Disease relevance of Liver Circulation

• Effects of L-arginine on the systemic, mesenteric, and hepatic circulation in patients with cirrhosis [1].
• We evaluated the effects of olprinone on systemic hemodynamics, hepatic circulation, and hepatic oxygen delivery in a porcine model of endotoxemia [2].
• CONCLUSION: These results suggest that NAC given intravenously effectively improves hepatic circulation and hepatic function in dogs with obstructive jaundice [3].

High impact information on Liver Circulation

• To begin to determine the mechanisms of ANP-mediated protection, different parameters were investigated: ANP had no effect on portal pressure as an indicator of hepatic circulation, nor on intracellular energy depletion determined by adenosine nucleotide concentration [4].
• Endogenous nitric oxide attenuates ethanol-induced perturbation of hepatic circulation in the isolated perfused rat liver [5].
• In an effort to achieve high concentrations of 5-fluorouracil (5-FUra) in the hepatic circulation while minimizing systemic exposure, several routes of intrahepatic administration were compared in the canine model [6].
• These results suggested that on passage through the hepatic circulation exogenous PGD2 is converted to 9 alpha,11 beta-PGF2, the latter having a biological profile which differs from that of PGD2 and PGF2 alpha [7].
• In the present study, the central effect of CRF on hepatic circulation was investigated [8].

Chemical compound and disease context of Liver Circulation

• CONCLUSION: L-NAME in endotoxemia had detrimental effects on liver circulation, while AE-ITU improved liver blood flow and attenuated the late increase in liver enzymes [9].
• These data suggest that, even with a very low dose of nitroglycerin, partial improvement of the hepatic circulation can be expected with minimal change in the systemic circulation in patients with cirrhosis and portal hypertension [10].

Biological context of Liver Circulation

• To compare the effects of sevoflurane and isoflurane on hepatic circulation, eighteen dogs were chronically instrumented for measurements of mean aortic blood pressure and cardiac output and for simultaneous measurements of hepatic and portal blood flows [11].
• Microbes and their virulence factors enter the hepatic circulation where they first activate sinusoidal endothelial cells and Kupffer cells to produce proinflammatory mediators, including TNF-alpha, IL-1, IL-6, reactive oxygen metabolites, and eicosanoids [12].
• Effects of propofol (12.5 mg kg-1, i.v. bolus injection) or 0.9% sodium chloride on arterial blood pressure, arterial blood gases and hepatic circulation (radio-labelled microsphere technique) were studied in 15 conscious and unpremedicated rabbits [13].
• As the substance is mainly metabolized in the liver, changes in liver circulation and/or function might lead to changes in the pharmacokinetics of omeprazole [14].
• Neither basal vascular tone nor acetylcholine-induced vasorelaxation are mediated by the opening of glybenclamide-sensitive K+ channels in the hepatic circulation in pigs [15].

Anatomical context of Liver Circulation

• 3. Meclofenamate also reduced adrenal perfusion but, in contrast, caused a dose-dependent increase in blood flow to the brain, bronchial and hepatic circulation and to the testis [16].
• The influence of intracisternal injection of the stable thyrotropin-releasing hormone (TRH) analogue RX 77368 on histamine levels in gastric secretion, interstitial fluid of the fundic submucosa, and portal hepatic circulation was investigated in rats [17].

Associations of Liver Circulation with chemical compounds

• These changes in hepatic circulation by intracisternal CRF were abolished by 6-hydroxydopamine and hepatic plexus denervation, but not by atropine or hepatic vagotomy [8].
• Liver circulation and function during isoflurane and halothane anesthesia [18].
• Effects of sevoflurane and isoflurane on hepatic circulation in the chronically instrumented dog [11].
• The effects of 3 micrograms.kg-1.min-1 dobutamine on hepatic circulation and oxygen balance were examined in patients anesthetized with enflurane, nitrous oxide, and oxygen for liver surgery [19].
• Hepatic circulation during sodium nitroprusside infusion in the dog [20].

Gene context of Liver Circulation

• BACKGROUND/AIMS: We investigated which endothelin receptors mediate the vasoconstrictive effects of endothelin-1 on liver circulation [21].
• Effect of central corticotropin releasing factor on hepatic circulation in rats: the role of the CRF2 receptor in the brain [8].
• CRF (0.1-4 nmol), urocortin II (a selective CRF2 receptor agonist 2.5-100 pmol), or saline vehicle was injected intracisternally, and changes in hepatic circulation were observed for 120 minutes [8].
• The net overflow of neuropeptide Y to plasma observed at rest across the hepatic circulation, but not the cardiac, forearm, or cerebral circulations, indicates that the gut, the liver, or both make a major contribution to systemic plasma neuropeptide Y levels in humans [22].
• Effect of glucagon on hepatic circulation in the pig [23].

Analytical, diagnostic and therapeutic context of Liver Circulation

• Influences of cardiopulmonary bypass and fentanyl anesthesia on hepatic circulation and oxygen metabolism in beagles [24].
• We measured indocyanine green (ICG) clearance in 20 patients scheduled for elective surgery during spinal anesthesia to determine whether ephedrine affects the hepatic circulation during spinal anesthesia [25].
• The effect of intravenous injection of 50 mug/kg of glucagon on the hepatic circulation of the pig was studied in 12 animals [23].
• Furthermore, the addition of taurine to the preservation medium was shown to improve hepatic circulation and enhance viability of the liver upon reperfusion [26].

References