Disease relevance of Suisynchron

• Administration of methallibure (50 mg/kg body weight, daily) to male rabbits resulted in a 45% reduction in sperm number in ejaculates obtained during the treatment period [1].
• Compensatory hypertrophy of the remaining ovary and the effects of methallibure in the unilaterally ovariectomized Tilapia aurea [2].
• Effect of dexamethasone, methallibure and fetal decapitation on porcine gestation [3].

High impact information on Suisynchron

• Serum FSH concentrations were reduced by 27%, whereas serum concentrations of PRL, GH, thyroid hormones and cortisol were not affected after 7 days of AIMAX treatment [4].
• Although an effect at the level of the pituitary remains to be conclusively ruled out, these results suggest that the predominant in vivo effect of Methallibure in the castrate male rat is to suppress pituitary LH release due to diminished secretion of LHRH by the hypothalamus [5].
• A single intratesticular injection of 3HP (2 ng in 2.0 microliters oil) in Methallibure-treated rats resulted in a significant increase in late pachytene spermatocyte numbers from 0.77 +/- 0.12 in Methallibure-only-treated rats to 1.70 +/- 0.10 (p less than 0.001) cells per tubule cross section in 28-day-old rats [6].
• Following administration of methallibure B2 (FSH) and B3 (ICSH) cells of the pars distalis exhibited significant alterations with concomitant changes in the seminiferous tubules, and in the interstitial cells and epididymis respectively [7].
• There was a marked reduction in the gonadotrophic activity of the pituitary gland and blood serum within 3 weeks of methallibure treatment (100 microng/g) [8].

Biological context of Suisynchron

• Effect of methallibure on gestation in the guppy, Poecilia reticulata [9].
• Methallibure treatment may exert marked inhibitory influence on vitellogenesis in the fish and cause atresia of vitellogenic follicles, the oogonial proliferation is stepped up [10].
• Estrus synchronization obtained with methallibure treatment provided a reference point for dating the onset of the follicular phase of each sow in the experiment [11].
• Inhibition of spermatogenesis in the pigeon, Columba livia Gmelin, following the administration of methallibure (ICI 33828): a confirmation [12].
• The effect of methallibure (I.C.I. 33,828) on the steriodogenesis in the ovary and testis of a fresh water teleost, Cyprinus carpio [13].

Anatomical context of Suisynchron

• The antigonadotropin methallibure blocked testes regeneration and recovery of spawning in castrated males but it had no effect on reproductive functions of intact males [14].
• In the ovaries of the methallibure treated females, there was a great atresia of the follicles and of the corpora lutea [15].
• Serotonin levels in the hen ovarian follicles after methallibure (I.C.I 33, 828) treatment [16].
• Methallibure treatment of mature Cyprinus carpio causes a marked reduction in the steroidogenesis, as indicated by the fall in 3beta-HSD activity in the gonads [13].
• Morphometric investigations on endocrine glands. III. The effect of turisynchron and suisynchron on the thyroid gland of the Wistar rats [17].

Associations of Suisynchron with other chemical compounds

• 1. Synergistic action of alpha-chlorohydrin with methallibure (ICI, 33828) on the testicular function of Presbytis entellus entellus Dufresne has been studied [18].
• Parturition was delayed in sows up to 1.5 days by altrenogest, 1.6 days by meclofenamic acid, 2.7 days by indomethacin, and 3 days by methallibure without increased incidence of stillborn piglets compared with control sows [19].
• Prolactin content of the pituitary gland in response to hypertonic saline medium, antithyroid drugs, methallibure and thyroxine in a freshwater teleost Heteropneustes fossilis [20].

Gene context of Suisynchron

• Proceedings: Effect of methallibure on prolactin release from pigeon pituitaries incubated in vitro [21].
• The latter compartment increases in methallibure-treated mice 2.3 fold and is remarkably depleted after administration of HCG [22].
• Serum LH concentrations were suppressed (P < .005) in both AIMAX- and DDC-treated rats compared with control animals [23].
• Hormonal regulation of reproduction and the antler cycle in the male Columbian black-tailed deer (Odocoileus hemionus columbianus). Part II. The effects of methallibure and hormone treatment [24].
• Uterine horns became thin after methallibure treatment [15].

Analytical, diagnostic and therapeutic context of Suisynchron

• This decrease in sperm number did not occur when oxytocin (0-2 i.u./kg body weight) was administered simultaneously with methallibure [1].
• Methallibure treatment is as effective as hypophysectomy in reducing thyroid activity in H. fossilis [25].

References