Disease relevance of Cardiac Output, Low

• Similarly, blood lactate at all times after the induction of low cardiac output and hypotension was significantly lower in the Mv animals (P less than 0.005) [1].
• A patient with acute right ventricular infarction who showed hyposecretion of atrial natriuretic peptide (ANP) in spite of abnormally high right atrial pressure and who died of a severe low cardiac output syndrome is reported [2].
• OBJECTIVE: In several forms of heart disease characterised by low cardiac output, activated neurohumoral systems including increased vasopressin plasma levels play a key role in the changes in cardiovascular function [3].
• Bosentan (3 mg/kg, i.v. bolus) and placebo were given at control, at 1 week of pacing (stage of left ventricular dysfunction with perserved cardiac output) and at 3 weeks of pacing (phase of heart failure with low cardiac output) [4].
• We examined the effect of parenteral phentolamine in 11 critically ill patients with a low cardiac output state and a high systemic resistance [5].

High impact information on Cardiac Output, Low

• There was one hospital death from low cardiac output in a 1-month-old infant and one late death 11 months after repair from preexisting and progressive right ventricular cardiomyopathy [6].
• Twenty-five patients with left ventricular failure and low cardiac output received a 72 hour infusion of dobutamine (10-15 microgram/kg/min) in order to determine the cardiovascular properties of this new inotropic agent [7].
• Two deaths were the result of low cardiac output, and the third death was related to recurrent ventricular septal defect after septal endocardial resection [8].
• However, he had persistent mental obtundation and low cardiac output, and adverse chronotropic responses to high doses of dopamine developed [9].
• Thus levosimendan has the potential to treat low cardiac output states after cardiopulmonary bypass surgery [10].

Chemical compound and disease context of Cardiac Output, Low

• Dopexamine hydrochloride is a synthetic catecholamine proposed for the short-term treatment of heart failure and postoperative low cardiac output [11].
• BACKGROUND: Recently, dopexamine (DX), which acts via adrenergic beta 2 and dopaminergic DA1 receptors, has been introduced in the treatment of low cardiac output states [12].
• Volume expansion versus norepinephrine in treatment of a low cardiac output complicating an acute increase in right ventricular afterload in dogs [13].
• Therefore, benefit from phentolamine in low cardiac output states is multifactorial and phentolamine likely improves left ventricular compliance in some patients [5].
• Nitric oxide does not influence tissue oxygen extraction capabilities in low cardiac output [14].

Biological context of Cardiac Output, Low

• CONCLUSIONS: The close-to-normal AUC, during low cardiac output, despite lower peak paracetamol, shows absorption was not suppressed, only delayed, because of decreased pyloric motility [15].
• For the practice of catecholamine therapy, our experiments imply that synthetic agents such as dobutamine and particularly dopexamine may be preferred in the treatment of low cardiac output states because they increase Q with the least metabolic effects [16].
• Amrinone in the management of low cardiac output after open heart surgery [17].
• The effects of an intravenous infusion of nitroglycerin on cardiac index and peripheral vascular resistance during infrarenal aortic cross-clamping were determined in normal animals and in animals subjected to low cardiac output state [18].
• Norepinephrine plus phentolamine improves regional blood flow during experimental low cardiac output syndrome [19].

Anatomical context of Cardiac Output, Low

• CONCLUSION: Taking the proportion of patients achieving clinical efficacy, the time to achieve it and the maintenance of it along with the adverse event profile, dopexamine was shown to be an effective and safe drug to use in the management of low cardiac output syndrome after coronary artery bypass graft surgery and may be superior to dopamine [20].
• Coenzyme Q10: the prophylactic effect on low cardiac output following cardiac valve replacement [21].
• Before study termination, esmolol hydrochloride was infused to induce low cardiac output and totally impair aortic valve opening [22].
• Nitroprusside was infused into the pulmonary artery in six patients with severe perioperative low cardiac output; four of these patients survived [23].
• In patients with direct femoral artery cannulation risk factors appear to be: arteriopathy (p<0.001), prolonged extra corporeal circulation (p<0.001), low cardiac output syndrome (p<0.001), continuous i.v. infusion of epinephrine (p<0.0001) [24].

Gene context of Cardiac Output, Low

• Action of endogenous atrial natriuretic peptide in calves with experimental acute central venous congestion and low cardiac output [25].
• A 47-yr-old woman with low cardiac output and dyspnea due to pulmonary hypertension associated with rheumatoid arthritis was treated with two vasodilators [26].
• Severe sepsis/septic shock (43.8%), major surgery (39.1), low cardiac output (29.7), and hypovolemia (28.2%) were the most common conditions associated with the development of acute renal failure [27].
• As DO2 declined due to low cardiac output, a significant decrease in VO2 (r = 0.75, p less than 0.001) and a significant increase in P50 (r = -0.74, p less than 0.001) were observed [28].
• These studies show the benefit of glucagon in the treatment of low cardiac output in the presence of beta-adrenergic blockade [29].

Analytical, diagnostic and therapeutic context of Cardiac Output, Low

• The hemodynamic effects of dopamine were measured during the immediate postoperative period in five infants with low cardiac output following repair of congenital cardiac defects [30].
• Phentolamine in low cardiac output states: an assessment with ECG-gated cardiac scintigraphy [5].
• Older patients and/or those with a prior history of peptic ulcer symptoms, as well as those who experience prolonged perfusion times, low cardiac output, or prolonged ventilatory support, should be under rigorous gastric pH surveillance and receive aggressive prophylactic treatment with high-dose H2 antagonists, antacids, and/or sucralfate [31].
• The EC group was characterized early by hypotension, low cardiac output, and increased systemic and pulmonary vascular resistances, along with leukopenia, hypoglycemia, lactacidemia, and elevated blood urea nitrogen [32].
• Previous studies of disordered water regulation in heart failure have used models of low cardiac output with normal cardiac function (e.g., inferior vena cava ligation) [33].

References