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Chemical Compound Review

Alinidin     N-(2,6-dichlorophenyl)-N- prop-2-enyl-4,5...

Synonyms: Alinidina, Alinidine, Alinidinum, CHEMBL278581, SureCN828946, ...
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Disease relevance of Alinidin


Psychiatry related information on Alinidin


High impact information on Alinidin


Chemical compound and disease context of Alinidin


Biological context of Alinidin


Anatomical context of Alinidin

  • Chronotropic action of alinidine on the isolated sinus node of the rabbit heart [15].
  • In pigs with normal hearts alinidine homogeneously reduced myocardial perfusion, but no imbalance in the myocardial oxygen supply-demand relationship was noticed due to a simultaneous reduction of the metabolic needs of the myocardium [6].
  • The effective refractory period of the right atrium, the atrioventricular node and the right ventricle, as well as the functional refractory period of the atrioventricular node, were unaffected by alinidine in both groups of patients [16].
  • Metabolic inhibition of intact B-cells by 250muM NaCN, most likely by a decrease of the ATP/ADP ratio, significantly diminished the K(ATP) channel-blocking effect of a low concentration of alinidine (10muM), whereas efaroxan proved to be susceptible even at a highly effective concentration (100muM) [17].
  • Given that the rank order of potency of the antagonists was similar in all tissues (i.e. glibenclamide greater than phentolamine = alinidine), this result may suggest vascular K+ channels opened by cromakalim are quantitatively but not qualitatively different in vascular compared with non-vascular smooth muscle [9].

Associations of Alinidin with other chemical compounds


Gene context of Alinidin

  • Pressures in the pulmonary artery and in capillary wedge position were significantly reduced after Alinidine by about 12 to 18% (mean PAP) and by about 19 to 28% (PCW) [19].

Analytical, diagnostic and therapeutic context of Alinidin


  1. Alinidine reduces heart-rate without blockade of beta-adrenoceptors. Harron, D.W., Riddell, J.G., Shanks, R.G. Lancet (1981) [Pubmed]
  2. Significance of arrhythmias during the first 24 hours of acute myocardial infarction treated with alteplase and effect of early administration of a beta-blocker or a bradycardiac agent on their incidence. Heidbüchel, H., Tack, J., Vanneste, L., Ballet, A., Ector, H., Van de Werf, F. Circulation (1994) [Pubmed]
  3. Bradycardia-induced coronary angiogenesis is dependent on vascular endothelial growth factor. Zheng, W., Brown, M.D., Brock, T.A., Bjercke, R.J., Tomanek, R.J. Circ. Res. (1999) [Pubmed]
  4. Acute effects of alinidine on heart rate and blood pressure in healthy subjects and patients with hyperkinetic heart syndrome. Stanek, B., Reiterer, W., Placheta, P., Raberger, G. Eur. J. Clin. Pharmacol. (1983) [Pubmed]
  5. Short-term effects of early intravenous treatment with a beta-adrenergic blocking agent or a specific bradycardiac agent in patients with acute myocardial infarction receiving thrombolytic therapy. Van de Werf, F., Janssens, L., Brzostek, T., Mortelmans, L., Wackers, F.J., Willems, G.M., Heidbüchel, H., Lesaffre, E., Scheys, I., Collen, D. J. Am. Coll. Cardiol. (1993) [Pubmed]
  6. Changes in systemic haemodynamics, regional myocardial function and perfusion induced by alinidine in pigs with and without narrowed coronary arteries. Verdouw, P.D., Duncker, D.J., Heere, T.J., Saxena, P.R. Eur. Heart J. (1987) [Pubmed]
  7. Circadian rhythm of heart rate in the rabbit: prolongation of action potential duration by sustained beta adrenoceptor blockade is not due to associated bradycardia. Vaughan Williams, E.M., Dennis, P.D., Garnham, C. Cardiovasc. Res. (1986) [Pubmed]
  8. Is reduced cardiac performance the only mechanism for myocardial infarct size reduction during beta adrenergic blockade? Stangeland, L., Grong, K., Vik-Mo, H., Andersen, K.S., Lekven, J. Cardiovasc. Res. (1986) [Pubmed]
  9. Characterization of responses to cromakalim and pinacidil in smooth and cardiac muscle by use of selective antagonists. McPherson, G.A., Angus, J.A. Br. J. Pharmacol. (1990) [Pubmed]
  10. Addition of alinidine, a specific bradycardic agent, to dobutamine in a canine model of endotoxic shock. Preiser, J.C., Moulart, D., Vincent, J.L. Crit. Care Med. (1992) [Pubmed]
  11. The clinical pharmacology of alinidine and its side-effects. Shanks, R.G. Eur. Heart J. (1987) [Pubmed]
  12. Prevention of supraventricular tachyarrhythmias post coronary artery bypass surgery. Kleinpeter, U.M., Iversen, S., Tesch, A., Schmiedt, W., Mayer, E., Oelert, H. Eur. Heart J. (1987) [Pubmed]
  13. Electrophysiological effects of alinidine (ST 567) on sinoatrial node fibres in the rabbit heart. Opthof, T., Duivenvoorden, J.J., Vanginneken, A.C., Jongsma, H.J., Bouman, L.N. Cardiovasc. Res. (1986) [Pubmed]
  14. Pacemaker selectivity: influence on rabbit atria of ionic environment and of alinidine, a possible anion antagonist. Millar, J.S., Williams, E.M. Cardiovasc. Res. (1981) [Pubmed]
  15. Chronotropic action of alinidine on the isolated sinus node of the rabbit heart. Haberl, R., Steinbeck, G. Eur. Heart J. (1985) [Pubmed]
  16. Alinidine in heart patients: electrophysiologic and antianginal actions. Meinertz, T., Kasper, W., Jähnchen, E. Eur. Heart J. (1987) [Pubmed]
  17. Antagonism of the insulinotropic action of first generation imidazolines by openers of K(ATP) channels. Wienbergen, A., Bleck, C., Lackmann, T.G., Rustenbeck, I. Biochem. Pharmacol. (2007) [Pubmed]
  18. Evidence that acetylcholine-mediated hyperpolarization of the rat small mesenteric artery does not involve the K+ channel opened by cromakalim. McPherson, G.A., Angus, J.A. Br. J. Pharmacol. (1991) [Pubmed]
  19. [Hemodynamic actions on alinidine during exercise in patients with coronary artery disease.]. Löllgen, H., Just, H., Wollschläger, H., Kersting, F. Zeitschrift für Kardiologie. (1981) [Pubmed]
  20. Value of a specific bradycardic agent in cardiac surgery compared to placebo. Skarvan, K. Eur. Heart J. (1987) [Pubmed]
  21. Effects of alinidine on survival and infarct size in rats with coronary artery occlusion. Reichhalter, R., Lillie, C., Kobinger, W. Eur. J. Pharmacol. (1988) [Pubmed]
  22. Determination of alinidine in human plasma by high-performance liquid chromatography. Wiegand, U.W., Meinertz, T., Kasper, W., Jähnchen, E. J. Chromatogr. (1981) [Pubmed]
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