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Chemical Compound Review

Andrographis     (3E,4R)-3-[2- [(1S,4aS,5S,6R,8aR)-6- hydroxy...

Synonyms: AC1NSWY5, CHEMBL186141, CHEBI:65408, SureCN12056309, MEGxp0_000978, ...
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Disease relevance of NSC383468


High impact information on NSC383468

  • These experiments show that BAA activates TRPV4 channels, and we discuss the possibility that activation of TRPV4 by BAA could play a role in some of the effects of Andrographis extract described in traditional medicine [4].
  • During the screening of a plant extract library of traditional Chinese herbal medicines, we found that NF-kappaB activity was potently inhibited by andrographolide (Andro), an abundant component of the plant Andrographis that has been commonly used as a folk remedy for alleviation of inflammatory disorders in Asia for millennia [5].
  • Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters [6].
  • When tested against PC7, these succinoylated derivatives of andrographolide also displayed strong inhibitory action, with Ki values again in the low micromolar range [6].
  • Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells [7].

Chemical compound and disease context of NSC383468


Biological context of NSC383468


Anatomical context of NSC383468


Associations of NSC383468 with other chemical compounds


Gene context of NSC383468


Analytical, diagnostic and therapeutic context of NSC383468


  1. Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse. Iruretagoyena, M.I., Tobar, J.A., González, P.A., Sepúlveda, S.E., Figueroa, C.A., Burgos, R.A., Hancke, J.L., Kalergis, A.M. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  2. Andrographolide suppresses the expression of inducible nitric oxide synthase in macrophage and restores the vasoconstriction in rat aorta treated with lipopolysaccharide. Chiou, W.F., Lin, J.J., Chen, C.F. Br. J. Pharmacol. (1998) [Pubmed]
  3. Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy. Coon, J.T., Ernst, E. Planta Med. (2004) [Pubmed]
  4. Bisandrographolide from Andrographis paniculata Activates TRPV4 Channels. Smith, P.L., Maloney, K.N., Pothen, R.G., Clardy, J., Clapham, D.E. J. Biol. Chem. (2006) [Pubmed]
  5. Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50. Xia, Y.F., Ye, B.Q., Li, Y.D., Wang, J.G., He, X.J., Lin, X., Yao, X., Ma, D., Slungaard, A., Hebbel, R.P., Key, N.S., Geng, J.G. J. Immunol. (2004) [Pubmed]
  6. Inhibition of proprotein convertases-1, -7 and furin by diterpines of Andrographis paniculata and their succinoyl esters. Basak, A., Cooper, S., Roberge, A.G., Banik, U.K., Chrétien, M., Seidah, N.G. Biochem. J. (1999) [Pubmed]
  7. Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells. Zhou, J., Zhang, S., Ong, C.N., Shen, H.M. Biochem. Pharmacol. (2006) [Pubmed]
  8. Protective effect of Andrographis paniculata and andrographolide on cyclophosphamide-induced urothelial toxicity. Sheeja, K., Kuttan, G. Integrative cancer therapies. (2006) [Pubmed]
  9. Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults. Thamlikitkul, V., Dechatiwongse, T., Theerapong, S., Chantrakul, C., Boonroj, P., Punkrut, W., Ekpalakorn, W., Boontaeng, N., Taechaiya, S., Petcharoen, S. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. (1991) [Pubmed]
  10. The usage of Andrographis paniculata following Extracorporeal Shock Wave Lithotripsy (ESWL). Muangman, V., Viseshsindh, V., Ratana-Olarn, K., Buadilok, S. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. (1995) [Pubmed]
  11. Andrographolide interferes with binding of nuclear factor-kappaB to DNA in HL-60-derived neutrophilic cells. Hidalgo, M.A., Romero, A., Figueroa, J., Cortés, P., Concha, I.I., Hancke, J.L., Burgos, R.A. Br. J. Pharmacol. (2005) [Pubmed]
  12. Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration. Tsai, H.R., Yang, L.M., Tsai, W.J., Chiou, W.F. Eur. J. Pharmacol. (2004) [Pubmed]
  13. Andrographolide isolated from Andrographis paniculata induces cell cycle arrest and mitochondrial-mediated apoptosis in human leukemic HL-60 cells. Cheung, H.Y., Cheung, S.H., Li, J., Cheung, C.S., Lai, W.P., Fong, W.F., Leung, F.M. Planta Med. (2005) [Pubmed]
  14. Inhibitory effect of Andrographis paniculata extract and its active diterpenoids on platelet aggregation. Thisoda, P., Rangkadilok, N., Pholphana, N., Worasuttayangkurn, L., Ruchirawat, S., Satayavivad, J. Eur. J. Pharmacol. (2006) [Pubmed]
  15. Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect. Shen, Y.C., Chen, C.F., Chiou, W.F. Br. J. Pharmacol. (2002) [Pubmed]
  16. Mechanisms of suppression of inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells by andrographolide. Chiou, W.F., Chen, C.F., Lin, J.J. Br. J. Pharmacol. (2000) [Pubmed]
  17. Andrographolide suppresses endothelial cell apoptosis via activation of phosphatidyl inositol-3-kinase/Akt pathway. Chen, J.H., Hsiao, G., Lee, A.R., Wu, C.C., Yen, M.H. Biochem. Pharmacol. (2004) [Pubmed]
  18. Activation of alpha1A-adrenoceptor by andrographolide to increase glucose uptake in cultured myoblast C2C12 cells. Hsu, J.H., Liou, S.S., Yu, B.C., Cheng, J.T., Wu, Y.C. Planta Med. (2004) [Pubmed]
  19. On-line coupling of dynamic microwave-assisted extraction with high-performance liquid chromatography for determination of andrographolide and dehydroandrographolide in Andrographis paniculata Nees. Chen, L., Jin, H., Ding, L., Zhang, H., Wang, X., Wang, Z., Li, J., Qu, C., Wang, Y., Zhang, H. Journal of chromatography. A (2007) [Pubmed]
  20. Andrograpanin, a compound isolated from anti-inflammatory traditional Chinese medicine Andrographis paniculata, enhances chemokine SDF-1alpha-induced leukocytes chemotaxis. Ji, L.L., Wang, Z., Dong, F., Zhang, W.B., Wang, Z.T. J. Cell. Biochem. (2005) [Pubmed]
  21. Andrographolide inhibits the production of TNF-alpha and interleukin-12 in lipopolysaccharide-stimulated macrophages: role of mitogen-activated protein kinases. Qin, L.H., Kong, L., Shi, G.J., Wang, Z.T., Ge, B.X. Biol. Pharm. Bull. (2006) [Pubmed]
  22. Isolation and identification of seven glucuronide conjugates of andrographolide in human urine. Cui, L., Qiu, F., Yao, X. Drug Metab. Dispos. (2005) [Pubmed]
  23. Determination of bioactive diterpenoids from Andrographis paniculata by micellar electrokinetic chromatography. Cheung, H.Y., Cheung, C.S., Kong, C.K. Journal of chromatography. A. (2001) [Pubmed]
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