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Chemical Compound Review

Auluton     [(2S,3S,5S,8R,9S,10S,13S,14S)- 2-hydroxy-10...

Synonyms: Aminosteroid, LS-19377, ORG 6001, AC1L232R, C19H31NO2.HCl, ...
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Disease relevance of Amafolone


High impact information on Amafolone


Chemical compound and disease context of Amafolone


Biological context of Amafolone


Anatomical context of Amafolone

  • All these results lead to the conclusion that aminosteroid treatment, at least in the conditions of the present study, is effective in reducing the morphological and biochemical alterations occurring in ischemic-reperfused myocardium [3].
  • Coronary artery ligation in anaesthetized rats as a model for the assessment of antidysrhythmic activity; the effects of lignocaine, propranolol and ORG 6001 [proceedings] [18].
  • Effect of the aminosteroid, U73122, on Ca2+ uptake and release properties of rat liver microsomes [19].
  • The aminosteroid U73122 has been established as potent, selective, and cell-permeable inhibitor C-type phosphatidylinositol-specific phospholipases (PI-PLCs), and has been used to define a contribution of PI-PLCs as part of exocytotic signalling pathways in rat peritoneal mast cells (RPMCs) [20].
  • U-73122, an aminosteroid phospholipase C inhibitor, may also block Ca2+ influx through phospholipase C-independent mechanism in neutrophil activation [21].

Associations of Amafolone with other chemical compounds


Gene context of Amafolone


Analytical, diagnostic and therapeutic context of Amafolone


  1. Effect of the aminosteroid U74006F after cardiopulmonary arrest in dogs. Natale, J.E., Schott, R.J., Hall, E.D., Braughler, J.M., D'Alecy, L.G. Stroke (1988) [Pubmed]
  2. Treatment of experimental brain injury with moderate hypothermia and 21-aminosteroids. Marion, D.W., White, M.J. J. Neurotrauma (1996) [Pubmed]
  3. Beneficial effects of the 21-aminosteroid U 74389G on the ischemia-reperfusion damage in pig hearts. Nediani, C., Perna, A.M., Liguori, P., Formigli, L., Ibba-Manneschi, L., Zecchi-Orlandini, S., Fiorillo, C., Rizzuti, G., Nassi, P. J. Mol. Cell. Cardiol. (1997) [Pubmed]
  4. The effects of postligation administration of ORG 6001 and disopyramide on early ischaemia-induced arrhythmias in the anaesthetized rat. Marshall, R.J., Muir, A.W., Winslow, E. Br. J. Pharmacol. (1982) [Pubmed]
  5. The effect of aminosteroid, ORG 6001, on hypothermia induced ventricular fibrillation in the cat. Kane, K.A., McDonald, F.M., Parratt, J.R. Br. J. Pharmacol. (1979) [Pubmed]
  6. The aminosteroid phospholipase C antagonist U-73122 (1-[6-[[17-beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione) potently inhibits human 5-lipoxygenase in vivo and in vitro. Feisst, C., Albert, D., Steinhilber, D., Werz, O. Mol. Pharmacol. (2005) [Pubmed]
  7. U73122 blocked the cGMP-induced calcium release in sea urchin eggs. Lee, S.J., Madden, P.J., Shen, S.S. Exp. Cell Res. (1998) [Pubmed]
  8. U-73122, an aminosteroid phospholipase C antagonist, noncompetitively inhibits thyrotropin-releasing hormone effects in GH3 rat pituitary cells. Smallridge, R.C., Kiang, J.G., Gist, I.D., Fein, H.G., Galloway, R.J. Endocrinology (1992) [Pubmed]
  9. Effect of the aminosteroid U73122 on prostaglandin E(2) production in a murine clonal osteoblast-like cell line, MC3T3-E1. Leis, H.J., Köfeler, H., Raspotnig, G., Zach, D., Fauler, G., Windischhofer, W. Biochem. Pharmacol. (2000) [Pubmed]
  10. Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation. Campo, G.M., Squadrito, F., Altavilla, D., Squadrito, G., Avenoso, A., Canale, P., Ioculano, M., Sperandeo, A., Caputi, A.P. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  11. Block of neurotensin receptor down-regulation by an aminosteroid in N1E-115 cells. Yamada, M., Yamada, M., Richelson, E. Eur. J. Pharmacol. (1992) [Pubmed]
  12. Mechanism underlying the strong positive inotropic effects of LND-623: specific inhibition of Na, K-ATPase isoforms and exclusion of cellular sites of contractile control. Maixent, J.M., Lelièvre, L., Berrebi-Bertrand, I. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. (1998) [Pubmed]
  13. Aminosteroids for acute traumatic brain injury. Roberts, I. Cochrane database of systematic reviews (Online) (2000) [Pubmed]
  14. Voltage- and time-dependent depression of maximum rate of depolarization of guinea-pig ventricular action potentials by two steroidal antiarrhythmic drugs, CCI 22277 and ORG 6001. Campbell, T.J. Br. J. Pharmacol. (1982) [Pubmed]
  15. Role of lipid peroxidation in tert-butylhydroperoxide-induced inhibition of endothelial cell calcium signaling. Elliott, S.J., Doan, T.N., Schilling, W.P. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  16. Nonselective effects of the putative phospholipase C inhibitor, U73122, on adenosine A1 receptor-mediated signal transduction events in Chinese hamster ovary cells. Walker, E.M., Bispham, J.R., Hill, S.J. Biochem. Pharmacol. (1998) [Pubmed]
  17. Ion transport ATPases as targets for free radical damage. Protection by an aminosteroid of the Ca2+ pump ATPase and Na+/K+ pump ATPase of human red blood cell membranes. Rohn, T.T., Hinds, T.R., Vincenzi, F.F. Biochem. Pharmacol. (1993) [Pubmed]
  18. Coronary artery ligation in anaesthetized rats as a model for the assessment of antidysrhythmic activity; the effects of lignocaine, propranolol and ORG 6001 [proceedings]. Kane, K., McDonald, F., Parratt, J.R. Br. J. Pharmacol. (1979) [Pubmed]
  19. Effect of the aminosteroid, U73122, on Ca2+ uptake and release properties of rat liver microsomes. De Moel, M.P., Van de Put, F.H., Vermegen, T.M., De Pont, J.H., Willems, P.H. Eur. J. Biochem. (1995) [Pubmed]
  20. Inhibition of phospholipase C-independent exocytotic responses in rat peritoneal mast cells by U73122. Gloyna, W., Schmitz, F., Seebeck, J. Regul. Pept. (2005) [Pubmed]
  21. U-73122, an aminosteroid phospholipase C inhibitor, may also block Ca2+ influx through phospholipase C-independent mechanism in neutrophil activation. Wang, J.P. Naunyn Schmiedebergs Arch. Pharmacol. (1996) [Pubmed]
  22. Electrophysiological and other effects on rabbit hearts of CCI22277, a new steroidal antiarrhythmic drug. Campbell, T.J., Vaughan Williams, E.M. Br. J. Pharmacol. (1982) [Pubmed]
  23. A cloned CCK-A receptor transduces multiple signals in response to full and partial agonists. Yule, D.I., Tseng, M.J., Williams, J.A., Logdson, C.D. Am. J. Physiol. (1993) [Pubmed]
  24. The anaesthetic action and modulation of GABAA receptor activity by the novel water-soluble aminosteroid Org 20599. Hill-Venning, C., Peters, J.A., Callachan, H., Lambert, J.J., Gemmell, D.K., Anderson, A., Byford, A., Hamilton, N., Hill, D.R., Marshall, R.J., Campbell, A.C. Neuropharmacology (1996) [Pubmed]
  25. Agonist and antagonist modulation of [35S]-GTP gamma S binding in transfected CHO cells expressing the neurotensin receptor. Hermans, E., Geurts, M., Maloteaux, J.M. Br. J. Pharmacol. (1997) [Pubmed]
  26. The 21-aminosteroid U-74389F attenuates hyperexpression of GAP-43 and NADPH-diaphorase in the spinal cord of wobbler mouse, a model for amyotrophic lateral sclerosis. González Deniselle, M.C., González, S.L., Lima, A.E., Wilkin, G., De Nicola, A.F. Neurochem. Res. (1999) [Pubmed]
  27. Antinociceptive properties of neurosteroids I. Spinally-mediated antinociceptive effects of water-soluble aminosteroids. Goodchild, C.S., Guo, Z., Nadeson, R. Pain (2000) [Pubmed]
  28. Beneficial effects of the radioprotectant 21-aminosteroid U-74389G in a radiosurgery rat malignant glioma model. Kondziolka, D., Mori, Y., Martinez, A.J., McLaughlin, M.R., Flickinger, J.C., Lunsford, L.D. Int. J. Radiat. Oncol. Biol. Phys. (1999) [Pubmed]
  29. Influence of aminosteroid and glucocorticoid treatment on inflammation and immune function during cardiopulmonary bypass. Volk, T., Schmutzler, M., Engelhardt, L., Döcke, W.D., Volk, H.D., Konertz, W., Kox, W.J. Crit. Care Med. (2001) [Pubmed]
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