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Chemical Compound Review

imidapril     (4S)-3-[(2S)-2-[[(1S)-1- ethoxycarbonyl-3...

Synonyms: Imidaprilum, Hipertene (TN), PubChem18235, SureCN34098, CHEMBL317094, ...
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Disease relevance of imidapril


High impact information on imidapril


Chemical compound and disease context of imidapril


Biological context of imidapril


Anatomical context of imidapril

  • In rats treated with imidapril the major finding was that imidapril rapidly ameliorated the damage to the blood-brain barrier and resolved brain oedema within 1 week [4].
  • CONCLUSIONS: Chronic oral treatment with imidapril and TCV-116 may have divergent influences on the renin-angiotensin system within the brain stem [15].
  • Three weeks after occluding the left coronary artery, rats were treated with or without imidapril (1 mg/kg/day), for 4 weeks [16].
  • Treatment of AVS animals with imidapril (1 or losartan (20 retarded the progression of heart failure; partially prevented changes in beta1-ARs, GRKs, and beta-arrestin-1 in the failing myocardium; and attenuated the increase in positive inotropic effect of isoproterenol [17].
  • Treatment of 3 weeks infarcted animals with imidapril (1 mg kg(-1) day(-1)) for a period of 5 weeks improved the left ventricle function and decreased the attenuation of inotropic response to ATP [18].

Associations of imidapril with other chemical compounds


Gene context of imidapril


Analytical, diagnostic and therapeutic context of imidapril

  • CONCLUSIONS: Already within 3 months after treatment initiation, high-dose ACE inhibition (with imidapril) is superior to low-dose [27].
  • METHODS AND RESULTS: For 3 weeks, we studied three groups of 20-week-old male SHR: a control group, a l-NAME group, and a group treated with L-NAME and the ACE inhibitor imidapril [3].
  • Histologically, the glomerular cell apoptosis labeling index, terminal doxynucleotidil transferase-mediated dUTP nick-end labeling of fragmented DNA (TUNEL) and active caspase-3, and TGF-beta 1 positive areas were also reduced by imidapril [3].
  • These results suggest that imidapril provides good blood pressure control without a large fluctuation of drug concentration in hypertensive patients undergoing chronic hemodialysis [10].
  • Force-length relationship in dogs as a measure of protective effect of imidapril on regional myocardial ischemia and reperfusion injury [9].


  1. Effect of the angiotensin-converting enzyme inhibitor imidapril on reactive hyperemia in patients with essential hypertension: relationship between treatment periods and resistance artery endothelial function. Higashi, Y., Sasaki, S., Nakagawa, K., Matsuura, H., Kajiyama, G., Oshima, T. J. Am. Coll. Cardiol. (2001) [Pubmed]
  2. Protective effects of imidapril on He-Ne laser-induced thrombosis in cerebral blood vessels of stroke-prone spontaneously hypertensive rats. Sasaki, Y., Noguchi, T., Seki, J., Giddings, J.C., Yamamoto, J. Thromb. Haemost. (2000) [Pubmed]
  3. Imidapril improves L-NAME-exacerbated nephrosclerosis with TGF-beta 1 inhibition in spontaneously hypertensive rats. Ono, H., Saitoh, M., Ono, Y., Ishimitu, T., Matsuoka, H. J. Hypertens. (2004) [Pubmed]
  4. Therapeutic effects of imidapril on cerebral lesions observed by magnetic resonance imaging in malignant stroke-prone spontaneously hypertensive rats. Takahashi, M., Fritz-Zieroth, B., Ohta, Y., Chikugo, T. J. Hypertens. (1994) [Pubmed]
  5. Cardiac mitogen-activated protein kinase activities are chronically increased in stroke-prone hypertensive rats. Izumi, Y., Kim, S., Murakami, T., Yamanaka, S., Iwao, H. Hypertension (1998) [Pubmed]
  6. Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension. Higashi, Y., Oshima, T., Sasaki, S., Nakano, Y., Kambe, M., Matsuura, H., Kajiyama, G. Hypertension (1998) [Pubmed]
  7. Nitric oxide release from kidneys of hypertensive rats treated with imidapril. Hirata, Y., Hayakawa, H., Kakoki, M., Tojo, A., Suzuki, E., Kimura, K., Goto, A., Kikuchi, K., Nagano, T., Hirobe, M., Omata, M. Hypertension (1996) [Pubmed]
  8. Associations between CYP11B2 gene polymorphisms and the response to angiotensin-converting enzyme inhibitors. Yu, H.M., Lin, S.G., Liu, G.Z., Zhang, Y.Q., Ma, W.J., Deng, C.Y. Clin. Pharmacol. Ther. (2006) [Pubmed]
  9. Force-length relationship in dogs as a measure of protective effect of imidapril on regional myocardial ischemia and reperfusion injury. Hosoya, K., Takeda, K., Nishikimi, T., Ishimitsu, T., Matsuoka, H. Eur. J. Pharmacol. (2000) [Pubmed]
  10. Clearance of imidapril, an Angiotensin-converting enzyme inhibitor, during hemodialysis in hypertensive renal failure patients: comparison with quinapril and enalapril. Tsuruoka, S., Kitoh, Y., Kawaguchi, A., Sugimoto, K., Hayasaka, T., Saito, T., Fujimura, A. Journal of clinical pharmacology (2007) [Pubmed]
  11. Antihypertensive agents prevent nephrosclerosis and left ventricular hypertrophy induced in rats by prolonged inhibition of nitric oxide synthesis. Akuzawa, N., Nakamura, T., Kurashina, T., Saito, Y., Hoshino, J., Sakamoto, H., Sumino, H., Ono, Z., Nagai, R. Am. J. Hypertens. (1998) [Pubmed]
  12. Modification of sarcolemmal Na+-K+-ATPase and Na+/Ca2+ exchanger expression in heart failure by blockade of renin-angiotensin system. Shao, Q., Ren, B., Elimban, V., Tappia, P.S., Takeda, N., Dhalla, N.S. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  13. Myocardial ischemia activates the JAK-STAT pathway through angiotensin II signaling in in vivo myocardium of rats. Omura, T., Yoshiyama, M., Ishikura, F., Kobayashi, H., Takeuchi, K., Beppu, S., Yoshikawa, J. J. Mol. Cell. Cardiol. (2001) [Pubmed]
  14. Single dose and steady state pharmacokinetics and pharmacodynamics of the ACE-inhibitor imidapril in hypertensive patients. Harder, S., Thürmann, P.A., Ungethüm, W. British journal of clinical pharmacology. (1998) [Pubmed]
  15. Effects of chronic oral treatment with imidapril and TCV-116 on the responsiveness to angiotensin II in ventrolateral medulla of SHR. Tsuchihashi, T., Kagiyama, S., Matsumura, K., Abe, I., Fujishima, M. J. Hypertens. (1999) [Pubmed]
  16. Modification of myosin gene expression by imidapril in failing heart due to myocardial infarction. Wang, J., Liu, X., Ren, B., Rupp, H., Takeda, N., Dhalla, N.S. J. Mol. Cell. Cardiol. (2002) [Pubmed]
  17. Upregulation of beta-adrenergic receptors in heart failure due to volume overload. Wang, X., Sentex, E., Saini, H.K., Chapman, D., Dhalla, N.S. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  18. Imidapril treatment improves the attenuated inotropic and intracellular calcium responses to ATP in heart failure due to myocardial infarction. Saini, H.K., Shao, Q., Musat, S., Takeda, N., Tappia, P.S., Dhalla, N.S. Br. J. Pharmacol. (2005) [Pubmed]
  19. Increased expression of protein kinase C isoforms in heart failure due to myocardial infarction. Wang, J., Liu, X., Sentex, E., Takeda, N., Dhalla, N.S. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  20. Induction of angiotensin converting enzyme and angiotensin II receptors in the atherosclerotic aorta of high-cholesterol fed Cynomolgus monkeys. Song, K., Shiota, N., Takai, S., Takashima, H., Iwasaki, H., Kim, S., Miyazaki, M. Atherosclerosis (1998) [Pubmed]
  21. Sarcoplasmic reticulum Ca2+ transport and gene expression in congestive heart failure are modified by imidapril treatment. Shao, Q., Ren, B., Saini, H.K., Netticadan, T., Takeda, N., Dhalla, N.S. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  22. Steady-state pharmacokinetics and pharmacodynamics of imidaprilat, an active metabolite of imidapril, a new angiotensin-converting enzyme inhibitor in spontaneously hypertensive rats. Yamanaka, K., Takehara, N., Murata, K., Banno, K., Sato, T. Journal of pharmaceutical sciences. (1996) [Pubmed]
  23. Effects of imidapril on endothelin-1 and ACE gene expression in failing hearts of salt-sensitive hypertensive rats. Kobayashi, N., Hara, K., Higashi, T., Matsuoka, H. Am. J. Hypertens. (2000) [Pubmed]
  24. Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD(P)H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats. Nakano, S., Kobayashi, N., Yoshida, K., Ohno, T., Matsuoka, H. Hypertens. Res. (2005) [Pubmed]
  25. Inhibition of nitric oxide synthesis induces coronary vascular remodeling and cardiac hypertrophy associated with the activation of p70 S6 kinase in rats. Minamino, T., Kitakaze, M., Papst, P.J., Ueda, Y., Sakata, Y., Asanuma, H., Ogai, A., Kuzuya, T., Terada, N., Hori, M. Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. (2000) [Pubmed]
  26. Important role of nitric oxide in the effect of angiotensin-converting enzyme inhibitor imidapril on vascular injury. Chen, R., Iwai, M., Wu, L., Suzuki, J., Min, L.J., Shiuchi, T., Sugaya, T., Liu, H.W., Cui, T.X., Horiuchi, M. Hypertension (2003) [Pubmed]
  27. High- versus low-dose ACE inhibition in chronic heart failure: a double-blind, placebo-controlled study of imidapril. van Veldhuisen, D.J., Genth-Zotz, S., Brouwer, J., Boomsma, F., Netzer, T., Man In 'T Veld, A.J., Pinto, Y.M., Lie, K.I., Crijns, H.J. J. Am. Coll. Cardiol. (1998) [Pubmed]
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