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Chemical Compound Review

Ammonapse     sodium 4-phenylbutanoate

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Disease relevance of NSC 295


High impact information on NSC 295


Chemical compound and disease context of NSC 295


Biological context of NSC 295


Anatomical context of NSC 295


Associations of NSC 295 with other chemical compounds


Gene context of NSC 295


Analytical, diagnostic and therapeutic context of NSC 295


  1. Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase. Warrell, R.P., He, L.Z., Richon, V., Calleja, E., Pandolfi, P.P. J. Natl. Cancer Inst. (1998) [Pubmed]
  2. Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate. Dover, G.J., Brusilow, S., Charache, S. Blood (1994) [Pubmed]
  3. Oral sodium phenylbutyrate therapy in homozygous beta thalassemia: a clinical trial. Collins, A.F., Pearson, H.A., Giardina, P., McDonagh, K.T., Brusilow, S.W., Dover, G.J. Blood (1995) [Pubmed]
  4. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Gore, S.D., Baylin, S., Sugar, E., Carraway, H., Miller, C.B., Carducci, M., Grever, M., Galm, O., Dauses, T., Karp, J.E., Rudek, M.A., Zhao, M., Smith, B.D., Manning, J., Jiemjit, A., Dover, G., Mays, A., Zwiebel, J., Murgo, A., Weng, L.J., Herman, J.G. Cancer Res. (2006) [Pubmed]
  5. Sodium phenylacetate inhibits adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice at multiple steps. Dasgupta, S., Zhou, Y., Jana, M., Banik, N.L., Pahan, K. J. Immunol. (2003) [Pubmed]
  6. Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease. Borovecki, F., Lovrecic, L., Zhou, J., Jeong, H., Then, F., Rosas, H.D., Hersch, S.M., Hogarth, P., Bouzou, B., Jensen, R.V., Krainc, D. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Mouse model for human arginase deficiency. Iyer, R.K., Yoo, P.K., Kern, R.M., Rozengurt, N., Tsoa, R., O'Brien, W.E., Yu, H., Grody, W.W., Cederbaum, S.D. Mol. Cell. Biol. (2002) [Pubmed]
  8. Enhanced fetal hemoglobin production by phenylacetate and 4-phenylbutyrate in erythroid precursors derived from normal donors and patients with sickle cell anemia and beta-thalassemia. Fibach, E., Prasanna, P., Rodgers, G.P., Samid, D. Blood (1993) [Pubmed]
  9. Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells. Vila-Carriles, W.H., Kovacs, G.G., Jovov, B., Zhou, Z.H., Pahwa, A.K., Colby, G., Esimai, O., Gillespie, G.Y., Mapstone, T.B., Markert, J.M., Fuller, C.M., Bubien, J.K., Benos, D.J. J. Biol. Chem. (2006) [Pubmed]
  10. Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome. Maslak, P., Chanel, S., Camacho, L.H., Soignet, S., Pandolfi, P.P., Guernah, I., Warrell, R., Nimer, S. Leukemia (2006) [Pubmed]
  11. Hydroxyurea and sodium phenylbutyrate therapy in thalassemia intermedia. Hoppe, C., Vichinsky, E., Lewis, B., Foote, D., Styles, L. Am. J. Hematol. (1999) [Pubmed]
  12. Defective trafficking of nephrin missense mutants rescued by a chemical chaperone. Liu, X.L., Doné, S.C., Yan, K., Kilpeläinen, P., Pikkarainen, T., Tryggvason, K. J. Am. Soc. Nephrol. (2004) [Pubmed]
  13. Mutant tamm-horsfall glycoprotein accumulation in endoplasmic reticulum induces apoptosis reversed by colchicine and sodium 4-phenylbutyrate. Choi, S.W., Ryu, O.H., Choi, S.J., Song, I.S., Bleyer, A.J., Hart, T.C. J. Am. Soc. Nephrol. (2005) [Pubmed]
  14. A phase I dose escalation and bioavailability study of oral sodium phenylbutyrate in patients with refractory solid tumor malignancies. Gilbert, J., Baker, S.D., Bowling, M.K., Grochow, L., Figg, W.D., Zabelina, Y., Donehower, R.C., Carducci, M.A. Clin. Cancer Res. (2001) [Pubmed]
  15. A novel approach for nasopharyngeal carcinoma treatment uses phenylbutyrate as a protein kinase C modulator: implications for radiosensitization and EBV-targeted therapy. Chung, Y.L., Lee, Y.H., Yen, S.H., Chi, K.H. Clin. Cancer Res. (2000) [Pubmed]
  16. A successful pregnancy in a heterozygote for OTC deficiency treated with sodium phenylbutyrate. Redonnet-Vernhet, I., Rouanet, F., Pedespan, J.M., Hocke, C., Parrot, F. Neurology (2000) [Pubmed]
  17. Pharmacological induction of peroxisomes in peroxisome biogenesis disorders. Wei, H., Kemp, S., McGuinness, M.C., Moser, A.B., Smith, K.D. Ann. Neurol. (2000) [Pubmed]
  18. Impact of the putative differentiating agents sodium phenylbutyrate and sodium phenylacetate on proliferation, differentiation, and apoptosis of primary neoplastic myeloid cells. Gore, S.D., Samid, D., Weng, L.J. Clin. Cancer Res. (1997) [Pubmed]
  19. Impact of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia. Gore, S.D., Weng, L.J., Zhai, S., Figg, W.D., Donehower, R.C., Dover, G.J., Grever, M., Griffin, C.A., Grochow, L.B., Rowinsky, E.K., Zabalena, Y., Hawkins, A.L., Burks, K., Miller, C.B. Clin. Cancer Res. (2001) [Pubmed]
  20. Sodium 4-phenylbutyrate acts as a chemical chaperone on misfolded myocilin to rescue cells from endoplasmic reticulum stress and apoptosis. Yam, G.H., Gaplovska-Kysela, K., Zuber, C., Roth, J. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
  21. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Chang, T.H., Szabo, E. Clin. Cancer Res. (2002) [Pubmed]
  22. Evidence of CFTR function in cystic fibrosis after systemic administration of 4-phenylbutyrate. Zeitlin, P.L., Diener-West, M., Rubenstein, R.C., Boyle, M.P., Lee, C.K., Brass-Ernst, L. Mol. Ther. (2002) [Pubmed]
  23. Lipases catalyse hydrolysis of fatty acid anhydrides. Pieroni, G., Fourneron, J.D. Eur. J. Biochem. (1990) [Pubmed]
  24. Tributyrin-induced differentiation promotes apoptosis of LS 174T colon cancer cells in vitro. Schröder, C.P., Maurer, H.R. Int. J. Oncol. (2002) [Pubmed]
  25. Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR. Rubenstein, R.C., Zeitlin, P.L. Am. J. Physiol., Cell Physiol. (2000) [Pubmed]
  26. Arginase induction by sodium phenylbutyrate in mouse tissues and human cell lines. Kern, R.M., Yang, Z., Kim, P.S., Grody, W.W., Iyer, R.K., Cederbaum, S.D. Mol. Genet. Metab. (2007) [Pubmed]
  27. Sodium 4-phenylbutyrate induces apoptosis of human lung carcinoma cells through activating JNK pathway. Zhang, X., Wei, L., Yang, Y., Yu, Q. J. Cell. Biochem. (2004) [Pubmed]
  28. Functional and trafficking defects in ATP binding cassette A3 mutants associated with respiratory distress syndrome. Cheong, N., Madesh, M., Gonzales, L.W., Zhao, M., Yu, K., Ballard, P.L., Shuman, H. J. Biol. Chem. (2006) [Pubmed]
  29. In vivo nitrogen metabolism in ornithine transcarbamylase deficiency. Yudkoff, M., Daikhin, Y., Nissim, I., Jawad, A., Wilson, J., Batshaw, M. J. Clin. Invest. (1996) [Pubmed]
  30. Long-term treatment with sodium phenylbutyrate in ornithine transcarbamylase-deficient patients. Burlina, A.B., Ogier, H., Korall, H., Trefz, F.K. Mol. Genet. Metab. (2001) [Pubmed]
  31. Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum-stress mediated apoptosis. Vilatoba, M., Eckstein, C., Bilbao, G., Smyth, C.A., Jenkins, S., Thompson, J.A., Eckhoff, D.E., Contreras, J.L. Surgery (2005) [Pubmed]
  32. Liver transplantation in urea cycle disorders. Saudubray, J.M., Touati, G., Delonlay, P., Jouvet, P., Narcy, C., Laurent, J., Rabier, D., Kamoun, P., Jan, D., Revillon, Y. Eur. J. Pediatr. (1999) [Pubmed]
  33. Attenuation of primary nonfunction for syngeneic islet graft using sodium 4-phenylbutyrate. Fu, S.H., Chen, S.T., Hsu, B.R. Transplant. Proc. (2005) [Pubmed]
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