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Gene Review

Itgb2  -  integrin beta 2

Mus musculus

Synonyms: 2E6, AI528527, Cd18, Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta, Complement receptor C3 subunit beta, ...
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Disease relevance of Itgb2


High impact information on Itgb2


Chemical compound and disease context of Itgb2


Biological context of Itgb2


Anatomical context of Itgb2


Associations of Itgb2 with chemical compounds


Physical interactions of Itgb2


Regulatory relationships of Itgb2


Other interactions of Itgb2


Analytical, diagnostic and therapeutic context of Itgb2


  1. Inhibition of accelerated coronary atherosclerosis with short-term blockade of intercellular adhesion molecule-1 and lymphocyte function-associated antigen-1 in a heterotopic murine model of heart transplantation. Suzuki, J., Isobe, M., Yamazaki, S., Horie, S., Okubo, Y., Sekiguchi, M. J. Heart Lung Transplant. (1997) [Pubmed]
  2. Prevention of endotoxin-induced acute lethality in Propionibacterium acnes-primed rabbits by an antibody to leukocyte integrin beta 2 with concomitant reduction of cytokine production. Ikeda, N., Mukaida, N., Kaneko, S., Fujioka, N., Su, S., Nariuchi, H., Unoura, M., Harada, K., Nakanuma, Y., Kobayashi, K. Infect. Immun. (1995) [Pubmed]
  3. Selective in vivo growth of lymphocyte function- associated antigen-1-positive murine myeloma cells. Involvement of function-associated antigen-1-mediated homotypic cell-cell adhesion. Asosingh, K., Vankerkhove, V., Van Riet, I., Van Camp, B., Vanderkerken, K. Exp. Hematol. (2003) [Pubmed]
  4. Prevention of adoptive transfer of murine Sjögren's syndrome into severe combined immunodeficient (SCID) mice by antibodies against intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1). Hayashi, Y., Haneji, N., Yanagi, K., Higashiyama, H., Yagita, H., Hamano, H. Clin. Exp. Immunol. (1995) [Pubmed]
  5. Antibodies to intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 prevent crescent formation in rat autoimmune glomerulonephritis. Nishikawa, K., Guo, Y.J., Miyasaka, M., Tamatani, T., Collins, A.B., Sy, M.S., McCluskey, R.T., Andres, G. J. Exp. Med. (1993) [Pubmed]
  6. Differential requirement for CD18 in T-helper effector homing. Lee, S.H., Prince, J.E., Rais, M., Kheradmand, F., Shardonofsky, F., Lu, H., Beaudet, A.L., Smith, C.W., Soong, L., Corry, D.B. Nat. Med. (2003) [Pubmed]
  7. Role for plastin in host defense distinguishes integrin signaling from cell adhesion and spreading. Chen, H., Mocsai, A., Zhang, H., Ding, R.X., Morisaki, J.H., White, M., Rothfork, J.M., Heiser, P., Colucci-Guyon, E., Lowell, C.A., Gresham, H.D., Allen, P.M., Brown, E.J. Immunity (2003) [Pubmed]
  8. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Heissmeyer, V., Macián, F., Im, S.H., Varma, R., Feske, S., Venuprasad, K., Gu, H., Liu, Y.C., Dustin, M.L., Rao, A. Nat. Immunol. (2004) [Pubmed]
  9. Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. Umemoto, E., Tanaka, T., Kanda, H., Jin, S., Tohya, K., Otani, K., Matsutani, T., Matsumoto, M., Ebisuno, Y., Jang, M.H., Fukuda, M., Hirata, T., Miyasaka, M. J. Exp. Med. (2006) [Pubmed]
  10. Suppression of atopic-like dermatitis by treatment with antibody to lymphocyte function-associated antigen-1 in NC/Nga mouse. Ohmura, T., Konomi, A., Satoh, Y., Hayashi, T., Tsunenari, I., Kadota, T., Panzenbeck, M.J., Satoh, H. Eur. J. Pharmacol. (2004) [Pubmed]
  11. Lymphocyte function-associated antigen-1 is required for maximum elicitation of allergic contact dermatitis. Kondo, S., Kono, T., Brown, W.R., Pastore, S., McKenzie, R.C., Sauder, D.N. Br. J. Dermatol. (1994) [Pubmed]
  12. Reduced streptozotocin-induced insulitis in CD-1 mice by treatment with anti-intercellular adhesion molecule-1 and anti-lymphocyte function associated antigen-1 monoclonal antibodies together with lactic dehydrogenase virus infection. Hayashi, T., Hashimoto, S., Kameyama, Y. International journal of experimental pathology. (1994) [Pubmed]
  13. Eradication of B-CLL by autologous and allogeneic host nonreactive anti-third-party CTLs. Arditti, F.D., Aviner, S., Dekel, B., Krauthgamer, R., Gan, J., Nagler, A., Tabilio, A., Martelli, M., Berrebi, A., Reisner, Y. Blood (2005) [Pubmed]
  14. Lymphocyte function-associated antigen-1-dependent inhibition of corneal wound healing. Li, Z., Burns, A.R., Smith, C.W. Am. J. Pathol. (2006) [Pubmed]
  15. Contributions of LFA-1 and Mac-1 to brain injury and microvascular dysfunction induced by transient middle cerebral artery occlusion. Arumugam, T.V., Salter, J.W., Chidlow, J.H., Ballantyne, C.M., Kevil, C.G., Granger, D.N. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  16. Beta2 integrin modulates platelet caspase activation and life span in mice. Piguet, P.F., Vesin, C., Rochat, A. Eur. J. Cell Biol. (2001) [Pubmed]
  17. Adhesion-related molecules in the central nervous system. Upregulation correlates with inflammatory cell influx during relapsing experimental autoimmune encephalomyelitis. Cannella, B., Cross, A.H., Raine, C.S. Lab. Invest. (1991) [Pubmed]
  18. Lymphocyte function-associated antigen 1 dominates very late antigen 4 in binding of activated T cells to endothelium. van Kooyk, Y., van de Wiel-van Kemenade, E., Weder, P., Huijbens, R.J., Figdor, C.G. J. Exp. Med. (1993) [Pubmed]
  19. Cytokine expression and tumorigenicity of large granular lymphocytic leukemia cells from mice transgenic for the tax gene of human T-cell leukemia virus type I. Grossman, W.J., Ratner, L. Blood (1997) [Pubmed]
  20. Lymphocyte migration to inflamed lacrimal glands is mediated by vascular cell adhesion molecule-1/alpha(4)beta(1) integrin, peripheral node addressin/l-selectin, and lymphocyte function-associated antigen-1 adhesion pathways. Mikulowska-Mennis, A., Xu, B., Berberian, J.M., Michie, S.A. Am. J. Pathol. (2001) [Pubmed]
  21. Acute mast cell-dependent neutrophil recruitment in the skin is mediated by KC and LFA-1: inhibitory mechanisms of dexamethasone. Schramm, R., Schaefer, T., Menger, M.D., Thorlacius, H. J. Leukoc. Biol. (2002) [Pubmed]
  22. Leukocyte adhesion in angiogenic blood vessels. Role of E-selectin, P-selectin, and beta2 integrin in lymphotoxin-mediated leukocyte recruitment in tumor microvessels. Borgström, P., Hughes, G.K., Hansell, P., Wolitsky, B.A., Sriramarao, P. J. Clin. Invest. (1997) [Pubmed]
  23. Mechanisms of drug-induced lupus. II. T cells overexpressing lymphocyte function-associated antigen 1 become autoreactive and cause a lupuslike disease in syngeneic mice. Yung, R., Powers, D., Johnson, K., Amento, E., Carr, D., Laing, T., Yang, J., Chang, S., Hemati, N., Richardson, B. J. Clin. Invest. (1996) [Pubmed]
  24. Ly49Q defines 2 pDC subsets in mice. Kamogawa-Schifter, Y., Ohkawa, J., Namiki, S., Arai, N., Arai, K., Liu, Y. Blood (2005) [Pubmed]
  25. Characterization of lymphocytic infiltrates in normal, preneoplastic, and neoplastic mouse mammary tissues. Wei, W.Z., Malone, K., Mahoney, K., Heppner, G. Cancer Res. (1986) [Pubmed]
  26. Lymphocyte function-associated antigen 1 (LFA-1) contains sulfated N-linked oligosaccharides. Dahms, N.M., Hart, G.W. J. Immunol. (1985) [Pubmed]
  27. ICAM-1 and LFA-1 play critical roles in LPS-induced neutrophil recruitment into the alveolar space. Basit, A., Reutershan, J., Morris, M.A., Solga, M., Rose, C.E., Ley, K. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  28. Inflammatory cytokines up-regulate intercellular adhesion molecule-1 expression on primary cultured mouse hepatocytes and T-lymphocyte adhesion. Morita, M., Watanabe, Y., Akaike, T. Hepatology (1994) [Pubmed]
  29. Monoclonal antibody against actin cross-reacts with the Thy-1 molecule and inhibits lymphocyte function-associated antigen-1 dependent cell-cell interaction of T cells. Nishimura, T., Takeuchi, Y., Gao, X.H., Urano, K., Habu, S. J. Immunol. (1991) [Pubmed]
  30. Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue. Nakajima, H., Sano, H., Nishimura, T., Yoshida, S., Iwamoto, I. J. Exp. Med. (1994) [Pubmed]
  31. Expression of intercellular adhesion molecule-1 in murine hearts with acute myocarditis caused by coxsackievirus B3. Seko, Y., Matsuda, H., Kato, K., Hashimoto, Y., Yagita, H., Okumura, K., Yazaki, Y. J. Clin. Invest. (1993) [Pubmed]
  32. Purification and structural characterization of LFA-1, a lymphocyte function-associated antigen, and Mac-1, a related macrophage differentiation antigen associated with the type three complement receptor. Kürzinger, K., Springer, T.A. J. Biol. Chem. (1982) [Pubmed]
  33. Protective effect of bicyclol on acute hepatic failure induced by lipopolysaccharide and D-galactosamine in mice. Wang, H., Li, Y. Eur. J. Pharmacol. (2006) [Pubmed]
  34. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. Metlay, J.P., Witmer-Pack, M.D., Agger, R., Crowley, M.T., Lawless, D., Steinman, R.M. J. Exp. Med. (1990) [Pubmed]
  35. The role of cytokines, adhesion molecules, and chemokines in interleukin-2-induced lymphocytic infiltration in C57BL/6 mice. Anderson, J.A., Lentsch, A.B., Hadjiminas, D.J., Miller, F.N., Martin, A.W., Nakagawa, K., Edwards, M.J. J. Clin. Invest. (1996) [Pubmed]
  36. The mouse leukocyte adhesion proteins Mac-1 and LFA-1: studies on mRNA translation and protein glycosylation with emphasis on Mac-1. Sastre, L., Kishimoto, T.K., Gee, C., Roberts, T., Springer, T.A. J. Immunol. (1986) [Pubmed]
  37. In vivo migration of radiolabelled lymphocytes in rheumatoid synovial tissue engrafted in SCID mice: implication of beta 2 and beta 7-integrin. Jorgensen, C., Couret, I., Hellier, I., Bologna, C., Canovas, F., Brochier, J., Reme, T., Sany, J. J. Rheumatol. (1996) [Pubmed]
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