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MeSH Review


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Disease relevance of Nephrosclerosis


High impact information on Nephrosclerosis

  • Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial [6].
  • Elevated levels of endogenous angiotensin can cause hypertensive nephrosclerosis as a result of the potent vasopressor action of the peptide [7].
  • It is suggested that the vascular changes of nephrosclerosis, which may be seen in both hypertensive and normal subjects, result in a reduction of afferent arteriolar distensibility, with impairment of basal renin secretion and responsiveness [8].
  • Thus, in patients with hypertensive nephrosclerosis and early impairment of glomerular filtration, alterations of glucose metabolism become evident only when creatinine clearance is < 50 ml.min(-1).1.73 m(-2) and are not related to microalbuminuria and cardiovascular complications [9].
  • Thus, the T-type (mibefradil) and L-type (amlodipine) calcium antagonists each prevented and reversed the pathophysiological alterations of L-NAME-exacerbated hypertensive nephrosclerosis in SHR [10].

Chemical compound and disease context of Nephrosclerosis


Biological context of Nephrosclerosis


Anatomical context of Nephrosclerosis


Gene context of Nephrosclerosis

  • CRP was higher in patients with a previous history of cardiovascular disease (P<0.01), as well as in patients in whom ischaemic nephropathy or nephrosclerosis was the cause of end-stage renal disease (P<0.01) [25].
  • CONCLUSION: In the remnant kidney model, the time course and localization of TSP-1 are consistent with its playing a role as a local activator of TGF-beta1, thereby potentially participating in the development of nephrosclerosis [26].
  • We studied the expression of TSP-1 mRNA and protein during the development of glomerular and tubulointerstitial nephrosclerosis in the renal ablation model particularly in relation to TGF-beta1 expression [26].
  • In human patients with essential hypertension, atherosclerosis, and nephrosclerosis, plasma ET-1 levels are increased compared with patients with uncomplicated essential hypertension [27].
  • L-PGDS was stained in the tubules and the interstitium of the kidney in nephrosclerosis [28].

Analytical, diagnostic and therapeutic context of Nephrosclerosis


  1. Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. The Angiotensin-Converting-Enzyme Inhibition in Progressive Renal Insufficiency Study Group. Maschio, G., Alberti, D., Janin, G., Locatelli, F., Mann, J.F., Motolese, M., Ponticelli, C., Ritz, E., Zucchelli, P. N. Engl. J. Med. (1996) [Pubmed]
  2. Evaluation of serum creatinine for estimating glomerular filtration rate in African Americans with hypertensive nephrosclerosis: results from the African-American Study of Kidney Disease and Hypertension (AASK) Pilot Study. Toto, R.D., Kirk, K.A., Coresh, J., Jones, C., Appel, L., Wright, J., Campese, V., Olutade, B., Agodoa, L. J. Am. Soc. Nephrol. (1997) [Pubmed]
  3. Expression of advanced glycation end products and their cellular receptor RAGE in diabetic nephropathy and nondiabetic renal disease. Tanji, N., Markowitz, G.S., Fu, C., Kislinger, T., Taguchi, A., Pischetsrieder, M., Stern, D., Schmidt, A.M., D'Agati, V.D. J. Am. Soc. Nephrol. (2000) [Pubmed]
  4. Diuretic potency of combined hydrochlorothiazide and furosemide therapy in patients with azotemia. Wollam, G.L., Tarazi, R.C., Bravo, E.L., Dustan, H.P. Am. J. Med. (1982) [Pubmed]
  5. Adverse effect of the calcium channel blocker nitrendipine on nephrosclerosis in rats with renovascular hypertension. Wenzel, U.O., Troschau, G., Schoeppe, W., Helmchen, U., Schwietzer, G. Hypertension (1992) [Pubmed]
  6. Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial. Agodoa, L.Y., Appel, L., Bakris, G.L., Beck, G., Bourgoignie, J., Briggs, J.P., Charleston, J., Cheek, D., Cleveland, W., Douglas, J.G., Douglas, M., Dowie, D., Faulkner, M., Gabriel, A., Gassman, J., Greene, T., Hall, Y., Hebert, L., Hiremath, L., Jamerson, K., Johnson, C.J., Kopple, J., Kusek, J., Lash, J., Lea, J., Lewis, J.B., Lipkowitz, M., Massry, S., Middleton, J., Miller, E.R., Norris, K., O'Connor, D., Ojo, A., Phillips, R.A., Pogue, V., Rahman, M., Randall, O.S., Rostand, S., Schulman, G., Smith, W., Thornley-Brown, D., Tisher, C.C., Toto, R.D., Wright, J.T., Xu, S. JAMA (2001) [Pubmed]
  7. Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. Niimura, F., Labosky, P.A., Kakuchi, J., Okubo, S., Yoshida, H., Oikawa, T., Ichiki, T., Naftilan, A.J., Fogo, A., Inagami, T. J. Clin. Invest. (1995) [Pubmed]
  8. Low-renin hypertension: nephrosclerosis? Swales, J.D. Lancet (1975) [Pubmed]
  9. Abnormalities of glucose metabolism in patients with early renal failure. Sechi, L.A., Catena, C., Zingaro, L., Melis, A., De Marchi, S. Diabetes (2002) [Pubmed]
  10. Differential effects of T- and L-type calcium antagonists on glomerular dynamics in spontaneously hypertensive rats. Nakamura, Y., Ono, H., Frohlich, E.D. Hypertension (1999) [Pubmed]
  11. Effects of amlodipine on glomerular filtration, growth, and injury in experimental hypertension. Dworkin, L.D., Tolbert, E., Recht, P.A., Hersch, J.C., Feiner, H., Levin, R.I. Hypertension (1996) [Pubmed]
  12. Renoprotective effects of felodipine and/or enalapril in spontaneously hypertensive rats with and without L-NAME. Francischetti, A., Ono, H., Frohlich, E.D. Hypertension (1998) [Pubmed]
  13. Aldosterone and the hypertensive kidney: its emerging role as a mediator of progressive renal dysfunction: a paradigm shift. Epstein, M. J. Hypertens. (2001) [Pubmed]
  14. L-arginine reverses severe nephrosclerosis in aged spontaneously hypertensive rats. Ono, H., Ono, Y., Frohlich, E.D. J. Hypertens. (1999) [Pubmed]
  15. Imidapril improves L-NAME-exacerbated nephrosclerosis with TGF-beta 1 inhibition in spontaneously hypertensive rats. Ono, H., Saitoh, M., Ono, Y., Ishimitu, T., Matsuoka, H. J. Hypertens. (2004) [Pubmed]
  16. N- and L-type calcium channel antagonist improves glomerular dynamics, reverses severe nephrosclerosis, and inhibits apoptosis and proliferation in an l-NAME/SHR model. Zhou, X., Ono, H., Ono, Y., Frohlich, E.D. J. Hypertens. (2002) [Pubmed]
  17. Effects of early and late antihypertensive treatment on extracellular matrix proteins and mononuclear cells in uninephrectomized SHR. Geiger, H., Fierlbeck, W., Mai, M., Ruchti, H., Schönfeld, V., Dämmrich, J., Hugo, C., Neumayer, H.H. Kidney Int. (1997) [Pubmed]
  18. Short- and long-term effects of fish oil on proteinuria, morphology and renal hemodynamics in the Milan normotensive rat model of spontaneous glomerulosclerosis. Eberhard, O.K., Pötschick, H., Neumann, K.H., Kliem, V., Brunkhorst, R. Kidney Blood Press. Res. (1999) [Pubmed]
  19. Crosslink breakers: a new approach to cardiovascular therapy. Susic, D., Varagic, J., Ahn, J., Frohlich, E.D. Curr. Opin. Cardiol. (2004) [Pubmed]
  20. Experimental studies on the role of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 in hypertensive nephrosclerosis. Mai, M., Hilgers, K.F., Geiger, H. Hypertension (1996) [Pubmed]
  21. Hyaline arteriolar nephrosclerosis. Immunofluorescence findings in the vascular lesions. Valenzuela, R., Gogate, P.A., Deodhar, S.D., Gifford, R.W. Lab. Invest. (1980) [Pubmed]
  22. Severe hypertensive sequelae in a child with Seckel syndrome (bird-like dwarfism). Sorof, J.M., Dow-Smith, C., Moore, P.J. Pediatr. Nephrol. (1999) [Pubmed]
  23. Renal insufficiency due to angiotensin-converting enzyme inhibitors. Toto, R.D. Mineral and electrolyte metabolism. (1994) [Pubmed]
  24. Angiotensin AT1/AT2 receptors: regulation, signalling and function. Kaschina, E., Unger, T. Blood Press. (2003) [Pubmed]
  25. Significance of high C-reactive protein levels in pre-dialysis patients. Ortega, O., Rodriguez, I., Gallar, P., Carreño, A., Ortiz, M., Espejo, B., Jimenez, J., Gutierrez, M., Oliet, A., Vigil, A. Nephrol. Dial. Transplant. (2002) [Pubmed]
  26. Sustained expression of thrombospondin-1 is associated with the development of glomerular and tubulointerstitial fibrosis in the remnant kidney model. Hugo, C., Kang, D.H., Johnson, R.J. Nephron (2002) [Pubmed]
  27. Endothelin-1 in chronic renal failure and hypertension. Larivière, R., Lebel, M. Can. J. Physiol. Pharmacol. (2003) [Pubmed]
  28. Lipocalin-type prostaglandin d synthase in essential hypertension. Hirawa, N., Uehara, Y., Yamakado, M., Toya, Y., Gomi, T., Ikeda, T., Eguchi, Y., Takagi, M., Oda, H., Seiki, K., Urade, Y., Umemura, S. Hypertension (2002) [Pubmed]
  29. Increased fibrinogen levels and hemostatic abnormalities in patients with arteriolar nephrosclerosis: association with cardiovascular events. Sechi, L.A., Zingaro, L., Catena, C., De Marchi, S. Thromb. Haemost. (2000) [Pubmed]
  30. Hydrochlorothiazide exacerbates nitric oxide-blockade nephrosclerosis with glomerular hypertension in spontaneously hypertensive rats. Ono, Y., Ono, H., Frohlich, E.D. J. Hypertens. (1996) [Pubmed]
  31. Tuberous sclerosis, associated with renal cell carcinoma and angiomyolipoma, in a patient who developed endstage renal failure after nephrectomy. Kida, Y., Yamaguchi, K., Suzuki, H., Kanda, E., Ando, M., Ohashi, K., Funata, N., Saito, H. Clin. Exp. Nephrol. (2005) [Pubmed]
  32. Possible relationship between hyperinsulinemia and glomerular hypertrophy in nephrosclerosis. Hotta, O., Taguma, Y., Chiba, S., Sudou, K., Horigome, I., Yusa, N., Furuta, T. Renal failure. (1996) [Pubmed]
  33. Clinical trials report. The effect of Ramipril versus Amlodipine on renal outcomes in hypertension nephrosclerosis. Vidt, D.G. Current hypertension reports. (2001) [Pubmed]
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