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Chemical Compound Review

TPC-I139     2,2,2-trichloroethanol

Synonyms: CHEMBL1171, CPD-9673, CCRIS 6763, T54801_ALDRICH, AG-D-36163, ...
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Disease relevance of NSC66407


High impact information on NSC66407


Chemical compound and disease context of NSC66407


Biological context of NSC66407


Anatomical context of NSC66407


Associations of NSC66407 with other chemical compounds


Gene context of NSC66407


Analytical, diagnostic and therapeutic context of NSC66407


  1. Fate of 2,2,2-trichloroacetaldehyde (chloral hydrate) produced during trichloroethylene oxidation by methanotrophs. Newman, L.M., Wackett, L.P. Appl. Environ. Microbiol. (1991) [Pubmed]
  2. Differential effects of anesthetics on mitochondrial K(ATP) channel activity and cardiomyocyte protection. Zaugg, M., Lucchinetti, E., Spahn, D.R., Pasch, T., Garcia, C., Schaub, M.C. Anesthesiology (2002) [Pubmed]
  3. Ethanol and trichloroethanol alter gating of 5-HT3 receptor-channels in NCB-20 neuroblastoma cells. Lovinger, D.M., Sung, K.W., Zhou, Q. Neuropharmacology (2000) [Pubmed]
  4. Trichloroethanol alters action potentials in a subgroup of primary sensory neurones. Gruss, M., Hempelmann, G., Scholz, A. Neuroreport (2002) [Pubmed]
  5. Biodegradation of trichloroethylene by Mycobacterium vaccae. Vanderberg, L.A., Burback, B.L., Perry, J.J. Can. J. Microbiol. (1995) [Pubmed]
  6. Identification of trichloroethanol visualized proteins from two-dimensional polyacrylamide gels by mass spectrometry. Ladner, C.L., Edwards, R.A., Schriemer, D.C., Turner, R.J. Anal. Chem. (2006) [Pubmed]
  7. Issues in the pharmacokinetics of trichloroethylene and its metabolites. Chiu, W.A., Okino, M.S., Lipscomb, J.C., Evans, M.V. Environ. Health Perspect. (2006) [Pubmed]
  8. Application of cryopreserved human hepatocytes in trichloroethylene risk assessment: relative disposition of chloral hydrate to trichloroacetate and trichloroethanol. Bronley-DeLancey, A., McMillan, D.C., McMillan, J.M., Jollow, D.J., Mohr, L.C., Hoel, D.G. Environ. Health Perspect. (2006) [Pubmed]
  9. Trichloroethanol enhances the activity of recombinant human TREK-1 and TRAAK channels. Harinath, S., Sikdar, S.K. Neuropharmacology (2004) [Pubmed]
  10. Fluorescence quenching as an indicator for the exposure of tryptophyl residues in Streptomyces subtilisin inhibitor. Komiyama, T., Miwa, M. J. Biochem. (1980) [Pubmed]
  11. Trichloroethanol potentiates synaptic transmission mediated by gamma-aminobutyric acidA receptors in hippocampal neurons. Lovinger, D.M., Zimmerman, S.A., Levitin, M., Jones, M.V., Harrison, N.L. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  12. Mouse liver microsomal metabolism of chloral hydrate, trichloroacetic acid, and trichloroethanol leading to induction of lipid peroxidation via a free radical mechanism. Ni, Y.C., Wong, T.Y., Lloyd, R.V., Heinze, T.M., Shelton, S., Casciano, D., Kadlubar, F.F., Fu, P.P. Drug Metab. Dispos. (1996) [Pubmed]
  13. A maximum of two tryptophan residues in gene-32 protein from phage T4 undergo stacking interactions with single-stranded polynucleotides. Casas-Finet, J.R., Toulmé, J.J., Santus, R., Maki, A.H. Eur. J. Biochem. (1988) [Pubmed]
  14. Species differences in the metabolism of trichloroethylene to the carcinogenic metabolites trichloroacetate and dichloroacetate. Larson, J.L., Bull, R.J. Toxicol. Appl. Pharmacol. (1992) [Pubmed]
  15. Gel filtration of myelin using 2,2,2-trichloroethanol as the solvent. Wolfgram, F., Myers, L. J. Neurobiol. (1975) [Pubmed]
  16. Enhancement of gamma-aminobutyric acidA receptor activity by alpha-chloralose. Garrett, K.M., Gan, J. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  17. Trichloroethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in nodose ganglion neurons from the adult rat. Lovinger, D.M., Zhou, Q. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  18. The interaction of trichloroethanol with murine recombinant 5-HT3 receptors. Downie, D.L., Hope, A.G., Belelli, D., Lambert, J.J., Peters, J.A., Bentley, K.R., Steward, L.J., Chen, C.Y., Barnes, N.M. Br. J. Pharmacol. (1995) [Pubmed]
  19. 5-HT(3) receptor function and potentiation by alcohols in frontal cortex neurons from transgenic mice overexpressing the receptor. Sung, K.W., Engel, S.R., Allan, A.M., Lovinger, D.M. Neuropharmacology (2000) [Pubmed]
  20. Trichloroethanol potentiation of gamma-aminobutyric acid-activated chloride current in mouse hippocampal neurones. Peoples, R.W., Weight, F.F. Br. J. Pharmacol. (1994) [Pubmed]
  21. Studies of stools from pseudomembranous colitis, rotaviral, and other diarrheal syndromes by frequency-pulsed electron capture gas-liquid chromatography. Brooks, J.B., Nunez-Montiel, O.L., Basta, M.T., Hierholzer, J.C. J. Clin. Microbiol. (1984) [Pubmed]
  22. Trichloroethanol modulation of recombinant GABAA, glycine and GABA rho 1 receptors. Krasowski, M.D., Finn, S.E., Ye, Q., Harrison, N.L. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  23. Species- and sex-related differences in metabolism of trichloroethylene to yield chloral and trichloroethanol in mouse, rat, and human liver microsomes. Elfarra, A.A., Krause, R.J., Last, A.R., Lash, L.H., Parker, J.C. Drug Metab. Dispos. (1998) [Pubmed]
  24. Trichloroethanol impairs NMDA receptor function in rat mesencephalic and cortical neurones. Scheibler, P., Kronfeld, A., Illes, P., Allgaier, C. Eur. J. Pharmacol. (1999) [Pubmed]
  25. 5-hydroxytryptamine3 (5-HT3) receptor-mediated depolarisation of the rat isolated vagus nerve: modulation by trichloroethanol and related alcohols. Bentley, K.R., Barnes, N.M. Eur. J. Pharmacol. (1998) [Pubmed]
  26. Circadian variations in trichloroethylene toxicity under a 12:12 hr light-dark cycle and their alterations under constant darkness in rats. Motohashi, Y., Kawakami, T., Miyazaki, Y., Takano, T., Ekataksin, W. Toxicol. Appl. Pharmacol. (1990) [Pubmed]
  27. Interactive effects between trichloroethylene and pesticides at metabolic and genetic level in mice. Hrelia, P., Maffei, F., Vigagni, F., Fimognari, C., Flori, P., Stanzani, R., Cantelli Forti, G. Environ. Health Perspect. (1994) [Pubmed]
  28. Determination of trichloroethanol, the active metabolite of chloral hydrate, in plasma by liquid chromatography. Gupta, R.N. J. Chromatogr. (1990) [Pubmed]
  29. Visible fluorescent detection of proteins in polyacrylamide gels without staining. Ladner, C.L., Yang, J., Turner, R.J., Edwards, R.A. Anal. Biochem. (2004) [Pubmed]
  30. Resolved fluorescence of the two tryptophan residues in horse apomyoglobin. Glandières, J.M., Twist, C., Haouz, A., Zentz, C., Alpert, B. Photochem. Photobiol. (2000) [Pubmed]
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