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Chemical Compound Review

Demetrin     9-chloro-2- (cyclopropylmethyl)-6-phenyl- 2...

Synonyms: Lysanxia, Prazeene, Sedapran, Trepidan, Verstran, ...
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Disease relevance of prazepam


Psychiatry related information on prazepam


High impact information on prazepam

  • Comparative single-dose kinetics and dynamics of lorazepam, alprazolam, prazepam, and placebo [9].
  • In this simple and rapid "high-performance" liquid-chromatographic method for determining nitrazepam in plasma, serum, or whole blood, the sample at pH 7.4 is extracted into diethyl ether with an internal standard (prazepam), chromatographed, and detected at 280 nm with a fixed-wavelength ultraviolet detector [10].
  • A double-blind, random design, parallel group, four-week study of prazepam, diazepam, lorazepam, and placebo was conducted in diverse private outpatient practices (surgeon, internist, and obstetrician-gynecologist) using a common protocol, in order to evaluate their comparative efficacy in these settings [11].
  • The method can be used to quantify prazepam and its metabolites in human plasma covering a variety of pharmacokinetic or bioequivalence studies [12].
  • Concentrations of D and ND were determined in body fluids by capillary column gas chromatography after adding prazepam as internal standard and solvent extraction with butyl acetate [13].

Biological context of prazepam


Anatomical context of prazepam


Associations of prazepam with other chemical compounds


Gene context of prazepam


Analytical, diagnostic and therapeutic context of prazepam


  1. Stereoselective metabolism of prazepam and halazepam by human liver microsomes. Lu, X.L., Guengerich, F.P., Yang, S.K. Drug Metab. Dispos. (1991) [Pubmed]
  2. Comparison of performance of healthy volunteers given prazepam alone or combined with ethanol. Relation to drug plasma concentrations. Girre, C., Hirschhorn, M., Bertaux, L., Palombo, S., Fournier, P.E. International clinical psychopharmacology. (1991) [Pubmed]
  3. Ranitidine versus ranitidine and prazepam in the short-term treatment of duodenal ulcer--a double-blind controlled trial. Hüscher, C., Magni, G., Salmi, A., Bossini, S., Felini, C., Besozzi, F., de Leo, D. Eur. J. Clin. Pharmacol. (1985) [Pubmed]
  4. Acute poisonings with ethyle loflazepate, flunitrazepam, prazepam and triazolam in children. Pulce, C., Mollon, P., Pham, E., Frantz, P., Descotes, J. Veterinary and human toxicology. (1992) [Pubmed]
  5. Influence of anxiolytic drugs (Prazepam and Diazepam) on respiratory center output and CO2 chemosensitivity in patients with lung diseases. Delpierre, S., Jammes, Y., Grimaud, C., Dugué, P., Arnaud, A., Charpin, J. Respiration; international review of thoracic diseases. (1981) [Pubmed]
  6. Duration of benzodiazepine clinical activity: lack of direct relationship with plasma half-life. A comparison of single vs divided dosage schedules of prazepam. Ansseau, M., Doumont, A., von Frenckell, R., Collard, J. Psychopharmacology (Berl.) (1984) [Pubmed]
  7. Tranquillizer effects in an experimental analog of group psychotherapy. Krüger, H.P., Kohnen, R. International pharmacopsychiatry. (1982) [Pubmed]
  8. Classification and assessment of cerebral bioavailability of lopirazepam (D-12524) by quantitative EEG and psychometric analysis. Saletu, B., Grünberger, J., Linzmayer, L., Stadler, R. Arzneimittel-Forschung. (1980) [Pubmed]
  9. Comparative single-dose kinetics and dynamics of lorazepam, alprazolam, prazepam, and placebo. Greenblatt, D.J., Harmatz, J.S., Dorsey, C., Shader, R.I. Clin. Pharmacol. Ther. (1988) [Pubmed]
  10. Liquid-chromatographic measurement of nitrazepam in plasma. Kelly, H., Huggett, A., Dawling, S. Clin. Chem. (1982) [Pubmed]
  11. A comparison of prazepam, diazepam, lorazepam and placebo in anxious outpatients in non-psychiatric private practices. Zung, W.W., Daniel, J.T., King, R.E., Moore, D.T. The Journal of clinical psychiatry. (1981) [Pubmed]
  12. Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the quantitation of prazepam and its main metabolites in human plasma. Valavani, P., Atta-Politou, J., Panderi, I. Journal of mass spectrometry : JMS. (2005) [Pubmed]
  13. Distribution of diazepam and nordiazepam between plasma and whole blood and the influence of hematocrit. Jones, A.W., Larsson, H. Therapeutic drug monitoring. (2004) [Pubmed]
  14. Comparative single-dose kinetics of oxazolam, prazepam, and clorazepate: three precursors of desmethyldiazepam. Ochs, H.R., Greenblatt, D.J., Verburg-Ochs, B., Locniskar, A. Journal of clinical pharmacology. (1984) [Pubmed]
  15. Pharmacokinetics of prazepam in man. Smith, M.T., Evans, L.E., Eadie, M.J., Tyrer, J.H. Eur. J. Clin. Pharmacol. (1979) [Pubmed]
  16. An improved method for the preparation of human fetal and adult hepatocytes. Liddiard, C., Merker, H.J., Nau, H. Arch. Toxicol. (1980) [Pubmed]
  17. Desmethyldiazepam kinetics in the elderly after oral prazepam. Allen, M.D., Greenblatt, D.J., Harmatz, J.S., Shader, R.I. Clin. Pharmacol. Ther. (1980) [Pubmed]
  18. A sensitive benzodiazepine radioimmunoassay of broad specificity. Robinson, K., Rutterford, M.G., Smith, R.N. J. Pharm. Pharmacol. (1980) [Pubmed]
  19. Anti-spasticity agents for multiple sclerosis. Shakespeare, D.T., Boggild, M., Young, C. Cochrane database of systematic reviews (Online) (2003) [Pubmed]
  20. Benzodiazepines prescription in Dakar: a study about prescribing habits and knowledge in general practitioners, neurologists and psychiatrists. Dièye, A.M., Sylla, M., Ndiaye, A., Ndiaye, M., Guata Yoro, S., Faye, B. Fundamental & clinical pharmacology. (2006) [Pubmed]
  21. Quantitative analysis of prazepam and its metabolites by electron capture gas chromatography and selected ion monitoring. Application to diaplacetal passage and fetal hepatic metabolism in early human pregnancy. Nau, H., Liddiard, C., Jesdinsky, D., Wittfoht, W. J. Chromatogr. (1978) [Pubmed]
  22. Comparison of the effect of two prazepam formulations on psychomotor and cognitive function in healthy volunteers. Girre, C., Bertaux, L., Dussaucy, E., Bonnet, D., Palombo, S., Fournier, P.E. International clinical psychopharmacology. (1990) [Pubmed]
  23. Carcinogenesis bioassay of prazepam (Verstran) in rats and mice. de la Iglesia, F.A., Barsoum, N., Gough, A., Mitchell, L., Martin, R.A., Di Fonzo, C., McGuire, E.J. Toxicol. Appl. Pharmacol. (1981) [Pubmed]
  24. Radioimmunoassay for determination of prazepam and its metabolites. Köhler-Schmidt, H., Bohn, G. Forensic Sci. Int. (1983) [Pubmed]
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