The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Glycolide     1,4-dioxane-2,5-dione

Synonyms: Glycollide, SureCN15066, AGN-PC-0CZEFE, ACMC-1AYBF, AG-F-68939, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Glycolide

  • Human parainfluenza type 3 (PI3) virus was incorporated into microspheres composed of a biocompatible and biodegradable DL-lactide and glycolide copolymer [1].
  • DESIGN AND PATIENTS: The implants of slowly biodegradable polylactide/glycolide (molar ratio 75:25) containing 3.3 mg buserelin, D-Ser (But)6-GnRH (1-9)-nonapeptide-ethylamide, in a rod 1 cm long and 0.13 cm diameter were injected s.c. in patients with endometriosis (3.3 mg buserelin in four patients, 6.6 mg buserelin in six patients) [2].
  • CONCLUSIONS: The use of glycolide copolymer staple-line reinforcement sleeves in patients undergoing laparoscopic gastric bypass is safe and significantly reduces staple-line bleeding sites and may reduce the incidence of gastrointestinal hemorrhage [3].
  • A vaccine preparation consisting of tetanus toxoid (TT) encapsulated in biodegradable poly (D,L-Lactide) glycolide polymer has been developed [4].
  • The purpose of this study was to evaluate guided periodontal tissue regeneration (GPTR) wound healing in Class II furcation defects following surgical treatment with a synthetic bioabsorbable barrier manufactured from a copolymer of glycolide and lactide [5].

Psychiatry related information on Glycolide


High impact information on Glycolide


Chemical compound and disease context of Glycolide


Biological context of Glycolide

  • Six patients with mastalgia were treated with polylactide/glycolide 50:50 implants containing 6.6 mg buserelin once every 4 weeks, to study the relationship between buserelin pharmacokinetics and suppression of pituitary-ovarian function [12].
  • Regulation of smooth muscle cell proliferation using paclitaxel-loaded poly(ethylene oxide)-poly(lactide/glycolide) nanospheres [13].
  • Size-dependency of DL-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium [14].
  • Mice receiving 50 micrograms VEE virus in microspheres composed of an equimolar ratio of DL-lactide and glycolide (50:50 DL-PLG) exhibited a primary circulating IgG antibody response which was approximately 32-times higher than the response induced with the same dose of unencapsulated (free) virus [15].
  • Glycolide monomer, that has moderate solubility in water, was a non-toxic and biodegradable additive as a derivative material of hydrolysis of PLGA in order to obtain desirable drugs release rates [16].

Anatomical context of Glycolide

  • In the rat cecum model, six of seven animals treated with a hydrogel, with glycolide in the precursor as the comonomer, showed no adhesions; untreated animals and animals treated with precursor, but not gelled with light, showed consistent dense adhesions [17].
  • Bone marrow stromal cells (BMSCs), ACL, and skin fibroblasts were seeded onto a resorbable suture material [poly(L-lactide/glycolide) multifilaments] at five different seeding densities, and cultured for up to 12 days [18].
  • This study examined histologic and histometric responses to 2 bioabsorbable membranes made from a synthetic copolymer of glycolide and lactide [19].
  • The purpose of this prospective study was to review, using expanded clinical assessment tools, the initial use of a bioabsorbable interference screw (copolymer 85/15 D, L lactide/glycolide) in anterior cruciate ligament (ACL) reconstruction at the Wels Hospital, Austria [20].
  • A novel bioabsorbable suture anchor has been introduced for shoulder rotator cuff surgical repair made of the co-polymer 85/15 D,L lactide/glycolide [21].

Associations of Glycolide with other chemical compounds


Gene context of Glycolide


Analytical, diagnostic and therapeutic context of Glycolide


  1. Microencapsulated human parainfluenza virus induces a protective immune response. Ray, R., Novak, M., Duncan, J.D., Matsuoka, Y., Compans, R.W. J. Infect. Dis. (1993) [Pubmed]
  2. Long-acting gonadotrophin releasing hormone agonist implant causes variable duration of suppression of ovarian steroid and inhibin secretion. Fraser, H.M., Haining, R., Cowen, G.M., Sandow, J., Smith, K.B., Smith, S.K. Clin. Endocrinol. (Oxf) (1992) [Pubmed]
  3. Glycolide copolymer staple-line reinforcement reduces staple site bleeding during laparoscopic gastric bypass: a prospective randomized trial. Nguyen, N.T., Longoria, M., Welbourne, S., Sabio, A., Wilson, S.E. Archives of surgery (Chicago, Ill. : 1960) (2005) [Pubmed]
  4. Poly (D,L-lactide) glycolide polymer microsphere entrapped tetanus toxoid: safety evaluation in Wistar rats. Chaudhury, M.R., Sharma, K., Giri, D.K. Human & experimental toxicology. (1996) [Pubmed]
  5. Guided periodontal tissue regeneration in Class II furcation defects following treatment with a synthetic bioabsorbable barrier. Hürzeler, M.B., Quiñones, C.R., Caffesse, R.G., Schüpbach, P., Morrison, E.C. J. Periodontol. (1997) [Pubmed]
  6. Copolymerizations of epsilon-caprolactone and glycolide-a comparison of tin(II)octanoate and bismuth(III)subsalicylate as initiators. Kricheldorf, H.R., Rost, S. Biomacromolecules (2005) [Pubmed]
  7. Derivation of neointima in vascular grafts. Greisler, H.P., Dennis, J.W., Endean, E.D., Ellinger, J., Buttle, K.F., Kim, D.U. Circulation (1988) [Pubmed]
  8. VEGF scaffolds enhance angiogenesis and bone regeneration in irradiated osseous defects. Kaigler, D., Wang, Z., Horger, K., Mooney, D.J., Krebsbach, P.H. J. Bone Miner. Res. (2006) [Pubmed]
  9. Poly(DL-lactide-co-glycolide)/norethisterone microcapsules: an injectable biodegradable contraceptive. Beck, L.R., Pope, V.Z., Flowers, C.E., Cowsar, D.R., Tice, T.R., Lewis, D.H., Dunn, R.L., Moore, A.B., Gilley, R.M. Biol. Reprod. (1983) [Pubmed]
  10. Polyglycolic acid-induced inflammation: role of hydrolysis and resulting complement activation. Ceonzo, K., Gaynor, A., Shaffer, L., Kojima, K., Vacanti, C.A., Stahl, G.L. Tissue engineering. (2006) [Pubmed]
  11. Effect of preparative variables on the properties of poly(dl-lactide-co-glycolide)-methoxypoly(ethyleneglycol) copolymers related to their application in controlled drug delivery. Beletsi, A., Leontiadis, L., Klepetsanis, P., Ithakissios, D.S., Avgoustakis, K. International journal of pharmaceutics. (1999) [Pubmed]
  12. The relation between pharmacokinetics and endocrine effects of buserelin implants in patients with mastalgia. Klijn, J.G., van Geel, B., de Jong, F.H., Sandow, J., Krauss, B. Clin. Endocrinol. (Oxf) (1991) [Pubmed]
  13. Regulation of smooth muscle cell proliferation using paclitaxel-loaded poly(ethylene oxide)-poly(lactide/glycolide) nanospheres. Suh, H., Jeong, B., Rathi, R., Kim, S.W. J. Biomed. Mater. Res. (1998) [Pubmed]
  14. Size-dependency of DL-lactide/glycolide copolymer particulates for intra-articular delivery system on phagocytosis in rat synovium. Horisawa, E., Kubota, K., Tuboi, I., Sato, K., Yamamoto, H., Takeuchi, H., Kawashima, Y. Pharm. Res. (2002) [Pubmed]
  15. Enhancement of protective immune responses to Venezuelan equine encephalitis (VEE) virus with microencapsulated vaccine. Greenway, T.E., Eldridge, J.H., Ludwig, G., Staas, J.K., Smith, J.F., Gilley, R.M., Michalek, S.M. Vaccine (1995) [Pubmed]
  16. Co-effect of aqueous solubility of drugs and glycolide monomer on in vitro release rates from poly(D,L-lactide-co-glycolide) discs and polymer degradation. Kim, J.M., Seo, K.S., Jeong, Y.K., Hai, B.L., Kim, Y.S., Khang, G. Journal of biomaterials science. Polymer edition. (2005) [Pubmed]
  17. Optimization of photopolymerized bioerodible hydrogel properties for adhesion prevention. Sawhney, A.S., Pathak, C.P., van Rensburg, J.J., Dunn, R.C., Hubbell, J.A. J. Biomed. Mater. Res. (1994) [Pubmed]
  18. Tissue engineering of ligaments: a comparison of bone marrow stromal cells, anterior cruciate ligament, and skin fibroblasts as cell source. Van Eijk, F., Saris, D.B., Riesle, J., Willems, W.J., Van Blitterswijk, C.A., Verbout, A.J., Dhert, W.J. Tissue engineering. (2004) [Pubmed]
  19. Guided tissue regeneration: comparison of bioabsorbable and non-bioabsorbable membranes. Histologic and histometric study in dogs. Caffesse, R.G., Nasjleti, C.E., Morrison, E.C., Sanchez, R. J. Periodontol. (1994) [Pubmed]
  20. Serial magnetic resonance imaging evaluation of a bioabsorbable interference screw and the adjacent bone. Lajtai, G., Humer, K., Aitzetmüller, G., Unger, F., Noszian, I., Orthner, E. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. (1999) [Pubmed]
  21. Bioabsorbable suture anchor (co-polymer 85/15 D,L lactide/glycolide) implanted in bone: correlation of physical/mechanical properties, magnetic resonance imaging, and histological response. Balch, O.K., Collier, M.A., DeBault, L.E., Johnson, L.L. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association. (1999) [Pubmed]
  22. Induction of cellular immunity to a mycobacterial antigen adsorbed on lamellar particles of lactide polymers. Venkataprasad, N., Coombes, A.G., Singh, M., Rohde, M., Wilkinson, K., Hudecz, F., Davis, S.S., Vordermeier, H.M. Vaccine (1999) [Pubmed]
  23. Amphiphilic diblock copolymeric nanospheres composed of methoxy poly(ethylene glycol) and glycolide: properties, cytotoxicity and drug release behaviour. Kim, S.Y., Shin, I.G., Lee, Y.M. Biomaterials (1999) [Pubmed]
  24. Uniform encapsulation of stable protein nanoparticles produced by spray freezing for the reduction of burst release. Leach, W.T., Simpson, D.T., Val, T.N., Anuta, E.C., Yu, Z., Williams, R.O., Johnston, K.P. Journal of pharmaceutical sciences. (2005) [Pubmed]
  25. Sustained suppression of pituitary-gonadal axis with an injectable, in situ forming implant of leuprolide acetate. Ravivarapu, H.B., Moyer, K.L., Dunn, R.L. Journal of pharmaceutical sciences. (2000) [Pubmed]
  26. Controllable delivery of non-viral DNA from porous scaffolds. Jang, J.H., Shea, L.D. Journal of controlled release : official journal of the Controlled Release Society. (2003) [Pubmed]
  27. Intraocular pharmacokinetics and safety of a humanized monoclonal antibody in rabbits after intravitreal administration of a solution or a PLGA microsphere formulation. Mordenti, J., Thomsen, K., Licko, V., Berleau, L., Kahn, J.W., Cuthbertson, R.A., Duenas, E.T., Ryan, A.M., Schofield, C., Berger, T.W., Meng, Y.G., Cleland, J. Toxicol. Sci. (1999) [Pubmed]
  28. Sustained release of salmon calcitonin in vivo from lactide: glycolide copolymer depots. Millest, A.J., Evans, J.R., Young, J.J., Johnstone, D. Calcif. Tissue Int. (1993) [Pubmed]
  29. Structure-property relationships of copolymers obtained by ring-opening polymerization of glycolide and epsilon-caprolactone. Part 1. Synthesis and characterization. Dobrzynski, P., Li, S., Kasperczyk, J., Bero, M., Gasc, F., Vert, M. Biomacromolecules (2005) [Pubmed]
  30. Biodegradable, somatostatin acetate containing microspheres prepared by various aqueous and non-aqueous solvent evaporation methods. Herrmann, J., Bodmeier, R. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V. (1998) [Pubmed]
  31. Efficacy of microencapsulated rifampin in Mycobacterium tuberculosis-infected mice. Quenelle, D.C., Staas, J.K., Winchester, G.A., Barrow, E.L., Barrow, W.W. Antimicrob. Agents Chemother. (1999) [Pubmed]
  32. In vivo characteristics of high molecular weight copoly(L-lactide/glycolide) with S-type degradation pattern for application in drug delivery systems. Fukuzaki, H., Yoshida, M., Asano, M., Kumakura, M., Mashimo, T., Yuasa, H., Imai, K., Yamanaka, H. Biomaterials (1991) [Pubmed]
  33. Guided periodontal tissue regeneration in interproximal intrabony defects following treatment with a synthetic bioabsorbable barrier. Hürzeler, M.B., Quiñones, C.R., Caffesse, R.G., Schüpbach, P., Morrison, E.C. J. Periodontol. (1997) [Pubmed]
  34. Bioabsorbable SR-PLGA horn stent after antegrade endopyelotomy: a case report. Talja, M., Multanen, M., Välimaa, T., Törmälä, P. J. Endourol. (2002) [Pubmed]
WikiGenes - Universities