Gene Review:
vpu - p16
Human immunodeficiency virus 1
- Immunogenicity of a novel DNA vaccine cassette expressing multiple human immunodeficiency virus (HIV-1) accessory genes. Ayyavoo, V., Kudchodkar, S., Ramanathan, M.P., Le, P., Muthumani, K., Megalai, N.M., Dentchev, T., Santiago-Barrios, L., Mrinalini, C., Weiner, D.B. AIDS (2000)
- Characterization of a novel simian immunodeficiency virus (SIVmonNG1) genome sequence from a mona monkey (Cercopithecus mona). Barlow, K.L., Ajao, A.O., Clewley, J.P. J. Virol. (2003)
- Murine retroviral vector that induces long-term expression of HIV-1 envelope protein. Fujita, K., Maldarelli, F., Purcell, D.F., Silver, J. J. Virol. Methods (1994)
- Contribution of Vpu, Env, and Nef to CD4 down-modulation and resistance of human immunodeficiency virus type 1-infected T cells to superinfection. Wildum, S., Schindler, M., Münch, J., Kirchhoff, F. J. Virol. (2006)
- The human immunodeficiency virus type 1 (HIV-1) Vpu protein interferes with an early step in the biosynthesis of major histocompatibility complex (MHC) class I molecules. Kerkau, T., Bacik, I., Bennink, J.R., Yewdell, J.W., Húnig, T., Schimpl, A., Schubert, U. J. Exp. Med. (1997)
- Identification of a new human immunodeficiency virus type 1 distinct from group M and group O. Simon, F., Mauclère, P., Roques, P., Loussert-Ajaka, I., Müller-Trutwin, M.C., Saragosti, S., Georges-Courbot, M.C., Barré-Sinoussi, F., Brun-Vézinet, F. Nat. Med. (1998)
- A novel gene of HIV-1, vpu, and its 16-kilodalton product. Strebel, K., Klimkait, T., Martin, M.A. Science (1988)
- Rev is necessary for translation but not cytoplasmic accumulation of HIV-1 vif, vpr, and env/vpu 2 RNAs. Arrigo, S.J., Chen, I.S. Genes Dev. (1991)
- Phosphorylation of both phosphoacceptor sites in the HIV-1 Vpu cytoplasmic domain is essential for Vpu-mediated ER degradation of CD4. Paul, M., Jabbar, M.A. Virology (1997)
- Functional analysis of the phosphorylation sites on the human immunodeficiency virus type 1 Vpu protein. Friborg, J., Ladha, A., Göttlinger, H., Haseltine, W.A., Cohen, E.A. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. (1995)
- The presence of the casein kinase II phosphorylation sites of Vpu enhances the CD4(+) T cell loss caused by the simian-human immunodeficiency virus SHIV(KU-lbMC33) in pig-tailed macaques. Singh, D.K., Griffin, D.M., Pacyniak, E., Jackson, M., Werle, M.J., Wisdom, B., Sun, F., Hout, D.R., Pinson, D.M., Gunderson, R.S., Powers, M.F., Wong, S.W., Stephens, E.B. Virology (2003)
- The human immunodeficiency virus type 1 Vpu protein enhances membrane permeability. González, M.E., Carrasco, L. Biochemistry (1998)
- Substitution of the transmembrane domain of Vpu in simian-human immunodeficiency virus (SHIVKU1bMC33) with that of M2 of influenza A results in a virus that is sensitive to inhibitors of the M2 ion channel and is pathogenic for pig-tailed macaques. Hout, D.R., Gomez, M.L., Pacyniak, E., Gomez, L.M., Fegley, B., Mulcahy, E.R., Hill, M.S., Culley, N., Pinson, D.M., Nothnick, W., Powers, M.F., Wong, S.W., Stephens, E.B. Virology (2006)
- Downregulation of CD4 is required for maintenance of viral infectivity of HIV-1. Tanaka, M., Ueno, T., Nakahara, T., Sasaki, K., Ishimoto, A., Sakai, H. Virology (2003)
- A simian human immunodeficiency virus with a nonfunctional Vpu (deltavpuSHIV(KU-1bMC33)) isolated from a macaque with neuroAIDS has selected for mutations in env and nef that contributed to its pathogenic phenotype. Singh, D.K., McCormick, C., Pacyniak, E., Lawrence, K., Dalton, S.B., Pinson, D.M., Sun, F., Berman, N.E., Calvert, M., Gunderson, R.S., Wong, S.W., Stephens, E.B. Virology (2001)
- Natural infection of chimpanzees with new lentiviruses related to HIV-1/SIVcpz. Takehisa, J., Bikandou, B., Ido, E., Mboudjeka, I., M'Vouenze, R., Nzoukoudi, M.Y., Harada, Y., Yamaguchi-Kabata, Y., Miura, T., M'Pandi, M., Parra, H.J., M'Pelé, P., Hayami, M. J. Med. Primatol. (1999)
- HIV-1 Genes vpr and nef Synergistically Damage Podocytes, Leading to Glomerulosclerosis. Zuo, Y., Matsusaka, T., Zhong, J., Ma, J., Ma, L.J., Hanna, Z., Jolicoeur, P., Fogo, A.B., Ichikawa, I. J. Am. Soc. Nephrol. (2006)
- A molecular clone of simian-human immunodeficiency virus (DeltavpuSHIV(KU-1bMC33)) with a truncated, non-membrane-bound vpu results in rapid CD4(+) T cell loss and neuro-AIDS in pig-tailed macaques. McCormick-Davis, C., Dalton, S.B., Hout, D.R., Singh, D.K., Berman, N.E., Yong, C., Pinson, D.M., Foresman, L., Stephens, E.B. Virology (2000)
- Intracellular membrane traffic of human immunodeficiency virus type 1 envelope glycoproteins: vpu liberates Golgi-targeted gp160 from CD4-dependent retention in the endoplasmic reticulum. Kimura, T., Nishikawa, M., Ohyama, A. J. Biochem. (1994)
- A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. Margottin, F., Bour, S.P., Durand, H., Selig, L., Benichou, S., Richard, V., Thomas, D., Strebel, K., Benarous, R. Mol. Cell (1998)
- Membrane interactions and alignment of structures within the HIV-1 Vpu cytoplasmic domain: effect of phosphorylation of serines 52 and 56. Henklein, P., Kinder, R., Schubert, U., Bechinger, B. FEBS Lett. (2000)
- The human immunodeficiency virus type 1 encoded Vpu protein is phosphorylated by casein kinase-2 (CK-2) at positions Ser52 and Ser56 within a predicted alpha-helix-turn-alpha-helix-motif. Schubert, U., Henklein, P., Boldyreff, B., Wingender, E., Strebel, K., Porstmann, T. J. Mol. Biol. (1994)
- Degradation of CD4 induced by human immunodeficiency virus type 1 Vpu protein: a predicted alpha-helix structure in the proximal cytoplasmic region of CD4 contributes to Vpu sensitivity. Yao, X.J., Friborg, J., Checroune, F., Gratton, S., Boisvert, F., Sékaly, R.P., Cohen, E.A. Virology (1995)
- Changes in the host range and growth potential of an HIV-1 clone are conferred by the vpu gene. Du, B., Wolf, A., Lee, S., Terwilliger, E. Virology (1993)
- Env and Vpu proteins of human immunodeficiency virus type 1 are produced from multiple bicistronic mRNAs. Schwartz, S., Felber, B.K., Fenyö, E.M., Pavlakis, G.N. J. Virol. (1990)
- Modulation of cell surface protein expression by infection with HIV-1. Speth, C., Dierich, M.P. Leukemia (1999)
- Cells surviving infection by human immunodeficiency virus type 1: vif or vpu mutants produce non-infectious or markedly less cytopathic viruses. Kishi, M., Nishino, Y., Sumiya, M., Ohki, K., Kimura, T., Goto, T., Nakai, M., Kakinuma, M., Ikuta, K. J. Gen. Virol. (1992)
- Association of Vpu-binding protein with microtubules and Vpu-dependent redistribution of HIV-1 Gag protein. Handley, M.A., Paddock, S., Dall, A., Panganiban, A.T. Virology (2001)
- Interaction between the cytoplasmic domains of HIV-1 Vpu and CD4: role of Vpu residues involved in CD4 interaction and in vitro CD4 degradation. Margottin, F., Benichou, S., Durand, H., Richard, V., Liu, L.X., Gomas, E., Benarous, R. Virology (1996)
- Human-immunodeficiency-virus-type-1-encoded Vpu protein is phosphorylated by casein kinase II. Schubert, U., Schneider, T., Henklein, P., Hoffmann, K., Berthold, E., Hauser, H., Pauli, G., Porstmann, T. Eur. J. Biochem. (1992)
- Presence of Intact vpu and nef genes in nonpathogenic SHIV is essential for acquisition of pathogenicity of this virus by serial passage in macaques. Mackay, G.A., Niu, Y., Liu, Z.Q., Mukherjee, S., Li, Z., Adany, I., Buch, S., Zhuge, W., McClure, H.M., Narayan, O., Smith, M.S. Virology (2002)