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MeSH Review

Drug Tolerance

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Disease relevance of Drug Tolerance


Psychiatry related information on Drug Tolerance


High impact information on Drug Tolerance

  • Drug tolerance in biomembranes: a spin label study of the effects of ethanol [7].
  • Trimetrexate, an investigational antifol, has been associated with marked variability in drug tolerance among patients [8].
  • slo K(+) channel gene regulation mediates rapid drug tolerance [9].
  • In the remaining seven patients, attenuation of initial response was not reversed by prolonged captopril therapy; hemodynamic variables after 2 to 8 weeks had returned to their pretreatment values, i.e., drug tolerance (type IV) [10].
  • The loss of biological activity of human serum albumin induced by ascorbate system appears of medical relevance, because it can affect drug metabolism and particularly drug tolerance in the elderly [11].

Chemical compound and disease context of Drug Tolerance


Biological context of Drug Tolerance


Anatomical context of Drug Tolerance

  • All the MDR cell lines exhibited decreased drug accumulation and increased intracellular drug tolerance as evidenced by the greater intracellular amount of drug required to cause a 50% growth inhibition (IC50int) compared to their parent cell line [16].

Associations of Drug Tolerance with chemical compounds

  • In Drosophila, a single sedation with the anesthetic benzyl alcohol changes the expression of the slo K(+) channel gene and induces rapid drug tolerance [9].
  • Long-term prazosin monotherapy effectively lowers BP without resulting in drug tolerance, however, sodium retention probably limits its antihypertensive effectiveness [17].
  • Decreased dopamine D(1) receptor function might underlie part of the known (drug withdrawal syndrome) or expected (drug tolerance) consequences of methamphetamine exposure in humans [18].
  • Aspects of benzodiazepine receptor structure and function with relevance to drug tolerance and dependence [19].
  • Single mutations at position 2032 in the adjacent hairpin loop, which have previously been shown to alter drug tolerances, gave no detectable effects on the structure of the peptidyl transferase loop or on erythromycin binding [20].

Gene context of Drug Tolerance

  • Because adaptation and learning are likely to be involved in the neural events leading to drug tolerance and dependence, the question logically arose whether OXT is able to influence the development of tolerance of and dependence on abused drugs [21].
  • Tumor response, drug tolerance, antiviral studies and CD4 changes were assessed [22].
  • Because of reports of drug tolerance occurring with chronic use of adrenergic agents in asthma, we investigated cardiopulmonary responsiveness to ephedrine and to the beta-2 agent, tebutaline, following chronic drug administration for periods up to one year [23].
  • Although drug tolerance and myelosuppression studies with Swiss albino mice revealed that the prodrug-liposomes were 5-10 times more toxic than free Ara-C, a substantial improvement of efficiency could be observed [24].
  • Thus, evaluation of changes in the composition of CSF AChE variants may yield important information referring to the therapeutic efficacy and/or development of drug tolerance in AD patients treated with anti-cholinesterases [25].

Analytical, diagnostic and therapeutic context of Drug Tolerance


  1. Randomized, open-label trial of azithromycin plus ethambutol vs. clarithromycin plus ethambutol as therapy for Mycobacterium avium complex bacteremia in patients with human immunodeficiency virus infection. Veterans Affairs HIV Research Consortium. Ward, T.T., Rimland, D., Kauffman, C., Huycke, M., Evans, T.G., Heifets, L. Clin. Infect. Dis. (1998) [Pubmed]
  2. Double-blind comparison of pantoprazole and omeprazole for the treatment of acute duodenal ulcer. Beker, J.A., Bianchi Porro, G., Bigard, M.A., Delle Fave, G., Devis, G., Gouerou, H., Maier, C. European journal of gastroenterology & hepatology. (1995) [Pubmed]
  3. Cisplatin-induced ototoxicity: the effect of pigmentation and inhibitory agents. Schweitzer, V.G. Laryngoscope (1993) [Pubmed]
  4. Folic acid supplements in vitamin tablets: a determinant of hematological drug tolerance in maintenance therapy of childhood acute lymphoblastic leukemia. Schrøder, H., Clausen, N., Ostergård, E., Pressler, T. Pediatric hematology and oncology. (1986) [Pubmed]
  5. Modern management of achalasia. Richter, J.E. Current treatment options in gastroenterology. (2005) [Pubmed]
  6. Chronic exposure to Delta9-tetrahydrocannabinol downregulates oxytocin and oxytocin-associated neurophysin in specific brain areas. Butovsky, E., Juknat, A., Elbaz, J., Shabat-Simon, M., Eilam, R., Zangen, A., Altstein, M., Vogel, Z. Mol. Cell. Neurosci. (2006) [Pubmed]
  7. Drug tolerance in biomembranes: a spin label study of the effects of ethanol. Chin, J.H., Goldstein, D.B. Science (1977) [Pubmed]
  8. Correlates of severe or life-threatening toxic effects from trimetrexate. Grem, J.L., Ellenberg, S.S., King, S.A., Shoemaker, D.D. J. Natl. Cancer Inst. (1988) [Pubmed]
  9. slo K(+) channel gene regulation mediates rapid drug tolerance. Ghezzi, A., Al-Hasan, Y.M., Larios, L.E., Bohm, R.A., Atkinson, N.S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  10. Hemodynamic patterns of response during long-term captopril therapy for severe chronic heart failure. Packer, M., Medina, N., Yushak, M., Meller, J. Circulation (1983) [Pubmed]
  11. Metal-catalyzed oxidation of human serum albumin: conformational and functional changes. Implications in protein aging. Meucci, E., Mordente, A., Martorana, G.E. J. Biol. Chem. (1991) [Pubmed]
  12. Baclofen versus diazepam for the treatment of spasticity and long-term follow-up of baclofen therapy. Roussan, M., Terrence, C., Fromm, G. Pharmatherapeutica. (1985) [Pubmed]
  13. Down-regulation of beta-adrenergic receptors on mononuclear leukocytes induced by dobutamine treatment in patients with congestive heart failure. Teng, J.K., Kwan, C.M., Lin, L.J., Tsai, L.M., Cheng, J.T., Chang, W.C., Chen, J.H. Eur. Heart J. (1993) [Pubmed]
  14. Hemodynamic and endocrinological effects of a new selective alpha 1-blocking agent, terazosin, in patients with essential hypertension. Results of long-term treatment. Tomoda, F., Takata, M., Yoshida, K., Yasumoto, K., Mikawa, M., Sasayama, S. Am. J. Hypertens. (1989) [Pubmed]
  15. Trypanosoma simiae: in vitro studies on drug susceptibility. Zweygarth, E., Moloo, S.K., Kaminsky, R. Acta Trop. (1993) [Pubmed]
  16. Comparison of mechanisms responsible for resistance to idarubicin and daunorubicin in multidrug resistant LoVo cell lines. Toffoli, G., Simone, F., Gigante, M., Boiocchi, M. Biochem. Pharmacol. (1994) [Pubmed]
  17. Effects of prazosin therapy on BP, renal function, and body fluid composition. Bauer, J.H., Jones, L.B., Gaddy, P. Arch. Intern. Med. (1984) [Pubmed]
  18. Decreased striatal dopamine D1 receptor-stimulated adenylyl cyclase activity in human methamphetamine users. Tong, J., Ross, B.M., Schmunk, G.A., Peretti, F.J., Kalasinsky, K.S., Furukawa, Y., Ang, L.C., Aiken, S.S., Wickham, D.J., Kish, S.J. The American journal of psychiatry. (2003) [Pubmed]
  19. Aspects of benzodiazepine receptor structure and function with relevance to drug tolerance and dependence. Schoch, P., Moreau, J.L., Martin, J.R., Haefely, W.E. Biochem. Soc. Symp. (1993) [Pubmed]
  20. Erythromycin binding is reduced in ribosomes with conformational alterations in the 23 S rRNA peptidyl transferase loop. Douthwaite, S., Aagaard, C. J. Mol. Biol. (1993) [Pubmed]
  21. Role of oxytocin in the neuroadaptation to drugs of abuse. Sarnyai, Z., Kovács, G.L. Psychoneuroendocrinology (1994) [Pubmed]
  22. Open-label phase I study of combination therapy with zidovudine and interferon-beta in patients with AIDS-related Kaposi's sarcoma: AIDS Clinical Trials Group Protocol 057. Miles, S., Levine, A., Feldstein, M., Carden, J., Cabriallas, S., Marcus, S., Mitsuyasu, R., Gill, P. Cytokines Cell. Mol. Ther. (1998) [Pubmed]
  23. Cardiopulmonary effects of long-term bronchodilator administration. Wilson, A.F., Novey, H.S., Cloninger, P., Davis, J., White, D. J. Allergy Clin. Immunol. (1976) [Pubmed]
  24. Treatment of murine L1210 lymphoid leukemia and melanoma B16 with lipophilic cytosine arabinoside prodrugs incorporated into unilamellar liposomes. Rubas, W., Supersaxo, A., Weder, H.G., Hartmann, H.R., Hengartner, H., Schott, H., Schwendener, R. Int. J. Cancer (1986) [Pubmed]
  25. Long-lasting acetylcholinesterase splice variations in anticholinesterase-treated Alzheimer's disease patients. Darreh-Shori, T., Hellström-Lindahl, E., Flores-Flores, C., Guan, Z.Z., Soreq, H., Nordberg, A. J. Neurochem. (2004) [Pubmed]
  26. Factors determining angiotensin-converting enzyme inhibitor underutilization in heart failure in a community setting. Philbin, E.F. Clinical cardiology. (1998) [Pubmed]
  27. Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge. MacGinnitie, A.J., Walensky, L.D., Turvey, S.E., Orange, J.S., Bonilla, F.A., Silverman, L.B., Oettgen, H. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. (2003) [Pubmed]
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