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Chemical Compound Review

Splenda     (2R,3R,4R,5R,6R)-2- [(2S,3S,4S,5R)-2,5...

Synonyms: Sucralose, SureCN3686, CCRIS 8449, NSC-759272, AC1Q3FKY, ...
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Disease relevance of C12285


Psychiatry related information on C12285


High impact information on C12285


Chemical compound and disease context of C12285


Biological context of C12285


Anatomical context of C12285


Associations of C12285 with other chemical compounds

  • This work describes an electrochemical technique that is suitable for the rapid and sensitive screening of the sweetener sucralose based on surface-stabilized bilayer lipid membranes (s-BLMs) composed of egg phosphatidylcholine [14].
  • 51Cr-EDTA and lactulose correlated in basal 0-6 h permeability testing (r = 0.529, P < 0.0001), as did 6-24 h excretion of 51Cr-EDTA and sucralose (r = 0.474, P < 0.001); 97% and 90% of the subjects had a permeability increase after indomethacin intake for 0-6 h and 6-24 h excretion of Cr-EDTA, respectively [16].
  • One urinary metabolite was detected after both intravenous and oral doses and was identified by mass spectrometry as a glucuronic acid conjugate of sucralose [17].
  • Additional information can be gained when sucralose is administered in combination with lactulose and a monosaccharide such as L-rhamnose in the form of a 'triple sugar test.' We describe a simple assay for urinary sucralose by HPLC with refractive index detection (HPLC-RI) [18].
  • The %Delta in FC were compared to %Delta in BWG after 52 weeks on study in one saccharin (825 rats), two sucralose (480 rats), two neotame (630 rats), and five dietary restriction (>1000 rats) studies [19].

Gene context of C12285

  • Our earlier work demonstrated that the sweetener sucralose, C12 H19 CI3 O8, mixed with water had no effect on intraoral plaque pH [12].

Analytical, diagnostic and therapeutic context of C12285


  1. Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease. Brown, G.R., Lindberg, G., Meddings, J., Silva, M., Beutler, B., Thiele, D. Gastroenterology (1999) [Pubmed]
  2. Glycemic effect of a single high oral dose of the novel sweetener sucralose in patients with diabetes. Mezitis, N.H., Maggio, C.A., Koch, P., Quddoos, A., Allison, D.B., Pi-Sunyer, F.X. Diabetes Care (1996) [Pubmed]
  3. The influence of sucralose on bacterial metabolism. Young, D.A., Bowen, W.H. J. Dent. Res. (1990) [Pubmed]
  4. The effects of sucralose on coronal and root-surface caries. Bowen, W.H., Young, D.A., Pearson, S.K. J. Dent. Res. (1990) [Pubmed]
  5. Female rats show a bimodal preference response to the artificial sweetener sucralose. Sclafani, A., Clare, R.A. Chem. Senses (2004) [Pubmed]
  6. Noncariogenic intense natural sweeteners. Kinghorn, A.D., Kaneda, N., Baek, N.I., Kennelly, E.J., Soejarto, D.D. Medicinal research reviews. (1998) [Pubmed]
  7. Sugarcane ShSUT1: analysis of sucrose transport activity and inhibition by sucralose. Reinders, A., Sivitz, A.B., Hsi, A., Grof, C.P., Perroux, J.M., Ward, J.M. Plant Cell Environ. (2006) [Pubmed]
  8. Migraine triggered by sucralose--a case report. Bigal, M.E., Krymchantowski, A.V. Headache. (2006) [Pubmed]
  9. Sucralose metabolism and pharmacokinetics in man. Roberts, A., Renwick, A.G., Sims, J., Snodin, D.J. Food Chem. Toxicol. (2000) [Pubmed]
  10. Sucralose: lack of effects on sperm glycolysis and reproduction in the rat. Kille, J.W., Ford, W.C., McAnulty, P., Tesh, J.M., Ross, F.W., Willoughby, C.R. Food Chem. Toxicol. (2000) [Pubmed]
  11. Neurotoxicity studies on sucralose and its hydrolysis products with special reference to histopathologic and ultrastructural changes. Finn, J.P., Lord, G.H. Food Chem. Toxicol. (2000) [Pubmed]
  12. Effect of sucralose in coffee on plaque pH in human subjects. Steinberg, L.M., Odusola, F., Mandel, I.D. Caries Res. (1996) [Pubmed]
  13. Sucralose: assessment of teratogenic potential in the rat and the rabbit. Kille, J.W., Tesh, J.M., McAnulty, P.A., Ross, F.W., Willoughby, C.R., Bailey, G.P., Wilby, O.K., Tesh, S.A. Food Chem. Toxicol. (2000) [Pubmed]
  14. A minisensor for the rapid screening of sucralose based on surface-stabilized bilayer lipid membranes. Nikolelis, D.P., Pantoulias, S. Biosensors & bioelectronics. (2000) [Pubmed]
  15. Lack of DNA-damaging activity of five non-nutritive sweeteners in the rat hepatocyte/DNA repair assay. Jeffrey, A.M., Williams, G.M. Food Chem. Toxicol. (2000) [Pubmed]
  16. In vivo influence of nicotine on human basal and NSAID-induced gut barrier function. Suenaert, P., Bulteel, V., Den Hond, E., Geypens, B., Monsuur, F., Luypaerts, A., Ghoos, Y., Rutgeerts, P. Scand. J. Gastroenterol. (2003) [Pubmed]
  17. The pharmacokinetics and metabolism of sucralose in the dog. Wood, S.G., John, B.A., Hawkins, D.R. Food Chem. Toxicol. (2000) [Pubmed]
  18. A simple method for the analysis of urinary sucralose for use in tests of intestinal permeability. Anderson, A.D., Poon, P., Greenway, G.M., MacFie, J. Ann. Clin. Biochem. (2005) [Pubmed]
  19. Long-term food consumption and body weight changes in neotame safety studies are consistent with the allometric relationship observed for other sweeteners and during dietary restrictions. Flamm, W.G., Blackburn, G.L., Comer, C.P., Mayhew, D.A., Stargel, W.W. Regulatory toxicology and pharmacology : RTP. (2003) [Pubmed]
  20. Acute and subchronic toxicity of sucralose. Goldsmith, L.A. Food Chem. Toxicol. (2000) [Pubmed]
  21. Determination of the artificial sweetener Sucralose by capillary electrophoresis. Stroka, J., Dossi, N., Anklam, E. Food additives and contaminants. (2003) [Pubmed]
  22. Repeated dose study of sucralose tolerance in human subjects. Baird, I.M., Shephard, N.W., Merritt, R.J., Hildick-Smith, G. Food Chem. Toxicol. (2000) [Pubmed]
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