Disease relevance of Il6ra

• Interleukin-6 and IL-6 receptor cell expression in testis of rats with autoimmune orchitis [1].
• Significant upregulation in IL-6, IL-6R, and gp130 occurred only at 24 hours of sustained ischemia [2].
• In contrast, the IL-6 receptor (IL-6R)-specific agonist antibody MT-18 inhibited bone resorption in a concentration-dependent manner (1:500 to 1:500 000) [3].
• The steady-state mRNA levels of the interleukin 6 receptor (IL-6R, gp80) and its signal transducing molecule, gp130, were examined in the rat hepatoma cell line, H-35, stimulated by cytokines IL-6, IL-1, oncostatin M (OSM) and/or Dexamethasone (Dex) [4].
• In peripheral nerve injury models, IL-6 and IL-6R are increased at the injured nerve and the respective dorsal root ganglion [5].

Psychiatry related information on Il6ra

• These results suggest that the IL6/IL6R chimera is a potential treatment for Huntington's disease [6].

High impact information on Il6ra

• More importantly, an antibody directed against the IL-6 receptor blocks moderate stimulation of osteoclast activity induced by the hormone [7].
• The IL-6 effect was abrogated by excess soluble IL-6 receptor (500 microg/l) [8].
• VOXEL-based confocal microscopy of nonpermeabilized osteoclasts incubated with anti- IL-6 receptor antibodies revealed intense, strictly peripheral plasma membrane fluorescence [8].
• We explored the signals required for neurite outgrowth of PC12 cells by using a series of mutants of a chimeric receptor consisting of the extracellular domain of the granulocyte-colony stimulating factor (G-CSF) receptor and the cytoplasmic domain of gp130, a signal-transducing subunit of the IL-6 receptor [9].
• Human interleukin (IL) 6 and IL-6 receptor genes induced lymphocytic alveolitis without marked fibroblast proliferation [10].

Biological context of Il6ra

• Total RNA obtained from rat decidual tissue on different days of pseudopregnancy was analyzed by RT-PCR using specific primers for IL-6, IL-6R, and 130-kDa glycoprotein (gp130) [11].
• Thus, common elements probably operate in the IL-6 signal transduction cascade in liver cells and B cells; (b), we have cloned the rat liver IL-6 receptor (IL-6-R) and derived its amino acid sequence [12].
• Our results suggest that IL-6 and IL-6R may be involved in the pathogenesis of autoimmune orchitis by promoting testicular inflammation and germ cell apoptosis [1].
• Our results suggest that IL-6 mRNA and IL-6R mRNA are colocalized, thus supporting a role of the cytokine in autocrine and paracrine communication [13].
• Regulation of IL-6R gene expression in the liver in vivo depends on a complex interaction between the hepatocyte and a combination of cytokines and other hormones [14].

Anatomical context of Il6ra

• It was 53% identical to the human leukocyte IL-6-R and all functional domains were highly conserved [12].
• A significant increase was noted in the number of IL-6R+ germ cells in rats with EAO compared to control rats [1].
• IL-6R immunoreactivity was observed in macrophages, Leydig and germ cells [1].
• Expression and regulation of C/EBP in rat myocardium after ischemia and reperfusion has not been defined, nor has the behavior of the specific IL-6 receptor (IL-6R) or the signal transducer gp130 [2].
• In summary, results of this investigation have revealed that the rat corpus luteum expresses the IL-6 receptor system and that luteal cells are able to secrete IL-6 [15].

Associations of Il6ra with chemical compounds

• This inhibition is induced by PRL and estradiol, which down-regulate not only IL-6 expression, but also the expression of IL-6 receptor and signaling proteins [11].
• Neuroprotective effect of interleukin-6 and IL6/IL6R chimera in the quinolinic acid rat model of Huntington's syndrome [6].
• Using in situ hybridization, we observed that IL-6R was barely expressed in the PVN under basal conditions, but was rapidly produced in response to LPS [16].
• In the air group, IL-6 and IL-6R mRNA levels were significantly reduced and serum levels of ACTH and corticosterone significantly increased relative to the control [17].
• In comparison, citralva restored the expression of IL-6 and IL-6R mRNAs and significantly increased serum ACTH and corticosterone levels [17].

Physical interactions of Il6ra

• Previous studies showed that CNTF regulates fibrinogen gene expression in rat hepatocytes by competitive binding to the IL-6 receptor [18].

Regulatory relationships of Il6ra

• Rat anti-mouse IL-6 receptor antibody effectively blocked biological activity of all three sources of IL-6 [19].
• In growth-arrested H-35 cells, TGF-beta still enhances the IL-6R expression but it attenuates all IL-6 effects on APP genes [20].

Other interactions of Il6ra

• However, PRL had no effect on IL-6R mRNA levels [11].
• In examining potential mechanisms for this synergy it was found that TGF-beta increased IL-6 receptor expression [21].
• A mild and late induction of the IL-6R, LIF-R, and IL-11R occurred after seizure with a scattered distribution [22].
• These findings suggest that the CNTF-induced stimulation of fibrinogen gene expression occurs, at least in part, by this cytokine's interaction with the IL-6 receptor [23].
• Moreover, our results demonstrate that a Trk receptor-specific cellular response can be achieved in the absence of NGF through amplification of its basal signaling activity by the IL-6 receptor system [24].

Analytical, diagnostic and therapeutic context of Il6ra

• IL-6R mRNA and protein were not detected in controls, but its mRNA was induced at 1 hour of reperfusion and its protein at 2 hours of reperfusion [2].
• The mRNAs for IL-6 and IL-6R in hippocampus and cerebellum are not different, as shown by Northern blot analyses of RNA isolated from these tissues [13].
• The expression of IL-6 receptor mRNA in hepatocytes increased markedly as early as 3 h after treatment and message levels began to decline by 6-12 h in all three models [14].
• To analyze the individual effects of raised corticosterone and IL-6 on the expression of hepatic IL-6R mRNA, rats were injected with either dexamethasone (Dex) or purified recombinant rat IL-6 (rIL-6) via intraperitoneal injection [14].
• IL-6 receptor expression in single osteoclasts was confirmed by in situ reverse transcriptase PCR histochemistry [8].

References