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Chemical Compound Review

Nepresol     (4-hydrazinylphthalazin-1- yl)hydrazine

Synonyms: Depressan, Dihyzin, Nepressol, Ophthazin, Tonolysin, ...
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Disease relevance of DIHYDRALAZINE


High impact information on DIHYDRALAZINE


Chemical compound and disease context of DIHYDRALAZINE


Biological context of DIHYDRALAZINE


Anatomical context of DIHYDRALAZINE

  • To understand the first steps leading to this immune reaction, we studied the covalent binding fo dihydralazine metabolites to microsomes from rat and human livers [16].
  • In human hepatocytes, dihydralazine produced a dose-dependent increase in the level of P4501A up to 0.1 mM; induction of P4501A was less strong at 0.2 mM and disappeared at 0.5 mM [3].
  • Mechanism-based inactivation of cytochrome P450s 1A2 and 3A4 by dihydralazine in human liver microsomes [17].
  • Anti-cytochrome P450 (CYP)1A2 autoantibodies are found in dihydralazine-induced hepatitis, and CYPs2B and 2C have been shown to follow vesicular flow to the plasma membrane (PM) [18].
  • The intervillous and umbilical vein blood flow were measured before and during dihydralazine infusion with 133Xenon method and with a combination of real-time and Doppler ultrasonic equipment, respectively [19].

Associations of DIHYDRALAZINE with other chemical compounds


Gene context of DIHYDRALAZINE


Analytical, diagnostic and therapeutic context of DIHYDRALAZINE


  1. Vascular effects of dihydralazine during prevention of genetic hypertension development in SHR rats. Freslon, J.L., Arbeille-Brassart, B., Giudicelli, J.F. Eur. Heart J. (1982) [Pubmed]
  2. Cerebral blood flow during dihydralazine-induced hypotension in hypertensive rats. Barry, D.I., Strandgaard, S., Graham, D.I., Svendsen, U.G., Braendstrup, O., Paulson, O.B. Stroke (1984) [Pubmed]
  3. Anti-liver microsomes autoantibodies and dihydralazine-induced hepatitis: specificity of autoantibodies and inductive capacity of the drug. Bourdi, M., Gautier, J.C., Mircheva, J., Larrey, D., Guillouzo, A., Andre, C., Belloc, C., Beaune, P.H. Mol. Pharmacol. (1992) [Pubmed]
  4. Loss of effectiveness of dihydralazine in the long-term treatment of chronic heart failure. Reifart, N., Kaltenbach, M., Bussmann, W.D. Eur. Heart J. (1984) [Pubmed]
  5. A comparison between the haemodynamic effects of oral nifedipine and intravenous dihydralazine in patients with severe pre-eclampsia. Visser, W., Wallenburg, H.C. J. Hypertens. (1995) [Pubmed]
  6. Genotoxicity of the antihypertensive drugs hydralazine and dihydralazine. Williams, G.M., Mazue, G., McQueen, C.A., Shimada, T. Science (1980) [Pubmed]
  7. Anti-liver endoplasmic reticulum autoantibodies are directed against human cytochrome P-450IA2. A specific marker of dihydralazine-induced hepatitis. Bourdi, M., Larrey, D., Nataf, J., Bernuau, J., Pessayre, D., Iwasaki, M., Guengerich, F.P., Beaune, P.H. J. Clin. Invest. (1990) [Pubmed]
  8. Hemodynamic effects of diltiazem in hypertension. Safar, M.E., Simon, A.C., Levenson, J.A., Cazor, J.L. Circ. Res. (1983) [Pubmed]
  9. Dihydralazine treatment limits liver injury after hemorrhagic shock in rats. Schmidt, R., Baechle, T., Hoetzel, A., Loop, T., Humar, M., Roesslein, M., Geiger, K.K., Pannen, B.H. Crit. Care Med. (2006) [Pubmed]
  10. Compared myocardial and vascular effects of captopril and dihydralazine during hypertension development in spontaneously hypertensive rats. Freslon, J.L., Giudicelli, J.F. Br. J. Pharmacol. (1983) [Pubmed]
  11. Ketanserin versus dihydralazine in the management of severe early-onset preeclampsia: maternal outcome. Bolte, A.C., van Eyck, J., Kanhai, H.H., Bruinse, H.W., van Geijn, H.P., Dekker, G.A. Am. J. Obstet. Gynecol. (1999) [Pubmed]
  12. Malignant ventricular arrhythmias in eclampsia: a comparison of labetalol with dihydralazine. Bhorat, I.E., Naidoo, D.P., Rout, C.C., Moodley, J. Am. J. Obstet. Gynecol. (1993) [Pubmed]
  13. Acute effects of dihydralazine mesylate, furosemide, and metoprolol on maternal hemodynamics in pregnancy-induced hypertension. Suonio, S., Saarikoski, S., Tahvanainen, K., Pääkkönen, A., Olkkonen, H. Am. J. Obstet. Gynecol. (1986) [Pubmed]
  14. Hemodynamics of the carotid artery after vasodilation in essential hypertension. Laurent, S., Lacolley, P., London, G., Safar, M. Hypertension (1988) [Pubmed]
  15. Synthesis and antihypertensive activity of new 6-heteroaryl-3-hydrazinopyridazine derivatives. Steiner, G., Gries, J., Lenke, D. J. Med. Chem. (1981) [Pubmed]
  16. Interactions of dihydralazine with cytochromes P4501A: a possible explanation for the appearance of anti-cytochrome P4501A2 autoantibodies. Bourdi, M., Tinel, M., Beaune, P.H., Pessayre, D. Mol. Pharmacol. (1994) [Pubmed]
  17. Mechanism-based inactivation of cytochrome P450s 1A2 and 3A4 by dihydralazine in human liver microsomes. Masubuchi, Y., Horie, T. Chem. Res. Toxicol. (1999) [Pubmed]
  18. Vesicular transport of newly synthesized cytochromes P4501A to the outside of rat hepatocyte plasma membranes. Robin, M.A., Descatoire, V., Le Roy, M., Berson, A., Lebreton, F.P., Maratrat, M., Ballet, F., Loeper, J., Pessayre, D. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  19. Effects of dihydralazine infusion on the fetoplacental blood flow and maternal prostanoids. Jouppila, P., Kirkinen, P., Koivula, A., Ylikorkala, O. Obstetrics and gynecology. (1985) [Pubmed]
  20. Dynamic responses to intravenous urapidil and dihydralazine in normal subjects. Belz, G.G., Matthews, J.H., Graf, D., Stern, H.C., Bachmann, R., Belz, G., Steinijans, V.W., Palm, D. Clin. Pharmacol. Ther. (1985) [Pubmed]
  21. Differential gene expression of renin and angiotensinogen in the TGR(mREN-2)27 transgenic rat. Lee, M.A., Böhm, M., Kim, S., Bachmann, S., Bachmann, J., Bader, M., Ganten, D. Hypertension (1995) [Pubmed]
  22. Intravenous use of the calcium-channel blocker nicardipine as second-line treatment in severe, early-onset pre-eclamptic patients. Hanff, L.M., Vulto, A.G., Bartels, P.A., Roofthooft, D.W., Bijvank, B.N., Steegers, E.A., Visser, W. J. Hypertens. (2005) [Pubmed]
  23. Epitope mapping of human CYP1A2 in dihydralazine-induced autoimmune hepatitis. Belloc, C., Gauffre, A., André, C., Beaune, P.H. Pharmacogenetics (1997) [Pubmed]
  24. Capillary/myocyte mismatch in the heart in renal failure--a role for erythropoietin? Amann, K., Buzello, M., Simonaviciene, A., Miltenberger-Miltenyi, G., Koch, A., Nabokov, A., Gross, M.L., Gless, B., Mall, G., Ritz, E. Nephrol. Dial. Transplant. (2000) [Pubmed]
  25. Cytochrome P450 enzymes and UDP-glucuronosyltransferases as hepatocellular autoantigens. Obermayer-Straub, P., Manns, M.P. Mol. Biol. Rep. (1996) [Pubmed]
  26. Dihydralazine-induced inactivation of cytochrome P450 enzymes in rat liver microsomes. Masubuchi, Y., Horie, T. Drug Metab. Dispos. (1998) [Pubmed]
  27. Involvement of local ischemia in endothelin-1 induced lesions of the neostriatum of the anaesthetized rat. Fuxe, K., Kurosawa, N., Cintra, A., Hallström, A., Goiny, M., Rosén, L., Agnati, L.F., Ungerstedt, U. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1992) [Pubmed]
  28. The effects of dihydralazine, labetalol and magnesium sulphate on the isolated, perfused human placental cotyledon. Petersen, O.B., Skajaa, K., Svane, D., Gregersen, H., Forman, A. British journal of obstetrics and gynaecology. (1994) [Pubmed]
  29. Detection of some antihypertensive drugs and their metabolites in urine by thin-layer chromatography: II. A further five beta blockers and dihydralazine. Jack, D.B., Dean, S., Kendall, M.J., Laugher, S. J. Chromatogr. (1980) [Pubmed]
  30. A randomized comparison of early with conservative use of antihypertensive drugs in the management of pregnancy-induced hypertension. Plouin, P.F., Breart, G., Llado, J., Dalle, M., Keller, M.E., Goujon, H., Berchel, C. British journal of obstetrics and gynaecology. (1990) [Pubmed]
  31. Effect of hydralazine and dihydralazine on connective tissue and binding to serum protein. Blumenkrantz, N., Christiansen, A.H., Asboe-Hansen, G. Scand. J. Rheumatol. (1979) [Pubmed]
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