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Gene Review

SPAG8  -  sperm associated antigen 8

Homo sapiens

Synonyms: BS-84, CILD28, CT142, HSD-1, SMP-1, ...
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Disease relevance of SPAG8

  • Escherichia coli transfected with the construct containing the alternative 5'-end failed to produce the recombinant product, whereas those transfected with the vector lacking the 5'-end produced hSMP-1 [1].
  • Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome [2].
  • At the cellular level, the enzyme hydroxysteroid dehydrogenase type 1 (HSD1) locally regenerates active cortisol from inactive cortisone, amplifying glucocorticoid receptor activation and promoting preadipocyte differentiation and adipocyte hypertrophy [2].
  • RESULTS: In cases of chorioamnionitis where mothers had not been treated with betamethasone, placental 32-kd 11beta HSD-1 protein expression was increased [3].

High impact information on SPAG8


Biological context of SPAG8


Anatomical context of SPAG8


Associations of SPAG8 with chemical compounds


Other interactions of SPAG8


Analytical, diagnostic and therapeutic context of SPAG8


  1. Assignment of chromosomal locus and evidence for alternatively spliced mRNAs of a human sperm membrane protein (hSMP-1). Wang, H., Miao, S., Chen, D., Wang, L., Koide, S.S. Biochim. Biophys. Acta (1999) [Pubmed]
  2. Enhanced 11beta-hydroxysteroid dehydrogenase activity, the metabolic syndrome, and systemic hypertension. Sukhija, R., Kakar, P., Mehta, V., Mehta, J.L. Am. J. Cardiol. (2006) [Pubmed]
  3. The effects of chorioamnionitis and betamethasone on 11beta hydroxysteroid dehydrogenase types 1 and 2 and the glucocorticoid receptor in preterm human placenta. Johnstone, J.F., Bocking, A.D., Unlugedik, E., Challis, J.R. J. Soc. Gynecol. Investig. (2005) [Pubmed]
  4. Sperm membrane protein (hSMP-1) and RanBPM complex in the microtubule-organizing centre. Tang, X., Zhang, J., Cai, Y., Miao, S., Zong, S., Koide, S.S., Wang, L. J. Mol. Med. (2004) [Pubmed]
  5. Differences in the antigen pattern recognized by antisperm antibodies in patients with infertility and vasectomy. Bohring, C., Krause, W. J. Urol. (2001) [Pubmed]
  6. Expression and characterization of a novel human sperm membrane protein. Liu, Q.Y., Wang, L.F., Miao, S.Y., Catterall, J.F. Biol. Reprod. (1996) [Pubmed]
  7. Increased expression of 11beta-hydroxysteroid dehydrogenase type 1 in type 2 diabetic myotubes. Abdallah, B.M., Beck-Nielsen, H., Gaster, M. Eur. J. Clin. Invest. (2005) [Pubmed]
  8. Sperm membrane incorporation into oolemma contributes to the oolemma block to sperm penetration: evidence based on intracytoplasmic sperm injection experiments in the mouse. Maleszewski, M., Kimura, Y., Yanagimachi, R. Mol. Reprod. Dev. (1996) [Pubmed]
  9. 11beta Hydroxysteroid dehydrogenase type 1 is expressed and is biologically active in human skeletal muscle. Jang, C., Obeyesekere, V.R., Dilley, R.J., Alford, F.P., Inder, W.J. Clin. Endocrinol. (Oxf) (2006) [Pubmed]
  10. Immune responses in rats following oral immunization with attenuated Salmonella typhimurium expressing human sperm antigen. Kuang, Y., Yan, Y.C., Gao, A.W., Zhai, Y.M., Miao, S.Y., Wang, L.F., Koide, S.S. Arch. Androl. (2000) [Pubmed]
  11. Usefulness of a triple fluorochrome combination Merocyanine 540/Yo-Pro 1/Hoechst 33342 in assessing membrane stability of viable frozen-thawed spermatozoa from Estonian Holstein AI bulls. Hallap, T., Nagy, S., Jaakma, U., Johannisson, A., Rodriguez-Martinez, H. Theriogenology (2006) [Pubmed]
  12. Pharmacodynamics and pharmacokinetics of synthetic mineralocorticoids and glucocorticoids: receptor transactivation and prereceptor metabolism by 11beta-hydroxysteroid-dehydrogenases. Diederich, S., Scholz, T., Eigendorff, E., Bumke-Vogt, C.h., Quinkler, M., Exner, P., Pfeiffer, A.F., Oelkers, W., Bähr, V. Horm. Metab. Res. (2004) [Pubmed]
  13. Inhibition of mouse acrosome reaction and sperm-zona pellucida binding by anti-human sperm membrane protein 1 antibody. Cheng, G.Y., Shi, J.L., Wang, M., Hu, Y.Q., Liu, C.M., Wang, Y.F., Xu, C. Asian J. Androl. (2007) [Pubmed]
  14. Effect of stress on hepatic 11beta-hydroxysteroid dehydrogenase activity and its influence on carbohydrate metabolism. Altuna, M.E., Lelli, S.M., Mart??n de Viale, L.C., Damasco, M.C. Can. J. Physiol. Pharmacol. (2006) [Pubmed]
  15. Investigation of some biochemical and functional effects of cryopreservation of human spermatozoa using an automated freezing-quick-thawing method. Morshedi, M., Oehninger, S., Blackmore, P., Bocca, S., Coddington, C., Hodgen, G. Int. J. Androl. (1995) [Pubmed]
  16. Electron microscopic study of human sperm membrane isolation. Levay, P.F., Lourens, N., Loots, G.P., Fourie, F.R. J. Assist. Reprod. Genet. (1994) [Pubmed]
  17. Human sperm membrane protein (hSMP-1): a developmental testis-specific component during germ cell differentiation. Zhang, X.D., Miao, S.Y., Wang, L.F., Li, Y., Zong, S.D., Yan, Y.C., Koide, S.S. Arch. Androl. (2000) [Pubmed]
  18. Effect of cryoprotective additives and cryopreservation protocol on sperm membrane lipid peroxidation and recovery of motile human sperm. Bell, M., Wang, R., Hellstrom, W.J., Sikka, S.C. J. Androl. (1993) [Pubmed]
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