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Chemical Compound Review

Rgds peptide     (3S)-3-[2-[[(2S)-2-amino-5...

Synonyms: CHEMBL265628, A9041_SIGMA, CHEBI:486404, AR-1J3020, LS-178134, ...
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Disease relevance of Arginyl-glycyl-aspartyl-serine


High impact information on Arginyl-glycyl-aspartyl-serine


Chemical compound and disease context of Arginyl-glycyl-aspartyl-serine


Biological context of Arginyl-glycyl-aspartyl-serine


Anatomical context of Arginyl-glycyl-aspartyl-serine


Associations of Arginyl-glycyl-aspartyl-serine with other chemical compounds


Gene context of Arginyl-glycyl-aspartyl-serine

  • In contrast, neither RGDS peptide nor MoAb 7E3, both known to block alphaIIbbeta3 engagement, had any effect on SIPA and pp125FAK [25].
  • Both the vitronectin-induced MMP-2 production and vitronectin-enhanced invasion were blocked by the peptide ligand Arg-Gly-Asp-Ser (RGDS) [26].
  • Neither control monoclonal antibodies nor the cell attachment peptide Arg-Gly-Asp-Ser inhibited tumor cell attachment to TSP, alone or in the presence of heparin [27].
  • In HEK-293 human embryonic kidney cells, LPA and thrombin receptor-mediated Erk 1/2 activation is partially sensitive to both the RGDS peptide and tyrphostin AG1478, suggesting that both focal adhesion and receptor tyrosine kinase scaffolds are employed in these cells [28].
  • We compared the effect of a synthetic dodecapeptide of residues 400-411 of the gamma chain of fibrinogen (gamma Fg 400-411) and of three synthetic peptides (15 to 18 aminoacids), of human von Willebrand Factor (vWF), containing the 1744-1747 Arg-Gly-Asp-Ser (RGDS) sequence, upon platelet adhesion to collagen in flowing blood [29].

Analytical, diagnostic and therapeutic context of Arginyl-glycyl-aspartyl-serine


  1. Fibronectin tetrapeptide is target for syphilis spirochete cytadherence. Thomas, D.D., Baseman, J.B., Alderete, J.F. J. Exp. Med. (1985) [Pubmed]
  2. Metastasis inhibition of different tumor types by purified laminin fragments and a heparin-binding fragment of fibronectin. McCarthy, J.B., Skubitz, A.P., Palm, S.L., Furcht, L.T. J. Natl. Cancer Inst. (1988) [Pubmed]
  3. P-selectin mediates adhesion of platelets to neuroblastoma and small cell lung cancer. Stone, J.P., Wagner, D.D. J. Clin. Invest. (1993) [Pubmed]
  4. C-terminal peptide of thrombospondin-1 induces platelet aggregation through the Fc receptor gamma-chain-associated signaling pathway and by agglutination. Tulasne, D., Judd, B.A., Johansen, M., Asazuma, N., Best, D., Brown, E.J., Kahn, M., Koretzky, G.A., Watson, S.P. Blood (2001) [Pubmed]
  5. The replication of human immunodeficiency virus type 1 in macrophages is enhanced after phagocytosis of apoptotic cells. Lima, R.G., Van Weyenbergh, J., Saraiva, E.M., Barral-Netto, M., Galvão-Castro, B., Bou-Habib, D.C. J. Infect. Dis. (2002) [Pubmed]
  6. Trypanosoma cruzi infection inhibited by peptides modeled from a fibronectin cell attachment domain. Ouaissi, M.A., Cornette, J., Afchain, D., Capron, A., Gras-Masse, H., Tartar, A. Science (1986) [Pubmed]
  7. Fibronectin receptor of human macrophages recognizes the sequence Arg-Gly-Asp-Ser. Wright, S.D., Meyer, B.C. J. Exp. Med. (1985) [Pubmed]
  8. Vitronectin binds to activated human platelets and plays a role in platelet aggregation. Asch, E., Podack, E. J. Clin. Invest. (1990) [Pubmed]
  9. RGD-independent cell adhesion to the carboxy-terminal heparin-binding fragment of fibronectin involves heparin-dependent and -independent activities. McCarthy, J.B., Skubitz, A.P., Qi, Z., Yi, X.Y., Mickelson, D.J., Klein, D.J., Furcht, L.T. J. Cell Biol. (1990) [Pubmed]
  10. Staphylococcus saprophyticus hemagglutinin binds fibronectin. Gatermann, S., Meyer, H.G. Infect. Immun. (1994) [Pubmed]
  11. Echistatin is a potent inhibitor of bone resorption in culture. Sato, M., Sardana, M.K., Grasser, W.A., Garsky, V.M., Murray, J.M., Gould, R.J. J. Cell Biol. (1990) [Pubmed]
  12. Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets. Ferrell, J.E., Martin, G.S. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  13. Arg-Gly-Asp-Ser-selective adhesion and the stabilization of long-term potentiation: pharmacological studies and the characterization of a candidate matrix receptor. Bahr, B.A., Staubli, U., Xiao, P., Chun, D., Ji, Z.X., Esteban, E.T., Lynch, G. J. Neurosci. (1997) [Pubmed]
  14. Inhibition of fibronectin binding to platelets by proteolytic fragments and synthetic peptides which support fibroblast adhesion. Ginsberg, M., Pierschbacher, M.D., Ruoslahti, E., Marguerie, G., Plow, E. J. Biol. Chem. (1985) [Pubmed]
  15. Synthesis and expression of the fibroblast fibronectin receptor in human monocytes. Brown, D.L., Phillips, D.R., Damsky, C.H., Charo, I.F. J. Clin. Invest. (1989) [Pubmed]
  16. Fibronectin degradation products containing the cytoadhesive tetrapeptide stimulate human neutrophil degranulation. Wachtfogel, Y.T., Abrams, W., Kucich, U., Weinbaum, G., Schapira, M., Colman, R.W. J. Clin. Invest. (1988) [Pubmed]
  17. Differential effects of laminin, intact type IV collagen, and specific domains of type IV collagen on endothelial cell adhesion and migration. Herbst, T.J., McCarthy, J.B., Tsilibary, E.C., Furcht, L.T. J. Cell Biol. (1988) [Pubmed]
  18. Modulation of matrix adhesive responses of human neuroblastoma cells by neighboring sequences in the fibronectins. Mugnai, G., Lewandowska, K., Carnemolla, B., Zardi, L., Culp, L.A. J. Cell Biol. (1988) [Pubmed]
  19. The fibronectin cell attachment sequence Arg-Gly-Asp-Ser promotes focal contact formation during early fibroblast attachment and spreading. Singer, I.I., Kawka, D.W., Scott, S., Mumford, R.A., Lark, M.W. J. Cell Biol. (1987) [Pubmed]
  20. Thrombospondin binds to monocytes-macrophages and mediates platelet-monocyte adhesion. Silverstein, R.L., Nachman, R.L. J. Clin. Invest. (1987) [Pubmed]
  21. Inhibition of binding of fibronectin to matrix assembly sites by anti-integrin (alpha 5 beta 1) antibodies. Fogerty, F.J., Akiyama, S.K., Yamada, K.M., Mosher, D.F. J. Cell Biol. (1990) [Pubmed]
  22. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Musial, J., Niewiarowski, S., Rucinski, B., Stewart, G.J., Cook, J.J., Williams, J.A., Edmunds, L.H. Circulation (1990) [Pubmed]
  23. Characterization of the cellular receptor for fibronectin through a hydropathic complementarity approach. Brentani, R.R., Ribeiro, S.F., Potocnjak, P., Pasqualini, R., Lopes, J.D., Nakaie, C.R. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  24. Time-dependent association between platelet-bound fibrinogen and the Triton X-100 insoluble cytoskeleton. Peerschke, E.I. Blood (1991) [Pubmed]
  25. Activation of pp125FAK by type 2B recombinant von Willebrand factor binding to platelet GPIb at a high shear rate occurs independently of alpha IIb beta 3 engagement. Mekrache, M., Bachelot-Loza, C., Ajzenberg, N., Saci, A., Legendre, P., Baruch, D. Blood (2003) [Pubmed]
  26. Intact vitronectin induces matrix metalloproteinase-2 and tissue inhibitor of metalloproteinases-2 expression and enhanced cellular invasion by melanoma cells. Bafetti, L.M., Young, T.N., Itoh, Y., Stack, M.S. J. Biol. Chem. (1998) [Pubmed]
  27. Cellular attachment to thrombospondin. Cooperative interactions between receptor systems. Asch, A.S., Tepler, J., Silbiger, S., Nachman, R.L. J. Biol. Chem. (1991) [Pubmed]
  28. Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases. Della Rocca, G.J., Maudsley, S., Daaka, Y., Lefkowitz, R.J., Luttrell, L.M. J. Biol. Chem. (1999) [Pubmed]
  29. Synthetic RGDS-containing peptides of von Willebrand factor inhibit platelet adhesion to collagen. Fressinaud, E., Girma, J.P., Sadler, J.E., Baumgartner, H.R., Meyer, D. Thromb. Haemost. (1990) [Pubmed]
  30. The C-terminal sequences of the gamma 57.5 chain of human fibrinogen constitute a plasmin sensitive epitope that is exposed in crosslinked fibrin. Haidaris, P.J., Peerschke, E.I., Marder, V.J., Francis, C.W. Blood (1989) [Pubmed]
  31. Selective inactivation of the Arg-Gly-Asp-Ser (RGDS) binding site in von Willebrand factor by site-directed mutagenesis. Beacham, D.A., Wise, R.J., Turci, S.M., Handin, R.I. J. Biol. Chem. (1992) [Pubmed]
  32. Evidence for the involvement of a Src-related tyrosine kinase in Xenopus egg activation. Sato, K., Iwao, Y., Fujimura, T., Tamaki, I., Ogawa, K., Iwasaki, T., Tokmakov, A.A., Hatano, O., Fukami, Y. Dev. Biol. (1999) [Pubmed]
  33. Activation of human neutrophils by Arg-Gly-Asp-Ser immobilized on microspheres. Kasuya, Y., Fujimoto, K., Miyamoto, M., Kawaguchi, H. J. Biomed. Mater. Res. (1994) [Pubmed]
  34. An RGDS peptide-binding receptor, FR-1R, localizes to the basal side of the ectoderm and to primary mesenchyme cells in sand dollar embryos. Katow, H., Sofuku, S. Dev. Growth Differ. (2001) [Pubmed]
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