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Gene Review

PGR  -  progesterone receptor

Bos taurus

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Disease relevance of PGR


High impact information on PGR

  • The results of our study suggest that SH group modifications differentially influence the properties of mammalian PR complexed with either R5020 or RU486 [6].
  • Pretreatment of uterine cytosol at 4 degrees C with NEM (4-10 mM) reduced the binding of [3H]RU486 to PR by 40%, but [3H] R5020 binding was completely abolished [6].
  • Modulation of calf uterine progesterone receptor (PR), in relation to its binding to synthetic steroids with known agonist (R5020) and antagonist (RU486) properties, was studied in the presence of iodoacetamide (IA), N-ethylmaleimide (NEM), beta-mercaptoethanol (MER), and dithiothreitol (DTT) [6].
  • Gonadotropin-Induced Expression of Messenger Ribonucleic Acid for Cyclooxygenase-2 and Production of Prostaglandins E and F2{alpha} in Bovine Preovulatory Follicles Are Regulated by the Progesterone Receptor [7].
  • In summary, the LH surge induces expression of PR by granulosa cells and withdrawal from the cell cycle, and these events promote resistance to apoptosis [8].

Chemical compound and disease context of PGR


Biological context of PGR


Anatomical context of PGR


Associations of PGR with chemical compounds


Other interactions of PGR


Analytical, diagnostic and therapeutic context of PGR


  1. Epidermal growth factor receptor in breast cancer: storage conditions affecting measurement, and relationship to steroid receptors. McLeay, W.R., Horsfall, D.J., Seshadri, R., Morrison, D.A., Saccone, G.T. Breast Cancer Res. Treat. (1992) [Pubmed]
  2. In two genes, synergism of steroid hormone action is not mediated by cooperative binding of receptors to adjacent sites. Bailly, A., Rauch, C., Cato, A.C., Milgrom, E. Mol. Cell. Endocrinol. (1991) [Pubmed]
  3. Bovine uterine, cervical and ovarian cytosol estrogen and progesterone receptor concentrations in cystic ovarian disease. Vesanen, M. Acta Vet. Scand. (1993) [Pubmed]
  4. Comparative pathology of endometrial carcinoma. Elsinghorst, T.A., Timmermans, H.J., Hendriks, H.G. The Veterinary quarterly. (1984) [Pubmed]
  5. Parathyroid hormone mRNA levels are increased by progestins and vary during rat estrous cycle. Epstein, E., Silver, J., Almogi, G., Livni, N., Naveh-Many, T. Am. J. Physiol. (1996) [Pubmed]
  6. Mammalian progesterone receptor shows differential sensitivity to sulfhydryl group modifying agents when bound to agonist and antagonist ligands. Moudgil, V.K., Anter, M.J., Hurd, C. J. Biol. Chem. (1989) [Pubmed]
  7. Gonadotropin-Induced Expression of Messenger Ribonucleic Acid for Cyclooxygenase-2 and Production of Prostaglandins E and F2{alpha} in Bovine Preovulatory Follicles Are Regulated by the Progesterone Receptor. Bridges, P.J., Komar, C.M., Fortune, J.E. Endocrinology (2006) [Pubmed]
  8. Progesterone receptor and the cell cycle modulate apoptosis in granulosa cells. Quirk, S.M., Cowan, R.G., Harman, R.M. Endocrinology (2004) [Pubmed]
  9. Progesterone receptor quantification with radiolabeled promegestone (R 5020) in frozen sections of endometrium and breast cancer tissue. De Goeij, A.F., Scheres, H.M., Rousch, M.J., Hondius, G.G., Bosman, F.T. J. Steroid Biochem. (1988) [Pubmed]
  10. Expression and localization of estrogen receptor alpha, estrogen receptor beta and progesterone receptor in the bovine oviduct in vivo and in vitro. Ulbrich, S.E., Kettler, A., Einspanier, R. J. Steroid Biochem. Mol. Biol. (2003) [Pubmed]
  11. Chromosomal mapping and quantitative analysis of estrogen-related receptor alpha-1, estrogen receptors alpha and beta and progesterone receptor in the bovine mammary gland. Connor, E.E., Wood, D.L., Sonstegard, T.S., da Mota, A.F., Bennett, G.L., Williams, J.L., Capuco, A.V. J. Endocrinol. (2005) [Pubmed]
  12. Gonadotropin surge induces two separate increases in messenger RNA for progesterone receptor in bovine preovulatory follicles. Jo, M., Komar, C.M., Fortune, J.E. Biol. Reprod. (2002) [Pubmed]
  13. Expression and localisation of oestrogen and progesterone receptors in the bovine mammary gland during development, function and involution. Schams, D., Kohlenberg, S., Amselgruber, W., Berisha, B., Pfaffl, M.W., Sinowatz, F. J. Endocrinol. (2003) [Pubmed]
  14. Effect of systemic progesterone concentration on the expression of progesterone-responsive genes in the bovine endometrium during the early luteal phase. McNeill, R.E., Sreenan, J.M., Diskin, M.G., Cairns, M.T., Fitzpatrick, R., Smith, T.J., Morris, D.G. Reprod. Fertil. Dev. (2006) [Pubmed]
  15. A bovine oviduct epithelial cell suspension culture system suitable for studying embryo-maternal interactions: morphological and functional characterization. Rottmayer, R., Ulbrich, S.E., K??lle, S., Prelle, K., Neumueller, C., Sinowatz, F., Meyer, H.H., Wolf, E., Hiendleder, S. Reproduction (2006) [Pubmed]
  16. Characterization of the calf uterine progesterone receptor and its stabilization by nucleic acids. Theofan, G., Notides, A.C. Endocrinology (1984) [Pubmed]
  17. Toxic effects of in vitro exposure to p-tert-octylphenol on bovine oocyte maturation and developmental competence. Pocar, P., Augustin, R., Gandolfi, F., Fischer, B. Biol. Reprod. (2003) [Pubmed]
  18. Bovine uterine, cervical and ovarian androgen receptor concentrations. Correlation with estrogen and progesterone receptor concentrations. Vesanen, M., Isomaa, V., Alanko, M., Vihko, R. Acta Vet. Scand. (1992) [Pubmed]
  19. Regulation of progesterone receptor gene expression in MCF-7 breast cancer cells: a comparison of the effects of cyclic adenosine 3',5'-monophosphate, estradiol, insulin-like growth factor-I, and serum factors. Cho, H., Aronica, S.M., Katzenellenbogen, B.S. Endocrinology (1994) [Pubmed]
  20. An autocrine progesterone positive feedback loop mediates oxytocin upregulation in bovine granulosa cells during luteinization. Lioutas, C., Einspanier, A., Kascheike, B., Walther, N., Ivell, R. Endocrinology (1997) [Pubmed]
  21. The effect of lyophilization on steroid receptor behavior, as defined by sucrose density gradient analysis. Janes, G.R., Koenders, A.J., Benraad, T.J. J. Steroid Biochem. (1982) [Pubmed]
  22. Decreased progesterone levels and progesterone receptor antagonists promote apoptotic cell death in bovine luteal cells. Rueda, B.R., Hendry, I.R., Hendry III, W.J., Stormshak, F., Slayden, O.D., Davis, J.S. Biol. Reprod. (2000) [Pubmed]
  23. The effect of pregnancy on the expression of uterine oxytocin, oestrogen and progesterone receptors during early pregnancy in the cow. Robinson, R.S., Mann, G.E., Lamming, G.E., Wathes, D.C. J. Endocrinol. (1999) [Pubmed]
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