Disease relevance of Leptofen

• RESULTS: Emesis rate in the acetaminophen group was 9%, and the fentanyl-droperidol group was 13% (not statistically significant) [1].
• Innovar-induced hypertensive crises in patients with pheochromocytoma [2].
• In a rat model of generalized absence epilepsies (Genetic Absence Epilepsy Rats from Strasbourg, GAERS), multiunit activity was recorded simultaneously at different sites of the thalamocortical system under neurolept anaesthesia (fentanyl-droperidol) [3].
• The authors conclude that pentobarbital and fentanyl-droperidol (Innovar) limit the extent of cerebral edema, but that inhaled anesthetics do not [4].
• Age, chronic obstructive pulmonary disease, and Innovar induced ventilatory depression during regional anesthesia [5].

Psychiatry related information on Leptofen

• The anesthetic agents methohexital (Brevital), Innovar, and ketamine (Ketaject) were examined for their effect on seizure duration following electroconvulsive stimulation in a rat model of electroconvulsive therapy (ECT) [6].
• Reversal of Innovar-induced postanesthetic somnolence and disorientation with physostigmine [7].
• Innovar, administered intramuscularly 45 minutes preoperatively, provides excellent operative sedation, analgesia, and patient cooperation [8].
• Midazolam scored consistently better than diazepam, fentanyl, placebo and fentanyl-droperidol for incidence of amnesia, stability of cardiovascular measurements and physician's acceptance [9].

High impact information on Leptofen

• METHODS: A prospective, comparative, randomized study to assess rectal acetaminophen (n = 45) to intravenous fentanyl-droperidol (n = 45) to resolve recovery profile, emesis rate, and adequacy of analgesia in a pediatric strabismus repair population was performed, with standardization of the anesthetic technique [1].
• 6. Peak intracranial pressures (ICP) were 15.4 +/- 1.3 torr with pentobarbital, 21.6 +/- 1.8 torr with N2O/Innovar, and 31.1 +/- 2.6 to 38.3 +/- 4.5 torr with the halogenated anesthetics [4].
• The water content of white matter and ICP were significantly lower (P less than 0.05) in animals receiving pentobarbital or N2O/Innovar anesthesia than in animals receiving inhalation anesthetics [4].
• Internal carotid artery stump pressure and cerebral blood flow during carotid endarterectomy: modification by halothane, enflurane, and innovar [10].
• Addition of 60 per cent nitrous oxide following fentanyl or fentanyl-droperidol infusion significantly decreased mean arterial pressure, heart rate, and cardiac index [11].

Chemical compound and disease context of Leptofen

• Ventricular tachycardia induced by ouabain was generally converted to sinus rhythm following administration of Innovar, ketamine, or droperidol but not after administration of fentayl alone or after pentobarbital [12].
• A combination of fentanyl-droperidol was administered intravenously alone or with atropine sulfate (2 doses--0.04 or 0.02 mg/kg of body weight) to determine if stable neuroleptanalgesia could be produced in the dog [13].
• Effects of saline solution (groups 1, 2, and 3), xylazine (2.2 mg/kg of body weight, groups 4 and 5), acepromazine (0.1 mg/kg, groups 6 and 7), diazepam (1.0 mg/kg, groups 8 and 9), morphine (1.0 mg/kg, groups 10 and 11), or fentanyl-droperidol (0.055 ml/kg, groups 12 and 13), IM were compared in groups of atropinized dogs [14].
• Xylazine HCl (3-70 mg/kg) and fentanyl-droperidol (0.28-1.11 ml/kg( produced varying degrees of ataxia and intermittent recumbency [15].
• Anaphylaxis developed shortly following induction of anaesthesia with thiopentone, Innovar and gallamine [16].

Biological context of Leptofen

• With the passage of time after administration of a single dose of Innovar, there were some changes in cardiac output, heart rate, and stroke volume, probably representing normal changes of sedated sleep [17].
• Fentanyl-Droperidol produced no substantial blood pressure change [18].
• Fentanyl-droperidol given alone caused a significant increase of peripheral resistance and mean arterial pressure at 5 minutes and then a decrease of these values over a postinjection period of 30 minutes [13].
• Myocardial oxygen consumption and coronary haemodynamics during fentanyl-droperidol-nitrous oxide anaesthesia in patients with ischaemic heart disease [19].
• The greatest right to left energy transfer during the seizure occurred with Innovar anesthesia [20].

Associations of Leptofen with other chemical compounds

• Administration of ketamine or Innovar by the microdrip technic: a double blind study [21].
• One hundred twenty-four were treated using local anesthesia with supplemental diazepam or Innovar [22].
• This apparent difference suggests that a prospective study of Innovar and droperidol be made to determine whether there are changes in patient attitude that lead to refusal of surgery [23].
• The effect of Innovar on ventilatory response to CO2 was studied in 35 patients undergoing peripheral surgery with regional anesthesia [5].
• In dogs given atropine concurrently with fentanyl-droperidol, there was significant increase in heart rate and decrease in stroke volume [13].

Gene context of Leptofen

• Fentanyl-droperidol technique is the choice for epilepsy surgery [24].

Analytical, diagnostic and therapeutic context of Leptofen

• Fentanyl-droperidol neuroleptanalgesia in gastrointestinal endoscopy [25].
• Patient refusal of surgery following Innovar premedication [23].
• Oxygen-high dose fentanyl-droperidol anesthesia for aortocoronary bypass surgery [26].
• After Innovar, the dogs became somnolent and tolerated minor surgical procedures [27].
• Urinary excretion of N-nitrosodimethylamine (NDMA) in Sprague--Dawley rats was investigated after oral administration and inhalation of NDMA and concomitant narcosis by Thalamonal and diethyl ether [28].

References