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Gene Review

Il6r  -  interleukin 6 receptor

Rattus norvegicus

Synonyms: IL-6 receptor subunit alpha, IL-6R 1, IL-6R subunit alpha, IL-6R-alpha, IL-6RA, ...
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Disease relevance of Il6ra


Psychiatry related information on Il6ra


High impact information on Il6ra


Biological context of Il6ra


Anatomical context of Il6ra


Associations of Il6ra with chemical compounds


Physical interactions of Il6ra


Regulatory relationships of Il6ra

  • Rat anti-mouse IL-6 receptor antibody effectively blocked biological activity of all three sources of IL-6 [19].
  • In growth-arrested H-35 cells, TGF-beta still enhances the IL-6R expression but it attenuates all IL-6 effects on APP genes [20].

Other interactions of Il6ra

  • However, PRL had no effect on IL-6R mRNA levels [11].
  • In examining potential mechanisms for this synergy it was found that TGF-beta increased IL-6 receptor expression [21].
  • A mild and late induction of the IL-6R, LIF-R, and IL-11R occurred after seizure with a scattered distribution [22].
  • These findings suggest that the CNTF-induced stimulation of fibrinogen gene expression occurs, at least in part, by this cytokine's interaction with the IL-6 receptor [23].
  • Moreover, our results demonstrate that a Trk receptor-specific cellular response can be achieved in the absence of NGF through amplification of its basal signaling activity by the IL-6 receptor system [24].

Analytical, diagnostic and therapeutic context of Il6ra


  1. Interleukin-6 and IL-6 receptor cell expression in testis of rats with autoimmune orchitis. Rival, C., Theas, M.S., Guazzone, V.A., Lustig, L. J. Reprod. Immunol. (2006) [Pubmed]
  2. Regulation of CCAAT/Enhancer binding protein, interleukin-6, interleukin-6 receptor, and gp130 expression during myocardial ischemia/reperfusion. Chandrasekar, B., Mitchell, D.H., Colston, J.T., Freeman, G.L. Circulation (1999) [Pubmed]
  3. Differential effects of interleukin-6 receptor activation on intracellular signaling and bone resorption by isolated rat osteoclasts. Moonga, B.S., Adebanjo, O.A., Wang, H.J., Li, S., Wu, X.B., Troen, B., Inzerillo, A., Abe, E., Minkin, C., Huang, C.L., Zaidi, M. J. Endocrinol. (2002) [Pubmed]
  4. Cytokines oncostatin M and interleukin 1 regulate the expression of the IL-6 receptor (gp80, gp130). Geisterfer, M., Richards, C.D., Gauldie, J. Cytokine (1995) [Pubmed]
  5. Exogenous interleukin-6 increases cold allodynia in rats with a mononeuropathy. Vissers, K.C., De Jongh, R.F., Hoffmann, V.L., Meert, T.F. Cytokine (2005) [Pubmed]
  6. Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome. Bensadoun, J.C., de Almeida, L.P., Dréano, M., Aebischer, P., Déglon, N. Eur. J. Neurosci. (2001) [Pubmed]
  7. Adenyl cyclase and interleukin 6 are downstream effectors of parathyroid hormone resulting in stimulation of bone resorption. Greenfield, E.M., Shaw, S.M., Gornik, S.A., Banks, M.A. J. Clin. Invest. (1995) [Pubmed]
  8. Mode of action of interleukin-6 on mature osteoclasts. Novel interactions with extracellular Ca2+ sensing in the regulation of osteoclastic bone resorption. Adebanjo, O.A., Moonga, B.S., Yamate, T., Sun, L., Minkin, C., Abe, E., Zaidi, M. J. Cell Biol. (1998) [Pubmed]
  9. Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6. Ihara, S., Nakajima, K., Fukada, T., Hibi, M., Nagata, S., Hirano, T., Fukui, Y. EMBO J. (1997) [Pubmed]
  10. A histologically distinctive interstitial pneumonia induced by overexpression of the interleukin 6, transforming growth factor beta 1, or platelet-derived growth factor B gene. Yoshida, M., Sakuma, J., Hayashi, S., Abe, K., Saito, I., Harada, S., Sakatani, M., Yamamoto, S., Matsumoto, N., Kaneda, Y. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  11. The expression of interleukin-6 (IL-6), IL-6 receptor, and gp130-kilodalton glycoprotein in the rat decidua and a decidual cell line: regulation by 17beta-estradiol and prolactin. Deb, S., Tessier, C., Prigent-Tessier, A., Barkai, U., Ferguson-Gottschall, S., Srivastava, R.K., Faliszek, J., Gibori, G. Endocrinology (1999) [Pubmed]
  12. Gene regulation by interleukin 6. Fey, G.H., Hattori, M., Hocke, G., Brechner, T., Baffet, G., Baumann, M., Baumann, H., Northemann, W. Biochimie (1991) [Pubmed]
  13. Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain. Schöbitz, B., de Kloet, E.R., Sutanto, W., Holsboer, F. Eur. J. Neurosci. (1993) [Pubmed]
  14. Regulation of IL-6 and the hepatic IL-6 receptor in acute inflammation in vivo. Geisterfer, M., Richards, C., Baumann, M., Fey, G., Gywnne, D., Gauldie, J. Cytokine (1993) [Pubmed]
  15. The expression of interleukin-6 in the pregnant rat corpus luteum and its regulation by progesterone and glucocorticoid. Telleria, C.M., Ou, J., Sugino, N., Ferguson, S., Gibori, G. Endocrinology (1998) [Pubmed]
  16. Interleukin-6 is a needed proinflammatory cytokine in the prolonged neural activity and transcriptional activation of corticotropin-releasing factor during endotoxemia. Vallières, L., Rivest, S. Endocrinology (1999) [Pubmed]
  17. Effects of odorants on the hypothalamic-pituitary-adrenal axis and interleukin-6 (IL-6) and IL-6 receptor mRNA expression in rat hypothalamus after restraint stress. Komori, T., Miyahara, S., Yamamoto, M., Matsumoto, T., Zhang, K., Nakagawa, M., Nomura, S., Motomura, E., Shiroyama, T., Okazaki, Y. Chem. Senses (2003) [Pubmed]
  18. Interleukin-6 and ciliary neurotrophic factor trigger janus kinase activation and early gene response in rat hepatocytes. Wang, Y., Fuller, G.M. Gene (1995) [Pubmed]
  19. Expression and functional characterization of killer whale (Orcinus orca) interleukin-6 (IL-6) and development of a competitive immunoassay. Funke, C., King, D.P., McBain, J.F., Adelung, D., Stott, J.L. Vet. Immunol. Immunopathol. (2003) [Pubmed]
  20. Divergent transforming growth factor-beta effects on IL-6 regulation of acute phase plasma proteins in rat hepatoma cells. Campos, S.P., Wang, Y., Koj, A., Baumann, H. J. Immunol. (1993) [Pubmed]
  21. Interleukin-6 and transforming growth factor-beta synergistically stimulate chondrosarcoma cell proliferation. Guerne, P.A., Lotz, M. J. Cell. Physiol. (1991) [Pubmed]
  22. Spatiotemporal distribution of gp130 cytokines and their receptors after status epilepticus: comparison with neuronal degeneration and microglial activation. Rosell, D.R., Nacher, J., Akama, K.T., McEwen, B.S. Neuroscience (2003) [Pubmed]
  23. Ciliary neurotrophic factor regulates fibrinogen gene expression in hepatocytes by binding to the interleukin-6 receptor. Nesbitt, J.E., Fuentes, N.L., Fuller, G.M. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  24. Interleukin-6 induces expression of peripherin and cooperates with Trk receptor signaling to promote neuronal differentiation in PC12 cells. Sterneck, E., Kaplan, D.R., Johnson, P.F. J. Neurochem. (1996) [Pubmed]
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