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Gene Review

CXCL13  -  chemokine (C-X-C motif) ligand 13

Homo sapiens

Synonyms: ANGIE, ANGIE2, Angie, B cell-attracting chemokine 1, B lymphocyte chemoattractant, ...
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Disease relevance of CXCL13


Psychiatry related information on CXCL13

  • Preliminary psychometric properties of a new instrument, Angie/Andy Cartoon Trauma Scales (ACTS), are presented [5].

High impact information on CXCL13


Biological context of CXCL13


Anatomical context of CXCL13


Chemical compound and disease context of CXCL13


Associations of CXCL13 with chemical compounds

  • Interestingly, monocytes from healthy donors stimulated in vitro with lipopolysaccharide secrete CXCL13 [2].
  • In addition, human BCA-1 is an agonist in stimulating GTP gamma S binding [14].
  • Cyclosporine inhibited CTL expansion and cytotoxicity similarly in both EC- and BLC-stimulated cultures but did not affect the phenotype of those CTL that did emerge [15].
  • A synthetic peptide corresponding to the CaM-binding domain of BCA1p (Ala-19 to Leu-43) strongly inhibited ATP-dependent Ca(2+) pumping by BCA1p in cauliflower low-density membranes, indicating that the CaM-binding region of BCA1p also has an autoinhibitory function [16].
  • CONCLUSIONS: BLC stimulation is sufficient to reinstate cocaine-seeking behavior in the rat [17].

Regulatory relationships of CXCL13

  • Interestingly, ligation of the CD40 molecule down-regulated BLC expression in monocyte-derived DC [18].

Other interactions of CXCL13

  • Moreover, OBs from OA patients released a higher amount of CXCL13 than those of PT patients while no differences were found for CXCL12 [9].
  • Correspondingly, TNF-alpha-stimulated pre-B cells chemotaxed towards CCL19 and CXCL13, in contrast to non-TNF-alpha-stimulated controls [19].
  • SDF-1alpha and BCA-1 also induced DNA synthesis and chondrocyte proliferation, as was shown by the up-regulation of S100A4 in cartilage explants as well [20].
  • Our data suggest that CXCL13 may modulate angiogenesis by interfering with FGF-2 activity [21].
  • The third wave, which occurs after 24 to 48 hours, when DCs have reached the lymphoid organs, includes CCL19, CCL22, and CXCL13, which attract naive T and B lymphocytes [22].

Analytical, diagnostic and therapeutic context of CXCL13


  1. Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma. Smith, J.R., Braziel, R.M., Paoletti, S., Lipp, M., Uguccioni, M., Rosenbaum, J.T. Blood (2003) [Pubmed]
  2. Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis. Carlsen, H.S., Baekkevold, E.S., Morton, H.C., Haraldsen, G., Brandtzaeg, P. Blood (2004) [Pubmed]
  3. Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection. Widney, D.P., Breen, E.C., Boscardin, W.J., Kitchen, S.G., Alcantar, J.M., Smith, J.B., Zack, J.A., Detels, R., Martínez-Maza, O. J. Interferon Cytokine Res. (2005) [Pubmed]
  4. Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment. Krumbholz, M., Theil, D., Cepok, S., Hemmer, B., Kivisäkk, P., Ransohoff, R.M., Hofbauer, M., Farina, C., Derfuss, T., Hartle, C., Newcombe, J., Hohlfeld, R., Meinl, E. Brain (2006) [Pubmed]
  5. A preliminary study of a cartoon measure for children's reactions to chronic trauma. Praver, F., DiGiuseppe, R., Pelcovitz, D., Mandel, F.S., Gaines, R. Child maltreatment. (2000) [Pubmed]
  6. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. Schaerli, P., Willimann, K., Lang, A.B., Lipp, M., Loetscher, P., Moser, B. J. Exp. Med. (2000) [Pubmed]
  7. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. Legler, D.F., Loetscher, M., Roos, R.S., Clark-Lewis, I., Baggiolini, M., Moser, B. J. Exp. Med. (1998) [Pubmed]
  8. BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma. Mazzucchelli, L., Blaser, A., Kappeler, A., Schärli, P., Laissue, J.A., Baggiolini, M., Uguccioni, M. J. Clin. Invest. (1999) [Pubmed]
  9. CXCL12 (SDF-1) and CXCL13 (BCA-1) chemokines significantly induce proliferation and collagen type I expression in osteoblasts from osteoarthritis patients. Lisignoli, G., Toneguzzi, S., Piacentini, A., Cristino, S., Grassi, F., Cavallo, C., Facchini, A. J. Cell. Physiol. (2006) [Pubmed]
  10. Distinct transcriptional programs activated by interleukin-10 with or without lipopolysaccharide in dendritic cells: induction of the B cell-activating chemokine, CXC chemokine ligand 13. Perrier, P., Martinez, F.O., Locati, M., Bianchi, G., Nebuloni, M., Vago, G., Bazzoni, F., Sozzani, S., Allavena, P., Mantovani, A. J. Immunol. (2004) [Pubmed]
  11. Selectively frequent expression of CXCR5 enhances resistance to apoptosis in CD8(+)CD34(+) T cells from patients with T-cell-lineage acute lymphocytic leukemia. Qiuping, Z., Jie, X., Youxin, J., Qun, W., Wei, J., Chun, L., Jin, W., Yan, L., Chunsong, H., Mingzhen, Y., Qingping, G., Qun, L., Kejian, Z., Zhimin, S., Junyan, L., Jinquan, T. Oncogene (2005) [Pubmed]
  12. CXCL13 (BCA-1) is produced by follicular lymphoma cells: role in the accumulation of malignant B cells. Husson, H., Freedman, A.S., Cardoso, A.A., Schultze, J., Munoz, O., Strola, G., Kutok, J., Carideo, E.G., De Beaumont, R., Caligaris-Cappio, F., Ghia, P. Br. J. Haematol. (2002) [Pubmed]
  13. Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia. Bürkle, A., Niedermeier, M., Schmitt-Gräff, A., Wierda, W.G., Keating, M.J., Burger, J.A. Blood (2007) [Pubmed]
  14. Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor. Jenh, C.H., Cox, M.A., Hipkin, W., Lu, T., Pugliese-Sivo, C., Gonsiorek, W., Chou, C.C., Narula, S.K., Zavodny, P.J. Cytokine (2001) [Pubmed]
  15. Human vascular endothelial cells stimulate memory but not naive CD8+ T cells to differentiate into CTL retaining an early activation phenotype. Dengler, T.J., Pober, J.S. J. Immunol. (2000) [Pubmed]
  16. Regulatory role of the N terminus of the vacuolar calcium-ATPase in cauliflower. Malmström, S., Akerlund, H.E., Askerlund, P. Plant Physiol. (2000) [Pubmed]
  17. Electrical and chemical stimulation of the basolateral complex of the amygdala reinstates cocaine-seeking behavior in the rat. Hayes, R.J., Vorel, S.R., Spector, J., Liu, X., Gardner, E.L. Psychopharmacology (Berl.) (2003) [Pubmed]
  18. BLC (CXCL13) is expressed by different dendritic cell subsets in vitro and in vivo. Vissers, J.L., Hartgers, F.C., Lindhout, E., Figdor, C.G., Adema, G.J. Eur. J. Immunol. (2001) [Pubmed]
  19. Developmental stage-specific shift in responsiveness to chemokines during human B-cell development. Honczarenko, M., Glodek, A.M., Swierkowski, M., Na, I.K., Silberstein, L.E. Exp. Hematol. (2006) [Pubmed]
  20. A role for chemokines in the induction of chondrocyte phenotype modulation. Mazzetti, I., Magagnoli, G., Paoletti, S., Uguccioni, M., Olivotto, E., Vitellozzi, R., Cattini, L., Facchini, A., Borzì, R.M. Arthritis Rheum. (2004) [Pubmed]
  21. The chemokine CXCL13 (BCA-1) inhibits FGF-2 effects on endothelial cells. Spinetti, G., Camarda, G., Bernardini, G., Romano Di Peppe, S., Capogrossi, M.C., Napolitano, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  22. Upon viral exposure, myeloid and plasmacytoid dendritic cells produce 3 waves of distinct chemokines to recruit immune effectors. Piqueras, B., Connolly, J., Freitas, H., Palucka, A.K., Banchereau, J. Blood (2006) [Pubmed]
  23. Expression of the B cell-attracting chemokine CXCL13 in the target organ and autoantibody production in ectopic lymphoid tissue in the chronic inflammatory disease Sjögren's syndrome. Salomonsson, S., Larsson, P., Tengnér, P., Mellquist, E., Hjelmström, P., Wahren-Herlenius, M. Scand. J. Immunol. (2002) [Pubmed]
  24. BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection. Steinmetz, O.M., Panzer, U., Kneissler, U., Harendza, S., Lipp, M., Helmchen, U., Stahl, R.A. Kidney Int. (2005) [Pubmed]
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