Gustafsson, T., Andersson, P., Chen, Y., Magnusson, J.O., Arnqvist, H.J. Am. J. Physiol. (1999) [Pubmed]
  25. Regulation by glucocorticoids of cell differentiation and insulin-like growth factor binding protein production in cultured fetal rat nasal chondrocytes. Nadra, R., Menuelle, P., Chevallier, S., Berdal, A. J. Cell. Biochem. (2003) [Pubmed]
  26. Developmental changes in the expression patterns of IGFs, type 1 IGF receptor and IGF-binding proteins-2 and -4 in perinatal rat lung. Batchelor, D.C., Hutchins, A.M., Klempt, M., Skinner, S.J. J. Mol. Endocrinol. (1995) [Pubmed]
  27. Insulin-like growth factors sustain insulin-like growth factor-binding protein-5 expression in osteoblasts. Gabbitas, B., Canalis, E. Am. J. Physiol. (1998) [Pubmed]
  28. Differential regulation by TGF-beta 1 and insulin of insulin-like growth factor binding protein-2 in IEC-6 cells. Guo, Y.S., Townsend, C.M., Jin, G.F., Beauchamp, R.D., Thompson, J.C. Am. J. Physiol. (1995) [Pubmed]
  29. Corticosterone regulation of insulin-like growth factor I, IGF-binding proteins, and growth in streptozotocin-induced diabetic rats. Rodgers, B.D., Strack, A.M., Dallman, M.F., Hwa, L., Nicoll, C.S. Diabetes (1995) [Pubmed]
  30. Complex pattern of insulin-like growth factor binding protein expression in primary rat osteoblast enriched cultures: regulation by prostaglandin E2, growth hormone, and the insulin-like growth factors. McCarthy, T.L., Casinghino, S., Centrella, M., Canalis, E. J. Cell. Physiol. (1994) [Pubmed]
  31. Effect of protein restriction on the messenger RNA contents of bone-matrix proteins, insulin-like growth factors and insulin-like growth factor binding proteins in femur of ovariectomized rats. Higashi, Y., Takenaka, A., Takahashi, S.I., Noguchi, T. Br. J. Nutr. (1996) [Pubmed]
  32. Cloning and sequence determination of bovine insulin-like growth factor binding protein-2 (IGFBP-2): comparison of its structural and functional properties with IGFBP-1. Bourner, M.J., Busby, W.H., Siegel, N.R., Krivi, G.G., McCusker, R.H., Clemmons, D.R. J. Cell. Biochem. (1992) [Pubmed]
  33. Identification, localization, and regulation of insulin-like growth factor binding proteins and their messenger ribonucleic acids in the newborn rat olfactory bulb. Russo, V.C., Edmondson, S.R., Mercuri, F.A., Buchanan, C.R., Werther, G.A. Endocrinology (1994) [Pubmed]
  34. Reduction of insulin-like growth factor-I (IGF-I) in protein-restricted rats is associated with differential regulation of IGF-binding protein messenger ribonucleic acids in liver and kidney, and peptides in liver and serum. Lemozy, S., Pucilowska, J.B., Underwood, L.E. Endocrinology (1994) [Pubmed]
  35. Regulation of insulin-like growth factor (IGF) binding proteins in transgenic mice with altered expression of growth hormone and IGF-I. Camacho-Hubner, C., Clemmons, D.R., D'Ercole, A.J. Endocrinology (1991) [Pubmed]
  36. Characterization of insulin-like growth factor binding proteins produced in the rat central nervous system. Ocrant, I., Fay, C.T., Parmelee, J.T. Endocrinology (1990) [Pubmed]
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