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Chemical Compound Review

Parapres     1- cyclohexyloxycarbonyloxyethyl 2-ethoxy-3...

Synonyms: Atacand, Racanda, Kenzen, ATACAND HCT, CHEMBL1014, ...
 
 
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Disease relevance of Candesartan cilexetil

 

High impact information on Candesartan cilexetil

  • Tumor growth was also reduced in WT mice treated with TCV-116, a selective blocker of AT1 receptor [4].
  • TCV-116 (10 mg.kg-1.d-1), a selective nonpeptide AT1 receptor antagonist, or vehicle was administered orally to rats from 1 day before to 14 days after balloon injury [5].
  • Immunohistological studies indicated that TCV-116 decreased not only the intimal thickening but also the amount of these extracellular matrix proteins in the intima [5].
  • In the in vitro study, neonatal rat cardiomyocytes were cultured on deformable silicone dishes and mechanically stretched with or without pretreatment of CV-11974 (an active metabolite of TCV-116), and [3H]phenylalanine incorporation, activity of mitogen-activated protein (MAP) kinase, and c-fos mRNA expression were analyzed [1].
  • Further evaluation of the effect of TCV-116 revealed that SHR treated with a low dose of TCV-116 (1 mg/kg per day) showed a decrease in left ventricular mass with only a little decrease in blood pressure and that the incidence of VT/Vf was reduced in association with the degree of regression of LVH [6].
 

Chemical compound and disease context of Candesartan cilexetil

 

Biological context of Candesartan cilexetil

 

Anatomical context of Candesartan cilexetil

 

Associations of Candesartan cilexetil with other chemical compounds

 

Gene context of Candesartan cilexetil

 

Analytical, diagnostic and therapeutic context of Candesartan cilexetil

References

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  2. The angiotensin II receptor antagonist candesartan cilexetil (TCV-116) ameliorates retinal disorders in rats. Nagisa, Y., Shintani, A., Nakagawa, S. Diabetologia (2001) [Pubmed]
  3. Angiotensin II type 1 receptor antagonist decreases plasma levels of tumor necrosis factor alpha, interleukin-6 and soluble adhesion molecules in patients with chronic heart failure. Tsutamoto, T., Wada, A., Maeda, K., Mabuchi, N., Hayashi, M., Tsutsui, T., Ohnishi, M., Sawaki, M., Fujii, M., Matsumoto, T., Kinoshita, M. J. Am. Coll. Cardiol. (2000) [Pubmed]
  4. Role of host angiotensin II type 1 receptor in tumor angiogenesis and growth. Egami, K., Murohara, T., Shimada, T., Sasaki, K., Shintani, S., Sugaya, T., Ishii, M., Akagi, T., Ikeda, H., Matsuishi, T., Imaizumi, T. J. Clin. Invest. (2003) [Pubmed]
  5. Angiotensin II type 1 receptor blockade inhibits the expression of immediate-early genes and fibronectin in rat injured artery. Kim, S., Kawamura, M., Wanibuchi, H., Ohta, K., Hamaguchi, A., Omura, T., Yukimura, T., Miura, K., Iwao, H. Circulation (1995) [Pubmed]
  6. Regression of left ventricular hypertrophy prevents ischemia-induced lethal arrhythmias. Beneficial effect of angiotensin II blockade. Kohya, T., Yokoshiki, H., Tohse, N., Kanno, M., Nakaya, H., Saito, H., Kitabatake, A. Circ. Res. (1995) [Pubmed]
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  12. Role of angiotensin II in renal injury of deoxycorticosterone acetate-salt hypertensive rats. Kim, S., Ohta, K., Hamaguchi, A., Omura, T., Yukimura, T., Miura, K., Inada, Y., Wada, T., Ishimura, Y., Chatani, F. Hypertension (1994) [Pubmed]
  13. Effect of the angiotensin II type 1 receptor blocker candesartan on endothelial function in patients with essential hypertension. Ghiadoni, L., Virdis, A., Magagna, A., Taddei, S., Salvetti, A. Hypertension (2000) [Pubmed]
  14. Improvement in baroreflex function by an oral angiotensin receptor antagonist in rats with myocardial infarction. Nishizawa, M., Kumagai, H., Ichikawa, M., Oshima, N., Suzuki, H., Saruta, T. Hypertension (1997) [Pubmed]
  15. Type 1 angiotensin II receptor antagonism reduces antigen-induced airway reactions. Myou, S., Fujimura, M., Kurashima, K., Tachibana, H., Watanabe, K., Hirose, T. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
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  17. Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist. Otsuka, M., Takahashi, H., Shiratori, M., Chiba, H., Abe, S. Thorax (2004) [Pubmed]
  18. Effects of chronic oral treatment with imidapril and TCV-116 on the responsiveness to angiotensin II in ventrolateral medulla of SHR. Tsuchihashi, T., Kagiyama, S., Matsumura, K., Abe, I., Fujishima, M. J. Hypertens. (1999) [Pubmed]
  19. TCV-116, a novel angiotensin II receptor antagonist, prevents intimal thickening and impairment of vascular function after carotid injury in rats. Kawamura, M., Terashita, Z., Okuda, H., Imura, Y., Shino, A., Nakao, M., Nishikawa, K. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  20. Angiotensin II type 1 receptor blockade prevents up-regulation of angiotensin II type 1A receptors in rat injured artery. Tazawa, S., Nakane, T., Chiba, S. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  21. Inhibition by angiotensin II type 1 receptor antagonist of cardiac phenotypic modulation after myocardial infarction. Hanatani, A., Yoshiyama, M., Kim, S., Omura, T., Toda, I., Akioka, K., Teragaki, M., Takeuchi, K., Iwao, H., Takeda, T. J. Mol. Cell. Cardiol. (1995) [Pubmed]
  22. Chymase as a proangiogenic factor. A possible involvement of chymase-angiotensin-dependent pathway in the hamster sponge angiogenesis model. Muramatsu, M., Katada, J., Hayashi, I., Majima, M. J. Biol. Chem. (2000) [Pubmed]
  23. Characterization of the angiotensin II receptor antagonist TCV-116 in healthy volunteers. Delacrétaz, E., Nussberger, J., Biollaz, J., Waeber, B., Brunner, H.R. Hypertension (1995) [Pubmed]
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  28. Effects of TCV-116 on endothelin-1 and PDGF A-chain expression in angiotensin II-induced hypertensive rats. Hara, K., Kobayashi, N., Nakano, S., Mori, Y., Tsubokou, Y., Matsuoka, H. Hypertens. Res. (2001) [Pubmed]
  29. Angiotensin II receptor antagonist TCV-116 reduces graft coronary artery disease and preserves graft status in a murine model. A comparative study with captopril. Furukawa, Y., Matsumori, A., Hirozane, T., Sasayama, S. Circulation (1996) [Pubmed]
  30. Candesartan cilexetil protects against loss of autoregulatory efficiency in angiotensin II-infused rats. Inscho, E.W., Imig, J.D., Deichmann, P.C., Cook, A.K. J. Am. Soc. Nephrol. (1999) [Pubmed]
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  32. Use of candesartan cilexetil decreases proteinuria in renal transplant patients with chronic allograft dysfunction. Omoto, K., Tanabe, K., Tokumoto, T., Shimmura, H., Ishida, H., Toma, H. Transplantation (2003) [Pubmed]
 
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