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Gene Review

Figf  -  c-fos induced growth factor

Mus musculus

Synonyms: AI325264, FIGF, VEGF-D, Vascular endothelial growth factor D, Vegfd, ...
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Disease relevance of Figf


High impact information on Figf


Biological context of Figf


Anatomical context of Figf

  • The secreted glycoprotein vascular endothelial growth factor-D (VEGF-D) is angiogenic, lymphangiogenic, and promotes metastatic spread of tumor cells via lymphatic vessels [11].
  • VEGF-D, expressed only by cadherin-11-positive cells of the mesenchyme, is first detected at embryonic day (E) 13.5, a period of active vasculogenesis [15].
  • Mouse Vegfd mRNA was expressed in kidney, pregnant oviduct, and neural tissues [12].
  • FIGF overexpression induces morphological alterations in fibroblasts [14].
  • RESULTS: VEGF-D overexpressing clonal MCF-7 and MDA-MB-231 cell lines displayed increased proliferative activities and upregulation of cyclins A, D1 and D3, compared to the vector control [16].

Associations of Figf with chemical compounds

  • Furthermore, in a solid phase binding assay recombinant VEGF-C and -D bound to purified alpha9beta1 integrin in a dose- and cation-dependent fashion showing that VEGF-C and VEGF-D are ligands for the integrin alpha9beta1 [17].
  • Ca(2+) deprivation from the culture medium determined the loss of cadherin-11 from the cell surfaces and down-regulation of Vegf-D mRNA [18].

Regulatory relationships of Figf


Other interactions of Figf

  • These results also suggest that the expression of FIGF in response to c-fos activation induces specific differentiation patterns and its aberrant activation contributes to the malignant phenotype of tumors [14].
  • We show that in the long bones of newborn mice, VEGF-D and VEGFR-3 are expressed in the osteoblasts of the growing plate [21].

Analytical, diagnostic and therapeutic context of Figf


  1. The angiogenic and lymphangiogenic factor vascular endothelial growth factor-D exhibits a paracrine mode of action in cancer. Achen, M.G., Williams, R.A., Baldwin, M.E., Lai, P., Roufail, S., Alitalo, K., Stacker, S.A. Growth Factors (2002) [Pubmed]
  2. Embryonic expression pattern of the murine figf gene, a growth factor belonging to platelet-derived growth factor/vascular endothelial growth factor family. Avantaggiato, V., Orlandini, M., Acampora, D., Oliviero, S., Simeone, A. Mech. Dev. (1998) [Pubmed]
  3. Loss of neural cell adhesion molecule induces tumor metastasis by up-regulating lymphangiogenesis. Crnic, I., Strittmatter, K., Cavallaro, U., Kopfstein, L., Jussila, L., Alitalo, K., Christofori, G. Cancer Res. (2004) [Pubmed]
  4. Distinct roles of vascular endothelial growth factor-d in lymphangiogenesis and metastasis. Kopfstein, L., Veikkola, T., Djonov, V.G., Baeriswyl, V., Schomber, T., Strittmatter, K., Stacker, S.A., Achen, M.G., Alitalo, K., Christofori, G. Am. J. Pathol. (2007) [Pubmed]
  5. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics. Stacker, S.A., Caesar, C., Baldwin, M.E., Thornton, G.E., Williams, R.A., Prevo, R., Jackson, D.G., Nishikawa, S., Kubo, H., Achen, M.G. Nat. Med. (2001) [Pubmed]
  6. Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. Mäkinen, T., Jussila, L., Veikkola, T., Karpanen, T., Kettunen, M.I., Pulkkanen, K.J., Kauppinen, R., Jackson, D.G., Kubo, H., Nishikawa, S., Ylä-Herttuala, S., Alitalo, K. Nat. Med. (2001) [Pubmed]
  7. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins. Karkkainen, M.J., Haiko, P., Sainio, K., Partanen, J., Taipale, J., Petrova, T.V., Jeltsch, M., Jackson, D.G., Talikka, M., Rauvala, H., Betsholtz, C., Alitalo, K. Nat. Immunol. (2004) [Pubmed]
  8. Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis. Nagy, J.A., Vasile, E., Feng, D., Sundberg, C., Brown, L.F., Detmar, M.J., Lawitts, J.A., Benjamin, L., Tan, X., Manseau, E.J., Dvorak, A.M., Dvorak, H.F. J. Exp. Med. (2002) [Pubmed]
  9. Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. Baluk, P., Tammela, T., Ator, E., Lyubynska, N., Achen, M.G., Hicklin, D.J., Jeltsch, M., Petrova, T.V., Pytowski, B., Stacker, S.A., Ylä-Herttuala, S., Jackson, D.G., Alitalo, K., McDonald, D.M. J. Clin. Invest. (2005) [Pubmed]
  10. c-fos-induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro. Marconcini, L., Marchio, S., Morbidelli, L., Cartocci, E., Albini, A., Ziche, M., Bussolino, F., Oliviero, S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  11. Multiple forms of mouse vascular endothelial growth factor-D are generated by RNA splicing and proteolysis. Baldwin, M.E., Roufail, S., Halford, M.M., Alitalo, K., Stacker, S.A., Achen, M.G. J. Biol. Chem. (2001) [Pubmed]
  12. Comparative integromics on VEGF family members. Katoh, Y., Katoh, M. Int. J. Oncol. (2006) [Pubmed]
  13. Restricted expression pattern of vegf-d in the adult and fetal mouse: high expression in the embryonic lung. Farnebo, F., Piehl, F., Lagercrantz, J. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  14. Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family. Orlandini, M., Marconcini, L., Ferruzzi, R., Oliviero, S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  15. Mesenchymal expression of vascular endothelial growth factors D and A defines vascular patterning in developing lung. Greenberg, J.M., Thompson, F.Y., Brooks, S.K., Shannon, J.M., McCormick-Shannon, K., Cameron, J.E., Mallory, B.P., Akeson, A.L. Dev. Dyn. (2002) [Pubmed]
  16. A potential role for vascular endothelial growth factor-D as an autocrine growth factor for human breast carcinoma cells. Akahane, M., Akahane, T., Shah, A., Okajima, E., Thorgeirsson, U.P. Anticancer Res. (2005) [Pubmed]
  17. The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1. Vlahakis, N.E., Young, B.A., Atakilit, A., Sheppard, D. J. Biol. Chem. (2005) [Pubmed]
  18. In fibroblasts Vegf-D expression is induced by cell-cell contact mediated by cadherin-11. Orlandini, M., Oliviero, S. J. Biol. Chem. (2001) [Pubmed]
  19. A mutant form of vascular endothelial growth factor (VEGF) that lacks VEGF receptor-2 activation retains the ability to induce vascular permeability. Stacker, S.A., Vitali, A., Caesar, C., Domagala, T., Groenen, L.C., Nice, E., Achen, M.G., Wilks, A.F. J. Biol. Chem. (1999) [Pubmed]
  20. Enhancement of pleural dissemination and lymph node metastasis of intrathoracic lung cancer cells by vascular endothelial growth factors (VEGFs). Ishii, H., Yazawa, T., Sato, H., Suzuki, T., Ikeda, M., Hayashi, Y., Takanashi, Y., Kitamura, H. Lung Cancer (2004) [Pubmed]
  21. Vascular endothelial growth factor-D activates VEGFR-3 expressed in osteoblasts inducing their differentiation. Orlandini, M., Spreafico, A., Bardelli, M., Rocchigiani, M., Salameh, A., Nucciotti, S., Capperucci, C., Frediani, B., Oliviero, S. J. Biol. Chem. (2006) [Pubmed]
  22. Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer. Von Marschall, Z., Scholz, A., Stacker, S.A., Achen, M.G., Jackson, D.G., Alves, F., Schirner, M., Haberey, M., Thierauch, K.H., Wiedenmann, B., Rosewicz, S. Int. J. Oncol. (2005) [Pubmed]
  23. Regulation of vascular endothelial growth factor (VEGF)-C and VEGF-D expression by the organ microenvironment in human colon carcinoma. Onogawa, S., Kitadai, Y., Tanaka, S., Kuwai, T., Kuroda, T., Chayama, K. Eur. J. Cancer (2004) [Pubmed]
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